DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment didum and Myo7b

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:NP_001178870.1 Gene:Myo7b / 498834 RGDID:1561153 Length:2152 Species:Rattus norvegicus


Alignment Length:1702 Identity:471/1702 - (27%)
Similarity:731/1702 - (42%) Gaps:374/1702 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    46 GKLKEVKLK-------------ADGSDLPPLR--NPAILVGQNDLTTLSYLHEPGVLHNLRVRFC 95
            |.:||.||.             ....||..||  :|....|.:|:..|..|:|.||:|||.:|: 
  Rat    26 GIVKETKLGKTLIEDDEGKEHWISAEDLSTLRPMHPNSAQGVDDMIRLGDLNEAGVVHNLLIRY- 89

  Fly    96 ERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLEPHIFALAEEAYTKLERENCNLSI 160
            ::..||||.|.||||:||:..:|||....::.|....||:|.||:||:|...|..:::...:...
  Rat    90 QQHKIYTYTGSILVAVNPFQMLPLYTLEQVQIYYSRHMGELPPHVFAIANSCYFNMKKNKRDQCC 154

  Fly   161 IVSGESGAGKTVSAKYAMRYFAAVGGSESETQVERKVLASSPIMEAFGNAKTTRNDNSSRFGKFT 225
            |:|||||||||.:.|..:::.|.|.|..|  .:|::||.::||:||||||||.||||||||||:.
  Rat   155 IISGESGAGKTETTKLILQFLATVSGQHS--WIEQQVLEANPILEAFGNAKTIRNDNSSRFGKYI 217

  Fly   226 KLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHIFYQLCAARSKYPE--LVLDHQDKFQ 288
            .:.| |..||  ::||::..:|||||||..||..||||||||.:....|...:  |.|....::.
  Rat   218 DIHF-NSSGV--IEGASIEHFLLEKSRVCRQAAEERNYHIFYCMLMGMSLEEKNMLGLGMPSEYH 279

  Fly   289 FLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIADIVKILAGILHLGNIQ-VSKKFNEGSEE 352
            :|.||.....|.:|||:.:.....||.:|.||..:..||.|:||.||||||:. ::..|      
  Rat   280 YLTMGNCTSYEGLSDAKDYAHVRSAMKILQFSDSENWDISKLLAAILHLGNVGFMAAVF------ 338

  Fly   353 EDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHI 417
            |:.||.|:..... ......||.|....||..|:...|..:.|:|..|.:|..|...|||..|.|
  Rat   339 ENLDSSDVMETPA-FPFAMKLLEVQHQALRDCLIKHTIPILGEFVSRPLNIAQAADRRDAFVKGI 402

  Fly   418 YAKLFQYIVGVLNKSLNNGSKQ-----CSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQ 477
            |..||.:||..:|.::.....|     ...||:|||:|||.|:.|||||.|||:|||.|||.|.:
  Rat   403 YGHLFLWIVKKINAAIFTPQAQDPQNVRRAIGLLDIFGFENFQNNSFEQLCINFANEHLQQFFVK 467

  Fly   478 HVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIESR-LGVLDLLDEECRMPKGSDESWAGKL--IG 539
            |||.:||||||.|.|||..|.:.||||.:|::..: :.::.|||||.|.|:|:|.:...||  |.
  Rat   468 HVFTMEQEEYLSENITWNYIHYTDNQPILDMLALKPMSIISLLDEESRFPQGTDVTMLQKLNSIH 532

  Fly   540 KCNKFPHFEKPR-FGTTSFFIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTL 603
            ..||  .|.:|: ...|.|.|.||:..|.|...||||||||.:|.::..::..|.....|::..|
  Rat   533 ANNK--SFLRPKSIHDTRFGIAHFAGDVYYQAEGFLEKNRDVLSTDILILIHSSKNKFLKEIFNL 595

  Fly   604 E------EIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLASLI 662
            :      ...|:|  ..|:.| ||::.      :..:.|:|.|        |:.|||::||..|:
  Rat   596 DLPQTKLGHGTIC--QVKTKT-GGQIF------KPSDSTKRSV--------TLSSQFKQSLEQLM 643

  Fly   663 STLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQL 727
            ..|....|::|||||||:.|....::....|||||..|::|||.|..:|||.|:.:.:|..|:::
  Rat   644 KILTNCQPYFVRCIKPNEYKKPLLFDRELCIQQLRYSGMMETVHIRKSGFPIRYTFDEFSQRFRV 708

  Fly   728 LV---YRSKLDKNDMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIV 789
            |:   .|.:......:::.| |....:..:.:::.|.|:||.:..|...||..|:.........:
  Rat   709 LLPSPERVQFQNKHRQMTSR-IADLCLGTDKEWKMGKTKIFLKDHQDTMLEIQRSQALDGAAIRI 772

  Fly   790 QSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAGLILSKYARGWLCRRRYLRLR 854
            |.|:|...||::|||.::....:|...||:..|:..:        |||..:.|            
  Rat   773 QRVLRGHKYRKEFLRQKRAAVTLQAVWRGHNQRKNFK--------LILMGFER------------ 817

  Fly   855 HSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAYQKRRRNIIICQAAIRRFLARR 919
                 :|..||..|...:|..||.  :.||:|...||.|.|:..|.:||.::|.||..|..:||:
  Rat   818 -----LQAIARSHLLMRQFQTMRQ--KIVQLQARCRGYLVRQQVQAKRRAVVIIQAHARGMVARK 875

  Fly   920 KFKRMKAEA-KTISHMENKYMGLENKIISMQQRIDELNRDNSNLKHKTSEISVLK---------- 973
            .:.:.|:.. ..|...|.|..|:            .|:|...::....::.::::          
  Rat   876 SYWQQKSSGPPVILAKEPKGQGV------------ALDRKRKSIYDTVTDTAMVEKVFGFLPAMI 928

  Fly   974 -------------MKLELKKTLEAEFKNV---KAACQDKDKLIEALNKQLEAERDEKMQ------ 1016
                         ::::.:|..|.:...|   :...:|.|.|.|....:......:|..      
  Rat   929 GGQEGPAPTRFEDLEVKTQKLHEVDLDTVPMTEMPGEDVDGLAEYTFPKFAVTYFQKSASHTHIQ 993

  Fly  1017 -------LLEEN----GHAQEEWI---------SQKQTWRQEN---EELRRQIDEIIDMAKNAEV 1058
                   |..||    ..|...||         .:.|.:.:.:   ..:.|||.:.:|   ...|
  Rat   994 KPLRYPLLYHENDTDHSAALAVWIIILRFMGDLPEPQAYGRSSLTGSSVMRQIHDRLD---KDSV 1055

  Fly  1059 NQRNQEDRMLAEIDNRELNEAYQRAIKDKEVIENENFMLKEELSRLTAGSFSLHARKASNASSQN 1123
            .|..|.        ||....|.|:.| .:||.:.:..:....:|.|....|.             
  Rat  1056 TQGPQH--------NRSTQVASQQNI-GEEVFKFDGPISDRPMSNLEKVHFI------------- 1098

  Fly  1124 EDDVGYASAKNTLDINRPPDLLSKNYSYNDSTSLVVKLRSILEEEKQKHKVLQEQYIKLSSRHK- 1187
               ||||..:        |.|..:.|.                   |..|.|.|.| |.|||.: 
  Rat  1099 ---VGYAIMR--------PGLRDEIYC-------------------QICKQLSENY-KTSSRARG 1132

  Fly  1188 -----------PTEDSFRVSELEVENEKLRSEY-----DQLRTSIKHGVEIN-----ELNA---- 1227
                       |..:.|....|...::...| |     ::|:.:..:||...     ||.|    
  Rat  1133 WILLSLCLGCFPPSERFMKYLLNFISQGPAS-YGPFCAERLQRTFANGVRAEPPTWLELQAVKSK 1196

  Fly  1228 QHAALQ-------------EEVRRRREECIQLKAVLLQQSQSMRSLEPESLQMR--------GND 1271
            :|..:|             :.....||.|.|     :.|.|.:|.....|||:.        ||.
  Rat  1197 KHIPIQVILATGRSLTISVDSASTSREICQQ-----IAQKQGLRDKLGFSLQVAVYDKFWSLGNS 1256

  Fly  1272 VNELMEAF-HSQKLINRQLESELKA----------ITEEHNSKLVEMTQEI-----------ERL 1314
            .:.:|:|. ..::|...:.||:.:|          .|..|:|:...::.|:           ...
  Rat  1257 CDHVMDAVAQCEQLAWERGESQRQAPWRIYFRKEFFTPWHDSREDPVSTELIYHQVLRGVWSGEY 1321

  Fly  1315 NNEKDELQKVMFESIDEFEDSNVDTLRQNDRYLRRELQKAVAQFLLVQEELKLANAKLKAYRQDG 1379
            |.||:|                             :|.:.:|:...||..   |..|..|.::  
  Rat  1322 NFEKEE-----------------------------DLVELLARHCYVQLG---ATVKSNAVQE-- 1352

  Fly  1380 GQLEHKIEEEMIRNKSNG------TSADVGANVTKQKSQNPQGLMKFHSSDLDKILQRLLSA--L 1436
             .|...:..::.|.||..      .:|...|..|:.|:...:  :|..:.:..::|..||.:  .
  Rat  1353 -LLPSCVPSKLYRTKSPEKWASLVIAAHAKAPYTQSKATPLE--VKEQTVEAARLLWPLLFSRLF 1414

  Fly  1437 TPRTVVGLLPGFPAYLIFMCIRYTDLTNADDDVRELLSKFVIQIKKMHRTPHPIENRVIWLVNSI 1501
            ...|:.|  |..|...:.:.|.:..:...|...|.||.....::..:      |.||......|:
  Rat  1415 EVTTLSG--PRLPKTQLILAINWKGMYFLDQKERTLLGLSFAEVMGL------IANRDAPGGKSL 1471

  Fly  1502 TLLNLMKQY------------------GDVDEYVKFNTEKQNQQQLKNFNLFEYRRVILDLIVNL 1548
            .|..|.::|                  ..:.|...|....|:::...:..|..:::.  ||::  
  Rat  1472 LLSTLHEEYEFASPSSVAIAEMVALFLAGLKERSVFAMALQDRKATDDVTLLPFKKG--DLLI-- 1532

  Fly  1549 YQALIMQIQGLL 1560
                :.:.||||
  Rat  1533 ----LTKKQGLL 1540

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 283/733 (39%)
MYSc_Myo5 84..767 CDD:276831 274/703 (39%)
IQ 900..922 CDD:197470 8/21 (38%)
GBP_C <971..1086 CDD:303769 27/169 (16%)
coiled coil 1049..1068 CDD:293879 4/18 (22%)
coiled coil 1077..1086 CDD:293879 3/8 (38%)
JAKMIP_CC3 <1190..1299 CDD:292653 31/154 (20%)
Myo5_CBD 1424..1792 CDD:271254 29/157 (18%)
Myo7bNP_001178870.1 MYSc 60..761 CDD:214580 283/733 (39%)
MYSc_Myo7 79..750 CDD:276832 274/703 (39%)
IQ 787..809 CDD:197470 5/21 (24%)
MyTH4 991..1194 CDD:214535 51/259 (20%)
B41 1201..1414 CDD:214604 46/254 (18%)
FERM_B-lobe 1304..1405 CDD:271216 21/137 (15%)
FERM_C1_MyoVII 1408..1504 CDD:270019 18/103 (17%)
SH3 1505..1565 CDD:302595 9/44 (20%)
MyTH4 1646..1793 CDD:214535
B41 1802..2014 CDD:214604
FERM_M 1912..2014 CDD:278785
FERM_C2_MyoVII 2010..2105 CDD:270020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100101
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

Return to query results.
Submit another query.