DRSC/TRiP Functional Genomics Resources

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Protein Alignment didum and MYO7A

DIOPT Version :10

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:XP_011543348.2 Gene:MYO7A / 4647 HGNCID:7606 Length:2258 Species:Homo sapiens


Alignment Length:1662 Identity:464/1662 - (27%)
Similarity:727/1662 - (43%) Gaps:360/1662 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 DLVWESATLEESYRKGAG-FLKICTDSGKLKEVKLKADGSD------------LPPLRNPAILVG 71
            |.||....|.:.:....| .:|:| |||:::.|    |..|            :.|: :|..:.|
Human    38 DHVWMDLRLGQEFDVPIGAVVKLC-DSGQVQVV----DDEDNEHWISPQNATHIKPM-HPTSVHG 96

  Fly    72 QNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDL 136
            ..|:..|..|:|.|:|.||.:|:.: .:||||.|.||||:|||..:.:|.|..||.|....:|::
Human    97 VEDMIRLGDLNEAGILRNLLIRYRD-HLIYTYTGSILVAVNPYQLLSIYSPEHIRQYTNKKIGEM 160

  Fly   137 EPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESETQVERKVLASS 201
            .|||||:|:..|..::|.:.:...|:|||||||||.|.|..:::.||:.|..|  .:|::||.::
Human   161 PPHIFAIADNCYFNMKRNSRDQCCIISGESGAGKTESTKLILQFLAAISGQHS--WIEQQVLEAT 223

  Fly   202 PIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHIF 266
            ||:||||||||.||||||||||:..:.| |:.|.  ::||.:..||||||||..||..|||||:|
Human   224 PILEAFGNAKTIRNDNSSRFGKYIDIHF-NKRGA--IEGAKIEQYLLEKSRVCRQALDERNYHVF 285

  Fly   267 YQLCAARS--KYPELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIADIVK 329
            |.:....|  :..:|.|.....:.:|.||.....|...|::::.....||.||.|:..:..:|.|
Human   286 YCMLEGMSEDQKKKLGLGQASDYNYLAMGNCITCEGRVDSQEYANIRSAMKVLMFTDTENWEISK 350

  Fly   330 ILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKIESVN 394
            :||.||||||:|.     |....|:.|:|::..:. .|...|.||.|:..||...|..|.:.:..
Human   351 LLAAILHLGNLQY-----EARTFENLDACEVLFSP-SLATAASLLEVNPPDLMSCLTSRTLITRG 409

  Fly   395 EYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLN--------KSLNNGSKQCSFIGVLDIYGF 451
            |.|..|.|.|.|...|||..|.||.:||.:||..:|        :.:.|..:.   ||:|||:||
Human   410 ETVSTPLSREQALDVRDAFVKGIYGRLFVWIVDKINAAIYKPPSQDVKNSRRS---IGLLDIFGF 471

  Fly   452 ETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIESR-LGV 515
            |.|.||||||.|||:|||.|||.|.:||||||||||..|.|.|..|:|.|||..:|:|.:: :.:
Human   472 ENFAVNSFEQLCINFANEHLQQFFVRHVFKLEQEEYDLESIDWLHIEFTDNQDALDMIANKPMNI 536

  Fly   516 LDLLDEECRMPKGSDESWAGKLIGKCNKFPHFEKPRFG-TTSFFIKHFSDTVEYDVNGFLEKNRD 579
            :.|:|||.:.|||:|.:...||..:.....::..|:.. .|.|.|.||:..|.|:..||||||||
Human   537 ISLIDEESKFPKGTDTTMLHKLNSQHKLNANYIPPKNNHETQFGINHFAGIVYYETQGFLEKNRD 601

  Fly   580 TVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSK 644
            |:..::.|::..|.....||:..        .|.|                 .|.:||:|     
Human   602 TLHGDIIQLVHSSRNKFIKQIFQ--------ADVA-----------------MGAETRKR----- 636

  Fly   645 QHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISA 709
              ..|:.|||:.||..|:.||.|..|.:|||||||:.|....::....::|||..|::||:||..
Human   637 --SPTLSSQFKRSLELLMRTLGACQPFFVRCIKPNEFKKPMLFDRHLCVRQLRYSGMMETIRIRR 699

  Fly   710 AGFPSRWLYPDFYMRYQLLV--YRSKLDKNDMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVA 772
            ||:|.|:.:.:|..||::|:  .:....:.|::.:|:.:....:...|.::.|.|:||.:.....
Human   700 AGYPIRYSFVEFVERYRVLLPGVKPAYKQGDLRGTCQRMAEAVLGTHDDWQIGKTKIFLKDHHDM 764

  Fly   773 FLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAGLIL 837
            .||..|.......:.::|.|:|.|..|..||:::.....||:|.||:                  
Human   765 LLEVERDKAITDRVILLQKVIRGFKDRSNFLKLKNAATLIQRHWRGH------------------ 811

  Fly   838 SKYARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAYQKRR 902
                   .||:.|..:|.....:|...|......::...|.  |.:|.|...|..|.|:|::.|.
Human   812 -------NCRKNYGLMRLGFLRLQALHRSRKLHQQYRLARQ--RIIQFQARCRAYLVRKAFRHRL 867

  Fly   903 RNIIICQAAIRRFLARRKFKRMKAEAKTISHMENKYMGLENKIISMQQRIDELNRDNSNLKHKTS 967
            ..::..||..|..:|||..:|::||          |:                            
Human   868 WAVLTVQAYARGMIARRLHQRLRAE----------YL---------------------------- 894

  Fly   968 EISVLKMKLELKKTLEAEFKNVKAACQDKDKLIEALNKQLEAERDEKMQLLEENGHAQEEWISQK 1032
                  .:||.:|...||.:.::       |.:.|...:.||||..:.:|.:......|..:.:|
Human   895 ------WRLEAEKMRLAEEEKLR-------KEMSAKKAKEEAERKHQERLAQLAREDAERELKEK 946

  Fly  1033 QTWRQENEELRRQIDEIIDMAKNAEVNQRNQEDRMLAEIDNR-----ELNEAYQRAIKDKEVIEN 1092
            :..|::.|.|     |.::.|::..||..:..|:|...:...     :..:| ....:|.|....
Human   947 EAARRKKELL-----EQMERARHEPVNHSDMVDKMFGFLGTSGGLPGQEGQA-PSGFEDLERGRR 1005

  Fly  1093 ENFMLKEELSRLTAGSFSLHARKASNASSQNEDDVG----------YASAKNTLDINRPPDLLSK 1147
            |  |::|:|.            .|.....::|:|:.          |.....|....|.|  |.:
Human  1006 E--MVEEDLD------------AALPLPDEDEEDLSEYKFAKFAATYFQGTTTHSYTRRP--LKQ 1054

  Fly  1148 NYSYNDS-----TSLVV--------------KLRSILEEEKQKHKVLQEQYIKLSSRHKPTEDSF 1193
            ...|:|.     .:|.|              |..:.:.:..:|..|:.:.|..|..:....|   
Human  1055 PLLYHDDEGDQLAALAVWITILRFMGDLPEPKYHTAMSDGSEKIPVMTKIYETLGKKTYKRE--- 1116

  Fly  1194 RVSELEVENEKLRSEYDQLRTSIKHGVEINELNAQHAALQEEVRRR---REECIQLKAVLLQQSQ 1255
             :..|:.|.|....| .|.::|::|.: ::....:.:.|.|||.:|   .|..:|..::|  :.:
Human  1117 -LQALQGEGEAQLPE-GQKKSSVRHKL-VHLTLKKKSKLTEEVTKRLHDGESTVQGNSML--EDR 1176

  Fly  1256 SMRSLEPESLQMRGNDV--NELMEAFHSQKLINRQLESELKAITEEHN-SK--------LVEMTQ 1309
            ...:||.... :.||.:  ..|.:..:.|  |::||         .|| ||        ||.:..
Human  1177 PTSNLEKLHF-IIGNGILRPALRDEIYCQ--ISKQL---------THNPSKSSYARGWILVSLCV 1229

  Fly  1310 EIERLNNEKDELQKVMFESIDEFEDSNVDTLRQNDRYLRRELQKAVAQFLLVQEELKLANAKLKA 1374
            .              .|...::|.           :|||..:.                      
Human  1230 G--------------CFAPSEKFV-----------KYLRNFIH---------------------- 1247

  Fly  1375 YRQDGGQLEHK--IEEEMIRNKSNGTSADVGANVTKQ--KSQNP--------QGLMKFHSSDLDK 1427
                ||...:.  .||.:.|...|||.....:.:..|  ||:.|        .|..|...:|...
Human  1248 ----GGPPGYAPYCEERLRRTFVNGTRTQPPSWLELQATKSKKPIMLPVTFMDGTTKTLLTDSAT 1308

  Fly  1428 ILQRLLSALTPRTVVGLLPGFPAYLIFMCIRYTDLTNADDDVRELLSK----------------F 1476
            ..:.|.:||..:..:....||..| |.:..:.:.|.:..|.|.:.:|:                :
Human  1309 TAKELCNALADKISLKDRFGFSLY-IALFDKVSSLGSGSDHVMDAISQCEQYAKEQGAQERNAPW 1372

  Fly  1477 VIQIKKMHRTP--HPIENRVIWLVNSITLLNLMKQYGDVDEYVKFN----------TEKQNQQQL 1529
            .:..:|...||  .|.|:.|        ..||:  |..|...|||.          .|..:||..
Human  1373 RLFFRKEVFTPWHSPSEDNV--------ATNLI--YQQVVRGVKFGEYRCEKEDDLAELASQQYF 1427

  Fly  1530 KNFNLFEYRRVILDLIVNLYQALIMQIQGLLDPKIVP 1566
            .::.    ..:||:.::||....|.      |.:|.|
Human  1428 VDYG----SEMILERLLNLVPTYIP------DREITP 1454

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc_Myo5 84..767 CDD:276831 271/696 (39%)
IQ 900..922 CDD:197470 7/21 (33%)
SMC_prok_B <942..1365 CDD:274008 83/470 (18%)
Myo5_CBD 1424..1792 CDD:271254 36/171 (21%)
MYO7AXP_011543348.2 MYSc_Myo7 109..759 CDD:276832 271/696 (39%)
CBD_MYO6-like <796..>839 CDD:409646 11/67 (16%)
tolA <826..>996 CDD:236545 45/228 (20%)
MAP7 <887..963 CDD:461709 22/131 (17%)
MyTH4 1047..1283 CDD:214535 57/308 (19%)
FERM1_F1_Myosin-VII 1287..1385 CDD:340612 18/98 (18%)
B41 1289..1504 CDD:214604 38/187 (20%)
FERM_C1_MyoVII 1498..1634 CDD:270019
SH3 1635..1699 CDD:473055
MyTH4 1793..1926 CDD:214535
FERM2_F1_Myosin-VII 1931..2028 CDD:340613
B41 1933..2145 CDD:214604
Blue background indicates that the domain is not in the aligned region.

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