Protein Alignment didum and MYO1B

DIOPT Version :10

• Sequence 1: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Sequence 2: XP_047300366.1
• Gene: MYO1B / 4430
• HGNCID: 7596
• Length: 1156
• Species: Homo sapiens
• Alignment Length: 1234
• Identity: 376/1234 - (30%)
• Similarity: 597/1234 - (48%)
• Gaps: 221/1234 - (17%)

  Fly    49 KEVKLKA---DGSDLPPLRNPAI-------LVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTY 103
            ||.:|.:   .||:|..:....:       ::|..|:..|..|:|...::||:.|| :...||||
Human     4 KEERLTSWGRRGSELETMAKMEVKTSLLDNMIGVGDMVLLEPLNEETFINNLKKRF-DHSEIYTY 67

  Fly   104 CGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGA 168
            .|.:::::|||..:|:|.|..:..||.....:|.||||||::|||..|..::.:..|:::|||||
Human    68 IGSVVISVNPYRSLPIYSPEKVEEYRNRNFYELSPHIFALSDEAYRSLRDQDKDQCILITGESGA 132

  Fly   169 GKTVSAKYAMRYFAAVGGSESE-TQVERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQ 232
            |||.::|..|.|.|||.|..:| .||:.::|.|:|::||||||||.||||||||||:..:.|..:
Human   133 GKTEASKLVMSYVAAVCGKGAEVNQVKEQLLQSNPVLEAFGNAKTVRNDNSSRFGKYMDIEFDFK 197

  Fly   233 MGVMFLQGATMHTYLLEKSRVVYQAQGERNYHIFYQLCAARSK--YPELVLDHQ-DKFQFLNMGG 294
            ...:   |..:..|||||||||.|.:||||:|:||||.:..|:  ..:|.|:.. .::.:|::..
Human   198 GDPL---GGVISNYLLEKSRVVKQPRGERNFHVFYQLLSGASEELLNKLKLERDFSRYNYLSLDS 259

  Fly   295 APEIERVSDAEQFNETVQAMTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCD 359
            | ::..|.||..|.....||.::||...:...::.::|.:|.||||:    |...|.....|...
Human   260 A-KVNGVDDAANFRTVRNAMQIVGFMDHEAESVLAVVAAVLKLGNIE----FKPESRVNGLDESK 319

  Fly   360 IFHNDIHLQITADLLRVSADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQY 424
            |...: .|:...:|..:....|.|....|.:|:..|.|....::..|..|||||||::|::||.:
Human   320 IKDKN-ELKEICELTGIDQSVLERAFSFRTVEAKQEKVSTTLNVAQAYYARDALAKNLYSRLFSW 383

  Fly   425 IVGVLNKSLNNGSK-QCSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYL 488
            :|..:|:|:...:| :...:|||||||||.||.||||||.|||.||||||.|.:...|.|||||:
Human   384 LVNRINESIKAQTKVRKKVMGVLDIYGFEIFEDNSFEQFIINYCNEKLQQIFIELTLKEEQEEYI 448

  Fly   489 KEGITWTMIDFYDNQPCIDLIESRL-GVLDLLDEECRMP-KGSDESWAGKLIGKCNKFPHFEK-- 549
            :|.|.||.||:::|....||||:.. |:|.:|||||..| ..:||::..||...|....|||.
Human   449 REDIEWTHIDYFNNAIICDLIENNTNGILAMLDEECLRPGTVTDETFLEKLNQVCATHQHFESRM 513

  Fly   550 ---PRF-GTTS-----FFIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEE 605
               .|| ..||     |.|:|::..|.|.|.||::||.|.:.::|:|.:.:::.:|.|.:.
Human   514 SKCSRFLNDTSLPHSCFRIQHYAGKVLYQVEGFVDKNNDLLYRDLSQAMWKASHALIKSLF---- 574

  Fly   606 IDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQHRK---TVGSQFQESLASLISTLHA 667
                                     .:||       |:|.:.|   |.||||:.|:|:|:..|..
Human   575 -------------------------PEGN-------PAKINLKRPPTAGSQFKASVATLMKNLQT 607

  Fly   668 TTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRS 732
            ..|:|:|||||||.|.|..:..|.:..|:|..|:||.||:..||:..|..|.....||::|
Human   608 KNPNYIRCIKPNDKKAAHIFNEALVCHQIRYLGLLENVRVRRAGYAFRQAYEPCLERYKML---- 668

  Fly   733 KLDKNDMKLSCRNIVMKW----------IQDE-----DKYRFGNTQIFFRAGQVAF-LEQVRANL 781
                      |:.....|          :.:|     ::|.||.::||.|..:..| ||.:|...
Human   669 ----------CKQTWPHWKGPARSGVEVLFNELEIPVEEYSFGRSKIFIRNPRTLFKLEDLRKQR 723

  Fly   782 RKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAGLILSKYARGWLC 846
            .:...|::|.:.|.:..|..||.::|....|....|.|..::|.|:.:.  :.|::..|.|||..
Human   724 LEDLATLIQKIYRGWKCRTHFLLMKKSQIVIAAWYRRYAQQKRYQQTKS--SALVIQSYIRGWKA 786

  Fly   847 RRRYLRLRH------SISGIQTYARGMLARNKFHAMRD-----HYRAVQIQRFVRGALARRAYQK 900
            |:....|:|      :::.|..|..|..||.:...:::     |..|| |..:..|:.|||..::
Human   787 RKILRELKHQKRCKEAVTTIAAYWHGTQARRELRRLKEEARNKHAIAV-IWAYWLGSKARRELKR 850

  Fly   901 -----RRRNIIICQAA------IRRFLARRKFKRMKAEAK----TISHMENKY-MGLENKIISMQ 949
                 ||::.:....|      :||  ..|||.|..|..|    |:..:..|| :.::||:.|:.
Human   851 LKEEARRKHAVAVIWAYWLGLKVRR--EYRKFFRANAGKKIYEFTLQRIVQKYFLEMKNKMPSLS 913

  Fly   950 QRIDE-------LNRDNSNLKHKTSEISVLKMKLELKKTLEA-EFKNVKAACQDKDKLIEALNKQ 1006
            . ||:       |..|::   ||           |||:.... ..|..:....|:.|||
Human   914 P-IDKNWPSRPYLFLDST---HK-----------ELKRIFHLWRCKKYRDQFTDQQKLI------ 957

  Fly  1007 LEAERDEKMQLLEENGHAQEEWISQKQTWRQE-NEELRRQIDEIIDMAKNAEVNQRNQEDRMLAE 1070
                       .||...|.|.:..:|..:... .:..:....||....|..::....:|..::||
Human   958 -----------YEEKLEASELFKDKKALYPSSVGQPFQGAYLEINKNPKYKKLKDAIEEKIIIAE 1011

  Fly  1071 IDNRELNEAYQRAIKDKEVIENENFML------------------KEELSRLTAGSFSLHARKAS 1117
            :.|: :|.|..::.....::.|.|.:|                  |..:|....|.|::|.::.|
Human  1012 VVNK-INRANGKSTSRIFLLTNNNLLLADQKSGQIKSEVPLVDVTKVSMSSQNDGFFAVHLKEGS 1075

  Fly  1118 NASSQNEDDVGYASAKNTLDINRPPDLLSKNYSYNDSTSLVVKLRSILEEEKQKHKV-LQEQYI 1180
            .|:|:.:                  .|.|.::....:|.|   .|:.|.:.|||..: :.::::
Human  1076 EAASKGD------------------FLFSSDHLIEMATKL---YRTTLSQTKQKLNIEISDEFL 1118

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	262/718 (36%)
		IQ	900..922	CDD:197470	7/32 (22%)
		SMC_prok_B	<942..1365	CDD:274008	51/267 (19%)
		Myo5_CBD	1424..1792	CDD:271254
MYO1B	XP_047300366.1	MYSc_Myo1	49..708	CDD:276829	262/718 (36%)
		IQ	769..791	CDD:197470	6/23 (26%)
		Myosin_TH1	961..1138	CDD:461801	32/180 (18%)