Protein Alignment didum and myo1eb

DIOPT Version :10

• Sequence 1: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Sequence 2: NP_956930.1
• Gene: myo1eb / 393609
• ZFINID: ZDB-GENE-040426-1347
• Length: 1096
• Species: Danio rerio
• Alignment Length: 1186
• Identity: 336/1186 - (28%)
• Similarity: 560/1186 - (47%)
• Gaps: 236/1186 - (19%)

  Fly    71 GQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGD 135
            |.:|:..||.:.|..:..||:.|:.: ..|:||.|.:|:::||:.::|.:....|..|:|.|..:
Zfish    18 GVDDMVLLSKITEDAITDNLKKRYMD-DYIFTYIGPVLISVNPFKQLPYFTDREIELYQGAAQYE 81

  Fly   136 LEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESETQ-VERKVLA 199
            ..|||:|||:..|..:..::.|..:|:||||||||||:|||.|.|.:.|.|...:.| |:..:|.
Zfish    82 NPPHIYALADNMYRNMMIDSENQCVIISGESGAGKTVAAKYIMSYISKVSGGGPKVQHVKDIILQ 146

  Fly   200 SSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYH 264
            |:|::||||||||.||:|||||||:.::.| ::.|..  .|..:..:||||||||.|..||||:|
Zfish   147 SNPLLEAFGNAKTVRNNNSSRFGKYFEIQF-SRGGEP--DGGKISNFLLEKSRVVSQNNGERNFH 208

  Fly   265 IFYQLC--AARSKYPELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIADI 327
            |:|||.  |.:.:...|.:...|.:.:||......:|.|:|.::|.:|:.||:|:|.|:.....:
Zfish   209 IYYQLLKGATKEQRENLGVTTPDYYFYLNQSDTYTVEDVNDKKEFEDTMNAMSVVGLSMDAQDSV 273

  Fly   328 VKILAGILHLGNIQVSKKFNEG-SEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKIE 391
            ::|:|||||||||...::.|.. .|.||           .|...:.||.::.|.|:..|..|.::
Zfish   274 LQIVAGILHLGNIAFREEGNYAVVESED-----------FLAFPSYLLGINQDGLKSKLTSRIMD 327

  Fly   392 S----VNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIYGFE 452
            |    ..|.:.:..:.|.|...||||:|.:|::||.|:|..:||::....::.: ||||||||||
Zfish   328 SKWGGKTETISVTLNTEQASFTRDALSKALYSRLFDYLVDAINKAMQKDREELN-IGVLDIYGFE 391

  Fly   453 TFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIESRL---G 514
            .|:.|.|||||||:.||||||.|.:...|.|||||::|||:||.|::::|:...|||||:|   |
Zfish   392 IFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGISWTPIEYFNNKVVCDLIESKLNPPG 456

  Fly   515 VLDLLDEEC----RMPKGSDESWAGKLIGKCNKFPHFEKPRFGTTSFFIKHFSDTVEYDVNGFLE 575
            ::.:||:.|    ...:|:|::...||..:.....||.....|   |.:.|::..|.|||:||.|
Zfish   457 IMSILDDVCATMHAKGEGADQTLLQKLQSQIGTHEHFNSWNKG---FVVHHYAGKVSYDVSGFCE 518

  Fly   576 KNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRV 640
            :|||.:..::.:::..|..:..|.:.. |.|:.                     :::|..|
Zfish   519 RNRDVLFSDIIELMQSSEFAFIKGLFP-ENIEA---------------------EKRGRPT---- 557

  Fly   641 VPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETV 705
                    |.||:.::...:|:.||...||||:||||||:.|.:..||.:::..|:...|:.|.:
Zfish   558 --------TAGSKIKKQANTLVQTLMKCTPHYIRCIKPNETKKSRDWEESRVKHQVEYLGLRENI 614

  Fly   706 RISAAGFPSRWLYPDFYMRYQLLVYRSKLD-KNDMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAG 769
            |:..||:..|.::..|..||.:|...:... :.|.|....:::.....|.|:|:.|.|:||.:|.
Zfish   615 RVRRAGYAFRRIFKKFLHRYAILTRETWPQWRGDEKQGVLHLLKSVNMDSDQYQLGKTKIFIKAP 679

  Fly   770 QVAF-LEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARA 833
            :..| ||::|......|..::|...|:.:..|:::|                       |||..:
Zfish   680 ESLFLLEEMRERKYNGYARVIQQAWRKHIAVRKYVR-----------------------MREEAS 721

  Fly   834 GLILSKYARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAY 898
            .|:|:|..|                     .:..|.||                ||...:....:
Zfish   722 DLLLNKKER---------------------RKNSLNRN----------------FVGDYIGTDNH 749

  Fly   899 QKRRRNIIICQAAIRRFLARRKFKRMKAEAKTISHMENKYMGLENKIISMQQRIDELNRDNSNLK 963
            .:           ||:|:.||  :|:.. |..:...:.::..::..:|...:.:..:.|:.....
Zfish   750 PE-----------IRQFVGRR--ERIDF-ADVVVKYDRRFKSVKRDLILTPKFLYLIGREKVKQG 800

  Fly   964 HKTSEI-SVLKMKLELKKTLEAEFKNVKAACQD------------------KDKLIEALNKQLEA 1009
            .:..:| .|||.|:|::|........:    ||                  |.:.:..|.|:.|.
Zfish   801 PEKGQIREVLKRKIEVEKIQSVSLSTL----QDDIFILHEDQYDSVLQSVFKTEFLSLLYKRFEE 861

  Fly  1010 ERDEKMQLLEENGHAQEEWISQKQTW--------RQENEELRRQIDEII-------------DMA 1053
            :..:|:.|...|   ..|:..:|..|        ||...::.:..|.::             .:.
Zfish   862 KTKKKLPLKFNN---LLEFKVKKGGWGPFASAGSRQIQFQMGQGDDAVLKPSSKILTVSIGSGLP 923

  Fly  1054 KNAEVNQRNQEDRMLAEIDNRELNEAYQRAIKDKEVIENENFMLKEELSRLTAGSFSLHARKASN 1118
            ||....:|          |||:                 .:||..:..|   ||.:|..|.| |.
Zfish   924 KNTRPTRR----------DNRK-----------------SSFMGNQNRS---AGQYSREAPK-SA 957

  Fly  1119 ASSQNEDDVGYASAKNTLDINRP--PDLLS------KNYSYNDSTSLVVKLRSILEEEKQKHKVL 1175
            ...:.:..|.::..:....:::|  |.|..      ::..|.|...:.|..:.:....:::.|
Zfish   958 GRGRGQPAVRHSLLRQQSTMDQPTLPRLQGSVRSQRESQVYTDMGFMKVPDQGVAGMHRRRSK-- 1020

  Fly  1176 QEQYIKL--SSRHKPT 1189
              :|..|  |.|.||:
Zfish  1021 --EYKPLPGSGRPKPS 1034

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	249/698 (36%)
		IQ	900..922	CDD:197470	5/21 (24%)
		SMC_prok_B	<942..1365	CDD:274008	53/298 (18%)
		Myo5_CBD	1424..1792	CDD:271254
myo1eb	NP_956930.1	MYSc_Myo1	31..677	CDD:276829	249/698 (36%)
		Myosin_TH1	717..918	CDD:461801	42/258 (16%)
		SH3_MyoIe_If_like	1043..1095	CDD:212761