DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment didum and MYH3

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:NP_002461.2 Gene:MYH3 / 4621 HGNCID:7573 Length:1940 Species:Homo sapiens


Alignment Length:2017 Identity:531/2017 - (26%)
Similarity:908/2017 - (45%) Gaps:449/2017 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 EESYRKGA------GFLKICTDSGKLKEVKLKADGSDLPPLRNPAILVGQNDLTTLSYLHEPGVL 87
            :|.|.||.      |.:.:.|:..:...||    ..|:..: ||.......|:..|::|:||.||
Human    44 KEEYAKGKIKSSQDGKVTVETEDNRTLVVK----PEDVYAM-NPPKFDRIEDMAMLTHLNEPAVL 103

  Fly    88 HNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLEPHIFALAEEAYTKLE 152
            :||:.|:.. .:||||.|:..|.:|||..:|:|.|.::..|||....:..||||::::.||..:.
Human   104 YNLKDRYTS-WMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFML 167

  Fly   153 RENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGG---------SESETQVERKVLASSPIMEAFG 208
            .:..|.||:::|||||||||:.|..::|||.:..         |:.:..:|.::::::|::||||
Human   168 TDRENQSILITGESGAGKTVNTKRVIQYFATIAATGDLAKKKDSKMKGTLEDQIISANPLLEAFG 232

  Fly   209 NAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHIFYQLCAAR 273
            ||||.|||||||||||.::.| ...|.  |..|.:.|||||||||.:|.:.||:||||||:.:  
Human   233 NAKTVRNDNSSRFGKFIRIHF-GTTGK--LASADIETYLLEKSRVTFQLKAERSYHIFYQILS-- 292

  Fly   274 SKYPE-----LVLDHQDKFQFLNMGGAPEI--ERVSDAEQFNETVQAMTVLGFSIQQIADIVKIL 331
            :|.||     |:..:...:.|::.|   ||  ..:.|||:...|..|:.:|||:.::.:.:.|:.
Human   293 NKKPELIELLLITTNPYDYPFISQG---EILVASIDDAEELLATDSAIDILGFTPEEKSGLYKLT 354

  Fly   332 AGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKIESVNEY 396
            ..::|.||::..:|..|  |:.:.|..::...      ||.|:.:::.||.:.|...:::..|||
Human   355 GAVMHYGNMKFKQKQRE--EQAEPDGTEVADK------TAYLMGLNSSDLLKALCFPRVKVGNEY 411

  Fly   397 VLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIYGFETFEVNSFEQ 461
            |....:::....|.:||:|.:|.|||.::|..:|:.|:....:..|||||||.|||.||.||.||
Human   412 VTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQ 476

  Fly   462 FCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDF-YDNQPCIDLIESRLGVLDLLDEECRM 525
            .|||:.||||||.||.|:|.||||||.||||.||.||| .|...||:|||..:|:..:|:|||..
Human   477 LCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMF 541

  Fly   526 PKGSDESWAGKL----IGKCNKFPHFEKPRF----GTTSFFIKHFSDTVEYDVNGFLEKNRDTVS 582
            ||.:|.|:..||    :||.|   :|:||:.    ....|.:.|::.||:|.|:|:||||:|.::
Human   542 PKATDTSFKNKLYDQHLGKSN---NFQKPKVVKGRAEAHFSLIHYAGTVDYSVSGWLEKNKDPLN 603

  Fly   583 KELTQVLSE-SNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQH 646
            :.:..:..: ||..||....|....|   .||.|...          .|::|:..          
Human   604 ETVVGLYQKSSNRLLAHLYATFATAD---ADSGKKKV----------AKKKGSSF---------- 645

  Fly   647 RKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAG 711
             :||.:.|:|:|..|:|.|..|.||:||||.||:.|.....|.:.::.|||..||||.:||...|
Human   646 -QTVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKG 709

  Fly   712 FPSRWLYPDFYMRYQLLVYRSKLDKN---DMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAF 773
            ||:|.||.||..||::| ..|.:.:.   |.|.:|..::.....|..:|:||:|::||:||.:..
Human   710 FPNRILYGDFKQRYRVL-NASAIPEGQFIDSKKACEKLLASIDIDHTQYKFGHTKVFFKAGLLGT 773

  Fly   774 LEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAGLILS 838
            ||::|.:...|.||..|:|                       .||:|.|...|||.:.|..:...
Human   774 LEEMRDDRLAKLITRTQAV-----------------------CRGFLMRVEFQKMVQRRESIFCI 815

  Fly   839 KY-------ARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARR 896
            :|       .:.|...:.:.:::..:...:|.......:.:|...:|.                 
Human   816 QYNIRSFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKTKDE----------------- 863

  Fly   897 AYQKRRRNIIICQAAIRRFLARRKFKRMKAEAKTISHMENK------YMGLENKIISMQQRIDEL 955
                               ||:.:.||.:.|.|.::.::.|      .......::..::|.|:|
Human   864 -------------------LAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQL 909

  Fly   956 NRDNSNLKHK--------------TSEISVLKMKL-----ELKKTLE------AEFKNVKAACQD 995
            .:....|:.|              .:|::..|.||     ||||.::      |:.:..|.|.::
Human   910 IKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATEN 974

  Fly   996 K-----------DKLIEALNKQLEAERDEKMQLLEENGHAQEEWISQ----KQTWRQENEELRRQ 1045
            |           |:.|..|.::.:|.::...|.|::. .|:|:.::.    |....|:.|:|...
Human   975 KVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDL-QAEEDKVNSLNKTKSKLEQQVEDLESS 1038

  Fly  1046 IDEIIDMAKNAEVNQRNQE-DRMLA-------EIDNRELNEAYQRAIKDKEV------IENENFM 1096
            :::...:..:.|.|:|..| |..||       |.|.::|:|..::  ||.|.      :|:|..:
Human  1039 LEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKK--KDFEYCQLQSKVEDEQTL 1101

  Fly  1097 -------LKEELSRL----------------TAGSFSLHARKASNASSQNEDDVGYASAKNTLDI 1138
                   :||..:|:                |....|.:||:....|.:.|:..|..|.:..|:.
Human  1102 GLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNK 1166

  Fly  1139 NRPPDLLSKNYSYNDSTSLVVKLRSILEEEKQKHKVLQEQYIKLSSRHKPTEDSF---------- 1193
            .|..:.|              |||..|||...:|:.:      :::..|...||.          
Human  1167 KREAEFL--------------KLRRDLEEATLQHEAM------VAALRKKHADSVAELGEQIDNL 1211

  Fly  1194 -RVSE-LEVENEKLRSEYDQLRTSI------KHGVE-----------------------INELNA 1227
             ||.: ||.|..:.:.|.|.|.:|:      |..:|                       ::||..
Human  1212 QRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTT 1276

  Fly  1228 QHAALQE---EVRRRREE----CIQL---KAVLLQQSQSM-RSLEPE---------SLQMRGNDV 1272
            |.:.||.   |:.|:.||    ..||   |....||::.: |.||.|         :||...:|.
Human  1277 QKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDC 1341

  Fly  1273 NELMEAFHSQKLINRQLESEL-KAITE------EHNSKLVEMTQEIE--------RLNNEKDELQ 1322
            :.|.|.:..::....:|:..| ||.:|      ::.:..::.|:|:|        ||.:.:::::
Human  1342 DLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVE 1406

  Fly  1323 KVMFE--SID--------EFEDSNVDTLRQN------DRYLRRELQKAVAQFLLVQEELKLANAK 1371
            .|..:  |::        |.||..||..|.|      |: .:|...|.:|::....||   :.|:
Human  1407 AVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDK-KQRNFDKVLAEWKTKCEE---SQAE 1467

  Fly  1372 LKAYRQDGG-------QLEHKIEE-----EMIRNKSNGTSADVGANVTKQKSQNPQGLMKFHSSD 1424
            |:|..::..       :|::..||     |.::.::.....:: |::|:|.::|.:.:.:...|.
Human  1468 LEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEI-ADLTEQIAENGKTIHELEKSR 1531

  Fly  1425 LDKILQRLLSALTPRTVVGLLPGFPAYLIFMCIRYTDLTNADDDVRELLSK--FVIQIKKMH-RT 1486
            ....|::....|........|....|.::.:.:..|.:.:..|  |::..|  .:.|:|:.: ||
Human  1532 KQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEID--RKIAEKDEEIEQLKRNYQRT 1594

  Fly  1487 PHPIENRVIWLVNS----ITLLNLMKQYGDVDEYVKFNTEKQNQQQLKNF-NLFEYRRVILDLIV 1546
            ...:::.:...|.|    |.|...|:  ||::| ::......|:|..:.. :|...:..:.|..:
Human  1595 VETMQSALDAEVRSRNEAIRLKKKME--GDLNE-IEIQLSHANRQAAETLKHLRSVQGQLKDTQL 1656

  Fly  1547 NLYQALIMQIQGLLDPKIVPAILNNDEIQRGRQAHGMRSRATSIGASSSPEHGGGPAWKQLIGQL 1611
            :|..||    :|..|.|...||:.       |:|:.:::....:.|:              :.|.
Human  1657 HLDDAL----RGQEDLKEQLAIVE-------RRANLLQAEVEELRAT--------------LEQT 1696

  Fly  1612 EHFYKQFQHFGLDNCYAEQIFH----QLLYFICAVALNCLMLRGDICMWETGMIIRYNIGCIEDW 1672
            |...|..:...||:....|:.|    .|::....:..:.:.|:.:                :||.
Human  1697 ERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSE----------------VEDA 1745

  Fly  1673 VRSKKMSNDVLTALAPLNQVSQLLQSRKSEQDV------------QTICDLCTSLSTAQVLKVMK 1725
            .|..:.:.:  .|...:...:.:.:..|.|||.            ||:.||...|..|:.|.:..
Human  1746 SRDARNAEE--KAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKG 1808

  Fly  1726 SYK-LDDYESEITNVFLE------KLTEKLNARQMQKSNSDEFTIDQKFIQPFKVVFRYSDI--K 1781
            ..| :...|:.|..:..|      |.||.:...:..:....|.|...:  :..|.|.|..|:  |
Human  1809 GKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSE--EDRKNVLRLQDLVDK 1871

  Fly  1782 LE 1783
            |:
Human  1872 LQ 1873

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 282/741 (38%)
MYSc_Myo5 84..767 CDD:276831 271/711 (38%)
IQ 900..922 CDD:197470 2/21 (10%)
GBP_C <971..1086 CDD:303769 34/148 (23%)
coiled coil 1049..1068 CDD:293879 5/19 (26%)
coiled coil 1077..1086 CDD:293879 1/8 (13%)
JAKMIP_CC3 <1190..1299 CDD:292653 41/176 (23%)
Myo5_CBD 1424..1792 CDD:271254 74/393 (19%)
MYH3NP_002461.2 Myosin_N 36..73 CDD:280832 6/28 (21%)
Myosin_head 88..767 CDD:278492 275/723 (38%)
MYSc_Myh3 100..767 CDD:276878 271/711 (38%)
Actin-binding 656..678 12/21 (57%)
Actin-binding 758..772 7/13 (54%)
GrpE 843..>962 CDD:295646 23/154 (15%)
Myosin_tail_1 847..1924 CDD:279860 223/1141 (20%)
BAR <956..1063 CDD:299863 21/107 (20%)
MIT_CorA-like <1296..>1408 CDD:294313 24/111 (22%)
COG6 1373..>1506 CDD:303003 27/136 (20%)
TMPIT 1739..>1850 CDD:285135 22/128 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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