DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment didum and myh4

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:NP_001001244.1 Gene:myh4 / 407946 XenbaseID:XB-GENE-989283 Length:1935 Species:Xenopus tropicalis


Alignment Length:2076 Identity:527/2076 - (25%)
Similarity:909/2076 - (43%) Gaps:496/2076 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 SSEEMLYAQGAKIWVPHADLVWESATLEESYRKGA------GFLKICTDSGKLKEVKLKADGSDL 60
            |.:|.|.||.......:...|.:   ::|.|.||.      |.:.:.||.|:...||    .:.:
 Frog    19 SEKERLEAQSKPFDAKNTVFVDD---VKELYVKGMVTAREDGKITVKTDDGRTVTVK----ENQI 76

  Fly    61 PPLRNPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSII 125
            .| :||.......|:..:::|:|..||:||:.|:. ..:||||.|:....:|||..:|:|.|.::
 Frog    77 YP-QNPPKFDKIEDMAMMTHLNEASVLYNLKERYA-AWMIYTYSGLFCATVNPYKWLPVYNPEVV 139

  Fly   126 RAYRGHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYF---AAVGGS 187
            ..|||....:..||||:|::.||..:..:..|.|::::|||||||||:.|..::||   ||:|..
 Frog   140 AGYRGKKRMEAPPHIFSLSDNAYQAMLTDRENQSVLITGESGAGKTVNTKRVIQYFATIAALGDK 204

  Fly   188 ESET------QVERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTY 246
            :.|:      .:|.:::.::|::||||||||.|||||||||||.::.| ...|.  |..|.:.||
 Frog   205 KKESSNSLQGNLEDQIIQANPLLEAFGNAKTVRNDNSSRFGKFIRIHF-GTTGK--LSSADIETY 266

  Fly   247 LLEKSRVVYQAQGERNYHIFYQLCAARSKYPELV---LDHQDKFQFLNMG-GAPEIERVSDAEQF 307
            |||||||.:|...||:||||||:..  :|.||:|   |...:.:.:.::. |...::.::|.|:.
 Frog   267 LLEKSRVTFQLSAERSYHIFYQILT--NKKPEIVEMLLLTTNPYDYPSISQGELVVKSINDEEEL 329

  Fly   308 NETVQAMTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITAD 372
            ..|..|:.||||:.::...|.|:...::|.||::..:|..|  |:.:.||.::...      .|.
 Frog   330 MATDSAIDVLGFNQEEKMGIYKMTGAVMHHGNLKFKQKQRE--EQAEPDSTEVADK------IAY 386

  Fly   373 LLRVSADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGS 437
            ||.:::.||.:.|...:::..||:|....::.....:..||.|.::.|||.::|..:|:.|:...
 Frog   387 LLGLNSADLLKGLCYPRVKVGNEFVTKGQTVPQVYNSVGALCKSVFEKLFLWMVTRINQQLDTKQ 451

  Fly   438 KQCSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDF-YD 501
            .:..|||||||.|||.|:.||.||.|||:.||||||.||.|:|.||||||.||||.|..||| .|
 Frog   452 PRQFFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIDWEFIDFGMD 516

  Fly   502 NQPCIDLIESRLGVLDLLDEECRMPKGSDESWAGKL----IGKCNKFPHFEKPRFG----TTSFF 558
            ...||:|||..||:..:|:|||..||.:|.|:..||    :|||.   :||||:.|    ...|.
 Frog   517 LAACIELIEKPLGIFSILEEECMFPKATDTSFKNKLYEQHLGKCK---NFEKPKPGKGKAEAHFS 578

  Fly   559 IKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRV 623
            :.|::.||:|:::|:||||:|.:::.:.|:..:|::.|...:.:..        :|.....||: 
 Frog   579 LVHYAGTVDYNISGWLEKNKDPLNESVVQLYQKSSVKLLSLLYSSY--------AATDGDAGGK- 634

  Fly   624 VISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWE 688
               .|:|::|:..           :||...|:|:|..|::.|.:|.||:|||:.||:.|.....:
 Frog   635 ---GGKKKKGSSF-----------QTVSGLFRENLNKLMTNLRSTHPHFVRCLIPNETKTPGIMD 685

  Fly   689 TAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKN---DMKLSCRNIVMKW 750
            ...:|.|||..||||.:||...|||||.||.||..||::| ..|.:.:.   |.|.:|..::...
 Frog   686 NHLLIHQLRCNGVLEGIRICRKGFPSRILYGDFKQRYKVL-NASAIPEGQFIDSKKACEKLLGSI 749

  Fly   751 IQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKH 815
            ..|..:|:||:|::||:||.:..||::|.....:.||..|::                       
 Frog   750 DVDHTQYKFGHTKVFFKAGLLGTLEEMRDEKLAQLITRTQAL----------------------- 791

  Fly   816 ARGYLARERTQKMREARAGLILSKY-------ARGWLCRRRYLRLRHSISGIQTYARGMLARNKF 873
            .||||.|....||.|.|..:.:.:|       .:.|...:.|.:::..:...:|       ..:.
 Frog   792 CRGYLMRLEFTKMMERREAIYVIQYNLRSFMNVKHWPWMKLYFKIKPLLKSAET-------EKEM 849

  Fly   874 HAMRDHYRAVQIQRFVRGALARRAYQKR------RRNIIICQAAIRRFLARRKFKRMKAEAKTIS 932
            ..|::.:...: :..|:....::..:::      .:|.::.|              :::|::|::
 Frog   850 ANMKEEFEKTK-EALVKAEARKKELEEKMVAMLQEKNDLVLQ--------------VQSESETLA 899

  Fly   933 HMENKYMGLENKIISMQQRIDELNRDNSNLKHKTSEISVLKMKL-----ELKKTLE------AEF 986
            ..|.:..||....|.::.:|.||.....:.:...:|::..|.||     ||||.::      |:.
 Frog   900 DSEERCEGLIKVKIQLESKIKELTERLEDEEESNAELTAKKRKLEDECSELKKDIDDLELTLAKV 964

  Fly   987 KNVKAACQDK-----------DKLIEALNKQLEAERDEKMQLLEENGHAQEEWISQKQTWRQENE 1040
            :..|.|.::|           |:.|..|:|:.:|.::...|.|::. .|:|:.:|   :..:...
 Frog   965 EKEKHATENKVKNLTEEMAVLDENISKLSKEKKALQEAHQQTLDDL-QAEEDKVS---SLSKAKT 1025

  Fly  1041 ELRRQIDEI---IDMAKNAEVN------------QRNQEDRMLAEIDNRELNEAYQRAIKDKEV- 1089
            :|.:|:|::   ::..|...::            :..||..|..|.|.::..|..::  ||.|: 
 Frog  1026 KLEQQVDDLEGSLEQEKKLRLDLERAKRKLEGDLKLTQETVMDLENDKQQTEEKLKK--KDFEIS 1088

  Fly  1090 -----IENENFM-------LKEELSRLTAGSFSLHARKASNASSQNEDDVGYASAKNTLDINRPP 1142
                 ||:|..:       :||..:|:......:.|.:|:.|..:          |...|::|..
 Frog  1089 QLQGKIEDEQSLGTQLQKKIKELQARIEEVEEEIEAERAARAKVE----------KQRADLSREL 1143

  Fly  1143 DLLSKNY-SYNDSTSLVVKLRSILEEEKQKHKVLQEQYIKLSSRHKPTEDSFR------VSE--- 1197
            :.:|:.. ....:||..:::....|.|.||   |:....:.:.:|:.|..:.|      |:|   
 Frog  1144 EEISERLEEAGGATSAQIEMNKKREAEFQK---LRRDLEEATLQHEATAGALRKKHADSVAELGE 1205

  Fly  1198 -----------LEVENEKLRSEYDQLRTSI-----------------------------KHGVEI 1222
                       ||.|..:|:.|.|.|.:::                             :|...:
 Frog  1206 QIDNLQRVKQKLEKEKSELKMEIDDLASNLENVSKSKANLEKVNRVIEDQLSEVKAKDDEHQRLL 1270

  Fly  1223 NELNAQHAALQE---EVRRRREECIQL-------KAVLLQQSQSM-RSLEPE---------SLQM 1267
            |:|:.|.|.||.   |:.|:.||...|       |....||.:.: |.||.|         :||.
 Frog  1271 NDLSTQKARLQTETGELSRQLEERESLISQLSRGKQGFTQQVEELKRQLEEETKAKNALAHALQS 1335

  Fly  1268 RGNDVNELMEAFHSQKLINRQLESELKAIT---------------------EEHNSKLVEMTQ-- 1309
            ..:|.:.|.|.|..::....:|:..|....                     ||...||.:..|  
 Frog  1336 ARHDCDLLREQFEEEQEAKAELQRSLSKANGEVSQWRTKYETDAIQRTEELEEAKKKLAQRLQDA 1400

  Fly  1310 --EIERLNNEKDELQKVMFESIDEFEDSNVDTLRQN-------------DRYL----------RR 1349
              ::|.:|::...|:|.......|.||..||..|.|             |:.|          :.
 Frog  1401 EEQVEAVNSKCASLEKTKQRLQSEVEDLMVDVERANSAAAALDKKQRNFDKVLVEWKQKYEEGQA 1465

  Fly  1350 ELQKAVAQFLLVQEEL-KLANAKLKAYRQDGGQLEH----KIEEEMIRNKSNGTSADVG------ 1403
            ||:.|:.:...:..|: |:.||..:|       |||    |.|.:.::.:.:..:..:|      
 Frog  1466 ELEAALKESRSLSTEIFKMKNAYEEA-------LEHVETLKRENKNLQQEISDLTEQIGESGKSV 1523

  Fly  1404 ANVTKQKSQNPQGLMKFHSSDLDKILQRLLSALTPRTVVGLLPGFPAYLIFMCIRYTD------- 1461
            ..:.|.|.|..|     ..:||...|:.         ..|.|....|.::.:.:....       
 Frog  1524 VELEKAKKQVEQ-----EKNDLQAALEE---------AEGSLEHEEAKILRIQLELNQVKSEVDR 1574

  Fly  1462 -LTNADDDVRELLSKFVIQIKKMHRTPHPIENRVIWLVNSITLLNLMKQYGDVDEYVKFNTEKQN 1525
             :...|:::.:|.......|..|..|   :::.:....:::.|...|:  ||::| ::......|
 Frog  1575 KIAEKDEEIEQLKRNSQRSIDTMQST---LDSEIRSRNDALRLKKKME--GDLNE-LEIQLGHAN 1633

  Fly  1526 ------QQQLKNF-NLFEYRRVILDLIVNLYQALIMQIQGLLDPKIVPAILNN---DEIQRGRQA 1580
                  |:||:|. ..|:..::.||..:...:.|..|:       .|....||   .||:..|..
 Frog  1634 RQASEAQKQLRNVQGQFKETQLQLDEAIRAQEDLKEQV-------AVTERRNNLFQAEIEENRAG 1691

  Fly  1581 HGMRSRATSIGASSSPEHGGGPAWKQLIGQLEHFYKQFQHFGLDNCYAEQIFHQLLYFICAVALN 1645
            .....|:..|            |.::|:...|..                   |||:......:|
 Frog  1692 LEQTERSRKI------------AEQELLDASERL-------------------QLLHSQNTSLIN 1725

  Fly  1646 C-LMLRGDICMWETGMIIRYNIGCIEDWVRSKKMSNDVLTALAPLNQVSQLLQSRKSEQDV---- 1705
            . ..|..|||..:..         .|:.|:..:.:.:  .|...:...:.:.:..|.|||.    
 Frog  1726 SKKKLESDICQLQNE---------AEEAVQEARNAEE--KAKKAITDAALMAEELKKEQDTSAHL 1779

  Fly  1706 --------QTICDLCTSLSTAQVLKVMKSYKLDDYESEITNVFLEKLTEKLNARQMQKSNS---- 1758
                    ||:.||              .::||:         .|:|..|...:|:||..|    
 Frog  1780 ERMKKNLEQTVKDL--------------QHRLDE---------AEQLAMKGGKKQLQKLESRVRE 1821

  Fly  1759 --DEFTIDQKF-IQPFKVVFRY----------------SDIKLEDIELPSHLNLDEFLTKI 1800
              :|...:||. ::..|.|.:|                :.::|:|:       :|:..:|:
 Frog  1822 LENELDNEQKHGVEAVKGVRKYERRVKELTYQTEEDKKNILRLQDL-------VDKLQSKV 1875

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 275/737 (37%)
MYSc_Myo5 84..767 CDD:276831 265/707 (37%)
IQ 900..922 CDD:197470 2/27 (7%)
GBP_C <971..1086 CDD:303769 31/151 (21%)
coiled coil 1049..1068 CDD:293879 3/33 (9%)
coiled coil 1077..1086 CDD:293879 1/8 (13%)
JAKMIP_CC3 <1190..1299 CDD:292653 37/198 (19%)
Myo5_CBD 1424..1792 CDD:271254 73/421 (17%)
myh4NP_001001244.1 Myosin_N 34..72 CDD:397036 9/40 (23%)
MYSc_class_II 99..766 CDD:276951 265/707 (37%)
Myosin_tail_1 846..1923 CDD:396244 218/1170 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.000

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