Protein Alignment didum and myo6

DIOPT Version :10

• Sequence 1: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Sequence 2: XP_031758531.1
• Gene: myo6 / 493193
• XenbaseID: XB-GENE-1012303
• Length: 1300
• Species: Xenopus tropicalis
• Alignment Length: 1446
• Identity: 398/1446 - (27%)
• Similarity: 646/1446 - (44%)
• Gaps: 372/1446 - (25%)

  Fly    11 GAKIWVPH----------ADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLRN 65
            |..:|.||          .|:..:|.|:|...:||..||      ..:.:|        .|...:
 Frog     4 GKPVWAPHPTDGFQLGKIVDIGPDSLTIEPLNQKGKTFL------APINQV--------FPAEED 54

  Fly    66 PAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMP-LYGPSIIRAYR 129
            .:..|..|  .:|.||:|..:|||::||: .:..||||...||:|:|||.::| ||....|:.|.
 Frog    55 TSKHVEDN--CSLMYLNEATLLHNIQVRY-SKDKIYTYVANILIAVNPYFDVPKLYTSEQIKQYH 116

  Fly   130 GHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESETQVE 194
            |.::|.|.||::|:|::|:..::....:.|||||||||||||.:.|:.:||.....||..:  ::
 Frog   117 GKSLGTLPPHVYAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTESYGSGQD--ID 179

  Fly   195 RKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQG 259
            .:::.::|::||||||||.||:||||||||.::.|..:..|:   |..:..|||||||:..|.|.
 Frog   180 ERIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKNSVV---GGFVSHYLLEKSRICVQGQD 241

  Fly   260 ERNYHIFYQLCAARSKYPE-----LVLDHQDKFQFLNMG-------------------------- 293
            ||||||||:|||..   ||     |.|...|.|::||.|
 Frog   242 ERNYHIFYRLCAGA---PEDIRQKLFLCSPDTFRYLNRGCTRYFASKDTDKQILQNRKSPEEDEY 303

  Fly   294 ---GAPEIERVSDAEQFNETVQAMTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEEEDS 355
               ||.:...:.|...||....||..:|....:..|:.:::||:||||||.    |.|..  ..|
 Frog   304 LKHGALKDPLLDDHGDFNRMCIAMKKIGLDDTEKLDLFRVVAGVLHLGNID----FEEAG--STS 362

  Fly   356 DSCDIFHNDIH-LQITADLLRVSADDLR-----RWLLMRKIESVNEYVLIPNSIEAAQAARDALA 414
            ..|.:...... ||..|.||.:..|||:     |.:|.....:....:.:|..::.|:.||||||
 Frog   363 GGCTLRKKSSESLQCCAKLLGLDQDDLQVSLTSRVMLTTAGGTKGTVIKVPLKVQQAENARDALA 427

  Fly   415 KHIYAKLFQYIVGVLNKSLNNGSKQC-------SFIGVLDIYGFETFEVNSFEQFCINYANEKLQ 472
            |.||:.||.::|..:|        ||       .|||||||.|||.||.||||||||||.|||||
 Frog   428 KAIYSHLFDHVVNRVN--------QCFPFERSSFFIGVLDIAGFEYFEHNSFEQFCINYCNEKLQ 484

  Fly   473 QQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIESRL-GVLDLLDEECRMPKGSDESWAGK 536
            |.||:.:.|.|||.|.|||:....:.:.|||.||||||::| |:||:||||.|:|:.:|:.:...
 Frog   485 QFFNERILKEEQELYQKEGLGVNEVHYVDNQDCIDLIEAKLVGILDILDEENRLPQPTDQHFTSA 549

  Fly   537 LIGKCNKFPHFEKPRFGTTS----------FFIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSE 591
            :..|.........||....:          |.::||:..|.|:...|:|||.|.:...|..::.|
 Frog   550 VHQKHKNHFRLTIPRKSKLAVHRNIRDDEGFIVRHFAGAVCYETTQFVEKNNDALHMSLESLICE 614

  Fly   592 SNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQE 656
            |.....:::.          :||.:.                .|.:::.  .|....:||::|:.
 Frog   615 SKDKFVRELF----------ESANNH----------------KDLKQKT--GKLSFISVGNKFKT 651

  Fly   657 SLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDF 721
            .|..|:..|.:|...::||||||....:.::|.|:|:.||:..|::..:.:...|||||..:.:.
 Frog   652 QLNLLLEKLRSTGSSFIRCIKPNLKMTSHQFEGAQILSQLQCSGMVSVLDLMQGGFPSRASFHEL 716

  Fly   722 YMRYQLLVYRSKLDKNDMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYI 786
            |..|:..: .:|:.:.|.:|.|:.:......:|:.|:||.|::|||.|:.|..:|
 Frog   717 YNMYKKYM-PAKMSRLDPRLFCKALFKALGLNENDYKFGLTKVFFRPGKFAEFDQ---------- 770

  Fly   787 TIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAGLILSKYARGWLCRRRYL 851
                                     |.|....:||    :.:|.....||.|::.:...|....:
 Frog   771 -------------------------IMKSDPDHLA----ELIRRVNHWLICSRWKKVQWCALCVI 806

  Fly   852 RLRHSISGIQTYARGMLARNKFHAMRDHYRA---VQIQRFVRGALARRAYQKRRRNIIICQAAIR 913
            :|::.|                     .|||   :::|:.:|..|.|:.::.|...::
 Frog   807 KLKNKI---------------------QYRASACIKMQKTIRMWLCRKKHKPRIDGMV------- 843

  Fly   914 RFLARRKFKRMKAEAKTISHMENKYMGLENKIISMQQRIDELNRDNSNLKHKTSEISVLKMKLEL 978
                                          |:.::::|:|:.|...:.||...:|:|.....|||
 Frog   844 ------------------------------KVQTLKKRLDKFNEVVNALKEGKAEMSKQVKDLEL 878

  Fly   979 ---------------KKTLEAEFKN-VKAACQDKDKLIEALNKQLEAERDEKMQLLEENGHAQEE 1027
                           ::.:|.|:.| ||::.|..:.|.:...::.||||..|:|          |
 Frog   879 SIDALLSKIKNTIMTREQIEREYDNLVKSSGQLLNSLQKRKKEEEEAERLHKIQ----------E 933

  Fly  1028 WISQKQTWRQENEELRRQID-------EIIDMAKNAEVNQRNQED---RMLAEID-----NRELN 1077
            .:.:::..|:..|||||:.:       ||....|..|..::.:|:   |:.||::     :|| .
 Frog   934 EMERERKRREAEEELRRKEENERRLKAEIEAKRKQEEEERKKREEEEKRIQAEVEMQLARDRE-E 997

  Fly  1078 EAYQRAIKDKEVIENENFMLKEELSRLTAGSFSLHARKASNASSQNEDDVGYASAKNTLDINRPP 1142
            |:.|:||.::|..:.|..|      |:.          .|.|...|||....|...:|:.:.:|.
 Frog   998 ESQQQAILEQERRDRELAM------RIA----------QSEAELINEDGPDSALRSDTVGVLQPS 1046

  Fly  1143 DLLSKNY-SYNDSTSLVVKLRSILEEEKQKHKVLQEQYIKLSSRHKPTEDSFRVSELEVENEKLR 1206
            .:   || :..|.|.|.::     |..|:...:|..     ..:.:.|:.:..|.:.::...|
 Frog  1047 PV---NYKAGEDRTKLTME-----EMAKEMTDILSR-----GGQVQATKSAASVKKHDLSKWK-- 1096

  Fly  1207 SEYDQLRTSIKHGVEINELNAQHAALQEEVRRRREECIQLKAVLLQQSQSMRSLEPESLQMRGND 1271
              |.:||.:|....:|..|    ||.:||..||
 Frog  1097 --YAELRDAINTSCDIELL----AACREEFHRR-------------------------------- 1123

  Fly  1272 VNELMEAFHSQKLINRQLESEL-----KAITE------EHNS-------KLVEMTQEIERLNNEK 1318
                ::.:|:.|..|::..::.     |::|:      .:||       :|....|||| :|.::
 Frog  1124 ----LKVYHAWKSKNKKRNADTEQRAPKSVTDYDFAPFMNNSPQQNPVVQLPARQQEIE-MNRQQ 1183

  Fly  1319 DELQKVMFESIDEFED 1334
            ...:.......|:::|
 Frog  1184 RYFRIPFIRPADQYKD 1199

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	259/741 (35%)
		IQ	900..922	CDD:197470	1/21 (5%)
		SMC_prok_B	<942..1365	CDD:274008	95/443 (21%)
		Myo5_CBD	1424..1792	CDD:271254
myo6	XP_031758531.1	Myosin_N	2..40	CDD:460670	10/35 (29%)
		MYSc_Myo6	71..761	CDD:276833	259/741 (35%)
		CBD_MYO6-like	772..916	CDD:409646	35/205 (17%)
		MYO6_MIU_linker	1001..1074	CDD:412090	23/96 (24%)
		MyUb_Myo6	1088..1128	CDD:439319	13/83 (16%)
		Myosin-VI_CBD	1183..1273	CDD:465157	2/17 (12%)