Protein Alignment didum and MYH8

DIOPT Version :10

• Sequence 1: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Sequence 2: NP_002463.2
• Gene: MYH8 / 4626
• HGNCID: 7578
• Length: 1937
• Species: Homo sapiens
• Alignment Length: 2098
• Identity: 532/2098 - (25%)
• Similarity: 897/2098 - (42%)
• Gaps: 523/2098 - (24%)

  Fly     2 SSEEMLYAQGAKIWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLR-- 64
            |.:|.:.||........:..|.|.   :|||.|.....|   :.||   |.:|.:|.....:|
Human    22 SEKERIEAQNKPFDAKTSVFVAEP---KESYVKSTIQSK---EGGK---VTVKTEGGATLTVRED 77

  Fly    65 -----NPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSI 124
                 ||.......|:..:::|||||||:||:.|:. ..:||||.|:..|.:|||..:|:|.|.:
Human    78 QVFPMNPPKYDKIEDMAMMTHLHEPGVLYNLKERYA-AWMIYTYSGLFCVTVNPYKWLPVYKPEV 141

  Fly   125 IRAYRGHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFA--AVGGS 187
            :.||||....:..||||::::.||..:..:..|.||:::|||||||||:.|..::|||  ||.|.
Human   142 VAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGE 206

  Fly   188 ESETQ-------VERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHT 245
            :.:.:       :|.::::::|::||||||||.|||||||||||.::.| ...|.  |..|.:.|
Human   207 KKKDESGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHF-GTTGK--LASADIET 268

  Fly   246 YLLEKSRVVYQAQGERNYHIFYQLCAARSKYPE-----LVLDHQDKFQFLNMGGAPEIERVSDAE 305
            ||||||||.:|.:.||:||||||:.:  :|.|:     |:..:...:.|::.|.. .:..:.|.|
Human   269 YLLEKSRVTFQLKAERSYHIFYQITS--NKKPDLIEMLLITTNPYDYAFVSQGEI-TVPSIDDQE 330

  Fly   306 QFNETVQAMTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQI- 369
            :...|..|:.:|||:.::...|.|:...::|.||::..:|..|  |:.:.|..::.....:||.
Human   331 ELMATDSAIDILGFTPEEKVSIYKLTGAVMHYGNMKFKQKQRE--EQAEPDGTEVADKAAYLQSL 393

  Fly   370 -TADLLRVSADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSL 433
             :||||:.        |...:::..||||....:::....|..||||.:|.|:|.::|..:|:.|
Human   394 NSADLLKA--------LCYPRVKVGNEYVTKGQTVQQVYNAVGALAKAVYEKMFLWMVTRINQQL 450

  Fly   434 NNGSKQCSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMID 498
            :....:..|||||||.|||.|:.||.||.|||:.||||||.||.|:|.||||||.||||.||.||
Human   451 DTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFID 515

  Fly   499 F-YDNQPCIDLIESRLGVLDLLDEECRMPKGSDESWAGKLIGK-CNKFPHFEKPRF----GTTSF 557
            | .|...||:|||..||:..:|:|||..||.:|.|:..||..: ..|..:|:||:.    ....|
Human   516 FGMDLAACIELIEKPLGIFSILEEECMFPKATDTSFKNKLYDQHLGKSANFQKPKVVKGKAEAHF 580

  Fly   558 FIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNM-SLAKQVMTL--EEIDTLCVDSAKSSTL 619
            .:.|::.||:|::.|:|:||:|.::..:..:..:|.| :||....|.  .|.|:    |||.
Human   581 SLIHYAGTVDYNITGWLDKNKDPLNDTVVGLYQKSAMKTLASLFSTYASAEADS----SAKK--- 638

  Fly   620 GGRVVISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVA 684
                    |.|::|:..           :||.:.|:|:|..|::.|.:|.||:||||.||:.|..
Human   639 --------GAKKKGSSF-----------QTVSALFRENLNKLMTNLRSTHPHFVRCIIPNETKTP 684

  Fly   685 FKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKN---DMKLSCRNI 746
            ...|...::.|||..||||.:||...|||||.||.||..||::| ..|.:.:.   |.|.:...:
Human   685 GAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYGDFKQRYKVL-NASAIPEGQFIDSKKASEKL 748

  Fly   747 VMKWIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVING 811
            :.....|..:|:||:|::||:||.:..||::|.....:.||..|:|
Human   749 LASIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDEKLAQIITRTQAV------------------- 794

  Fly   812 IQKHARGYLARERTQKMREARAGLILSKY-------ARGWLCRRRYLRLRHSISGIQTYARGMLA 869
                .||:|.|...|||.:.|..|...:|       .:.|...:.:.:::..:...:|.......
Human   795 ----CRGFLMRVEYQKMLQRREALFCIQYNVRAFMNVKHWPWMKLFFKIKPLLKSAETEKEMATM 855

  Fly   870 RNKFHAMRDHYRAVQIQRFVRGALARRAYQK-----RRRNIIICQAAIRRFLARRKFKRMKAEAK 929
            :.:|...:|.....:.:|       :...:|     :.:|.:..|              :::||.
Human   856 KEEFQKTKDELAKSEAKR-------KELEEKMVTLLKEKNDLQLQ--------------VQSEAD 899

  Fly   930 TISHMENKYMGLENKIISMQQRIDELNRDNSNLKHKTSEISVLKMKL-----ELKKTLE------ 983
            :::..|.:...|....|.::.:|.|:.......:...:|::..|.||     ||||.::
Human   900 SLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTL 964

  Fly   984 AEFKNVKAACQDK-----------DKLIEALNKQ--------------LEAERDEKMQL------ 1017
            |:.:..|.|.::|           |:.|..|:|:              |:||.|:...|
Human   965 AKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTK 1029

  Fly  1018 LEENGHAQEEWISQKQTWRQENEELRRQIDEIIDMAKNAEVNQRNQEDRMLAEIDNRELNEAYQR 1082
            ||:.....|..:.|::..|.:.|..:|:::..:.:|         ||..|..|.|.::|:|..::
Human  1030 LEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLA---------QESTMDMENDKQQLDEKLEK 1085

  Fly  1083 ----------AIKDKEVIENE-NFMLKEELSRLTAGSFSLHARKASNASSQNEDDVGYASAKNTL 1136
                      .|:|::.:|.: ...:||..:|:......:.|.:||.|.::          |...
Human  1086 KEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAE----------KQRS 1140

  Fly  1137 DINRPPDLLSKNY-SYNDSTSLVVKLRSILEEEKQK------HKVLQEQYIKLSSRHKPTEDSFR 1194
            |::|..:.:|:.. ....:||..|:|....|.|.||      ...||.:.:..:.|.|..:....
Human  1141 DLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAE 1205

  Fly  1195 VSE-----------LEVENEKLRSEYDQLRTS------IKHGVE--------------------- 1221
            :.|           ||.|..:|:.|.|.|.::      .|..:|
Human  1206 LGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQ 1270

  Fly  1222 --INELNAQHAALQEEVRRRREECIQLKAVLLQQSQSMRS-----------LEPE---------S 1264
              ||:|.||.|.||.|......:..:..|::.|.|:|.::           ||.|         :
Human  1271 RLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHA 1335

  Fly  1265 LQMRGNDVNELMEAFHSQKLINRQLESELKAITEEHNSKLVEMTQEIERLNNEKDELQKVMFESI 1329
            ||...:|.:.|.|.:..:    ::.::||:....:.||::.:.     |...|.|.:|:.
Human  1336 LQSSRHDCDLLREQYEEE----QEGKAELQRALSKANSEVAQW-----RTKYETDAIQRT----- 1386

  Fly  1330 DEFEDSNVDTLRQNDRYLRRELQKAVAQFLLVQEELKLANAKLKAYRQDGGQLEHKIEEEMIR-N 1393
            :|.|::.        :.|.:.||:|       :|.::..|||..:..:...:|::::|:.|:. .
Human  1387 EELEEAK--------KKLAQRLQEA-------EEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVE 1436

  Fly  1394 KSNGTSA---------DVGANVTKQKSQNPQGLMKFHSSDLDKILQRLLSALTPRTVVGLLPGFP 1449
            :||...|         |...:..|||.:..|..::....:     .|.||
Human  1437 RSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKE-----SRSLS--------------- 1481

  Fly  1450 AYLIFMCIRYTDLTNADDDVRELLSKFVIQIKKMHRTPHPIENRVIWLVNSITLLNLMKQYGDVD 1514
                      |:|..    |:.:..:.:.|::.:.|     ||:           ||.::..|:.
Human  1482 ----------TELFK----VKNVYEESLDQLETLRR-----ENK-----------NLQQEISDLT 1516

  Fly  1515 EYV--------KFNTEKQNQQQLKNFNLFEYRRVILDLIVNL---------YQALIMQIQGLLDP 1562
            |.:        :....|:..:|.|    .|.:..:.:...:|         .|..:.|::..:|.
Human  1517 EQIAEGGKQIHELEKIKKQVEQEK----CEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDR 1577

  Fly  1563 KIVPAILNNDEIQRGRQAHG--MRSRATSIGASSSPEHGGGPAWKQLIGQLEHFYKQFQH----- 1620
            ||..   .::||.:.::.|.  :.:..:::.|.....:......|::.|.|.....|..|
Human  1578 KIAE---KDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLA 1639

  Fly  1621 ------------------FGLDNCYAEQIFHQLLYFICAVALNCLMLRGDI-CMWETGMIIRYNI 1666
                              ..||:....|  ..|...:..|.....:|:.:| .:|.|
Human  1640 AESLRNYRNTQGILKETQLHLDDALRGQ--EDLKEQLAIVERRANLLQAEIEELWAT-------- 1694

  Fly  1667 GCIEDWVRS-----------------------------KKMSNDVLTALAPLNQVSQ-------- 1694
              :|...||                             ||:.|||....:.:.:|.|
Human  1695 --LEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEK 1757

  Fly  1695 ----------LLQSRKSEQDV------------QTICDLCTSLSTAQVLKVMKSYK--------L 1729
                      :.:..|.|||.            ||:.||...|..|:.|.:....|        :
Human  1758 AKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARV 1822

  Fly  1730 DDYESEITNVFLEKLTEKLNARQMQKSNSDEFTIDQKFIQ---PFKVVFRYSDI----------- 1780
            .:.|.|:.|      .:|.||..::.....|..:.:...|   ..|.|.|..|:
Human  1823 RELEGEVEN------EQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSY 1881

  Fly  1781 --KLEDIELPSHLNLDEF 1796
              :.|:.|..|:.||.:|
Human  1882 KRQAEEAEEQSNANLSKF 1899

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	270/710 (38%)
		IQ	900..922	CDD:197470	3/26 (12%)
		SMC_prok_B	<942..1365	CDD:274008	111/542 (20%)
		Myo5_CBD	1424..1792	CDD:271254	79/493 (16%)
MYH8	NP_002463.2	Myosin_N	35..79	CDD:460670	13/52 (25%)
		MYSc_Myh8	102..769	CDD:276882	270/710 (38%)
		Actin-binding	658..680		11/21 (52%)
		Actin-binding	760..774		7/13 (54%)
		Myosin_tail_1	849..1926	CDD:460256	217/1195 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1126..1146		7/29 (24%)