DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment didum and MYH11

DIOPT Version :9

Sequence 1:	NP_724569.1	Gene:	didum / 35680	FlyBaseID:	FBgn0261397	Length:	1800	Species:	Drosophila melanogaster
Sequence 2:	NP_001035203.1	Gene:	MYH11 / 4629	HGNCID:	7569	Length:	1979	Species:	Homo sapiens

Alignment Length:	1712	Identity:	492/1712 - (28%)
Similarity:	804/1712 - (46%)	Gaps:	290/1712 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 IWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLRNPAILVGQNDLTTL 78
            :|||.....:|:|:::|  .||...:....::||    |:.....|:..: ||.......|:..|
Human    36 VWVPSEKQGFEAASIKE--EKGDEVVVELVENGK----KVTVGKDDIQKM-NPPKFSKVEDMAEL 93

  Fly    79 SYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLEPHIFAL 143
            :.|:|..||||||.|:.. .:||||.|:..|.:|||..:|:|...|:..|:|....::.|||:|:
Human    94 TCLNEASVLHNLRERYFS-GLIYTYSGLFCVVVNPYKHLPIYSEKIVDMYKGKKRHEMPPHIYAI 157

  Fly   144 AEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSE------SETQ--------VE 194
            |:.||..:.::..:.||:.:||||||||.:.|..::|.|.|..|.      |.||        :|
Human   158 ADTAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAVVASSHKGKKDTSITQGPSFAYGELE 222

  Fly   195 RKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQG 259
            :::|.::||:||||||||.:||||||||||.::.| :..|  ::.||.:.||||||||.:.||:.
Human   223 KQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINF-DVTG--YIVGANIETYLLEKSRAIRQARD 284

  Fly   260 ERNYHIFYQLCA-ARSKY-PELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQ 322
            ||.:||||.:.| |:.|. .:|:|:..:.:.||:.|..| |....|.|.|.|||:||.::|||.:
Human   285 ERTFHIFYYMIAGAKEKMRSDLLLEGFNNYTFLSNGFVP-IPAAQDDEMFQETVEAMAIMGFSEE 348

  Fly   323 QIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLM 387
            :...|:|:::.:|.|||| |.||      |.::|...:..|.. .|....|:.::..|..|.:|.
Human   349 EQLSILKVVSSVLQLGNI-VFKK------ERNTDQASMPDNTA-AQKVCHLMGINVTDFTRSILT 405

  Fly   388 RKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQ-CSFIGVLDIYGF 451
            .:|:...:.|....:.|.|..|.:||||..|.:||::|:..:||:|:...:| .||:|:|||.||
Human   406 PRIKVGRDVVQKAQTKEQADFAVEALAKATYERLFRWILTRVNKALDKTHRQGASFLGILDIAGF 470

  Fly   452 ETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDF-YDNQPCIDLIE---SR 512
            |.||||||||.||||.||||||.||..:|.||||||.:|||.|..||| .|.||||:|||   :.
Human   471 EIFEVNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIELIERPNNP 535

  Fly   513 LGVLDLLDEECRMPKGSDESWAGKLIGKCNKFPHFEKPR--FGTTSFFIKHFSDTVEYDVNGFLE 575
            .|||.||||||..||.:|:|:..||..:....|.|:||:  ...|.|.|.|::..|:|:.:.:|.
Human   536 PGVLALLDEECWFPKATDKSFVEKLCTEQGSHPKFQKPKQLKDKTEFSIIHYAGKVDYNASAWLT 600

  Fly   576 KNRDTVSKELTQVLSESNMSLAKQVMTL-EEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRR 639
            ||.|.::..:|.:|   |.|..|.|..| :::|              |:|   |..|....|...
Human   601 KNMDPLNDNVTSLL---NASSDKFVADLWKDVD--------------RIV---GLDQMAKMTESS 645

  Fly   640 VVPSKQHRK----TVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACG 700
            :..:.:.:|    |||..::|.|..|::||..|||::||||.||.:|.:.|.:...:::|||..|
Human   646 LPSASKTKKGMFRTVGQLYKEQLGKLMTTLRNTTPNFVRCIIPNHEKRSGKLDAFLVLEQLRCNG 710

  Fly   701 VLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKN--DMKLSCRNIVMKWIQDEDKYRFGNTQ 763
            |||.:||...|||:|.::.:|..||::|. .:.:.|.  |.|.:|..::.....|.:.||.|.::
Human   711 VLEGIRICRQGFPNRIVFQEFRQRYEILA-ANAIPKGFMDGKQACILMIKALELDPNLYRIGQSK 774

  Fly   764 IFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLAR----ER 824
            ||||.|.:|.||:.|.                       |:|..||...|...||||||    :|
Human   775 IFFRTGVLAHLEEERD-----------------------LKITDVIMAFQAMCRGYLARKAFAKR 816

  Fly   825 TQKM-------REARAGLILSKYARGWLCRRRYLRLRHSISGI--------------QTYARGML 868
            .|::       |...|.|.|    |.|...|.:.:::..:...              :|..|...
Human   817 QQQLTAMKVIQRNCAAYLKL----RNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQK 877

  Fly   869 ARN-------KFHAMRDHYRAVQIQRFVRGALARRAYQKRRRNIIICQAAIRRFLARRKFKRMKA 926
            |.|       |...:.:....:|.|......|...|.:.|.|            ||.:     |.
Human   878 AENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR------------LAAK-----KQ 925

  Fly   927 EAKTISH-MENKYMGLENKIISMQQRIDELNRDNSNLKHKTSEISVLKMKLELKK-TLEAEFKNV 989
            |.:.|.| ||.:....|::...:|....::.:...:|:.:..|....:.||:|:| |.||:.|.:
Human   926 ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKL 990

  Fly   990 KAACQDKDKLIEALNKQLEAERDEKMQLLEENGHAQEEWISQKQTWRQENEELRRQIDEIIDMAK 1054
                :|:..:::..|.:|..||    :||||.       ||...|...|.||..:.:.::
Human   991 ----EDEILVMDDQNNKLSKER----KLLEER-------ISDLTTNLAEEEEKAKNLTKL----- 1035

  Fly  1055 NAEVNQRNQEDRMLAEIDNRELNE--AYQRAIKDKEVIENENFMLKEELSRLTAGSFSLHARKAS 1117
                  :|:.:.|::|::.|...|  :.|...|.|..:|.:.....|:::.|.|....|..:.|
Human  1036 ------KNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLA- 1093

  Fly  1118 NASSQNEDDVGYASAKNTLDINRPPDLLSKNYSYNDSTSLVVKLRSILEE-----------EKQK 1171
                :.|:::..|.|:  ||    .::..||.:......|...:..:.|:           ||||
Human  1094 ----KKEEELQAALAR--LD----DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1148

  Fly  1172 HKVLQEQYIKLSSRHKPTEDSFRVSELEVENEKLRSEYDQLRTSIK---------HGVEINELNA 1227
             :.|.|:...|.:..:.|.||      ....::||::.:|..|.:|         |..::.|:..
Human  1149 -RDLGEELEALKTELEDTLDS------TATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ 1206

  Fly  1228 QHAALQEEVRRRREECIQLKAVLLQQSQSMRSLEPESLQMRGNDVNEL-------MEAFHSQKLI 1285
            :||...||:..:.|:..:.||.|   .::.::||.|:..:.|    ||       .|..|.:|.:
Human  1207 KHAQAVEELTEQLEQFKRAKANL---DKNKQTLEKENADLAG----ELRVLGQAKQEVEHKKKKL 1264

  Fly  1286 NRQLESELKAITEEHNSKLVEMTQEIERLNNEKDELQKVMFESIDEFEDSNVDTLRQNDRYLRRE 1350
            ..|:: ||::...:......|:..::.:|.||.:.:..::.|:     :.....|.::...|..:
Human  1265 EAQVQ-ELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA-----EGKAIKLAKDVASLSSQ 1323

  Fly  1351 LQKAVAQFLLVQEELKL---ANAKLKAYRQDGGQLEHKIEEEMIRNKSNGTSADVGANVTKQKSQ 1412
            ||....   |:|||.:.   .:.||:...::...|:.:::|||               ..||..:
Human  1324 LQDTQE---LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM---------------EAKQNLE 1370

  Fly  1413 NPQGLMKFHSSDLDKILQRLLSALTPRTVVGLLPGFPAYLIFMCIRYTDLTNADDDVRELLSKFV 1477
            .....:....||..|.||...|     ||..|..|...:       ..::.|......|..:.:.
Human  1371 RHISTLNIQLSDSKKKLQDFAS-----TVEALEEGKKRF-------QKEIENLTQQYEEKAAAYD 1423

  Fly  1478 IQIKKMHRTPHPIENRVIWLVNSITLL-NLMKQYGDVDEYV----KFNTEKQNQQQLKNFNLFEY 1537
            ...|..:|....:::.|:.|.|...|: ||.|:....|:.:    ..:::..:::........|.
Human  1424 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1488

  Fly  1538 RRVILDLIVNLYQAL-----IMQIQGLLDPKIVPAILNNDEIQRGRQAHGMRSRATSIGASSSPE 1597
            ....|.|...|.:||     :.:...:|..::...:.:.|::  |:..|.:.....::...
Human  1489 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV--GKNVHELEKSKRALETQ---- 1547

  Fly  1598 HGGGPAWKQLIGQLEHFYKQFQ 1619
                  .:::..|||....:.|
Human  1548 ------MEEMKTQLEELEDELQ 1563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc	65..778	CDD:214580	296/742 (40%)
		MYSc_Myo5	84..767	CDD:276831	284/712 (40%)
		IQ	900..922	CDD:197470	4/21 (19%)
		GBP_C	<971..1086	CDD:303769	29/117 (25%)
		coiled coil	1049..1068	CDD:293879	1/18 (6%)
		coiled coil	1077..1086	CDD:293879	2/10 (20%)
		JAKMIP_CC3	<1190..1299	CDD:292653	29/124 (23%)
		Myo5_CBD	1424..1792	CDD:271254	35/206 (17%)
MYH11	NP_001035203.1	Myosin_N	34..71	CDD:280832	11/40 (28%)
		Myosin_head	87..778	CDD:278492	288/724 (40%)
		MYSc_class_II	99..778	CDD:276951	284/712 (40%)
		Actin-binding. /evidence=ECO:0000250	668..690		12/21 (57%)
		Actin-binding. /evidence=ECO:0000250	769..783		7/13 (54%)
		Myosin_tail_1	855..1935	CDD:279860	163/825 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	865..889		4/23 (17%)
		FAM76	<997..1089	CDD:292665	26/113 (23%)
		V_Alix_like	<1027..1299	CDD:187408	65/308 (21%)
		crotonase-like	1073..>1131	CDD:304874	13/68 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1751..1807
		DUF2570	1787..>1874	CDD:305162
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1873..1979
		C-terminal	1942..1979
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910