Protein Alignment didum and MYO1F

DIOPT Version :10

• Sequence 1: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Sequence 2: NP_001427538.1
• Gene: MYO1F / 4542
• HGNCID: 7600
• Length: 1119
• Species: Homo sapiens
• Alignment Length: 967
• Identity: 306/967 - (31%)
• Similarity: 483/967 - (49%)
• Gaps: 163/967 - (16%)

  Fly    71 GQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGD 135
            |.:|:..|..:.|..:..|||.||.: ..|:||.|.:|:::||:.:||.:....|..|:|.|..:
Human    18 GVDDMVLLPQITEDAIAANLRKRFMD-DYIFTYIGSVLISVNPFKQMPYFTDREIDLYQGAAQYE 81

  Fly   136 LEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAV-GGSESETQVERKVLA 199
            ..|||:||.:..|..:..:..|..:|:||||||||||:|||.|.|.:.| ||.|....|:..:|.
Human    82 NPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAAKYIMGYISKVSGGGEKVQHVKDIILQ 146

  Fly   200 SSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYH 264
            |:|::||||||||.||:|||||||:.::.| ::.|..  .|..:..:||||||||.|.:.|||:|
Human   147 SNPLLEAFGNAKTVRNNNSSRFGKYFEIQF-SRGGEP--DGGKISNFLLEKSRVVMQNENERNFH 208

  Fly   265 IFYQLC--AARSKYPELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGF--SIQQIA 325
            |:|||.  |::.:...|.|...|.:.:||.....:::...|...|.||:.||.|:|.  ||||:
Human   209 IYYQLLEGASQEQRQNLGLMTPDYYYYLNQSDTYQVDGTDDRSDFGETLSAMQVIGIPPSIQQL- 272

  Fly   326 DIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKI 390
             :::::|||||||||    .|.|.......:|.|:      |...|.||.:.:..|:..|..||:
Human   273 -VLQLVAGILHLGNI----SFCEDGNYARVESVDL------LAFPAYLLGIDSGRLQEKLTSRKM 326

  Fly   391 ES----VNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIYGF 451
            :|    .:|.:.:..::|.|...||||||.:||:||.::|..:|:::....::.| |||||||||
Human   327 DSRWGGRSESINVTLNVEQAAYTRDALAKGLYARLFDFLVEAINRAMQKPQEEYS-IGVLDIYGF 390

  Fly   452 ETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIESRL--- 513
            |.|:.|.|||||||:.||||||.|.:...|.|||||::|||.||.|.:::|:...||||::|
Human   391 EIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIQYFNNKVVCDLIENKLSPP 455

  Fly   514 GVLDLLDEECRMPK----GSDESWAGKLIGKCNKFPHFEKPRFGTTSFFIKHFSDTVEYDVNGFL 574
            |::.:||:.|....    |:|::...||........||..   .:..|.|.|::..|.|||:||.
Human   456 GIMSVLDDVCATMHATGGGADQTLLQKLQAAVGTHEHFNS---WSAGFVIHHYAGKVSYDVSGFC 517

  Fly   575 EKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRR 639
            |:|||.:..:|.:::..|..:..:.:.. |::|.  ....:.||.|.::      |:|.||
Human   518 ERNRDVLFSDLIELMQTSEQAFLRMLFP-EKLDG--DKKGRPSTAGSKI------KKQAND---- 569

  Fly   640 VVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWE------------TAKI 692
                                 |::||...||||:||||||:.|....||            :|..
Human   570 ---------------------LVATLMRCTPHYIRCIKPNETKRPRDWEENRTGDSPPRGDSAYP 613

  Fly   693 IQQLRACGVLETVRISAAGFPSRWLYP---------DFYMRYQLLVYRS-KLDKNDMKLSCRNIV 747
            ..|.:|.|.:........|..||...|         ...:||.:|...: ...:.|.:...::::
Human   614 PHQSQAPGGIPGPEGEHQGAQSRLRLPPPVRQIPAEPSALRYAILTPETWPRWRGDERQGVQHLL 678

  Fly   748 MKWIQDEDKYRFGNTQIFFRAGQVAF-LEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVING 811
            .....:.|:|:.|:|::|.:..:..| ||:||.              |:|   ..|.|.
Human   679 RAVNMEPDQYQMGSTKVFVKNPESLFLLEEVRE--------------RKF---DGFART------ 720

  Fly   812 IQKHARGYLARERTQKMREARAGLILSKYARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAM 876
            |||..|.::|..:.::|||..:.::|:|..          |.|:||:           ||    .
Human   721 IQKAWRRHVAVRKYEEMREEASNILLNKKE----------RRRNSIN-----------RN----F 760

  Fly   877 RDHYRAVQIQRFVRGALARR----------AYQKR----RRNIIICQAAIRRFLARRKFKRMKAE 927
            ...|..::.:..:|..|.:|          .|.:|    :|::|:....: ..:.|.|.|:...:
Human   761 VGDYLGLEERPELRQFLGKRERVDFADSVTKYDRRFKPIKRDLILTPKCV-YVIGREKVKKGPEK 824

  Fly   928 AKTISHMENKYMGLENKIISMQQRIDE---LNRD--NSNLK--HKTSEISVLKMKLE 977
            .:....::.|......:.:|:..|.|:   |..|  :|.|:  .||..:|:|..:.|
Human   825 GQVCEVLKKKVDIQALRGVSLSTRQDDFFILQEDAADSFLESVFKTEFVSLLCKRFE 881

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	253/720 (35%)
		IQ	900..922	CDD:197470	5/25 (20%)
		SMC_prok_B	<942..1365	CDD:274008	12/43 (28%)
		Myo5_CBD	1424..1792	CDD:271254
MYO1F	NP_001427538.1	None