Protein Alignment didum and myo3a

DIOPT Version :10

• Sequence 1: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Sequence 2: XP_068073147.1
• Gene: myo3a / 402814
• ZFINID: ZDB-GENE-041026-4
• Length: 1790
• Species: Danio rerio
• Alignment Length: 1526
• Identity: 395/1526 - (25%)
• Similarity: 657/1526 - (43%)
• Gaps: 355/1526 - (23%)

  Fly    73 NDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLE 137
            :||.||..|.|..:...|:.|:.:.| ||||.|.||:|:||:.:..||.|...::|.|.......
Zfish   368 DDLATLEVLDENTITEQLQRRYTKEQ-IYTYVGDILIAVNPFHKTELYTPEHTKSYVGAKRTSNP 431

  Fly   138 PHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESETQVERKVLASSP 202
            |||:|:|:.||..:...|.:..|::|||||||||.||...::....:|.:.:.| ::.|:|..:.
Zfish   432 PHIYAVADIAYQSMVSYNADQCIVISGESGAGKTESAHLLVQQLTVLGKANNRT-LQEKILLVNS 495

  Fly   203 IMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHIFY 267
            ::||||||.|..|||||||||:.::.|.....|:   ||.:..|||||||||:.|.||||:||||
Zfish   496 LVEAFGNACTVINDNSSRFGKYLEMKFTCGGTVV---GAQISDYLLEKSRVVHHAVGERNFHIFY 557

  Fly   268 QL---CAARSKYPELVLDHQDKFQFL---NMGGAPEIERVSDA---EQFNETVQAMTVLGFSIQQ 323
            .:   .|.|.|.....|......::|   |:...|:|  |.:|   |||....|...|:||::::
Zfish   558 YIYAGLAERKKLGHYKLSDSKTPRYLHNENVKLVPDI--VGNAFYKEQFETVEQCFKVIGFTLEE 620

  Fly   324 IADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMR 388
            :..:..||||||:.|:::    |...:.|..:|..:| .|...|:..|.||.:.||:|:..|...
Zfish   621 LGSVYGILAGILNTGDVE----FTSVASEHQTDKSNI-SNMAVLESAASLLCIRADELQEALTSH 680

  Fly   389 KIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLN-------------KSLNNGSKQC 440
            .:.:..|.::..|::|.|...|||:.|.:|.:||.:||..:|             |.||
Zfish   681 CVVTRGETIVRSNTVEKATEVRDAMGKALYGRLFSWIVNRINSLLKPDNQSGEDDKGLN------ 739

  Fly   441 SFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPC 505
              ||:|||:|||.|:.|||||.|||.|||::|..||||:|..||:|||.|.:...:|::.||:|.
Zfish   740 --IGILDIFGFENFKRNSFEQLCINIANEQIQFYFNQHIFAWEQDEYLNEDVDARVIEYEDNRPL 802

  Fly   506 IDL-IESRLGVLDLLDEECRMPKGSDESWAGKLIGKCNKFPHFEKPRFGTTSFFIKHFSDTVEYD 569
            :|| ::..:|:|.|||||.|.|:.:|::...|..... |..:|.:|:.....|.|.|::..|.|:
Zfish   803 LDLFLQKPMGMLSLLDEESRFPQATDQTLVEKFEDNL-KSKNFWRPKRVDLGFGIHHYAGKVIYN 866

  Fly   570 VNGFLEKNRDTVSKELTQVLSESNMSLAKQVMT--------LEEIDTLCVDSAKSST-------- 618
            ..|||.||||.:..::..:|..|...|.::::|        |.......|.||:..|
Zfish   867 AGGFLAKNRDALPADIVLLLRSSENELTRKLVTHPLTKTGNLAHTKGKAVGSARMGTQQSQRFAK 931

  Fly   619 -----LGGRVVI--SAGRK---------------------QQGNDTRRRVVPSKQHRKTVGSQFQ 655
                 |...|..  |:.||                     ..|:.|......:....:||.|.|:
Zfish   932 LDCLLLFSSVSFSESSSRKLTPPIDKSMLALPVDSVQTTESTGDTTHHPRETTNMKTQTVASYFR 996

  Fly   656 ESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPD 720
            .||..|:|.:.|..||:|||||||:|:.|.|::..|::.|||..|:|||.:|...|:..|.|:.:
Zfish   997 YSLMDLLSKMVAGQPHFVRCIKPNNDRQAHKFDREKVLIQLRYTGILETAKIRRQGYSHRILFNN 1061

  Fly   721 FYMRYQLLVYRSKLDKNDMKLSCRNIVMK-----WIQDEDKYRFGNTQIFFRAGQVAFLEQVRAN 780
            |..||.:|.:|:..:......:|..|:.|     ||       .|.|::|.:...|   ||:  |
Zfish  1062 FIERYSILAFRANEEPAISPETCAVILEKAKLENWI-------LGKTKVFLKYYHV---EQL--N 1114

  Fly   781 LRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREAR--AGLILSKYARG 843
            |      :|:....|.|.             :|.:.||::|.:|...::|.|  :.::|....||
Zfish  1115 L------MVRQTTDRIVL-------------VQAYVRGWMAFKRYCLLKEKREQSAVVLQSAYRG 1160

  Fly   844 WLCRRRYLRLRHS------ISGIQTYARGMLARNKFHAMRD--HYRAVQIQRFVRGALARRAYQK 900
            ...|:.....|..      .:.:|.:.||.|||..:..:.|  :..|.:||...||...|:::|:
Zfish  1161 HKARKSIADDRSKAKSEIVFTQLQAWCRGYLARQNYKELLDEKNKAAAKIQAHYRGQKERKSFQR 1225

  Fly   901 RR-------------------------------------------RNIIICQAAIRRFLARRKFK 922
            ::                                           :..::.|:..|.:..|:|||
Zfish  1226 KKEAMQKENTEKTERVTEVPLEADDPVSEEPLQEGGEVEMDDADEKAAVVLQSNYRGYRERKKFK 1290

  Fly   923 RMKAEAKTISHMENKYMGLENKIISMQQRIDELNRDNSNLKHKTSEISVLKMKLELKKTLEAEFK 987
            ..:...||:|.                   |||:..:|..:..||...:...:.:.::.:|.|..
Zfish  1291 ERQERNKTLSG-------------------DELDASSSTPEEMTSGEDLEATREDTQENVEKEGN 1336

  Fly   988 NVKAACQDKD-----KLIEALNKQLEAERDEKMQLLEENGHAQEEWISQKQTWRQENEELRRQI- 1046
            .|:....|:|     |....|.......::.|.  |:|.|...   :..|:..:...:|....|
Zfish  1337 EVEEGGGDEDPEQEAKAATVLQSNFRGHKERKR--LQEEGKIP---VRGKKEIKSPTDEEELPIP 1396

  Fly  1047 -----DEIIDMAKNAEVNQRN---QEDRMLAEIDNRELNEAYQRAIKDKEVIENENFMLK----- 1098
                 :|:::.::..|..:.|   :||...|.:    :.::..|..|:::.::.|..:.|
Zfish  1397 DPPPPEELMEFSEEMEFTEENPPGEEDEAKAAV----VLQSNFRGHKERKRLQEEGKIPKKKTKE 1457

  Fly  1099 ---------------------------EELSRLTAGSFSLHA-----------RKASNASSQNED 1125
                                       :||....:|....||           |:.....::.|:
Zfish  1458 EMDDPGASEPDIAIEELPPPPLELEHDQELDSSPSGGDEEHAATVLQSNFRGHRERKRLRAEKEE 1522

  Fly  1126 DVGYASAKNTLDINRPPDLLSKNYSYNDSTSLVVKLRSILEEEKQKHKVLQEQYIKLSSRHKPTE 1190
            ..|  ..::|.|:..     .:|....|.|.:.::.|   |||::.....::..||:.|..:..:
Zfish  1523 ATG--GGQSTGDVEE-----QENNDVLDITDVQLERR---EEEEEGQYDEEQAAIKIQSNFRGYK 1577

  Fly  1191 D------SFRVSELEVEN-----EKLRSEYDQLRTSIKHGVEINELN------------------ 1226
            |      :.:..:.|||:     .|...:|..|:..:...:..::||
Zfish  1578 DRKNLKATSQKQDEEVESLFKQVSKASEDYLSLQKKLNEIILAHQLNPSKNGMFVKGQPMNGYMG 1642

  Fly  1227 ----------------AQ-----------------HAALQEEVRRRREECIQLKAVLLQQSQSMR 1258
                            ||                 |.::|::.||.|:             ||.:
Zfish  1643 YYQPPADTKQSRTPRRAQQPKTLNTPEDSTYYTLIHRSVQDDKRRPRK-------------QSPK 1694

  Fly  1259 SLEPESLQMRGNDVNELMEAFHSQKLINRQLESELKAITEEHNSKLVEMTQEIERLNNEKDELQK 1323
            .|:.:....:|      :.:..|..|.|.:..|..:..::|..|....:: ::.:....||.|:|
Zfish  1695 KLDNDDQYYQG------LSSSKSTSLPNERRRSSKRRASDERRSSERPLS-DVPKSEIPKDPLEK 1752

  Fly  1324 -VMFESIDEFEDSNVDTLRQNDRYLRRELQK 1353
             ..|..:...|..:.|......:.||:..|:
Zfish  1753 RHSFSKMPSTESQSEDNPYDYRKILRKTSQR 1783

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	260/754 (34%)
		IQ	900..922	CDD:197470	4/64 (6%)
		SMC_prok_B	<942..1365	CDD:274008	86/532 (16%)
		Myo5_CBD	1424..1792	CDD:271254
myo3a	XP_068073147.1	Protein Kinases, catalytic domain	17..302	CDD:473864
		MYSc_Myo3	379..1106	CDD:276830	260/754 (34%)
		MBD_Myo3a	1577..1625	CDD:439318	8/47 (17%)