Protein Alignment didum and MYO9A

DIOPT Version :10

• Sequence 1: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Sequence 2: XP_011519915.1
• Gene: MYO9A / 4649
• HGNCID: 7608
• Length: 2638
• Species: Homo sapiens
• Alignment Length: 2226
• Identity: 531/2226 - (23%)
• Similarity: 873/2226 - (39%)
• Gaps: 679/2226 - (30%)

  Fly    73 NDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLE 137
            :||.:|..|:|..:|.|||.|| :.:.||||.|.||:.|||:..:|:|.|..::.|..|.:|.||
Human   149 DDLCSLPDLNEKTLLENLRNRF-KHEKIYTYVGSILIVINPFKFLPIYNPKYVKMYDNHQLGKLE 212

  Fly   138 PHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESETQVERKVLASSP 202
            |||:|:|:.||..:.:...|..|::|||||:|||.|..:.:.:..|:......:.||:.:|.:.|
Human   213 PHIYAVADVAYHAMLQRKKNQCIVISGESGSGKTQSTNFLIHHLTALSQKGFASGVEQIILGAGP 277

  Fly   203 IMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHIFY 267
            ::||||||||..|:||||||||.::.::....|:   ||.:..|||||||:|||...|||||:||
Human   278 VLEAFGNAKTAHNNNSSRFGKFIQVNYQETGTVL---GAYVEKYLLEKSRLVYQEHNERNYHVFY 339

  Fly   268 QLCAARS---------KYPELVLDHQDKFQFLNM---------------GGAPE---IERVSDAE 305
            .|.|..|         |.||       ::.:||.               ...|:   :|......
Human   340 YLLAGASEDERSAFHLKQPE-------EYHYLNQITKKPLRQSWDDYCYDSEPDCFTVEGEDLRH 397

  Fly   306 QFNETVQAMTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQIT 370
            .|.....||.::||..:....|..:|:.|||||||...||...      .||.||.:.:: |.|.
Human   398 DFERLQLAMEMVGFLPKTRRQIFSLLSAILHLGNICYKKKTYR------DDSIDICNPEV-LPIV 455

  Fly   371 ADLLRVSADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLN----- 430
            ::||.|..:.|...|:.||..:|.|.:::|..:..|...|:::||.:|:.||.:||..:|
Human   456 SELLEVKEEMLFEALVTRKTVTVGEKLILPYKLAEAVTVRNSMAKSLYSALFDWIVFRINHALLN 520

  Fly   431 -KSLNNGSKQCSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITW 494
             |.|.:.:|..| ||||||:|||.:|.|||||||||:|||:||..||||:||||||||..|||:|
Human   521 SKDLEHNTKTLS-IGVLDIFGFEDYENNSFEQFCINFANERLQHYFNQHIFKLEQEEYRTEGISW 584

  Fly   495 TMIDFYDNQPCIDLIESR-LGVLDLLDEECRMPKGSDESWAGKLIGKCNKFPHFEKPRFGTTSFF 558
            ..||:.||..||:||..: .|:|.|||||...|:.::::...|...:.....:.|.|.....:|.
Human   585 HNIDYIDNTCCINLISKKPTGLLHLLDEESNFPQATNQTLLDKFKHQHEDNSYIEFPAVMEPAFI 649

  Fly   559 IKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEI----------------- 606
            |||::..|:|.|..|.|||.|.:..::..:|..|..:....::.::.:
Human   650 IKHYAGKVKYGVKDFREKNTDHMRPDIVALLRSSKNAFISGMIGIDPVAVFRWAILRAFFRAMVA 714

  Fly   607 ----------------DTL----------------------------CVDSAKSST--------- 618
                            ||.                            |.:...|.|
Human   715 FREAGKRNIHRKTGHDDTAPCAILKSMDSFSFLQHPVHQRSLEILQRCKEEKYSITRKNPRTPLS 779

  Fly   619 --------------------LGGRVVISAGRKQQGND------------------------TRRR 639
                                ..||..|...|...|..                        ||.:
Human   780 DLQGMNALNEKNQHDTFDIAWNGRTGIRQSRLSSGTSLLDKDGIFANSTSSKLLERAHGILTRNK 844

  Fly   640 VVPSKQ-------------------------------HRK----TVGSQFQESLASLISTLHATT 669
            ...||.                               |:|    ::.:|||.||:.|:.||....
Human   845 NFKSKPALPKHLLEVNSLKHLTRLTLQDRITKSLLHLHKKKKPPSISAQFQASLSKLMETLGQAE 909

  Fly   670 PHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKL 734
            |::|:||:.|.:|:..::....:::|||..|:||||||..:|:.|::.:.||...:.:|:.|:.:
Human   910 PYFVKCIRSNAEKLPLRFSDVLVLRQLRYTGMLETVRIRQSGYSSKYSFQDFVSHFHVLLPRNII 974

  Fly   735 DKNDMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVY- 798
            ..   |.:.::...|...:.|.|:.|.|.:|.:       ||.|.:|:.   .:.|.|:||.:.
Human   975 PS---KFNIQDFFRKINLNPDNYQVGKTMVFLK-------EQERQHLQD---LLHQEVLRRIILL 1026

  Fly   799 ---------RRQFLRIQKVINGIQKHARGYLARERTQKMREARAGLILSKYA-------RGWLCR 847
                     |:.||.:::....||:..|.||.:::.:.....:...:::..|       |..|.|
Human  1027 QRWFRVLLCRQHFLHLRQASVIIQRFWRNYLNQKQVRDAAVQKDAFVMASAAALLQASWRAHLER 1091

  Fly   848 RRYLRLRHSISGIQTYARGMLARNKFHAMRDHYR-----AVQIQRFVRGALARRAYQKRRRNIII 907
            :|||.||         |..::.:.|:   ||:||     |:.||...:.....:.||::|:.||:
Human  1092 QRYLELR---------AAAIVIQQKW---RDYYRRRHMAAICIQARWKAYRESKRYQEQRKKIIL 1144

  Fly   908 CQAAIRRFLARRKFKRMKAEAKTISHMENKYMGLENKIISMQQRIDELNRDNSNLKHKTSEISVL 972
            .|:..|.|.||::||.:|                       :||          |:....|:.::
Human  1145 LQSTCRGFRARQRFKALK-----------------------EQR----------LRETKPEVGLV 1176

  Fly   973 KMK----LELKKTLEAEFKNVKAACQDKDKLIEALNKQLEA---ERDEKMQLLEENGHAQEEWI- 1029
            .:|    ||::.:..:.:::  .:..::.|.||.....:|:   .|:..:..|:|:.:.|:|..
Human  1177 NIKGYGSLEIQGSDPSGWED--CSFDNRIKAIEECKSVIESNRISRESSVDCLKESPNKQQERAQ 1239

  Fly  1030 SQKQTWRQENEELRRQIDEIIDMAKNAEVNQRNQEDRMLAEIDNRELNEAYQRAIKDKEVIE--- 1091
            ||.....||:..:|.:...:.|:.:. :|.:..:|.|.:.|:         ::||...|:::
Human  1240 SQSGVDLQEDVLVRERPRSLEDLHQK-KVGRAKRESRRMREL---------EQAIFSLELLKVRS 1294

  Fly  1092 ------NENFMLKEEL-------------SRLTAGSFSLHARKASNASS-----QNEDDVGYASA 1132
                  :|:.....||             |..:.||..|.:.:.|..|.     .:|.|:.:.|.
Human  1295 LGGISPSEDRRWSTELVPEGLQSPRGTPDSESSQGSLELLSYEESQKSKLESVISDEGDLQFPSP 1359

  Fly  1133 KNTLDINRPPDLLSKN--YSYNDSTSLVVKLRSILEEEKQKHKVLQEQYIKLSSRH---KP-TED 1191
            |    |:..|...|::  .|.::.||         ..|..|...::|..: .||..   || .:|
Human  1360 K----ISSSPKFDSRDNALSASNETS---------SAEHLKDGTMKEMVV-CSSESITCKPQLKD 1410

  Fly  1192 SFRVSELEV-----ENEKLRSEYDQLRTSIKHGVEINELNAQHAALQEEVRR--RREECI---QL 1246
            ||..:.|..     :.:.|::. .||.|||:....:...:....||..::.|  ||..|.   |:
Human  1411 SFISNSLPTFFYIPQQDPLKTN-SQLDTSIQRNKLLENEDTAGEALTLDINRETRRYHCSGKDQI 1474

  Fly  1247 KAVLLQQSQS--MRSL-------EPESLQMRGNDVNELMEAFHSQKLINRQLESELKAITEEHNS 1302
            ...|..:|.:  ::.|       |....|::..:..|:||....|..|   ||.|.||.......
Human  1475 VPSLNTESSNPVLKKLEKLNTEKEERQKQLQQQNEKEMMEQIRQQTDI---LEKERKAFKTIEKP 1536

  Fly  1303 KLVE---------MTQEIER------LNNE------------------------------KDELQ 1322
            ::.|         ..|.:||      ||..                              ||...
Human  1537 RIGECLVAPSSYQSKQRVERPSSLLSLNTSNKGELNVLGSLSLKDAALAQKDSSSAHLPPKDRPV 1601

  Fly  1323 KVMFE---------SIDEFEDS-------NVDTLRQNDRYLRRELQKAVAQF------------- 1358
            .|.||         ::.|...:       ||.....|:|..:||..:....:
Human  1602 TVFFERKGSPCQSSTVKELSKTDRMGTQLNVACKLSNNRISKREHFRPTQSYSHNSDDLSREGNA 1666

  Fly  1359 --------------LLVQEELKLANAKLKAYRQD-----------GGQLE------HKIEEEMIR 1392
                          |:.:|.|...|.:|  :::|           .||.|      ||.:..|.|
Human  1667 RPIFFTPKDNMSIPLVSKEALNSKNPQL--HKEDEPAWKPVKLAGPGQREQVARPAHKKKARMAR 1729

  Fly  1393 NKSN----GTSADVGANVTKQKSQNPQGLMKFHSSDLDKILQRLLS-------ALTPRTVVGLLP 1446
            .:|:    ||.|| |...|::             .|.|.|::.|||       .|.|...:|
Human  1730 TRSDFLTRGTFAD-GEGDTEE-------------DDYDDIIEPLLSLDQASHCELGPAPSLG--- 1777

  Fly  1447 GFPAYLIFMCIRYTDLTNADDDVRELLSKFVIQIKKMHRTPHPIENRVIWLVNSITLLNLMKQYG 1511
                          ..:::|.::.......|.:..|:|:|....|         ||.|.:.::..
Human  1778 --------------QASHSDSEMTSQRFSSVDEQAKLHKTMSQGE---------ITKLAVRQKAS 1819

  Fly  1512 DVD---------------EYVKFNTEKQNQQQLKNFNLFEYRRVI-----LDLIVNLYQALIMQI 1556
            |.|               :..|..|..:...|.:...||....||     .|.:...:..
Human  1820 DSDIRPQRAKMRFWAKGKQGEKKTTRVKPTTQSEVSPLFAGTDVIPAHQFPDELAAYHPT----- 1879

  Fly  1557 QGLLDPKIVPAILNN--DEIQRGRQAHGMRSRATSIGASS---SPEHGGGPAWK----QLIGQLE 1612
                 |.:.|.:..:  .|.:..::......|..|:..|:   ...|     |:    |:|..:.
Human  1880 -----PPLSPELPGSCRKEFKENKEPSPKAKRKRSVKISNVALDSMH-----WQNDSVQIIASVS 1934

  Fly  1613 HFYKQFQHF------GLDN------CYAEQIFHQLL---------YFICAVALNCLMLRGDICMW 1656
            .. |....|      .|||      ...:.:|.:.|         ::..|:|:
Human  1935 DL-KSMDEFLLKKVNDLDNEDSKKDTLVDVVFKKALKEFRQNIFSFYSSALAM------------ 1986

  Fly  1657 ETGMIIRY---------------------NIG--CIEDWVRSKKM-----SNDVLTALAPLNQV- 1692
            :.|..|||                     ::|  .:..||.:.|:     .|:..|:.....:|
Human  1987 DDGKSIRYKDLYALFEQILEKTMRLEQRDSLGESPVRVWVNTFKVFLDEYMNEFKTSDCTATKVP 2051

  Fly  1693 -SQLLQSRKSEQD----------------VQTICDLCTSL----STAQVLKVMKSYKLDDYESEI 1736
             ::..:.||.|.|                :.|.|:.|:||    ..|.|.|:.|.........:.
Human  2052 KTERKKRRKKETDLVEEHNGHIFKATQYSIPTYCEYCSSLIWIMDRASVCKLCKYACHKKCCLKT 2116

  Fly  1737 TNVFLEKLTEKLNARQ----MQKSNSDEFTID---QKFIQPFKV-------VFRYSDIKLEDIEL 1787
            |....:|...:|::||    :.:..|::.|:.   :|.|...::       ::|.|....:..||
Human  2117 TAKCSKKYDPELSSRQFGVELSRLTSEDRTVPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKEL 2181

  Fly  1788 PSHL-------NLDEF 1796
            ...|       |||::
Human  2182 RQGLDTDAESVNLDDY 2197

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	266/865 (31%)
		IQ	900..922	CDD:197470	8/21 (38%)
		SMC_prok_B	<942..1365	CDD:274008	107/570 (19%)
		Myo5_CBD	1424..1792	CDD:271254	85/495 (17%)
MYO9A	XP_011519915.1	RA_Myosin-IXa	15..110	CDD:340736
		MYSc_Myo9	160..1004	CDD:276836	266/865 (31%)
		C1_Myosin-IXa	2067..2124	CDD:410433	10/56 (18%)
		RhoGAP_myosin_IX	2133..2318	CDD:239842	12/65 (18%)