DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment didum and Myo1a

DIOPT Version :9

Sequence 1:	NP_724569.1	Gene:	didum / 35680	FlyBaseID:	FBgn0261397	Length:	1800	Species:	Drosophila melanogaster
Sequence 2:	NP_001074688.1	Gene:	Myo1a / 432516	MGIID:	107732	Length:	1043	Species:	Mus musculus

Alignment Length:	1183	Identity:	363/1183 - (30%)
Similarity:	589/1183 - (49%)	Gaps:	208/1183 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 LPPLRNPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSI 124
            :|.|..|   ||..||..|..|.|..::.||::|: |.:.||||.|.:::::|||.::|:|||..
Mouse     1 MPLLEGP---VGVEDLILLEPLDEESLIKNLQLRY-ENKEIYTYIGNVVISMNPYEQLPIYGPEF 61

  Fly   125 IRAYRGHAMGDLEPHIFALAEEAYTKL---ERENCNLSIIVSGESGAGKTVSAKYAMRYFAAV-G 185
            |..||.:...:|:|||:|||..||..|   :|:.|   |:::||||||||.::|..|.|.||| |
Mouse    62 IAKYRDYTFYELKPHIYALANVAYQSLKDRDRDQC---ILITGESGAGKTEASKLVMSYVAAVCG 123

  Fly   186 GSESETQVERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEK 250
            ..|....|:.::|.|:|::||||||||.||:|||||||:..:.|..:...:   |..:..|||||
Mouse   124 KGEQVNSVKEQLLQSNPVLEAFGNAKTIRNNNSSRFGKYMDIEFDFKGSPL---GGVITNYLLEK 185

  Fly   251 SRVVYQAQGERNYHIFYQLCAARSK--YPELVLDHQDK-FQFLNMGGAPEIERVSDAEQFNETVQ 312
            ||||.|.:||||:||||||.|....  ...|.|:.... :.:|| |...::..:.||..|.....
Mouse   186 SRVVKQLKGERNFHIFYQLLAGADAQLLKALKLEEDTSVYGYLN-GEVSKVNGMDDASNFRAVQH 249

  Fly   313 AMTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVS 377
            ||:|:|||.::|..::::.|.:|.|||::::.:| :.:....|..||    ...:|...:::.::
Mouse   250 AMSVIGFSEEEIRQVLEVTALVLKLGNVKLTDEF-QANGIPASGICD----GKGIQEIGEMMGLN 309

  Fly   378 ADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGS-KQCS 441
            :.:|.|.|..|.:|:..|.|:...::..||.|||||||:||::||.:||..:|:|:..|: ::..
Mouse   310 STELERALCSRTMETGKEKVVTVLNVTQAQYARDALAKNIYSRLFDWIVKRINESIKVGTGEKKK 374

  Fly   442 FIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCI 506
            .:|||||||||..|.||||||.|||.||:|||.|.:...|.|||||.:|||.||.::::||....
Mouse   375 VMGVLDIYGFEILEDNSFEQFVINYCNERLQQVFIELTLKEEQEEYKREGIPWTKVEYFDNGIIC 439

  Fly   507 DLIE-SRLGVLDLLDEECRMPKG--SDESWAGKLIGKCNKFPHFEKP-----------RFGTTSF 557
            :||| |:.|:|.:|||||..| |  ||.::..||....:|..|:|..           ..|.:.|
Mouse   440 NLIEHSQRGILAMLDEECLRP-GVVSDSTFLAKLNQLFSKHSHYESKVSQNAQRQYDRTMGLSCF 503

  Fly   558 FIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGR 622
            .|.|::..|.|:|.||::||.|.:.::|:|.:.::...|.|.:.
Mouse   504 RISHYAGKVTYNVTGFIDKNNDLLFRDLSQTMWKAQHPLLKSLF--------------------- 547

  Fly   623 VVISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKW 687
                    .:||...    .|.:...|.|:||:.|:|.|:..|::..|:|:|||||||.:...::
Mouse   548 --------PEGNPKE----ASLKRPPTAGTQFKNSVAVLMKNLYSKNPNYIRCIKPNDQQQKGRF 600

  Fly   688 ETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDK--NDMKLSCRNIVMKW 750
            .:..::.|.|..|:||.||:..||:..|..|..|..||:|| .||...:  .|.:.....::...
Mouse   601 TSEMVMVQARYLGLLENVRVRRAGYAFRQGYKPFLERYRLL-SRSTWPRWNGDDREGVEKVLGSL 664

  Fly   751 IQDEDKYRFGNTQIFFRAGQVAF-LEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQK 814
            ....::..:|.|:||.|:.:..| ||:.|.                       ||:|::...|||
Mouse   665 TLSSEELAYGKTKIFIRSPKTLFYLEEQRR-----------------------LRLQQLATLIQK 706

  Fly   815 HARGYLARERTQKMREARAGLILSKYARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDH 879
            ..||:..|...|:||:::  :::|.:.||...::.|.::|.|:..||.:.||..||..:   |.:
Mouse   707 VYRGWRCRTHYQQMRKSQ--ILISAWFRGNKQKKHYGKIRSSVLLIQAFVRGWRARKNY---RKY 766

  Fly   880 YR---AVQIQRFVRGALARRAYQKRRRNIIICQ--------AAIRRF-LARRKFKRMKAEAKTIS 932
            :|   |:.:..|:..::|::.....::|:...:        |..|.| .|.::.:|:..:.|.
Mouse   767 FRSGAALTLANFIYQSMAQKFLLNLKKNLPSTKVLDNTWPAAPYRCFNTANQELQRLFYQWKC-- 829

  Fly   933 HMENKYMGLENKIISMQQRIDELNRDNSNLKHKTSEISVLKMKL---ELKKTLEAEFKNVKAACQ 994
               .|:                  ||..:.|    ::..|:.||   ||       ||..||: .
Mouse   830 ---KKF------------------RDQLSPK----QVQTLREKLCASEL-------FKGKKAS-Y 861

  Fly   995 DKDKLIEALNKQLEAERDEKMQLLEENGHAQEEWISQKQTWRQENEELRRQIDEIIDMAKNAEVN 1059
            .:...|......:..:.:.|:|.|:               .|:|...|      :.|..|  :||
Mouse   862 PQSVPIPFRGDYIGLQGNPKLQRLK---------------GREEGPVL------VADTVK--KVN 903

  Fly  1060 QRNQEDR---MLAEIDNRELNEAYQRAIKDKEVIENENFMLKEELSRLTAGSFSLHARKASNASS 1121
            :.|.:..   :|....:..|.:|.:   ...:::.....:....:|.|..|.||||..:.|:|.|
Mouse   904 RGNGKTSARILLLTKGHVILTDAKK---SQAQIVIGLEDVAGVSVSSLQDGLFSLHLSEMSSAVS 965

  Fly  1122 QNEDDVGYASAKNTLDINRPPDLLSKNYSYNDSTSLVVKLRSILEEEKQKHKVLQEQYIKLSSRH 1186
            :.  |:...|       :...:||:|.|            :::|:..:::..|...:  |.|.|.
Mouse   966 KG--DILLVS-------DHVVELLTKMY------------QAVLDATQRQLSVTVTE--KFSVRF 1007

  Fly  1187 KPTEDSFRVSELE 1199
            |  |.|..|..::
Mouse  1008 K--EGSVAVKVIQ 1018

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc	65..778	CDD:214580	271/737 (37%)
		MYSc_Myo5	84..767	CDD:276831	259/706 (37%)
		IQ	900..922	CDD:197470	5/30 (17%)
		GBP_C	<971..1086	CDD:303769	24/120 (20%)
		coiled coil	1049..1068	CDD:293879	5/21 (24%)
		coiled coil	1077..1086	CDD:293879	1/8 (13%)
		JAKMIP_CC3	<1190..1299	CDD:292653	3/10 (30%)
		Myo5_CBD	1424..1792	CDD:271254
Myo1a	NP_001074688.1	MYSc_Myo1	22..681	CDD:276829	259/706 (37%)
		Actin-binding. /evidence=ECO:0000255	571..593		10/21 (48%)
		IQ	742..764	CDD:197470	8/24 (33%)
		Myosin_TH1	847..1042	CDD:368706	48/231 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910