DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment didum and myh2

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:NP_001006805.1 Gene:myh2 / 448514 XenbaseID:XB-GENE-5760121 Length:1939 Species:Xenopus tropicalis


Alignment Length:2071 Identity:532/2071 - (25%)
Similarity:903/2071 - (43%) Gaps:487/2071 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 SSEEMLYAQGAKIWVPHADLVWESATLEESYRKG------AGFLKICTDSGKLKEVKLKADGSDL 60
            |.:|.|.||.......:...|.:.   :|.|.||      .|.:.:.|:..:...||    .|.:
 Frog    19 SDKERLEAQNKAFDAKNTCFVEDD---KELYVKGLITAREGGKVTVKTEDARNVTVK----ESQV 76

  Fly    61 PPLRNPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSII 125
            .| :||.......|:..:::|:|..||:||:.|:. ..:||||.|:..|.:|||..:|:|.|.::
 Frog    77 YP-QNPPKFDKIEDMAMMTHLNEASVLYNLKERYA-AWMIYTYSGLFCVTVNPYKWLPVYNPEVV 139

  Fly   126 RAYRGHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYF---AAVGGS 187
            ..|||....:..||||::::.||..:.::..|.|::::|||||||||:.|..::||   ||:|.|
 Frog   140 AGYRGKKRQEAPPHIFSISDNAYQFMLQDRENQSVLITGESGAGKTVNTKRVIQYFATIAAIGDS 204

  Fly   188 ESETQ--------VERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMH 244
            ..:.:        :|.:::.::|::||||||||.|||||||||||.::.| ...|.  |..|.:.
 Frog   205 NKKKEMSNSMQGTLEDQIIQANPLLEAFGNAKTVRNDNSSRFGKFIRIHF-GTTGK--LASADIE 266

  Fly   245 TYLLEKSRVVYQAQGERNYHIFYQLCAARSKYPELV-----LDHQDKFQFLNMGGAPEIERVSDA 304
            |||||||||.:|...||:||||||:..  :|.||:|     ..:...:.|::.|.. .::.:.|.
 Frog   267 TYLLEKSRVTFQLSAERSYHIFYQILT--NKKPEIVEMLLLTTNPYDYAFISQGEI-AVKSIDDE 328

  Fly   305 EQFNETVQAMTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQI 369
            |:...|..|:.:|||:.::...|.|:...::|.||::..:|..|  |:.:.|..::         
 Frog   329 EELMATDSAIDILGFTAEEKMGIYKMTGSVMHKGNMKFKQKQRE--EQAEPDGTEV--------- 382

  Fly   370 TAD----LLRVSADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLN 430
             ||    |:.:::.||.:.|...:::..||:|....:::....|..||:|.::.|||.::|..:|
 Frog   383 -ADKIGYLMGLNSADLLKALCYPRVKVGNEFVTKGQTVQQVYNAIGALSKSVFEKLFLWMVTRIN 446

  Fly   431 KSLNNGSKQCSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWT 495
            :.|:....:..|||||||.|||.|::||.||.|||:.||||||.||.|:|.||||||.||||.|.
 Frog   447 QQLDTKLPRQYFIGVLDIAGFEIFDLNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIDWE 511

  Fly   496 MIDF-YDNQPCIDLIESRLGVLDLLDEECRMPKGSDESWAGKL----IGKCNKFPHFEKPR---- 551
            .||| .|...||:|||..:|:|.:|:|||..||.:|.|:..||    :|||.   :||||:    
 Frog   512 FIDFGMDLAACIELIEKPMGILSILEEECMFPKATDTSFKNKLYDQHLGKCK---NFEKPKPAKG 573

  Fly   552 FGTTSFFIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKS 616
            .....|.:.|::.||:|::.|:|:||:|.:::.:..:..:|::.|...:.           |:.:
 Frog   574 KAEAHFSLVHYAGTVDYNICGWLDKNKDPLNETVVGLYQKSSLKLLSFLY-----------SSYA 627

  Fly   617 STLGGRVVISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDD 681
            .|.|......:|:|::|:..           :||.:.|:|:|..|::.|.:|.||:|||:.||:.
 Frog   628 GTDGAGDGAKSGKKKKGSSF-----------QTVSALFRENLNKLMTNLRSTHPHFVRCLIPNES 681

  Fly   682 KVAFKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKN--DMKLSCR 744
            |.....|...||.|||..||||.:||...|||||.||.||..||::|...:..|..  |.|.:|.
 Frog   682 KTPGIMENHLIIHQLRCNGVLEGIRICRKGFPSRILYGDFKQRYKILNASAIPDGQFIDSKKACE 746

  Fly   745 NIVMKWIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVI 809
            .::.....|..:||||:|::||:||.:..||::|.:...:.||..|::                 
 Frog   747 KLLGSIDIDHTQYRFGHTKVFFKAGLLGTLEEMRDDKLAQLITRTQAL----------------- 794

  Fly   810 NGIQKHARGYLARERTQKMREARAGLILSKY-------ARGWLCRRRYLRLRHSISGIQTYARGM 867
                  .||:|.|...:||.|.|..:.:.:|       .:.|...:.|.:::..:...:|     
 Frog   795 ------CRGFLMRVEFKKMIERRDAIFVIQYNVRSFMNVKHWPWMKLYFKIKPLLKSAET----- 848

  Fly   868 LARNKFHAMRDHYRAVQIQRFVRGALARRAYQKR------RRNIIICQAAIRRFLARRKFKRMKA 926
              ..:...|::.:...: :...:....|:..:::      .:|.::.|.              ::
 Frog   849 --EKEMANMKEEFEKTK-EALTKSDARRKELEEKMVALLQEKNDLMLQC--------------QS 896

  Fly   927 EAKTISHMENKYMGLENKIISMQQRIDELNRDNSNLKHKTSEISVLKMKL-----ELKKTLE--- 983
            |.::::..|.:..||....|:::.:|.||.....:.:...:|::..|.||     ||||.::   
 Frog   897 ENESLADAEERCEGLIKNKINLEAKIKELTERLEDEEESNAELTAKKRKLEDECSELKKDIDDLE 961

  Fly   984 ---AEFKNVKAACQDK-----------DKLIEALNKQ--------------LEAERDEKMQL--- 1017
               |:.:..|.|.::|           |:.|..::|:              |:||.|:...|   
 Frog   962 LTLAKVEKEKHATENKVKNLTEEMAGLDETISKISKEKKALQEAHQQTLDDLQAEEDKVSSLSKA 1026

  Fly  1018 ---LEENGHAQEEWISQKQTWRQENEELRRQIDEIIDMAKNAEVNQRNQEDRMLAEIDNRELNEA 1079
               ||:.....|..:.|::..|.:.|..:|:::..:.:|         ||..|..|.|.::..|.
 Frog  1027 KTKLEQQVDDLEGSLEQEKKLRLDLERAKRKLEGDLKLA---------QETIMDLENDKQQTEEK 1082

  Fly  1080 YQRAIKDKEV------IENENFM-------LKEELSRLTAGSFSLHARKASNASSQNEDDVGYAS 1131
            .::  ||.|:      ||:|..:       :||..:|:......:.|.:|:.|..:         
 Frog  1083 LKK--KDFELSQLQGKIEDEQSVGCQLQKKIKELQARIEEVEEEIEAERAARAKVE--------- 1136

  Fly  1132 AKNTLDINRPPDLLSKNY-SYNDSTSLVVKLRSILEEEKQK------HKVLQEQYIKLSSRHKPT 1189
             |...|::|..:.:|:.. ....:||..:::....|.|.||      ...||.:....:.|.|..
 Frog  1137 -KQRADLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKLRRDLEESTLQHEATSAALRKKHA 1200

  Fly  1190 EDSFRVSE-----------LEVENEKLRSEYDQLRTSI--------------------------- 1216
            :....:.|           ||.|..:|:.|.|.|.:::                           
 Frog  1201 DSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDLASNLENVSKSKANLEKLSRVLEDQLSEIKSR 1265

  Fly  1217 --KHGVEINELNAQHAALQE---EVRRRREECIQL-------KAVLLQQSQSM-RSLEPE----- 1263
              :|...||:|.||.|.||.   |:.|:.||...|       |....||::.: |.||.|     
 Frog  1266 DDEHQRIINDLTAQKARLQTENGELSRQLEEKESLVSQLTRGKQGFTQQTEELKRQLEEETKAKN 1330

  Fly  1264 ----SLQMRGNDVNELMEAFHSQKLINRQLESEL-KAIT--------------------EEHNSK 1303
                :||...:|.:.|.|.:..::....:|:..| ||.|                    ||...|
 Frog  1331 ALAHALQSSRHDCDLLREQYEEEQEAKAELQRSLSKANTEVSQWRTKYETDAIQRTEELEEAKKK 1395

  Fly  1304 LVEMTQE----IERLNNEKDELQKVMFESIDEFEDSNVDTLRQNDRYL-----RRELQKAVAQFL 1359
            |.:..||    :|.:|::...|:|.......|.||..||..|.|....     :|...|.:.::.
 Frog  1396 LAQRLQEAEEQVEAVNSKCASLEKTKQRLQAEVEDLMVDVERANSAAAALDKKQRNFDKVLVEWK 1460

  Fly  1360 LVQEELKLANAKLKAYRQDGGQL-----------EHKIE--EEMIRNKSN------------GTS 1399
            ...||   :.|:|:|.:::...|           |..:|  |.|.|...|            |.|
 Frog  1461 QKYEE---SQAELEASQKESRSLSTEIFKMKNAYEEALEHLETMKRENKNLQQEISDLSEQIGES 1522

  Fly  1400 ADVGANVTKQKSQNPQGLMKFHSSDLDKILQRLLSALTPRTVVGLLPGFPAYLIFMCIRYTDLTN 1464
            |.....:.|.|.|..|     ...||...|:.         ..|.|....|.::.:.:   :|..
 Frog  1523 AKTTMELEKAKKQVEQ-----ERGDLQAALEE---------AEGSLEHEEAKILRIQL---ELNQ 1570

  Fly  1465 ADDDVRELLSKFVIQIKKMHRTPHPIENRVIWLVNSITL----------LNLMKQY-GDVDEYVK 1518
            ...:|...:::...:|:::.|.    ..|||..:.| ||          |.|.|:. ||::| ::
 Frog  1571 VKSEVDRKIAEKDEEIEQLKRN----SQRVIDTMQS-TLDSEIRSRNDALRLKKKMEGDLNE-LE 1629

  Fly  1519 FNTEKQN------QQQLKNFNL-FEYRRVILDLIVNLYQALIMQIQGLLDPKIVPAILNNDEIQR 1576
            ......|      |:||:|... .:..::.||..|...:.|..|: .::|.:   ..|...||:.
 Frog  1630 IQLGHANRQAGEAQKQLRNVQAQLKDTQIHLDDSVRAQEDLKEQL-AVVDRR---TTLQQAEIEE 1690

  Fly  1577 GRQAHGMRSRATSIGASSSPEHGGGPAWKQLIGQLEHFYKQFQHFGLDNCYAEQIFHQLLYFICA 1641
            .|.|                           :.|.|...|..:...||.....|:.|        
 Frog  1691 MRVA---------------------------LEQTERSRKMAEQELLDASERVQLLH-------- 1720

  Fly  1642 VALNCLMLRGDICMWETGMIIRYNIGCIEDWVRS--KKMSNDVLTALAPLNQVSQLLQSRKSEQD 1704
             :.|..::       .|...:..:.|.:::.:..  ::..|....|...:...:.:.:..|.|||
 Frog  1721 -SQNTSLI-------NTKKKLETDAGTLQNEMEEAVQEARNAEEKAKKAITDAALMAEELKKEQD 1777

  Fly  1705 V------------QTICDLCTSLSTAQVLKVMKSYKLDDYESEITNVFLEKLTEKLNARQMQKSN 1757
            .            ||:.||              .::||:         .|:|..|...:|:||..
 Frog  1778 TSAHLERMKKNLEQTVKDL--------------QHRLDE---------AEQLAMKGGKKQLQKLE 1819

  Fly  1758 S------DEFTIDQK-FIQPFKVVFRYSDIKLEDIELPSH------LNLDEFLTKI 1800
            |      :|...:|| .::..|.|.:| :.:::::...|.      |.|.:.:.|:
 Frog  1820 SRVRELENELDNEQKRSVEAVKGVRKY-ERRVKELTYQSEEDRKNVLRLQDLVDKL 1874

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 274/743 (37%)
MYSc_Myo5 84..767 CDD:276831 264/713 (37%)
IQ 900..922 CDD:197470 2/27 (7%)
GBP_C <971..1086 CDD:303769 33/156 (21%)
coiled coil 1049..1068 CDD:293879 3/18 (17%)
coiled coil 1077..1086 CDD:293879 1/8 (13%)
JAKMIP_CC3 <1190..1299 CDD:292653 39/189 (21%)
Myo5_CBD 1424..1792 CDD:271254 74/412 (18%)
myh2NP_001006805.1 Myosin_N 37..72 CDD:280832 7/37 (19%)
Myosin_head 87..769 CDD:278492 267/725 (37%)
MYSc_class_II 99..769 CDD:276951 264/713 (37%)
Myosin_tail_1 849..1926 CDD:279860 226/1159 (19%)
RILP-like 964..1097 CDD:304877 29/143 (20%)
DUF342 <1155..1254 CDD:302792 18/98 (18%)
MIT_CorA-like <1298..>1410 CDD:294313 25/111 (23%)
COG6 1375..>1510 CDD:303003 31/137 (23%)
TMPIT 1741..>1837 CDD:285135 22/118 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.000

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