DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment didum and MYO9B

DIOPT Version :10

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:NP_004136.2 Gene:MYO9B / 4650 HGNCID:7609 Length:2157 Species:Homo sapiens


Alignment Length:2029 Identity:506/2029 - (24%)
Similarity:819/2029 - (40%) Gaps:553/2029 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 GAKIWV-------PHADLVWESATLEESYRKGAGF--LKICTDSGKLKEV--KLKADGSDLPPLR 64
            |.:.||       .|..|:|.....:|..::...:  |:.....|.:|.|  :|.|..:....|.
Human    72 GGEEWVLDANDSPVHRVLLWPRRAQDEHPQEDGYYFLLQERNADGTIKYVHMQLVAQATATRRLV 136

  Fly    65 NPAILVGQ----NDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSII 125
            ...:|..|    :||..|..|.|..:|.||:.||.: |.||||.|.|||||||:..:|:|.|..:
Human   137 ERGLLPRQQADFDDLCNLPELTEGNLLKNLKHRFLQ-QKIYTYAGSILVAINPFKFLPIYNPKYV 200

  Fly   126 RAYRGHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESE 190
            :.|....:|.||||:||||:.||..:.|:..|..|::|||||:|||.|..:.:....|:......
Human   201 KMYENQQLGKLEPHVFALADVAYYTMLRKRVNQCIVISGESGSGKTQSTNFLIHCLTALSQKGYA 265

  Fly   191 TQVERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVY 255
            :.|||.:|.:.|::||||||||..|:||||||||.::.:. :.|:  ::||.:..|||||||:|.
Human   266 SGVERTILGAGPVLEAFGNAKTAHNNNSSRFGKFIQVSYL-ESGI--VRGAVVEKYLLEKSRLVS 327

  Fly   256 QAQGERNYHIFYQLC--AARSKYPELVLDHQDKFQFLNMGGAPEIERVSDAE----QFNETVQAM 314
            |.:.|||||:||.|.  .:..:..|..|...:.:.:||....    ::.|.|    .|....|||
Human   328 QEKDERNYHVFYYLLLGVSEEERQEFQLKQPEDYFYLNQHNL----KIEDGEDLKHDFERLKQAM 388

  Fly   315 TVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSAD 379
            .::||.......|..:|:.||:|||:...|:.. |.||    ..::...:: |...:.||:|..:
Human   389 EMVGFLPATKKQIFAVLSAILYLGNVTYKKRAT-GREE----GLEVGPPEV-LDTLSQLLKVKRE 447

  Fly   380 DLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIV-----GVLNKSLNNGSKQ 439
            .|...|..||..:||:.:::|.|:..|..|||::||.:|:.||.:||     .:|||.....:..
Human   448 ILVEVLTKRKTVTVNDKLILPYSLSEAITARDSMAKSLYSALFDWIVLRINHALLNKKDVEEAVS 512

  Fly   440 CSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQP 504
            |..||||||:|||.||.|||||||||||||:||..||||:||||||||..|||||..|.:.||..
Human   513 CLSIGVLDIFGFEDFERNSFEQFCINYANEQLQYYFNQHIFKLEQEEYQGEGITWHNIGYTDNVG 577

  Fly   505 CIDLIESR-LGVLDLLDEECRMPKGSDESWAGKLIGKCNKFPHFEKPRF-GT----TSFFIKHFS 563
            ||.||..: .|:..|||||...|..:.::...|.     |..|.:...| ||    .:|.|:||:
Human   578 CIHLISKKPTGLFYLLDEESNFPHATSQTLLAKF-----KQQHEDNKYFLGTPVMEPAFIIQHFA 637

  Fly   564 DTVEYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAG 628
            ..|:|.:..|.|||.|.:..::..:|..|:.|..::::.::.:........:::.....|:..||
Human   638 GKVKYQIKDFREKNMDYMRPDIVALLRGSDSSYVRELIGMDPVAVFRWAVLRAAIRAMAVLREAG 702

  Fly   629 RKQ--------------------------------------------------QGNDTR------ 637
            |.:                                                  ||.|.|      
Human   703 RLRAERAEKAAGMSSPGAQSHPEELPRGASTPSEKLYRDLHNQMIKSIKGLPWQGEDPRSLLQSL 767

  Fly   638 ------------------RRVVP-----SKQ--------------------HRK----TVGSQFQ 655
                              ::::|     ||.                    |:|    ::.:|||
Human   768 SRLQKPRAFILKSKGIKQKQIIPKNLLDSKSLKLIISMTLHDRTTKSLLHLHKKKKPPSISAQFQ 832

  Fly   656 ESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPD 720
            .||..|:..|....|.::|||:.|.:|....::...::||||..|:||||||..:|:.:::.:.|
Human   833 TSLNKLLEALGKAEPFFIRCIRSNAEKKELCFDDELVLQQLRYTGMLETVRIRRSGYSAKYTFQD 897

  Fly   721 FYMRYQLLVYRSKLDKNDMKLSCRNIVMKWIQ----DEDKYRFGNTQIFFRAGQVAFLEQV--RA 779
            |..::|:|     |.|:..  .||.::...::    |:..|:.|.|::|.:..:...|::.  |.
Human   898 FTEQFQVL-----LPKDAQ--PCREVISTLLEKMKIDKRNYQIGKTKVFLKETERQALQETLHRE 955

  Fly   780 NLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLAR---ERTQKMREARAGLILSKYA 841
            .:||  |.::||..|..:.||.||::::....||...|.|..|   ||||      |.:.|....
Human   956 VVRK--ILLLQSWFRMVLERRHFLQMKRAAVTIQACWRSYRVRRALERTQ------AAVYLQASW 1012

  Fly   842 RGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAYQKRRRNII 906
            ||:..|:.|...:.||..:|:..||.|.|..|..|...              .::|.:|.|..:.
Human  1013 RGYWQRKLYRHQKQSIIRLQSLCRGHLQRKSFSQMISE--------------KQKAEEKEREALE 1063

  Fly   907 ICQAAIRRFLARRKFKRMKAEAKTISHM------ENKYMGLENKIISMQQRIDELNRDNSNLKHK 965
            ..:|.     |....:...|..:.::..      :..::..|.::         ...|.|.|:|.
Human  1064 AARAG-----AEEGGQGQAAGGQQVAEQGPEPAEDGGHLASEPEV---------QPSDRSPLEHS 1114

  Fly   966 TSEISVLKMKLELKKTLEAEFKNVKAACQDKDKLIEALNKQLEAERDEKMQLLE-ENGHAQEEWI 1029
            :.|    |.....:|||..: |.|.|...:|   :.:..::.|:.|...::.:: :|.|.     
Human  1115 SPE----KEAPSPEKTLPPQ-KTVAAESHEK---VPSSREKRESRRQRGLEHVKFQNKHI----- 1166

  Fly  1030 SQKQTWRQEN---EELRRQIDEIIDMAKNAEVNQRNQEDRMLAEIDNRELNEAYQRAIKDKEVI- 1090
               |:.::|:   |..||...|  ......|..:.::||..|..::....|.:.::..:..:.: 
Human  1167 ---QSCKEESALREPSRRVTQE--QGVSLLEDKKESREDETLLVVETEAENTSQKQPTEQPQAMA 1226

  Fly  1091 ------ENENFM-----LKEELSRLTAGSFSLHARKASNASSQNEDDVGYASAKNT-LDINRP-- 1141
                  |.|..:     ...:|.|.|  |.:|.:|.:..|.         .||..| .|.::|  
Human  1227 VGKVSEETEKTLPSGSPRPGQLERPT--SLALDSRVSPPAP---------GSAPETPEDKSKPCG 1280

  Fly  1142 -PDLLSKNYSYNDSTSL-----VVKLRSILEEEKQKHKV-------LQEQYIKLSSRHK------ 1187
             |.:..|..|...||.:     ..:|.|.:|..:.|..|       :..|.:.||.||:      
Human  1281 SPRVQEKPDSPGGSTQIQRYLDAERLASAVELWRGKKLVAAASPSAMLSQSLDLSDRHRATGAAL 1345

  Fly  1188 -PTED---SFRVSELEVENEKLRSEYDQLRTSIKHGVEINELNAQHAALQEEVRRRREECIQLKA 1248
             |||:   ||..|::           .:|..|:        ..||.||                 
Human  1346 TPTEERRTSFSTSDV-----------SKLLPSL--------AKAQPAA----------------- 1374

  Fly  1249 VLLQQSQSMRSLEPESLQ-MRGNDVNELMEAFHSQKLINRQLESELKAITEEHNSKLVEMTQEIE 1312
               :.:...||.:..::| .:..|.:.|.:|..|.   ..|::|:                ...:
Human  1375 ---ETTDGERSAKKPAVQKKKPGDASSLPDAGLSP---GSQVDSK----------------STFK 1417

  Fly  1313 RLNNEKDELQKVMFESIDEFEDSNVDTLRQNDRYLRRELQKAVAQFLLVQEELKLANAKLKAYRQ 1377
            ||...|.:.:|...|..:                   ||:.||:..::::     |....|....
Human  1418 RLFLHKTKDKKYSLEGAE-------------------ELENAVSGHVVLE-----ATTMKKGLEA 1458

  Fly  1378 DGGQLEHKIEEEMIRNKSNGTSADVGANVTKQKSQNPQ-GLMKFHSSDLDKILQRLLSALTPRTV 1441
            ..|| :|:......|.|..|...        :|::|.: |.:.......:.:.:::.:|..    
Human  1459 PSGQ-QHRHAAGEKRTKEPGGKG--------KKNRNVKIGKITVSEKWRESVFRQITNANE---- 1510

  Fly  1442 VGLLPGFPAYLIFMCIRYTD--LTNADDDVR-----------ELLSKFVIQIKKMHRTPHPIENR 1493
                           ::|.|  |.|..:|:|           |...||...||.|:..|    |.
Human  1511 ---------------LKYLDEFLLNKINDLRSQKTPIESLFIEATEKFRSNIKTMYSVP----NG 1556

  Fly  1494 VIWLVNSITLLNLMKQYGDVDEYVKFNTEKQNQQQLKNFNLFEYRRVILDLIVNLYQALIMQIQG 1558
            .|    .:...:||:.|    :.|..|...:..|:..|            |::||:|:|:     
Human  1557 KI----HVGYKDLMENY----QIVVSNLATERGQKDTN------------LVLNLFQSLL----- 1596

  Fly  1559 LLDPKIVPAILNNDEIQRG---------RQAHGMRSRATSIGASSSPEHGGGPAWKQLIGQLEHF 1614
                         ||..||         :|:...:.:.....|..  ||.|            |.
Human  1597 -------------DEFTRGYTKNDFEPVKQSKAQKKKRKQERAVQ--EHNG------------HV 1634

  Fly  1615 YKQFQHFGLDNCYAEQIFHQLLYFI--------CAVALNCLMLRGDICMWETGMIIRYNIGCIED 1671
            :..:|.....:|      .|.|.:|        |:|   |.|.....|:.:......|..|    
Human  1635 FASYQVSIPQSC------EQCLSYIWLMDKALLCSV---CKMTCHKKCVHKIQSHCSYTYG---- 1686

  Fly  1672 WVRSKKMSNDVLTALAPLNQVSQLLQSRKSEQDVQT----IC-DLCTSLSTAQVLKVMKSYKLDD 1731
                                       ||.|..|:.    :| |..|| ..|.|..|::  ||.:
Human  1687 ---------------------------RKGEPGVEPGHFGVCVDSLTS-DKASVPIVLE--KLLE 1721

  Fly  1732 YESEITNVFLEKLTEKLNA----RQMQKS--------NSDEFTID----------QKFIQPFKVV 1774
            : .|:..::.|.|..|..|    |:::::        ..:.|.|.          ::..:|....
Human  1722 H-VEMHGLYTEGLYRKSGAANRTRELRQALQTDPAAVKLENFPIHAITGVLKQWLRELPEPLMTF 1785

  Fly  1775 FRYSDIKLEDIELP 1788
            .:|.|. |..:|||
Human  1786 AQYGDF-LRAVELP 1798

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc_Myo5 84..767 CDD:276831 266/806 (33%)
IQ 900..922 CDD:197470 4/21 (19%)
SMC_prok_B <942..1365 CDD:274008 88/465 (19%)
Myo5_CBD 1424..1792 CDD:271254 78/422 (18%)
MYO9BNP_004136.2 RA_Myosin-IXb 16..112 CDD:340737 8/39 (21%)
MYSc_Myo9 160..941 CDD:276836 266/806 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 709..734 0/24 (0%)
Actin-binding. /evidence=ECO:0000305 844..855 4/10 (40%)
Neck or regulatory domain. /evidence=ECO:0000305 940..1044 34/111 (31%)
IQCD 972..>1001 CDD:467745 9/28 (32%)
IQ 1000..1022 CDD:197470 9/27 (33%)
Tail. /evidence=ECO:0000305 1045..2157 184/1022 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1046..1298 55/308 (18%)
PTZ00121 <1050..1630 CDD:173412 139/790 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1320..1410 24/131 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1455..1484 7/37 (19%)
C1_Myosin-IXb 1628..1685 CDD:410434 15/79 (19%)
RhoGAP_myosin_IXB 1698..1883 CDD:239872 24/106 (23%)
Interaction with RHOA. /evidence=ECO:0000269|PubMed:26529257 1739..1744 1/4 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1980..2157
PHA03307 <1985..>2140 CDD:223039
Blue background indicates that the domain is not in the aligned region.

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