DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment didum and MYH10

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:XP_011522177.1 Gene:MYH10 / 4628 HGNCID:7568 Length:2037 Species:Homo sapiens


Alignment Length:2004 Identity:547/2004 - (27%)
Similarity:890/2004 - (44%) Gaps:412/2004 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 IWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLRNPAILVGQNDLTTL 78
            :|:|.....:|:|:::|  .:|...:....::||    |...:..|:..: ||.......|:..|
Human    66 VWIPSERHGFEAASIKE--ERGDEVMVELAENGK----KAMVNKDDIQKM-NPPKFSKVEDMAEL 123

  Fly    79 SYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLEPHIFAL 143
            :.|:|..|||||:.|:.. .:||||.|:..|.||||..:|:|..:||..|||....::.|||:|:
Human   124 TCLNEASVLHNLKDRYYS-GLIYTYSGLFCVVINPYKNLPIYSENIIEMYRGKKRHEMPPHIYAI 187

  Fly   144 AEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGS-----------------ESET 191
            :|.||..:.::..:.||:.:||||||||.:.|..::|.|.|..|                 :.:.
Human   188 SESAYRCMLQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSHKGRKDHNIPQESPKPVKHQG 252

  Fly   192 QVERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQ 256
            ::||::|.::||:|:||||||.:||||||||||.::.| :..|  ::.||.:.||||||||.|.|
Human   253 ELERQLLQANPILESFGNAKTVKNDNSSRFGKFIRINF-DVTG--YIVGANIETYLLEKSRAVRQ 314

  Fly   257 AQGERNYHIFYQLCAARSKY--PELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGF 319
            |:.||.:||||||.:...::  .:|:|:..:.::||:.|..| |....|.:.|.||::||.::||
Human   315 AKDERTFHIFYQLLSGAGEHLKSDLLLEGFNNYRFLSNGYIP-IPGQQDKDNFQETMEAMHIMGF 378

  Fly   320 SIQQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRW 384
            |.::|..::|:::.:|..|||...|       |.::|...:..|.: .|....||.::..:..|.
Human   379 SHEEILSMLKVVSSVLQFGNISFKK-------ERNTDQASMPENTV-AQKLCHLLGMNVMEFTRA 435

  Fly   385 LLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQ-CSFIGVLDI 448
            :|..:|:...:||....:.|.|..|.:||||..|.:||:::|..:||:|:...:| .||||:|||
Human   436 ILTPRIKVGRDYVQKAQTKEQADFAVEALAKATYERLFRWLVHRINKALDRTKRQGASFIGILDI 500

  Fly   449 YGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDF-YDNQPCIDLIE-- 510
            .|||.||:|||||.||||.||||||.||..:|.||||||.:|||.|..||| .|.||||||||  
Human   501 AGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDLIERP 565

  Fly   511 -SRLGVLDLLDEECRMPKGSDESWAGKLIGKCNKFPHFEKPR--FGTTSFFIKHFSDTVEYDVNG 572
             :..|||.||||||..||.:|:::..||:.:......|:|||  .....|.|.|::..|:|..:.
Human   566 ANPPGVLALLDEECWFPKATDKTFVEKLVQEQGSHSKFQKPRQLKDKADFCIIHYAGKVDYKADE 630

  Fly   573 FLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLG------GRVVISAGRKQ 631
            :|.||.|.::..:..:|.:|:.....::.. :||..:...|...|..|      .|:|   |..|
Human   631 WLMKNMDPLNDNVATLLHQSSDRFVAELWK-DEIQNIQRASFYDSVSGLHEPPVDRIV---GLDQ 691

  Fly   632 QGNDTRRRVVPSKQHRK----TVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKI 692
            ....|......:.:.:|    |||..::|||..|::||..|.|::||||.||.:|.|.|.:...:
Human   692 VTGMTETAFGSAYKTKKGMFRTVGQLYKESLTKLMATLRNTNPNFVRCIIPNHEKRAGKLDPHLV 756

  Fly   693 IQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKN--DMKLSCRNIVMKWIQDED 755
            :.|||..||||.:||...|||:|.::.:|..||::|. .:.:.|.  |.|.:|..::.....|.:
Human   757 LDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILT-PNAIPKGFMDGKQACERMIRALELDPN 820

  Fly   756 KYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYL 820
            .||.|.::||||||.:|.||:.|.                       |:|..:|...|...||||
Human   821 LYRIGQSKIFFRAGVLAHLEEERD-----------------------LKITDIIIFFQAVCRGYL 862

  Fly   821 ARERTQKMREARAGL-ILSKYARGWLCRRRYLRLRH-----SISGIQTYARGMLARNKFHAMRDH 879
            ||:...|.::..:.| :|.:....      ||:|||     ..:.::...:......:..|..:.
Human   863 ARKAFAKKQQQLSALKVLQRNCAA------YLKLRHWQWWRVFTKVKPLLQVTRQEEELQAKDEE 921

  Fly   880 YRAV-QIQRFVRGAL--ARRAYQK--RRRNIII--CQAAIRRFL----ARRKFKRMKAEAKTISH 933
            ...| :.|..|.|.|  ..|.:|:  ..:||:.  .||....|.    .|.:....|.|.:.|.|
Human   922 LLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILH 986

  Fly   934 ---------------MENKYMGLENKIISMQQRIDELN--RDNSNLKHKTSEISVLKMKLELKKT 981
                           ::|:...::..|..:::::||..  |....|:..|:|..:.||:.|:...
Human   987 DLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLL 1051

  Fly   982 LEAEFKNVKAACQDKDKLIEALNKQLEAERDEKMQLLEENGHAQEEWIS-------QKQTWRQEN 1039
            .:...|.:|.....:|::.|. :.|| ||.:||.:.|.:..:.||..||       :::..|||.
Human  1052 EDQNSKFIKEKKLMEDRIAEC-SSQL-AEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQEL 1114

  Fly  1040 E------------------ELRRQIDEI-IDMAKNAEVNQ------------RNQEDRMLAEIDN 1073
            |                  ||:.||||: :.:||..|..|            :|...:::.|:..
Human  1115 EKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQA 1179

  Fly  1074 R--ELNEAYQRAIKDKEVIENENFMLKEELSRLTAGSFSLHARKASNASSQNEDDVGYASAKNTL 1136
            :  ||.|.::.....:...|.:...|.|||..|               .::.||.:...:|:..|
Human  1180 QIAELQEDFESEKASRNKAEKQKRDLSEELEAL---------------KTELEDTLDTTAAQQEL 1229

  Fly  1137 DINRPPDLLSKNYSYNDSTSLVVKLRSILEEEKQKHKV---------------LQEQYIKLSSRH 1186
            ...|..:              |.:|:..||||.:.|:.               |.|| ::.:.|.
Human  1230 RTKREQE--------------VAELKKALEEETKNHEAQIQDMRQRHATALEELSEQ-LEQAKRF 1279

  Fly  1187 KPTEDSFRVSELEVENEKLRSE---YDQLRTSIKHGVEINELNAQ----HAALQEEVRRR---RE 1241
            |...:..: ..||.:|::|..|   ..|::...:|  :..:|:||    ||.:.|..|.|   .|
Human  1280 KANLEKNK-QGLETDNKELACEVKVLQQVKAESEH--KRKKLDAQVQELHAKVSEGDRLRVELAE 1341

  Fly  1242 ECIQLK------AVLLQQSQSMR---SLEPESLQMRGNDVNELMEAFHSQKLINRQLESELKAIT 1297
            :..:|:      :.||::::...   :.:..||:.:..|..||::....|||   .|.|.::.:.
Human  1342 KASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKL---NLSSRIRQLE 1403

  Fly  1298 EEHNSKLVEMTQEIE--RLNNEK----------DELQKVMFE--SIDEFEDSNVDTLRQNDRYLR 1348
            ||.|| |.|..:|.|  |.|.||          |..:||..:  :|:..|::....|:..:...:
Human  1404 EEKNS-LQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQ 1467

  Fly  1349 RELQKAVAQFLL------VQEELKLANAKLKAYRQDGGQLEHK--------IEEEMI--RNKSNG 1397
            |..:||:|...|      :|:||......|...||....||.|        .||:.|  |.....
Human  1468 RLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEER 1532

  Fly  1398 TSADVGANVTKQKSQNPQGLMKFHSSDLDKILQRLLSALTPRTVVGLLPGFPAYLIFMCIRYTDL 1462
            ..|:..|...:.|:.:           |.:.|:..|.|...         |......:.....||
Human  1533 DRAEAEAREKETKALS-----------LARALEEALEAKEE---------FERQNKQLRADMEDL 1577

  Fly  1463 TNADDDVRELLSKFVIQIKKMHRTPHPIENRVIWLVNSITLLNLMKQYGDVDEYVKFNTEKQNQQ 1527
            .::.|||    .|.|.:::|..|.   :|.:|   ....|.|..::......|..|...| .|.|
Human  1578 MSSKDDV----GKNVHELEKSKRA---LEQQV---EEMRTQLEELEDELQATEDAKLRLE-VNMQ 1631

  Fly  1528 QLKNFNLFEYRRVILDLIVNLYQ------ALIMQIQGLLDPKIVPAILNNDEIQRGRQAHGMRSR 1586
            .:|    .::.|   ||.....|      .||.|::.|      .|.|.::..||.......:..
Human  1632 AMK----AQFER---DLQTRDEQNEEKKRLLIKQVREL------EAELEDERKQRALAVASKKKM 1683

  Fly  1587 ATSIGASSSPEHGGGPAWKQLIGQLEHFYKQFQHF--GLDNCYA--EQIFHQLLYFICAVALNCL 1647
            ...:....:.......|..::|.||.....|.:.:  .|:...|  ::||.|             
Human  1684 EIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQ------------- 1735

  Fly  1648 MLRGDICMWETGMIIRYNIGCIEDWVRSKKMSNDVLTALAPLNQVSQLLQS-----RKSEQDVQT 1707
                                       ||:....:.:..|.:.|:.:.|.|     |.:||:...
Human  1736 ---------------------------SKESEKKLKSLEAEILQLQEELASSERARRHAEQERDE 1773

  Fly  1708 ICDLCTSLST-------------AQVLKVMKSYKLDDYESEITNVFLEKLT---EKLNA------ 1750
            :.|..|:.::             |::.::.:..:.:....|:.|....|.|   :.|||      
Human  1774 LADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAER 1838

  Fly  1751 ----------RQMQKSNSD--------EFTIDQKFIQPFKVVFRYSDIKLEDIE 1786
                      :|:::.|.:        |..:..|    ||......:.|:..:|
Human  1839 SAAQKSDNARQQLERQNKELKAKLQELEGAVKSK----FKATISALEAKIGQLE 1888

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 291/750 (39%)
MYSc_Myo5 84..767 CDD:276831 278/720 (39%)
IQ 900..922 CDD:197470 6/29 (21%)
GBP_C <971..1086 CDD:303769 37/154 (24%)
coiled coil 1049..1068 CDD:293879 5/31 (16%)
coiled coil 1077..1086 CDD:293879 1/8 (13%)
JAKMIP_CC3 <1190..1299 CDD:292653 29/127 (23%)
Myo5_CBD 1424..1792 CDD:271254 73/418 (17%)
MYH10XP_011522177.1 Myosin_N 64..102 CDD:280832 9/41 (22%)
Myosin_head 117..832 CDD:278492 282/732 (39%)
MYSc_Myh10 129..832 CDD:276952 278/720 (39%)
Myosin_tail_1 909..1989 CDD:279860 227/1107 (21%)
DUF342 <1105..1194 CDD:302792 19/88 (22%)
DUF2317 <1172..1283 CDD:302887 27/140 (19%)
COG5134 <1399..1527 CDD:227463 35/128 (27%)
GBP_C <1565..1671 CDD:303769 29/129 (22%)
coiled coil 1661..1671 CDD:293879 3/15 (20%)
DUF106 <1706..>1757 CDD:303007 12/90 (13%)
DUF2570 1834..>1928 CDD:305162 8/59 (14%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0160
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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