DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment didum and MYO18A

DIOPT Version :9

Sequence 1:	NP_724569.1	Gene:	didum / 35680	FlyBaseID:	FBgn0261397	Length:	1800	Species:	Drosophila melanogaster
Sequence 2:	NP_001333694.1	Gene:	MYO18A / 399687	HGNCID:	31104	Length:	2058	Species:	Homo sapiens

Alignment Length:	1774	Identity:	396/1774 - (22%)
Similarity:	729/1774 - (41%)	Gaps:	397/1774 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SEEMLYAQGA-----KIWVPHAD-------LVWESATLEESYRKGAGFLKICTDSGKLKEVKLKA 55
            :||.:.|:.|     |:|:.|.|       |..|...|.|               ||:: |||..
Human   348 TEEQIAAEEAWNETEKVWLVHRDGFSLASQLKSEELNLPE---------------GKVR-VKLDH 396

  Fly    56 DGS-------DLPPLRNPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINP 113
            ||:       |:.....|: .....||.:|.||:|..|||.||.|: ...:::||.|..|:.:.|
Human   397 DGAILDVDEDDVEKANAPS-CDRLEDLASLVYLNESSVLHTLRQRY-GASLLHTYAGPSLLVLGP 459

  Fly   114 YAEMPLYGPSIIRAYRGHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAM 178
            .....:|...::..::|....|:.|||:|:|:.||..:.....:.|||:.|.||:|||.|.::.:
Human   460 RGAPAVYSEKVMHMFKGCRREDMAPHIYAVAQTAYRAMLMSRQDQSIILLGSSGSGKTTSCQHLV 524

  Fly   179 RYFAAVGG-SESETQVERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGAT 242
            :|.|.:.| |.::.....|..|...::|||||:.|..|.|::||.:...|.| :|.|.  :..|:
Human   525 QYLATIAGISGNKVFSVEKWQALYTLLEAFGNSPTIINGNATRFSQILSLDF-DQAGQ--VASAS 586

  Fly   243 MHTYLLEKSRVVYQAQGERNYHIFYQL--CAARSKYPELVLDH---QDKFQFLNMGGAPEIERVS 302
            :.|.||||.||..:...|..:::||.|  |...:...||.|:|   .:.|..:.: ..|| |:..
Human   587 IQTMLLEKLRVARRPASEATFNVFYYLLACGDGTLRTELHLNHLAENNVFGIVPL-AKPE-EKQK 649

  Fly   303 DAEQFNETVQAMTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDI----FHN 363
            .|:||::...||.|||.|..:......|||.|.|||....:|:    :.||.:::.:.    |..
Human   650 AAQQFSKLQAAMKVLGISPDEQKACWFILAAIYHLGAAGATKE----APEEQAEAAEAGRKQFAR 710

  Fly   364 DIHLQITADLLRVSADDLRRWLLMRK-----IESVNEYVLIPNSIE---------AAQAARDALA 414
            ....|..|.||..|.::|...:...:     ::....:...|....         :|....:.:|
Human   711 HEWAQKAAYLLGCSLEELSSAIFKHQHKGGTLQRSTSFRQGPEESGLGDGTGPKLSALECLEGMA 775

  Fly   415 KHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIYGFETFEVN------SFEQFCINYANEKLQQ 473
            ..:|::||..:|.::|::|.:.......:.::|..||:..|..      |||:.|.||..::||:
Human   776 AGLYSELFTLLVSLVNRALKSSQHSLCSMMIVDTPGFQNPEQGGSARGASFEELCHNYTQDRLQR 840

  Fly   474 QFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCID-------------LIES------RLGVLDLL 519
            .|::..|..|.|.|.:|.|.   :.|.|.:|..|             |:.|      ..|:|.||
Human   841 LFHERTFVQELERYKEENIE---LAFDDLEPPTDDSVAAVDQASHQSLVRSLARTDEARGLLWLL 902

  Fly   520 DEECRMPKGSDESWAGKLIG--------KCNKFP--HFEKPRFGTTSFFIKHFSDT--VEYDVNG 572
            :||..:|..|:::...:|..        |..:.|  |..||.    .|.:.|...|  |||:|.|
Human   903 EEEALVPGASEDTLLERLFSYYGPQEGDKKGQSPLLHSSKPH----HFLLGHSHGTNWVEYNVTG 963

  Fly   573 FLE-KNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSST-LGGRVVISAGRKQQGND 635
            :|. ..::..::...::|.:|...:         |..|.:..|.|:| |.|.:   ||.:.....
Human   964 WLNYTKQNPATQNAPRLLQDSQKKI---------ISNLFLGRAGSATVLSGSI---AGLEGGSQL 1016

  Fly   636 TRRRVVPSKQ---------HRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWE--- 688
            ..||....::         .:|::..|.:..:.:||.|:..:..|:|.|..|    ||..|.
Human  1017 ALRRATSMRKTFTTGMAAVKKKSLCIQMKLQVDALIDTIKKSKLHFVHCFLP----VAEGWAGEP 1077

  Fly   689 ----------------------TAKIIQ--------QLRACGVLETVRISAAGFPSRWLYPDFYM 723
                                  .|.::|        |||...:|:.:|:...|:|...::.:|..
Human  1078 RSASSRRVSSSSELDLPSGDHCEAGLLQLDVPLLRTQLRGSRLLDAMRMYRQGYPDHMVFSEFRR 1142

  Fly   724 RYQLLV--YRSKLDKNDMKLSCRNIVMKWIQ----DEDKYRFGNTQIFFRAGQVAFLEQVRANLR 782
            |:.:|.  ...|..:|.:.:..|..|.:.::    ::.....|.:::|||||.:|.||:.|....
Human  1143 RFDVLAPHLTKKHGRNYIVVDERRAVEELLECLDLEKSSCCMGLSRVFFRAGTLARLEEQRDEQT 1207

  Fly   783 KKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQK-------MREARAGLILSKY 840
            .:.:|:.|:.                       .||||||:..:|       :|..:..:..:|.
Human  1208 SRNLTLFQAA-----------------------CRGYLARQHFKKRKIQDLAIRCVQKNIKKNKG 1249

  Fly   841 ARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAYQKRRRNI 905
            .:.|...:.:..:|..|. :|.....:  |||..         :||: :|..|.:.  :|.|..:
Human  1250 VKDWPWWKLFTTVRPLIE-VQLSEEQI--RNKDE---------EIQQ-LRSKLEKA--EKERNEL 1299

  Fly   906 IICQAAIRRFLARRKFKRMKAEAKTISHMENKYMGLENKIISMQQRID----ELNRDNSNLKHKT 966
                        |....|:::.   ||.:.::.....|...|..|.:|    |..|....:|...
Human  1300 ------------RLNSDRLESR---ISELTSELTDERNTGESASQLLDAETAERLRAEKEMKELQ 1349

  Fly   967 SEISVLKMKLELKKTLEAEFKNVKAA-----CQDKD-------------KLIEALNKQLEAERDE 1013
            ::...||.::|:.:....|.:.::||     ..|.|             :.::...|:|:.|.::
Human  1350 TQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFED 1414

  Fly  1014 KMQLLEENGHAQEEWISQKQTWRQENEELRRQID--------EIIDMAKNAEVNQ-RNQE-DRML 1068
            |:::.::|....|..:...|...:|::...:|:.        |:.|...:.|..| ||.| ::..
Human  1415 KLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQ 1479

  Fly  1069 AEIDNRELNEAYQRA----------IKDKEVIENENFMLKEELSR-------LTAGSFSLHARKA 1116
            ...|: ||::|::.|          .::|:::..|.|.||::|..       .|....||.|...
Human  1480 RRFDS-ELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQ 1543

  Fly  1117 SNASSQNEDDVGYASAKNTLDINRPPDLLSKNYSYNDSTSLVVKLRSILEE-----EKQKHKVLQ 1176
            ..:|.:::|:...|..|..|     .||.:|.....:..........:||:     |.:..::.|
Human  1544 DISSQESKDEASLAKVKKQL-----RDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQ 1603

  Fly  1177 EQYIKLSSRHKPTEDS-----FRVSELEVENEKLRSEYDQLRTSIKHGVEINELNAQHAALQEEV 1236
            ....::.||.:..|::     .::.::||:   |..||:..:..::   |..||..:.|.|.::|
Human  1604 THSKEMESRDEEVEEARQSCQKKLKQMEVQ---LEEEYEDKQKVLR---EKRELEGKLATLSDQV 1662

  Fly  1237 RRR--------REECIQLKAVL------LQQSQSMRSLEPESLQMRGNDVNELME-------AFH 1280
            .||        |::..:.||:|      |...::....:.|..|::    |:|.|       |..
Human  1663 NRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLK----NQLEESEFTCAAAVK 1723

  Fly  1281 SQKLINRQLE---------SELKAITEEHNSKLVEMTQEIE-RLNNEKDELQKVMFESIDEFEDS 1335
            ::|.:..::|         ::.|...||..|:|.....||: ||..:::::.::|.:.......:
Human  1724 ARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQA 1788

  Fly  1336 NVDTLRQNDRYLRRELQKAVAQFLLVQEELKLANAKLK-----------AYRQDG--GQLEHKIE 1387
            :.|..:.||  |:.:|::|..:...:||:|:...::::           ..||:.  .:||.::|
Human  1789 SRDLAQIND--LQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLE 1851

  Fly  1388 EEMIRNKS-NGTSADVGANVTKQKSQNPQGL-MKFHSSDLDKILQRLLSALTPRTVVGLLPGFPA 1450
            .|..:.|. ...::.:..|:.|...:..|.: .:....:.:|.|||
Human  1852 FERTQVKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQR------------------- 1897

  Fly  1451 YLIFMCIRYTDLTNADDDVRELLSKFVIQIKKMHRTPHPIENRVIWLVNSITLLNL---MKQYGD 1512
                      .|.:..:::.||..|.....:|.|.....:|:  :...|.....:|   .|:.||
Human  1898 ----------QLRDTKEEMGELARKEAEASRKKHELEMDLES--LEAANQSLQADLKLAFKRIGD 1950

  Fly  1513 VDEYVKFNTEKQNQQQLKN 1531
            :...::...|....:.|.|
Human  1951 LQAAIEDEMESDENEDLIN 1969

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc	65..778	CDD:214580	212/823 (26%)
		MYSc_Myo5	84..767	CDD:276831	198/793 (25%)
		IQ	900..922	CDD:197470	3/21 (14%)
		GBP_C	<971..1086	CDD:303769	29/152 (19%)
		coiled coil	1049..1068	CDD:293879	6/20 (30%)
		coiled coil	1077..1086	CDD:293879	2/18 (11%)
		JAKMIP_CC3	<1190..1299	CDD:292653	28/143 (20%)
		Myo5_CBD	1424..1792	CDD:271254	19/111 (17%)
MYO18A	NP_001333694.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34
		Interaction with actin	114..118
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	140..167
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1469..1499		9/30 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1871..1920		10/77 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910