DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment didum and MYH8

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:NP_002463.2 Gene:MYH8 / 4626 HGNCID:7578 Length:1937 Species:Homo sapiens


Alignment Length:2098 Identity:532/2098 - (25%)
Similarity:897/2098 - (42%) Gaps:523/2098 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 SSEEMLYAQGAKIWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLR-- 64
            |.:|.:.||........:..|.|.   :|||.|.....|   :.||   |.:|.:|.....:|  
Human    22 SEKERIEAQNKPFDAKTSVFVAEP---KESYVKSTIQSK---EGGK---VTVKTEGGATLTVRED 77

  Fly    65 -----NPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSI 124
                 ||.......|:..:::|||||||:||:.|:. ..:||||.|:..|.:|||..:|:|.|.:
Human    78 QVFPMNPPKYDKIEDMAMMTHLHEPGVLYNLKERYA-AWMIYTYSGLFCVTVNPYKWLPVYKPEV 141

  Fly   125 IRAYRGHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFA--AVGGS 187
            :.||||....:..||||::::.||..:..:..|.||:::|||||||||:.|..::|||  ||.|.
Human   142 VAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGE 206

  Fly   188 ESETQ-------VERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHT 245
            :.:.:       :|.::::::|::||||||||.|||||||||||.::.| ...|.  |..|.:.|
Human   207 KKKDESGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHF-GTTGK--LASADIET 268

  Fly   246 YLLEKSRVVYQAQGERNYHIFYQLCAARSKYPE-----LVLDHQDKFQFLNMGGAPEIERVSDAE 305
            ||||||||.:|.:.||:||||||:.:  :|.|:     |:..:...:.|::.|.. .:..:.|.|
Human   269 YLLEKSRVTFQLKAERSYHIFYQITS--NKKPDLIEMLLITTNPYDYAFVSQGEI-TVPSIDDQE 330

  Fly   306 QFNETVQAMTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQI- 369
            :...|..|:.:|||:.::...|.|:...::|.||::..:|..|  |:.:.|..::.....:||. 
Human   331 ELMATDSAIDILGFTPEEKVSIYKLTGAVMHYGNMKFKQKQRE--EQAEPDGTEVADKAAYLQSL 393

  Fly   370 -TADLLRVSADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSL 433
             :||||:.        |...:::..||||....:::....|..||||.:|.|:|.::|..:|:.|
Human   394 NSADLLKA--------LCYPRVKVGNEYVTKGQTVQQVYNAVGALAKAVYEKMFLWMVTRINQQL 450

  Fly   434 NNGSKQCSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMID 498
            :....:..|||||||.|||.|:.||.||.|||:.||||||.||.|:|.||||||.||||.||.||
Human   451 DTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFID 515

  Fly   499 F-YDNQPCIDLIESRLGVLDLLDEECRMPKGSDESWAGKLIGK-CNKFPHFEKPRF----GTTSF 557
            | .|...||:|||..||:..:|:|||..||.:|.|:..||..: ..|..:|:||:.    ....|
Human   516 FGMDLAACIELIEKPLGIFSILEEECMFPKATDTSFKNKLYDQHLGKSANFQKPKVVKGKAEAHF 580

  Fly   558 FIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNM-SLAKQVMTL--EEIDTLCVDSAKSSTL 619
            .:.|::.||:|::.|:|:||:|.::..:..:..:|.| :||....|.  .|.|:    |||.   
Human   581 SLIHYAGTVDYNITGWLDKNKDPLNDTVVGLYQKSAMKTLASLFSTYASAEADS----SAKK--- 638

  Fly   620 GGRVVISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVA 684
                    |.|::|:..           :||.:.|:|:|..|::.|.:|.||:||||.||:.|..
Human   639 --------GAKKKGSSF-----------QTVSALFRENLNKLMTNLRSTHPHFVRCIIPNETKTP 684

  Fly   685 FKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKN---DMKLSCRNI 746
            ...|...::.|||..||||.:||...|||||.||.||..||::| ..|.:.:.   |.|.:...:
Human   685 GAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYGDFKQRYKVL-NASAIPEGQFIDSKKASEKL 748

  Fly   747 VMKWIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVING 811
            :.....|..:|:||:|::||:||.:..||::|.....:.||..|:|                   
Human   749 LASIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDEKLAQIITRTQAV------------------- 794

  Fly   812 IQKHARGYLARERTQKMREARAGLILSKY-------ARGWLCRRRYLRLRHSISGIQTYARGMLA 869
                .||:|.|...|||.:.|..|...:|       .:.|...:.:.:::..:...:|.......
Human   795 ----CRGFLMRVEYQKMLQRREALFCIQYNVRAFMNVKHWPWMKLFFKIKPLLKSAETEKEMATM 855

  Fly   870 RNKFHAMRDHYRAVQIQRFVRGALARRAYQK-----RRRNIIICQAAIRRFLARRKFKRMKAEAK 929
            :.:|...:|.....:.:|       :...:|     :.:|.:..|              :::||.
Human   856 KEEFQKTKDELAKSEAKR-------KELEEKMVTLLKEKNDLQLQ--------------VQSEAD 899

  Fly   930 TISHMENKYMGLENKIISMQQRIDELNRDNSNLKHKTSEISVLKMKL-----ELKKTLE------ 983
            :::..|.:...|....|.::.:|.|:.......:...:|::..|.||     ||||.::      
Human   900 SLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTL 964

  Fly   984 AEFKNVKAACQDK-----------DKLIEALNKQ--------------LEAERDEKMQL------ 1017
            |:.:..|.|.::|           |:.|..|:|:              |:||.|:...|      
Human   965 AKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTK 1029

  Fly  1018 LEENGHAQEEWISQKQTWRQENEELRRQIDEIIDMAKNAEVNQRNQEDRMLAEIDNRELNEAYQR 1082
            ||:.....|..:.|::..|.:.|..:|:::..:.:|         ||..|..|.|.::|:|..::
Human  1030 LEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLA---------QESTMDMENDKQQLDEKLEK 1085

  Fly  1083 ----------AIKDKEVIENE-NFMLKEELSRLTAGSFSLHARKASNASSQNEDDVGYASAKNTL 1136
                      .|:|::.:|.: ...:||..:|:......:.|.:||.|.::          |...
Human  1086 KEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAE----------KQRS 1140

  Fly  1137 DINRPPDLLSKNY-SYNDSTSLVVKLRSILEEEKQK------HKVLQEQYIKLSSRHKPTEDSFR 1194
            |::|..:.:|:.. ....:||..|:|....|.|.||      ...||.:.:..:.|.|..:....
Human  1141 DLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAE 1205

  Fly  1195 VSE-----------LEVENEKLRSEYDQLRTS------IKHGVE--------------------- 1221
            :.|           ||.|..:|:.|.|.|.::      .|..:|                     
Human  1206 LGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQ 1270

  Fly  1222 --INELNAQHAALQEEVRRRREECIQLKAVLLQQSQSMRS-----------LEPE---------S 1264
              ||:|.||.|.||.|......:..:..|::.|.|:|.::           ||.|         :
Human  1271 RLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHA 1335

  Fly  1265 LQMRGNDVNELMEAFHSQKLINRQLESELKAITEEHNSKLVEMTQEIERLNNEKDELQKVMFESI 1329
            ||...:|.:.|.|.:..:    ::.::||:....:.||::.:.     |...|.|.:|:.     
Human  1336 LQSSRHDCDLLREQYEEE----QEGKAELQRALSKANSEVAQW-----RTKYETDAIQRT----- 1386

  Fly  1330 DEFEDSNVDTLRQNDRYLRRELQKAVAQFLLVQEELKLANAKLKAYRQDGGQLEHKIEEEMIR-N 1393
            :|.|::.        :.|.:.||:|       :|.::..|||..:..:...:|::::|:.|:. .
Human  1387 EELEEAK--------KKLAQRLQEA-------EEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVE 1436

  Fly  1394 KSNGTSA---------DVGANVTKQKSQNPQGLMKFHSSDLDKILQRLLSALTPRTVVGLLPGFP 1449
            :||...|         |...:..|||.:..|..::....:     .|.||               
Human  1437 RSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKE-----SRSLS--------------- 1481

  Fly  1450 AYLIFMCIRYTDLTNADDDVRELLSKFVIQIKKMHRTPHPIENRVIWLVNSITLLNLMKQYGDVD 1514
                      |:|..    |:.:..:.:.|::.:.|     ||:           ||.::..|:.
Human  1482 ----------TELFK----VKNVYEESLDQLETLRR-----ENK-----------NLQQEISDLT 1516

  Fly  1515 EYV--------KFNTEKQNQQQLKNFNLFEYRRVILDLIVNL---------YQALIMQIQGLLDP 1562
            |.:        :....|:..:|.|    .|.:..:.:...:|         .|..:.|::..:|.
Human  1517 EQIAEGGKQIHELEKIKKQVEQEK----CEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDR 1577

  Fly  1563 KIVPAILNNDEIQRGRQAHG--MRSRATSIGASSSPEHGGGPAWKQLIGQLEHFYKQFQH----- 1620
            ||..   .::||.:.::.|.  :.:..:::.|.....:......|::.|.|.....|..|     
Human  1578 KIAE---KDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLA 1639

  Fly  1621 ------------------FGLDNCYAEQIFHQLLYFICAVALNCLMLRGDI-CMWETGMIIRYNI 1666
                              ..||:....|  ..|...:..|.....:|:.:| .:|.|        
Human  1640 AESLRNYRNTQGILKETQLHLDDALRGQ--EDLKEQLAIVERRANLLQAEIEELWAT-------- 1694

  Fly  1667 GCIEDWVRS-----------------------------KKMSNDVLTALAPLNQVSQ-------- 1694
              :|...||                             ||:.|||....:.:.:|.|        
Human  1695 --LEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEK 1757

  Fly  1695 ----------LLQSRKSEQDV------------QTICDLCTSLSTAQVLKVMKSYK--------L 1729
                      :.:..|.|||.            ||:.||...|..|:.|.:....|        :
Human  1758 AKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARV 1822

  Fly  1730 DDYESEITNVFLEKLTEKLNARQMQKSNSDEFTIDQKFIQ---PFKVVFRYSDI----------- 1780
            .:.|.|:.|      .:|.||..::.....|..:.:...|   ..|.|.|..|:           
Human  1823 RELEGEVEN------EQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSY 1881

  Fly  1781 --KLEDIELPSHLNLDEF 1796
              :.|:.|..|:.||.:|
Human  1882 KRQAEEAEEQSNANLSKF 1899

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 281/740 (38%)
MYSc_Myo5 84..767 CDD:276831 270/710 (38%)
IQ 900..922 CDD:197470 3/26 (12%)
GBP_C <971..1086 CDD:303769 36/166 (22%)
coiled coil 1049..1068 CDD:293879 3/18 (17%)
coiled coil 1077..1086 CDD:293879 2/18 (11%)
JAKMIP_CC3 <1190..1299 CDD:292653 33/168 (20%)
Myo5_CBD 1424..1792 CDD:271254 79/493 (16%)
MYH8NP_002463.2 Myosin_N 38..75 CDD:280832 12/45 (27%)
Myosin_head 90..769 CDD:278492 274/722 (38%)
MYSc_Myh8 102..769 CDD:276882 270/710 (38%)
Actin-binding 658..680 11/21 (52%)
Actin-binding 760..774 7/13 (54%)
Myosin_tail_1 849..1926 CDD:279860 217/1195 (18%)
eIF-4B <1042..1099 CDD:283846 13/65 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1126..1146 7/29 (24%)
COG6 1375..>1510 CDD:303003 37/204 (18%)
DUF342 <1505..1581 CDD:302792 15/90 (17%)
TMPIT 1741..>1828 CDD:285135 15/86 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.910

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