Protein Alignment didum and MYO1C

DIOPT Version :10

• Sequence 1: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Sequence 2: NP_001074248.1
• Gene: MYO1C / 4641
• HGNCID: 7597
• Length: 1063
• Species: Homo sapiens
• Alignment Length: 1145
• Identity: 329/1145 - (28%)
• Similarity: 512/1145 - (44%)
• Gaps: 252/1145 - (22%)

  Fly    70 VGQNDLTTL-SYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAM 133
            ||..|...| ::..|...:.|||.||.| .:||||.|.:||::|||.::.:|....:..|||.:.
Human    46 VGVQDFVLLENFTSEAAFIENLRRRFRE-NLIYTYIGPVLVSVNPYRDLQIYSRQHMERYRGVSF 109

  Fly   134 GDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAV------GGSESETQ 192
            .::.||:||:|:..|..|..|..:.::::|||||||||.:.|..::::|..      ||:
Human   110 YEVPPHLFAVADTVYRALRTERRDQAVMISGESGAGKTEATKRLLQFYAETCPAPERGGA----- 169

  Fly   193 VERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMF-LQGATM--H--TYLLEKSR 252
            |..::|.|:|::||||||||.||||||||||:        |.|.| .:||.:  |  :|||||||
Human   170 VRDRLLQSNPVLEAFGNAKTLRNDNSSRFGKY--------MDVQFDFKGAPVGGHILSYLLEKSR 226

  Fly   253 VVYQAQGERNYHIFYQLC--AARSKYPELVLD-HQDKFQFLNMGGAPEIERVSDAEQFNETVQAM 314
            ||:|..||||:||||||.  ........|.|: :...:.:|..|...::..::|...:....:|:
Human   227 VVHQNHGERNFHIFYQLLEGGEEETLRRLGLERNPQSYLYLVKGQCAKVSSINDKSDWKVVRKAL 291

  Fly   315 TVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSAD 379
            ||:.|:..::.|::.|:|.:||||||..:.  ||.|..:.:       .:..|:....||.|...
Human   292 TVIDFTEDEVEDLLSIVASVLHLGNIHFAA--NEESNAQVT-------TENQLKYLTRLLSVEGS 347

  Fly   380 DLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGS------K 438
            .||..|..|||.:..|.:|.|.::|.|..|||||||.:|::.|.::||.:|:||.:..      :
Human   348 TLREALTHRKIIAKGEELLSPLNLEQAAYARDALAKAVYSRTFTWLVGKINRSLASKDVESPSWR 412

  Fly   439 QCSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQ 503
            ..:.:|:|||||||.|:.||||||||||.||||||.|.:...|.|||||..|||.|..:.:::|:
Human   413 STTVLGLLDIYGFEVFQHNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGIAWEPVQYFNNK 477

  Fly   504 PCIDLIESRL-GVLDLLDEECRMP-KGSDESWAGKLIGKCNKFPHF---------EKPRFGTTSF 557
            ...||:|.:. |::.:|||||..| :.:|.::..||.......|||         .:...|...|
Human   478 IICDLVEEKFKGIISILDEECLRPGEATDLTFLEKLEDTVKHHPHFLTHKLADQRTRKSLGRGEF 542

  Fly   558 FIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGR 622
            .:.|::..|.|.|.|||:||.|.:.:.|.:.:..|...:..|          |.|.::.|
Human   543 RLLHYAGEVTYSVTGFLDKNNDLLFRNLKETMCSSKNPIMSQ----------CFDRSELS----- 592

  Fly   623 VVISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKW 687
                                .|:..:||.:||:.||..|:..|.:..|.|||||||||.|...::
Human   593 --------------------DKKRPETVATQFKMSLLQLVEILQSKEPAYVRCIKPNDAKQPGRF 637

  Fly   688 ETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKNDMKLSCRNIVMKWI- 751
            :...|..|::..|:||.:|:..|||..|..|..|..||:.|              |......|.
Human   638 DEVLIRHQVKYLGLLENLRVRRAGFAYRRKYEAFLQRYKSL--------------CPETWPTWAG 688

  Fly   752 --QD------------EDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYI-TIVQSVVRRFVYRRQ 801
              ||            .::|:.|.|:||.|..:..|..:....:|::.: |.:|:..|.|.:|::
Human   689 RPQDGVAVLVRHLGYKPEEYKMGRTKIFIRFPKTLFATEDALEVRRQSLATKIQAAWRGFHWRQK 753

  Fly   802 FLRIQKVINGIQKHARGYLARERTQKMREARAGLILSKYARGWLCRRRYLRLRHSISGIQTYARG 866
            |||::                                   |..:|             ||::.||
Human   754 FLRVK-----------------------------------RSAIC-------------IQSWWRG 770

  Fly   867 MLARNKFHAMRDHYRAVQIQRFVRGALARRAYQKRRRNIIICQAAIRRFLARRKFKRMKAEAKTI 931
            .|.|.|  |.:..:.|..|:|.:||.:.|.|                        .|....|..:
Human   771 TLGRRK--AAKRKWAAQTIRRLIRGFVLRHA------------------------PRCPENAFFL 809

  Fly   932 SHMENKYMGLENKIISMQQRIDELNRDNSNLKHKTSEISVLKMKLEL-KKTLEAEFKNVKAACQD 995
            .|:...::                                |.::.:| :..|:..:.....|.::
Human   810 DHVRTSFL--------------------------------LNLRRQLPQNVLDTSWPTPPPALRE 842

  Fly   996 KDKLIEALN------KQLEAERDEKMQLLEENGHAQEEWISQKQTWRQENEEL----RRQIDEII 1050
            ..:|:..|.      |...:...|..|.|::...|.|.:..:|..:.|....|    |...|||.
Human   843 ASELLRELCIKNMVWKYCRSISPEWKQQLQQKAVASEIFKGKKDNYPQSVPRLFISTRLGTDEIS 907

  Fly  1051 DMAKNAEVNQRNQEDRMLAEIDNRELN-EAYQRAIKDKEVIENENFMLKEEL----------SRL 1104
            .....|..::..|....:.:.|.:... .:.|..:....|:..|:..:|:.:          |.|
Human   908 PRVLQALGSEPIQYAVPVVKYDRKGYKPRSRQLLLTPNAVVIVEDAKVKQRIDYANLTGISVSSL 972

  Fly  1105 TAGSFSLHARKASNASSQN----EDDVGYASAKNTLDINR 1140
            :...|.||.::|.|....:    .|.|.....|..|..||
Human   973 SDSLFVLHVQRADNKQKGDVVLQSDHVIETLTKTALSANR 1012

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	254/728 (35%)
		IQ	900..922	CDD:197470	0/21 (0%)
		SMC_prok_B	<942..1365	CDD:274008	39/225 (17%)
		Myo5_CBD	1424..1792	CDD:271254
MYO1C	NP_001074248.1	MYSc_Myo1	62..718	CDD:276829	254/727 (35%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	608..630		11/21 (52%)
		IQCG	751..781	CDD:467744	14/79 (18%)
		Myosin_TH1	874..1055	CDD:461801	29/139 (21%)