DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment didum and MYH6

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:NP_002462.2 Gene:MYH6 / 4624 HGNCID:7576 Length:1939 Species:Homo sapiens


Alignment Length:1885 Identity:512/1885 - (27%)
Similarity:854/1885 - (45%) Gaps:429/1885 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    43 TDSGKLKEVKLKADGSDLPPLRNPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGII 107
            |::||...||     .|....:||.......|:..|::||||.||.||:.|:. ..:||||.|:.
Human    63 TENGKTVTVK-----EDQVLQQNPPKFDKIEDMAMLTFLHEPAVLFNLKERYA-AWMIYTYSGLF 121

  Fly   108 LVAINPYAEMPLYGPSIIRAYRGHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTV 172
            .|.:|||..:|:|...::.||||....:..||||::::.||..:..:..|.||:::|||||||||
Human   122 CVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGKTV 186

  Fly   173 SAKYAMRYFAAV----------GGSESETQVERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKL 227
            :.|..::|||::          ..:.::..:|.:::.::|.:||||||||.|||||||||||.::
Human   187 NTKRVIQYFASIAAIGDRGKKDNANANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRI 251

  Fly   228 LFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHIFYQLCAARSKYPE-----LVLDHQDKF 287
            .| ...|.  |..|.:.|||||||||::|.:.|||||||||:.:  :|.||     ||.::...:
Human   252 HF-GATGK--LASADIETYLLEKSRVIFQLKAERNYHIFYQILS--NKKPELLDMLLVTNNPYDY 311

  Fly   288 QFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEE 352
            .|::.|.. .:..:.|:|:...|..|..||||:.::.|.:.|:...|:|.||::..:|..|...|
Human   312 AFVSQGEV-SVASIDDSEELMATDSAFDVLGFTSEEKAGVYKLTGAIMHYGNMKFKQKQREEQAE 375

  Fly   353 ----EDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDAL 413
                ||:|.            :|.|:.:::.||.:.|...:::..||||....|::....:..||
Human   376 PDGTEDADK------------SAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSVQQVYYSIGAL 428

  Fly   414 AKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQH 478
            ||.:|.|:|.::|..:|.:|.....:..|||||||.|||.|:.|||||.|||:.||||||.||.|
Human   429 AKAVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHH 493

  Fly   479 VFKLEQEEYLKEGITWTMIDF-YDNQPCIDLIESRLGVLDLLDEECRMPKGSDESWAGKL----I 538
            :|.||||||.||||.||.||| .|.|.||||||..:|::.:|:|||..||.:|.::..||    :
Human   494 MFVLEQEEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLYDNHL 558

  Fly   539 GKCNKFPHFEKPR----FGTTSFFIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNMSL-AK 598
            ||.|   :|:|||    .....|.:.|::.||:|::.|:||||:|.:::.:..:..:|::.| |.
Human   559 GKSN---NFQKPRNIKGKQEAHFSLIHYAGTVDYNILGWLEKNKDPLNETVVALYQKSSLKLMAT 620

  Fly   599 QVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLASLIS 663
            ...:....||  .||.||.          |.|::|:..           :||.:..:|:|..|::
Human   621 LFSSYATADT--GDSGKSK----------GGKKKGSSF-----------QTVSALHRENLNKLMT 662

  Fly   664 TLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLL 728
            .|..|.||:||||.||:.|.....:...::.|||..||||.:||...|||:|.||.||..||::|
Human   663 NLRTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRIL 727

  Fly   729 --VYRSKLDKNDMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQS 791
              |...:....|.:.....::.....|.::|:||:|::||:||.:..||::|..           
Human   728 NPVAIPEGQFIDSRKGTEKLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDE----------- 781

  Fly   792 VVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAGLILSKY-------ARGWLCRRR 849
                        |:.::|..:|..|||.|.|...:|:.|.|..|::.::       .:.|...:.
Human   782 ------------RLSRIITRMQAQARGQLMRIEFKKIVERRDALLVIQWNIRAFMGVKNWPWMKL 834

  Fly   850 YLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAYQKRRRNIIICQAAIRR 914
            |.:::..:...:|                                    :|....:         
Human   835 YFKIKPLLKSAET------------------------------------EKEMATM--------- 854

  Fly   915 FLARRKFKRMKAEAKTISHMENKYMGLENKIISMQQRIDELNRDNSNLKHKTSEISVLKMKLELK 979
               :.:|.|:|   :|:...|.:...||.|::|:                       |:.|.:|:
Human   855 ---KEEFGRIK---ETLEKSEARRKELEEKMVSL-----------------------LQEKNDLQ 890

  Fly   980 KTLEAEFKNVKAACQDKDKLIEALNK-QLEAERDEKMQLLEENGHAQEEWISQKQTWRQENEELR 1043
            ..::||..|:..|.:..|:||:  || ||||:..|..:.||:......|..::|:....|..||:
Human   891 LQVQAEQDNLNDAEERCDQLIK--NKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELK 953

  Fly  1044 RQIDEI------IDMAKNAEVNQ-RNQEDRM--LAEI------DNRELNEAYQRAIKDKEVIENE 1093
            :.||::      ::..|:|..|: :|..:.|  |.||      :.:.|.||:|:|:.|.:|.|::
Human   954 KDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDK 1018

  Fly  1094 NFMLKEELSRLTAGSFSLHARKASNASSQNEDDVGYA---SAKNTLDINRPPDLLSKNYSY---- 1151
            ...|.:...:|                .|..||:..:   ..|..:|:.|....|..:...    
Human  1019 VNSLSKSKVKL----------------EQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQES 1067

  Fly  1152 -----NDSTSLVVKL-RSILEEEKQKHKVLQEQYIKLSSRHKPTEDSFRVSELEVENE---KLRS 1207
                 ||...|..|| :...:..:|..|:..||.:.|..:.|..|:..|:.|||.|.|   ..|:
Human  1068 IMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARA 1132

  Fly  1208 EYDQLRTSIKHGVEINELNAQHAALQEEVRRRREECIQLKAVLLQQSQSMRSLEPESLQMRGNDV 1272
            :.::||:.:.     .||        ||:..|.||.....:|.::.:   :..|.|..:||    
Human  1133 KVEKLRSDLS-----REL--------EEISERLEEAGGATSVQIEMN---KKREAEFQKMR---- 1177

  Fly  1273 NELMEAFHSQKLINRQLESELKAITEEHNSKLVEMTQEIERLNNEKDELQKVMFESIDEFED--S 1335
            .:|.||       ..|.|:...|:.::|...:.|:.::|:.|...|.:|:|...|...|.:|  |
Human  1178 RDLEEA-------TLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTS 1235

  Fly  1336 NVDTL---RQNDRYLRRELQKAVAQFLLVQEELKLA-------NAKLKAYRQDGGQLEHKIEEE- 1389
            |::.:   :.|...:.|.|:....::.:..||.:.:       .|||:.   :.|:|..::||: 
Human  1236 NMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQT---ENGELARQLEEKE 1297

  Fly  1390 -MIRNKSNGTSADVGANVTKQKSQNPQGLMKFHSSDLDKILQRLLSAL-TPRTVVGLLPGFPAYL 1452
             :|...:.|.     .:.|:|...     :|....:..|....|..|| :.|....||..     
Human  1298 ALISQLTRGK-----LSYTQQMED-----LKRQLEEEGKAKNALAHALQSARHDCDLLRE----- 1347

  Fly  1453 IFMCIRYTDLTNADDDVRELLSKFVIQIKKMHRTPHPIENRVIWLVNSI--TLLNLMKQYGDVDE 1515
                 :|.:.|.|..:::.:|||...::.:. ||.:  |...|.....:  ....|.::..|.:|
Human  1348 -----QYEEETEAKAELQRVLSKANSEVAQW-RTKY--ETDAIQRTEELEEAKKKLAQRLQDAEE 1404

  Fly  1516 YV-----KFNTEKQNQQQLKNFNLFEYRRVILDLIVNLYQALIMQIQGLLDPKIVPAILNNDEIQ 1575
            .|     |.::.::.:.:|:|        .|.||:|::.::  ......||.|    ..|.|:|.
Human  1405 AVEAVNAKCSSLEKTKHRLQN--------EIEDLMVDVERS--NAAAAALDKK----QRNFDKIL 1455

  Fly  1576 RGRQAHGMRSRATSIGASSSPEHGGGPAWKQLI----GQLEHFYKQFQH-----FGLDNCYAEQI 1631
                                      ..|||..    .:||...|:.:.     |.|.|.|.|.:
Human  1456 --------------------------AEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESL 1494

  Fly  1632 FHQLLYFICAVALNCLM-----LRGDIC-----MWETGMIIRYNIGCIEDWVRSKKM-------- 1678
            .|          |....     |:.:|.     :.|.|..: :.:..:...:..:|:        
Human  1495 EH----------LETFKRENKNLQEEISDLTEQLGEGGKNV-HELEKVRKQLEVEKLELQSALEE 1548

  Fly  1679 --------SNDVLTALAPLNQVSQLLQSRKSEQDV---------QTICD-LCTSL-----STAQV 1720
                    ...:|.|....||:...::.:.:|:|.         |.:.| |.|||     |..:|
Human  1549 AEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEV 1613

  Fly  1721 LKVMKSYKLDDYESEITNVFLEKLTEKLNARQMQKSNSDEFTID-QKFIQPFKVVFRYSDIKLED 1784
            |:|.|                 |:...||..::|.|:::....: ||.::..:.:.:.:.|:|:|
Human  1614 LRVKK-----------------KMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDD 1661

  Fly  1785  1784
            Human  1662  1661

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 282/743 (38%)
MYSc_Myo5 84..767 CDD:276831 270/713 (38%)
IQ 900..922 CDD:197470 1/21 (5%)
GBP_C <971..1086 CDD:303769 39/130 (30%)
coiled coil 1049..1068 CDD:293879 5/27 (19%)
coiled coil 1077..1086 CDD:293879 4/8 (50%)
JAKMIP_CC3 <1190..1299 CDD:292653 28/111 (25%)
Myo5_CBD 1424..1792 CDD:271254 79/420 (19%)
MYH6NP_002462.2 Myosin_N 35..72 CDD:280832 3/8 (38%)
Myosin_head 87..768 CDD:278492 275/725 (38%)
MYSc_class_II 99..768 CDD:276951 270/713 (38%)
Actin-binding 657..679 11/21 (52%)
Actin-binding 759..773 7/13 (54%)
Myosin_tail_1 848..1925 CDD:279860 208/991 (21%)
SPEC 881..1043 CDD:295325 48/202 (24%)
MM_CoA_mutase <1134..1295 CDD:294532 42/190 (22%)
MIT_CorA-like <1297..>1409 CDD:294313 26/134 (19%)
TMPIT 1740..>1832 CDD:285135
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1826..1849
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1909..1939
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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