Protein Alignment didum and MYO7B

DIOPT Version :10

• Sequence 1: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Sequence 2: XP_047300391.1
• Gene: MYO7B / 4648
• HGNCID: 7607
• Length: 2298
• Species: Homo sapiens
• Alignment Length: 1501
• Identity: 433/1501 - (28%)
• Similarity: 671/1501 - (44%)
• Gaps: 303/1501 - (20%)

  Fly    40 KICTDSGKLKEVKLKA-DGSDLPPLRNPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTY 103
            |:..:..:.||..::| |...|.|: :|..:.|.:|:..|..|:|.|::|||.:|: ::..||||
Human    35 KVLVEDDEGKEHWIRAEDFGVLSPM-HPNSVQGVDDMIRLGDLNEAGMVHNLLIRY-QQHKIYTY 97

  Fly   104 CGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGA 168
            .|.||||:||:..:|||....::.|....||:|.||:||:|...|..::|...:...|:||||||
Human    98 TGSILVAVNPFQVLPLYTLEQVQLYYSRHMGELPPHVFAIANNCYFSMKRNKRDQCCIISGESGA 162

  Fly   169 GKTVSAKYAMRYFAAVGGSESETQVERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQM 233
            |||.:.|..:::.|.:.|..|  .:|::||.::||:||||||||.||||||||||:..:.| |..
Human   163 GKTETTKLILQFLATISGQHS--WIEQQVLEANPILEAFGNAKTIRNDNSSRFGKYIDIYF-NPS 224

  Fly   234 GVMFLQGATMHTYLLEKSRVVYQAQGERNYHIFY-QLCAARSKYPELV-LDHQDKFQFLNMGGAP 296
            ||  ::||.:..:|||||||..||..|||||||| .|....::..:|: |....::.:|.||...
Human   225 GV--IEGARIEQFLLEKSRVCRQAPEERNYHIFYCMLMGVSAEDKQLLSLGTPSEYHYLTMGNCT 287

  Fly   297 EIERVSDAEQFNETVQAMTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIF 361
            ..|.::||:.:.....||.:|.||..:..|::|:||.||||||:...     .|..|:.|:.|:.
Human   288 SCEGLNDAKDYAHIRSAMKILQFSDSESWDVIKLLAAILHLGNVGFM-----ASVFENLDASDVM 347

  Fly   362 HNDIHLQITADLLRVSADDLRRWLLMRKIESVNEYVLIPNSIEAAQAA--RDALAKHIYAKLFQY 424
            .... ......||.|...:||..|:...|....|:|  ..|:..||||  |||..|.||..||.:
Human   348 ETPA-FPTVMKLLEVQHQELRDCLIKHTILIRGEFV--TRSLNIAQAADRRDAFVKGIYGHLFLW 409

  Fly   425 IVGVLNKSLNNGSKQ-----CSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQ 484
            ||..:|.::.....|     ...||:|||:|||.||.|||||.|||:|||.|||.|.||||.:||
Human   410 IVKKINAAIFTPPAQDPKNVRRAIGLLDIFGFENFENNSFEQLCINFANEHLQQFFVQHVFTMEQ 474

  Fly   485 EEYLKEGITWTMIDFYDNQPCIDLIESR-LGVLDLLDEECRMPKGSDESWAGKL--IGKCNKFPH 546
            |||..|.|:|..|.:.||:|.:||:..: :.::.|||||.|.|:|:|.:...||  :...||  .
Human   475 EEYRSENISWDYIHYTDNRPTLDLLALKPMSIISLLDEESRFPQGTDLTMLQKLNSVHANNK--A 537

  Fly   547 FEKP------RFGTTSFFIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEE 605
            |.:|      |||     |.||:..|.|...||||||||.:|.::..::..|.....:::..||.
Human   538 FLQPKNIHDARFG-----IAHFAGEVYYQAEGFLEKNRDVLSTDILTLVYSSKNKFLREIFNLEL 597

  Fly   606 IDT-LCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATT 669
            .:| |...:.:.:..|..:..||       |:.:|  ||     |:||||::||..|:..|....
Human   598 AETKLGHGTIRQAKAGNHLFKSA-------DSNKR--PS-----TLGSQFKQSLDQLMKILTNCQ 648

  Fly   670 PHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKL 734
            |:::||||||:.|....::....::|||..|::|||.|..:|||.|:.:.:|..|:.:|:
Human   649 PYFIRCIKPNEYKKPLLFDRELCLRQLRYSGMMETVHIRKSGFPIRYTFEEFSQRFGVLL----- 708

  Fly   735 DKNDMKLSCR--------NIVMKWIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQS 791
             .|.|::..:        .|...|::.:..::.|.|:||.|..|...||..|:.:..:....:|.
Human   709 -PNAMRMQLQGKLRQMTLGITDVWLRTDKDWKAGKTKIFLRDHQDTLLEVQRSQVLDRAALSIQK 772

  Fly   792 VVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAGLILSKYARGWLCRRRYLRLRHS 856
            |:|.:.||::||                         |:.||.:.|..:.||:..||.:..:...
Human   773 VLRGYRYRKEFL-------------------------RQRRAAVTLQAWWRGYCNRRNFKLILVG 812

  Fly   857 ISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAYQKRRRNIIICQAAIRRFLARRKF 921
            ...:|..||......::.|||.  |.||:|...||.|.|:..|.:||.:::.||..|...|||.|
Human   813 FERLQAIARSQPLARQYQAMRQ--RTVQLQALCRGYLVRQQVQAKRRAVVVIQAHARGMAARRNF 875

  Fly   922 KRMKA-----------------------------EAKTISHMENKYMGLENKIISMQQRIDELNR 957
            ::.||                             :..|.:.|..|..|....:|..|:  .:.:.
Human   876 QQRKANGMQAPLVIPAEGQKSQGALPAKKRRSIYDTVTDTEMVEKVFGFLPAMIGGQE--GQASP 938

  Fly   958 DNSNLKHKTSEISVLKMKLELKKTLEAEFKNVKAA---CQDKDKLIE------------------ 1001
            ...:|:.||            :|.||.:...|..|   .:|.|.|.|
Human   939 HFEDLESKT------------QKLLEVDLDTVPMAEEPEEDVDGLAEYTFPKFAVTYFQKSASHT 991

  Fly  1002 ----ALNKQLEAERDEK---------MQLLEENGHAQEEWISQKQTWRQENEELRRQIDEIIDMA 1053
                .|...|....|:.         ..:|...|...|..:..:.:  |:...:.|||.:.:...
Human   992 HIRRPLRYPLLYHEDDTDCLAALVIWNVILRFMGDLPEPVLYARSS--QQGSSVMRQIHDTLGRE 1054

  Fly  1054 KNAEVNQRNQEDRMLAEIDNRELNEAYQRAIKDKEVIENENFMLKEELSRLTAGSFSLHARKASN 1118
            ..|:|.|.::              .|.:...|||...:..:..||.. ||:|       .:.||.
Human  1055 HGAQVPQHSR--------------SAQRSGCKDKGTKDISSMKLKRS-SRIT-------GQVASQ 1097

  Fly  1119 ASSQNEDDVGYASAKNTLDINRPPDLLSK-----NYSYNDSTSLVVKLRSILEEE--KQKHKVLQ 1176
            .:...|     |...:.|..:||...|.|     .|:.         ||..|.:|  .|..|.|.
Human  1098 LNIGEE-----ALEPDGLGADRPMSNLEKVHFIVGYAI---------LRPSLRDEIYCQICKQLS 1148

  Fly  1177 EQYIKLSSRHK------------PTEDSFRVSELEVENEKLRSEY-----DQLRTSIKHGVEIN- 1223
            |.: |.||..:            |..:.|....|....:. .:.|     ::||.:..:||...
Human  1149 ENF-KTSSLARGWILLSLCLGCFPPSERFMKYLLNFIGQG-PATYGPFCAERLRRTYANGVRAEP 1211

  Fly  1224 ----ELNA----QHAALQ-------------EEVRRRREECIQLKAVLLQQSQSMRSLEPESLQM 1267
                ||.|    :|..:|             :.....||.|:.     :...|.:......|||:
Human  1212 PTWLELQAVKSKKHIPIQVILATGESLTVPVDSASTSREMCMH-----IAHKQGLSDHLGFSLQV 1271

  Fly  1268 R--------GNDVNELMEAFHSQKLINRQLESELKAITEEHNSKLVEMTQEIERLNNEKDELQKV 1324
            .        |:..:.:|:|.                      ::..:|.|  ||..:::....::
Human  1272 AVYDKFWSLGSGRDHMMDAI----------------------ARCEQMAQ--ERGESQRQSPWRI 1312

  Fly  1325 MF--ESIDEFEDSNVDTLRQNDRYLRRELQKAV--AQFLLVQEELKLANAKLKAYRQDGGQLEHK 1385
            .|  |....:.||..|.:  :...:.|::.:.|  .::...:||..:.......|.|.|...|.|
Human  1313 YFRKEFFTPWHDSREDPV--STELIYRQVLRGVWSGEYSFEKEEELVELLARHCYVQLGASAESK 1375

  Fly  1386 IEEEMI 1391
            ..:|::
Human  1376 AVQELL 1381

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	271/709 (38%)
		IQ	900..922	CDD:197470	8/21 (38%)
		SMC_prok_B	<942..1365	CDD:274008	92/514 (18%)
		Myo5_CBD	1424..1792	CDD:271254
MYO7B	XP_047300391.1	MYSc_Myo7	79..748	CDD:276832	271/709 (38%)
		IQ	785..807	CDD:197470	8/21 (38%)
		MyTH4	992..1221	CDD:214535	54/268 (20%)
		FERM1_F1_Myosin-VII	1225..1323	CDD:340612	18/126 (14%)
		FERM_C1_MyoVII	1467..1550	CDD:270019
		SH3	1551..1611	CDD:473055
		MyTH4	1692..1839	CDD:214535
		FERM2_F1_Myosin-VII	1846..1943	CDD:340613
		B41	1848..2060	CDD:214604
		FERM_C2_MyoVII	2056..>2131	CDD:270020