Protein Alignment didum and MYH1

DIOPT Version :10

• Sequence 1: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Sequence 2: NP_005954.3
• Gene: MYH1 / 4619
• HGNCID: 7567
• Length: 1939
• Species: Homo sapiens
• Alignment Length: 2105
• Identity: 526/2105 - (24%)
• Similarity: 893/2105 - (42%)
• Gaps: 534/2105 - (25%)

  Fly     2 SSEEMLYAQG------AKIWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDL 60
            |..|.:.||.      ..::|......:..||::.  |:| |.:...|::|....||   |....
Human    20 SERERIEAQNKPFDAKTSVFVVDPKESFVKATVQS--REG-GKVTAKTEAGATVTVK---DDQVF 78

  Fly    61 PPLRNPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSII 125
            |  .||.......|:..:::||||.||:||:.|:. ..:||||.|:..|.:|||..:|:|...::
Human    79 P--MNPPKYDKIEDMAMMTHLHEPAVLYNLKERYA-AWMIYTYSGLFCVTVNPYKWLPVYNAEVV 140

  Fly   126 RAYRGHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFA--AVGGSE 188
            .||||....:..||||::::.||..:..:..|.||:::|||||||||:.|..::|||  ||.|.:
Human   141 TAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGEK 205

  Fly   189 SETQV---------ERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMH 244
            .:.:|         |.::::::|::||||||||.|||||||||||.::.| ...|.  |..|.:.
Human   206 KKEEVTSGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHF-GTTGK--LASADIE 267

  Fly   245 TYLLEKSRVVYQAQGERNYHIFYQLCAARSKYPE-----LVLDHQDKFQFLNMGGAPEIERVSDA 304
            |||||||||.:|.:.||:||||||:.:  :|.|:     |:..:...:.|::.|.. .:..:.|.
Human   268 TYLLEKSRVTFQLKAERSYHIFYQIMS--NKKPDLIEMLLITTNPYDYAFVSQGEI-TVPSIDDQ 329

  Fly   305 EQFNETVQAMTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQI 369
            |:...|..|:.:|||:..:...|.|:...::|.||::..:|..|  |:.:.|..::.....:||
Human   330 EELMATDSAIEILGFTSDERVSIYKLTGAVMHYGNMKFKQKQRE--EQAEPDGTEVADKAAYLQ- 391

  Fly   370 TADLLRVSADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLN 434
                 .:::.||.:.|...:::..||||....:::....|..||||.:|.|:|.::|..:|:.|:
Human   392 -----NLNSADLLKALCYPRVKVGNEYVTKGQTVQQVYNAVGALAKAVYDKMFLWMVTRINQQLD 451

  Fly   435 NGSKQCSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDF 499
            ....:..|||||||.|||.|:.||.||.|||:.||||||.||.|:|.||||||.||||.||.|||
Human   452 TKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDF 516

  Fly   500 -YDNQPCIDLIESRLGVLDLLDEECRMPKGSDESWAGKL----IGKCNKFPHFEKPRFG--TTSF 557
             .|...||:|||..:|:..:|:|||..||.:|.|:..||    :||.|.|.. .||..|  ...|
Human   517 GMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSNNFQK-PKPAKGKPEAHF 580

  Fly   558 FIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCV-----DSAKSS 617
            .:.|::.||:|::.|:|:||:|.:::.:..:..:|.|.            ||.:     ..|::.
Human   581 SLIHYAGTVDYNIAGWLDKNKDPLNETVVGLYQKSAMK------------TLALLFVGATGAEAE 633

  Fly   618 TLGGRVVISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDK 682
            ..||:    .|.|::|:..           :||.:.|:|:|..|::.|.:|.||:||||.||:.|
Human   634 AGGGK----KGGKKKGSSF-----------QTVSALFRENLNKLMTNLRSTHPHFVRCIIPNETK 683

  Fly   683 VAFKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKN---DMKLSCR 744
            .....|...::.|||..||||.:||...|||||.||.||..||::| ..|.:.:.   |.|.:..
Human   684 TPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVL-NASAIPEGQFIDSKKASE 747

  Fly   745 NIVMKWIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVI 809
            .::.....|..:|:||:|::||:||.:..||::|..                       ::.::|
Human   748 KLLGSIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDE-----------------------KLAQLI 789

  Fly   810 NGIQKHARGYLARERTQKMREARAGLILSKY-------ARGWLCRRRYLRLRHSISGIQTYARGM 867
            ...|...||:|||...|||.|.|..:...:|       .:.|...:.|.:::..:...:|.....
Human   790 TRTQAMCRGFLARVEYQKMVERRESIFCIQYNVRAFMNVKHWPWMKLYFKIKPLLKSAETEKEMA 854

  Fly   868 LARNKFHAMRDHYRAVQIQRFVRGALARRAYQKRRRNIIICQAAIRRFLARRKFKRMKAEAKTIS 932
            ..:.:|...::.                                    ||:.:.||.:.|.|.::
Human   855 NMKEEFEKTKEE------------------------------------LAKTEAKRKELEEKMVT 883

  Fly   933 HMENK------YMGLENKIISMQQRIDELNRDNSNLKHK--------------TSEISVLKMKL- 976
            .|:.|      .....:.:...::|.|:|.:....|:.|              .:|::..|.||
Human   884 LMQEKNDLQLQVQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLE 948

  Fly   977 ----ELKKTLE------AEFKNVKAACQDK-----------DKLIEALNKQ-------------- 1006
                ||||.::      |:.:..|.|.::|           |:.|..|.|:
Human   949 DECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDD 1013

  Fly  1007 LEAERDEKMQL------LEENGHAQEEWISQKQTWRQENEELRRQIDEIIDMAKNAEVNQRNQED 1065
            |:||.|:...|      ||:.....|..:.|::..|.:.|..:|:::..:.:|         ||.
Human  1014 LQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLA---------QES 1069

  Fly  1066 RMLAEIDNRELNEAYQRAIKDKEV--------IENENFM-------LKEELSRLTAGSFSLHARK 1115
            .|..|.|.::|:|    .:|.||.        ||:|..:       :||..:|:......:.|.:
Human  1070 TMDIENDKQQLDE----KLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAER 1130

  Fly  1116 ASNASSQNEDDVGYASAKNTLDINRPPDLLSKNY-SYNDSTSLVVKLRSILEEEKQKHK------ 1173
            ||.|.::          |...|::|..:.:|:.. ....:||..:::....|.|.||.:
Human  1131 ASRAKAE----------KQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEA 1185

  Fly  1174 VLQEQYIKLSSRHKPTEDSFRVSE-----------LEVENEKLRSEYDQLRTSI------KHGVE 1221
            .||.:....:.|.|..:....:.|           ||.|..:::.|.|.|.:::      |..:|
Human  1186 TLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLE 1250

  Fly  1222 -----------------------INELNAQHAALQ------------------------------ 1233
                                   ||:|.||.|.||
Human  1251 KMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQ 1315

  Fly  1234 -EEVRRRREECIQLKAVLLQQSQSMRSLEPESLQMRGNDVNELMEAFHSQKLINRQLESELKAIT 1297
             ||::|:.||.|:.|:.|....||.|           :|.:.|.|.:..:    ::.::||:...
Human  1316 IEELKRQLEEEIKAKSALAHALQSSR-----------HDCDLLREQYEEE----QEAKAELQRAM 1365

  Fly  1298 EEHNSKLVEMTQEIERLNNEKDELQKVMFESIDEFEDSNVDTLRQNDRYLRRELQKAVAQFLLVQ 1362
            .:.||::.:.     |...|.|.:|:.     :|.|::.        :.|.:.||.|       :
Human  1366 SKANSEVAQW-----RTKYETDAIQRT-----EELEEAK--------KKLAQRLQDA-------E 1405

  Fly  1363 EELKLANAKLKAYRQDGGQLEHKIEEEMI--------------------------RNKSNGTSAD 1401
            |.::..|||..:..:...:|::::|:.||                          :.|...|.|:
Human  1406 EHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAE 1470

  Fly  1402 VGANVTKQKSQNPQGLMKF---HSSDLDKI---------LQRLLSALTPRTVVGLLPGFPAYLIF 1454
            :.|:..:.:|.:.: |.|.   :...||::         ||:.:|.||.:...|
Human  1471 LEASQKESRSLSTE-LFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEG----------- 1523

  Fly  1455 MCIRYTDLTNADDDVRELLSKFVIQIKKMHRTPHPIENRVIWLVNSITLLNLMKQYGDVDEYVKF 1519
             ..|..:|......|.:..|:....:::...:....|.:::.:     .|.|.:...:||..:..
Human  1524 -GKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRI-----QLELNQVKSEVDRKIAE 1582

  Fly  1520 NTEKQNQQQLKNFNLFEYRRVILD----------------------LIVNLYQALIMQIQGLLDP 1562
            ..|:.:|.:..:..:.|..:..||                      :.:.|..|..|..:.|.:.
Human  1583 KDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNY 1647

  Fly  1563 KIVPAILNNDEIQRG---RQAHGMRSRATSIGASSSPEHGGGPAWKQLIGQLEHFYKQFQHFGLD 1624
            :...|||.:.::...   |....::.:...:...::.........:..:.|.|...|..:...||
Human  1648 RNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLD 1712

  Fly  1625 NCYAEQIFHQLLYFICAVALNC-LMLRGDICMWETGMIIRYNIGCIEDWVRSKKMSNDVLTALAP 1688
              .:|::  |||:......:|. ..|..||...:         |.:||.::..:.:.:  .|...
Human  1713 --ASERV--QLLHTQNTSLINTKKKLETDISQIQ---------GEMEDIIQEARNAEE--KAKKA 1762

  Fly  1689 LNQVSQLLQSRKSEQDV------------QTICDLCTSLSTAQVLKVMKSYKLDDYESEITNVFL 1741
            :...:.:.:..|.|||.            ||:.||...|..|:.| .:|..|
Human  1763 ITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQL-ALKGGK------------- 1813

  Fly  1742 EKLTEKLNAR---------QMQKSNSD-------------EFTIDQKFIQPFKVVFRYSDI---- 1780
             |..:||.||         ..||.|.:             |.|...:  :..|.:.|..|:
Human  1814 -KQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTE--EDRKNILRLQDLVDKL 1875

  Fly  1781 ---------KLEDIELPSHLNLDEF 1796
                     :.|:.|..|::||.:|
Human  1876 QAKVKSYKRQAEEAEEQSNVNLSKF 1900

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	266/713 (37%)
		IQ	900..922	CDD:197470	2/21 (10%)
		SMC_prok_B	<942..1365	CDD:274008	114/571 (20%)
		Myo5_CBD	1424..1792	CDD:271254	76/449 (17%)
MYH1	NP_005954.3	Myosin_N	33..77	CDD:460670	11/49 (22%)
		MYSc_Myh1_mammals	100..770	CDD:276875	266/713 (37%)
		Actin-binding. /evidence=ECO:0000250	659..681		11/21 (52%)
		Actin-binding. /evidence=ECO:0000250	761..775		7/13 (54%)
		Myosin_tail_1	850..1927	CDD:460256	216/1200 (18%)