Protein Alignment didum and MYH9

DIOPT Version :10

• Sequence 1: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Sequence 2: NP_002464.1
• Gene: MYH9 / 4627
• HGNCID: 7579
• Length: 1960
• Species: Homo sapiens
• Alignment Length: 1906
• Identity: 505/1906 - (26%)
• Similarity: 872/1906 - (45%)
• Gaps: 416/1906 - (21%)

  Fly    14 IWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLRNPAILVGQNDLTTL 78
            :|||.....:|.|:|:|..  |...:....::||    |:|.:..|:..: ||.......|:..|
Human    32 VWVPSDKSGFEPASLKEEV--GEEAIVELVENGK----KVKVNKDDIQKM-NPPKFSKVEDMAEL 89

  Fly    79 SYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLEPHIFAL 143
            :.|:|..|||||:.|:.. .:||||.|:..|.||||..:|:|...|:..|:|....::.|||:|:
Human    90 TCLNEASVLHNLKERYYS-GLIYTYSGLFCVVINPYKNLPIYSEEIVEMYKGKKRHEMPPHIYAI 153

  Fly   144 AEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGS----ESETQVERKVLASSPIM 204
            .:.||..:.::..:.||:.:||||||||.:.|..::|.|.|..|    :.:.::||::|.::||:
Human   154 TDTAYRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAYVASSHKSKKDQGELERQLLQANPIL 218

  Fly   205 EAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHIFYQL 269
            ||||||||.:||||||||||.::.| :..|  ::.||.:.||||||||.:.||:.||.:||||.|
Human   219 EAFGNAKTVKNDNSSRFGKFIRINF-DVNG--YIVGANIETYLLEKSRAIRQAKEERTFHIFYYL 280

  Fly   270 CAARSKY--PELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIADIVKILA 332
            .:...::  .:|:|:..:|::||: .|...|....|.:.|.||::||.::|...::...::::::
Human   281 LSGAGEHLKTDLLLEPYNKYRFLS-NGHVTIPGQQDKDMFQETMEAMRIMGIPEEEQMGLLRVIS 344

  Fly   333 GILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKIESVNEYV 397
            |:|.|||| |.||      |.::|...:..|.. .|..:.||.::..|..|.:|..:|:...:||
Human   345 GVLQLGNI-VFKK------ERNTDQASMPDNTA-AQKVSHLLGINVTDFTRGILTPRIKVGRDYV 401

  Fly   398 LIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQ-CSFIGVLDIYGFETFEVNSFEQ 461
            ....:.|.|..|.:||||..|.::|:::|..:||:|:...:| .||||:|||.|||.|::|||||
Human   402 QKAQTKEQADFAIEALAKATYERMFRWLVLRINKALDKTKRQGASFIGILDIAGFEIFDLNSFEQ 466

  Fly   462 FCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDF-YDNQPCIDLIESRL---GVLDLLDEE 522
            .||||.||||||.||..:|.||||||.:|||.|..||| .|.||||||||...   |:|.|||||
Human   467 LCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDLIEKPAGPPGILALLDEE 531

  Fly   523 CRMPKGSDESWAGKLIGKCNKFPHFEKPR--FGTTSFFIKHFSDTVEYDVNGFLEKNRDTVSKEL 585
            |..||.:|:|:..|::.:....|.|:||:  .....|.|.|::..|:|..:.:|.||.|.::..:
Human   532 CWFPKATDKSFVEKVMQEQGTHPKFQKPKQLKDKADFCIIHYAGKVDYKADEWLMKNMDPLNDNI 596

  Fly   586 TQVLSESNMSLAKQVMTLEEIDTLC----VDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQH 646
            ..:|.:|:.....::.  :::|.:.    |.....:.|.|..           .||:.:.
Human   597 ATLLHQSSDKFVSELW--KDVDRIIGLDQVAGMSETALPGAF-----------KTRKGMF----- 643

  Fly   647 RKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAG 711
             :|||..::|.||.|::||..|.|::||||.||.:|.|.|.:...::.|||..||||.:||...|
Human   644 -RTVGQLYKEQLAKLMATLRNTNPNFVRCIIPNHEKKAGKLDPHLVLDQLRCNGVLEGIRICRQG 707

  Fly   712 FPSRWLYPDFYMRYQLLVYRSKLDKN--DMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAFL 774
            ||:|.::.:|..||::|...| :.|.  |.|.:|..::.....|.:.||.|.:::|||||.:|.|
Human   708 FPNRVVFQEFRQRYEILTPNS-IPKGFMDGKQACVLMIKALELDSNLYRIGQSKVFFRAGVLAHL 771

  Fly   775 EQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAGLILSK 839
            |:.|.                       |:|..||.|.|...||||||:...|.::
Human   772 EEERD-----------------------LKITDVIIGFQACCRGYLARKAFAKRQQ--------- 804

  Fly   840 YARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAYQKRRRN 904
                                 |..|..:|.||                       ..||.|
Human   805 ---------------------QLTAMKVLQRN-----------------------CAAYLK---- 821

  Fly   905 IIICQAAIRRFLARRKFKRMKAEAKTISHMENKYMGLENKIISMQQRIDELNRDNSNLKHKTSEI 969
                   :|.:...|.|.::|...: :|..|.:.|..|.:::.::::  :|..:|...:.:|.:.
Human   822 -------LRNWQWWRLFTKVKPLLQ-VSRQEEEMMAKEEELVKVREK--QLAAENRLTEMETLQS 876

  Fly   970 SVLKMKLELKKTLE------AEFKNVKAACQDKDKLIEALNKQLEA---ERDEKMQLLEENGHAQ 1025
            .::..||:|::.|:      ||.:.::|....|.:.:|.:...|||   |.:|:.|      |.|
Human   877 QLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQ------HLQ 935

  Fly  1026 EEWISQKQTWRQENEELRRQIDEIIDMAKNAEVNQRNQEDRMLAEIDNRELNEAYQRAIKDKEVI 1090
            .|    |:..:|..:||..|::|      .....|:.|.:::..|...::|.|       ::.::
Human   936 AE----KKKMQQNIQELEEQLEE------EESARQKLQLEKVTTEAKLKKLEE-------EQIIL 983

  Fly  1091 ENENFMLKEELSRLTAGSFSLHARKASNASSQNEDDVGYASAKNTLDINRPPDLLSKNYSYNDST 1155
            |::|..|.:|...|                   ||.:.                   .::.|
Human   984 EDQNCKLAKEKKLL-------------------EDRIA-------------------EFTTN--- 1007

  Fly  1156 SLVVKLRSILEEEKQKHKVLQEQYIKLSSRHKPTEDSFRVSELEV---ENEKLRSEYDQLRTSIK 1217
                     |.||::|.|.|    .||.::|:.     .:::||.   ..||.|.|.::.|..::
Human  1008 ---------LTEEEEKSKSL----AKLKNKHEA-----MITDLEERLRREEKQRQELEKTRRKLE 1054

  Fly  1218 H-----GVEINELNAQHAALQEEVRRRREECIQLKAVLLQQSQSMRSLEPESLQMRGNDVNELME 1277
            .     ..:|.||.||.|.|:.::.::.|| :|.....:::..:.:::..:.::...:.::||.|
Human  1055 GDSTDLSDQIAELQAQIAELKMQLAKKEEE-LQAALARVEEEAAQKNMALKKIRELESQISELQE 1118

  Fly  1278 AFHSQKLI-------NRQLESELKAITEEHNSKLVEMTQEIERLNNEKDELQKVMFESIDE---F 1332
            ...|::..       .|.|..||:|:..|....| :.|...:.|.:::::...::.::::|   .
Human  1119 DLESERASRNKAEKQKRDLGEELEALKTELEDTL-DSTAAQQELRSKREQEVNILKKTLEEEAKT 1182

  Fly  1333 EDSNVDTLRQNDRYLRRELQKAVAQFLLVQEEL------------KLANAKLKAYRQDGGQLEHK 1385
            .::.:..:||.......||.:.:.|...|:..|            :||| ::|...|..|..|||
Human  1183 HEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELAN-EVKVLLQGKGDSEHK 1246

  Fly  1386 -------IEEEMIR-NKSNGTSADVGANVTKQKSQ--NPQGLMK---FHSSDLDKILQRLLSALT 1437
                   ::|..:: |:......::...|||.:.:  |..||:.   ..||.|.|....|.|.|
Human  1247 RKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQL- 1310

  Fly  1438 PRTVVGLLPGFPAYLIFMCIRYTDLTNADDDVRELLSKFVIQIKKMHRTPHPIENRVIWLVNSIT 1502
             :....||.......:.:..:...:.:..:..||       |:::.....|.:|.::..|...:.
Human  1311 -QDTQELLQEENRQKLSLSTKLKQVEDEKNSFRE-------QLEEEEEAKHNLEKQIATLHAQVA 1367

  Fly  1503 LLNLMKQYGD------VDEYVKFNTEK-------QNQQQLKNFNLFEYRRVIL-----DLIVNL- 1548
              ::.|:..|      ..|.||...:|       ::::::..::..|..:..|     ||:|:|
Human  1368 --DMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLD 1430

  Fly  1549 -----------YQALIMQIQGLLDPKIVPAILNNDEIQRGRQAHGMRSRATSIGASSSPEHGGGP 1602
                       .|....|:  |.:.|.:.|....:..:...:|....::|.|:..:..      .
Human  1431 HQRQSACNLEKKQKKFDQL--LAEEKTISAKYAEERDRAEAEAREKETKALSLARALE------E 1487

  Fly  1603 AWKQLIGQLEHFYKQFQHFGLDNCYAEQIFHQLLYFICAVALNCLMLRGDICMWETGMIIRYNIG 1667
            |.:|. .:||...|||:                                      |.|
Human  1488 AMEQK-AELERLNKQFR--------------------------------------TEM------- 1506

  Fly  1668 CIEDWVRSKKMSNDVLTALAPLNQVSQLLQSRKSEQDVQ--TICDLCTSLSTAQV-----LKVMK 1725
              ||.:.||   :||..::..|.:..:.|:.:..|...|  .:.|...:...|::     |:.||
Human  1507 --EDLMSSK---DDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMK 1566

  Fly  1726 S-YKLD----DYESEITNVFLEKLTEKLNARQMQKSNSDEFTIDQKFIQPFKVVFRYS-DIKLED 1784
            : ::.|    |.:||      ||  :|...||:::..::  ..|::..:...|..|.. ::.|:|
Human  1567 AQFERDLQGRDEQSE------EK--KKQLVRQVREMEAE--LEDERKQRSMAVAARKKLEMDLKD 1621

  Fly  1785 IELPSHL-----NLDEFLTKI 1800
            :|  :|:     |.||.:.::
Human  1622 LE--AHIDSANKNRDEAIKQL 1640

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	267/701 (38%)
		IQ	900..922	CDD:197470	3/21 (14%)
		SMC_prok_B	<942..1365	CDD:274008	87/449 (19%)
		Myo5_CBD	1424..1792	CDD:271254	73/415 (18%)
MYH9	NP_002464.1	Mediates interaction with LIMCH1. /evidence=ECO:0000269|PubMed:28228547	2..838		319/932 (34%)
		Myosin_N	27..72	CDD:460670	12/45 (27%)
		Motor_domain	95..764	CDD:473979	267/701 (38%)
		Actin-binding	654..676		12/21 (57%)
		Myosin_tail_1	841..1921	CDD:460256	186/969 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1035..1057		5/21 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1118..1137		3/18 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1877..1960