DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment didum and Myo19

DIOPT Version :9

Sequence 1:	NP_724569.1	Gene:	didum / 35680	FlyBaseID:	FBgn0261397	Length:	1800	Species:	Drosophila melanogaster
Sequence 2:	NP_001157208.1	Gene:	Myo19 / 497974	RGDID:	1559961	Length:	964	Species:	Rattus norvegicus

Alignment Length:	951	Identity:	302/951 - (31%)
Similarity:	455/951 - (47%)	Gaps:	187/951 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 LKAD-----GSDLPPLRNPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAIN 112
            ||.|     |.::|       |...:|||.::.:....||..|:.|:.| .|.||..|..|||:|
  Rat    20 LKGDLREFLGGEVP-------LHQLDDLTKVNPVTLETVLRCLQARYTE-DIFYTNAGCTLVALN 76

  Fly   113 PYAEMP-LYGPSIIRAYRGHAMGD---LEPHIFALAEEAYTKLER--ENCNLSIIVSGESGAGKT 171
            |:..:| ||.|.:::.|  ||...   |:||||.:.|:.|..::.  |..|.||:||||||||||
  Rat    77 PFKHIPQLYAPELMQEY--HAAPQPQKLKPHIFTVGEQTYRNVKSLIEPINQSIVVSGESGAGKT 139

  Fly   172 VSAKYAMRYFAAVGGSESETQ-------VERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKL-L 228
            .:::..|:::|.|..|.:..:       :|.::|.|:|:|||||||.|.||:||||||||.:| |
  Rat   140 WTSRCLMKFYAVVAASPTSCENHKMAERIEERILNSNPVMEAFGNACTLRNNNSSRFGKFIQLQL 204

  Fly   229 FRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHIFYQLCAARSKYPEL--VLDHQDKFQFLN 291
            .|.|.    :.||.:.||||||:||..||..|||:|||||:|...:|...|  .|.....|.:|
  Rat   205 NRAQQ----MTGAAVQTYLLEKTRVACQAASERNFHIFYQICKGATKEERLQWCLPEGTAFSWL- 264

  Fly   292 MGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSD 356
                |..|...:.:.|..|.:||..||.......:|.|:|||:|||||:...      ..|:::.
  Rat   265 ----PNPESSLEEDCFEVTREAMLHLGIDTPTQNNIFKVLAGLLHLGNVHFV------DSEDEAQ 319

  Fly   357 SCDIFHNDI-HLQITADLLRVSADDLRRWLLMRKIESVNEYVLI--PNSIEAAQAARDALAKHIY 418
            .|.:..... .::.:|.||::..:.|...:.:|.|::..:..:.  |.|.......||.|||.||
  Rat   320 PCQLMDGTKGSVRTSALLLQLPDNMLLESMQIRTIKAGKQQQVFQKPCSRAECDTRRDCLAKLIY 384

  Fly   419 AKLFQYIVGVLNKSL-NNGSKQCSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKL 482
            |:||.::|.|:|.|: .:.|...:|||:||:||||:|..||.||.|||||||||||.|..|..:.
  Rat   385 ARLFDWLVSVINSSICADFSSWTAFIGLLDVYGFESFPDNSLEQLCINYANEKLQQHFVAHYLRA 449

  Fly   483 EQEEYLKEGITWTMIDFYDNQPCIDLIE-SRLGVLDLLDEECRMPKGS---------DESWAGK- 536
            :||||..||:.|:.:::.|||.|:||:| |.:.:..|::||||:.:.|         :.:.||:
  Rat   450 QQEEYEVEGLEWSFVNYQDNQTCLDLLEGSPISICSLINEECRLNRPSSAAQLQTRIESTLAGRP 514

  Fly   537 LIG--KCNKFPHFEKPRFGTTSFFIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQ 599
            .:|  |.::.|          ||.:.||:..|.|...|.:|||:|.|..|||.:|.:|...|...
  Rat   515 CLGHNKLSREP----------SFVVMHFAGPVRYCTAGLVEKNKDPVPPELTGLLQQSQDPLLMM 569

  Fly   600 VM-------TLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQES 657
            :.       |.||             |.|:                    |:....||.|:|:.|
  Rat   570 LFPANPEEKTQEE-------------LSGQ--------------------SRAPALTVVSKFKAS 601

  Fly   658 LASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFY 722
            |..|:..||.|||||:||||||.......:...:::.||.|||::||:.|||||||.|..:.:|.
  Rat   602 LEQLLQVLHKTTPHYIRCIKPNSQSQPQTFLQEEVLNQLEACGLVETIHISAAGFPIRVSHQNFM 666

  Fly   723 MRYQLLVYRSKLDKNDMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYIT 787
            .||:||........:.::..|.             ..|::            ||...........
  Rat   667 ERYKLLTRLRPRTSSGLRSLCP-------------AKGSS------------EQPLCAKEATLQP 706

  Fly   788 IVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAGLILSKYARGWLCRRRYLR 852
            ::|.::                     ||...|.:..|.....|:...|      ...|.|..:.
  Rat   707 LLQDIL---------------------HALPALIQTATTPSDPAKTAQI------PLYCGRTKIF 744

  Fly   853 LRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAYQKRRRNIIICQAAIRRFLA 917
            :..|:..:....|..:.......::..:|..::|:          .:|:||..:|.|||.|.:|.
  Rat   745 MTDSMLELLECGRAQMLEQCARCIQCGWRRHRLQK----------QEKQRRAAVIIQAAFRSWLT 799

  Fly   918 RRKFKRMKAEAKTISHMENKYM------------GLENKII 946
            |:..:|:...|..|.|..:|:.            |:|.|::
  Rat   800 RKHIRRLHIAATVIKHAWHKWRIRMACLASKELDGMEEKLM 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc	65..778	CDD:214580	266/752 (35%)
		MYSc_Myo5	84..767	CDD:276831	260/722 (36%)
		IQ	900..922	CDD:197470	10/21 (48%)
		GBP_C	<971..1086	CDD:303769
		coiled coil	1049..1068	CDD:293879
		coiled coil	1077..1086	CDD:293879
		JAKMIP_CC3	<1190..1299	CDD:292653
		Myo5_CBD	1424..1792	CDD:271254
Myo19	NP_001157208.1	MYSc	38..754	CDD:214580	275/828 (33%)
		MYSc_Myo19	49..746	CDD:276846	271/809 (33%)
		IQ	784..804	CDD:279006	9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311886at2759
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820