DRSC/TRiP Functional Genomics Resources

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Protein Alignment didum and Myo61F

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:NP_476934.2 Gene:Myo61F / 38153 FlyBaseID:FBgn0010246 Length:1052 Species:Drosophila melanogaster


Alignment Length:1035 Identity:331/1035 - (31%)
Similarity:520/1035 - (50%) Gaps:175/1035 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    71 GQNDLTTL-SYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMG 134
            |..|...| :|..|...:.||:.|| :..:||||.|.:|:::|||.::|:|....::|||.....
  Fly    38 GVQDFVLLENYQSEEAFIGNLKKRF-QEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKHFY 101

  Fly   135 DLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESETQ-VERKVL 198
            ::.|||||:.:.|:..|..||....:::|||||:|||.::|..:::.||..|:::..: |:.|:|
  Fly   102 EMPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSGNQTTVEGVKDKLL 166

  Fly   199 ASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNY 263
            .|:|::||||||||.||||||||||:..:.|..:...:   |..:..|||||||||.|..||||:
  Fly   167 KSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPI---GGNILNYLLEKSRVVAQMGGERNF 228

  Fly   264 HIFYQLCAARSK--YPELVLDHQ-DKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIA 325
            ||||||.|...:  ..||.|:.. |.:.:|..|....:.|::||:.|.:..||:||:.|:.::..
  Fly   229 HIFYQLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRINDADSFKQVQQALTVIDFTKEEQR 293

  Fly   326 DIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQIT-ADLLRVSADDLRRWLLMRK 389
            :|..|:|.||||||:..::.  ||:.:.:|..         |.:| |.||.|:|.:|...|..|.
  Fly   294 EIFGIVASILHLGNVGFTEV--EGNAKVNSRD---------LVVTAARLLGVNASELEAALTHRT 347

  Fly   390 IESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCS---FIGVLDIYGF 451
            |::..:.|..|.:.|.|..|||||||.:|.:||.::|..||.||.....:.|   .:|:||||||
  Fly   348 IDARGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGILDIYGF 412

  Fly   452 ETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIESR-LGV 515
            |.|:.|||||||||:.||||||.|.:...|.||:||.:|||.|..::::||:...:|||.: .|:
  Fly   413 EIFQKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKHKGI 477

  Fly   516 LDLLDEECRMP-KGSDESWAGKLIGK--------CN-KFPHFEKPRFGTTSFFIKHFSDTVEYDV 570
            :.:|||||..| :.:|:::..||..|        |: |.|...|.......|.:.|::..|.|.|
  Fly   478 ISILDEECLRPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIKKIMLRDEFRLVHYAGEVTYSV 542

  Fly   571 NGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGND 635
            ||||:||.|.:.::|.:.||::                                        ||.
  Fly   543 NGFLDKNNDLLFRDLKETLSKA----------------------------------------GNG 567

  Fly   636 TRRRVVPSKQHR-----KTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQ 695
            ..|...|.|:.|     :|..:||:.||.:|:..|....|.|:|||||||.:.|..:....::.|
  Fly   568 IVRNCFPEKELRSLKRPETAITQFRASLNNLMDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQ 632

  Fly   696 LRACGVLETVRISAAGFPSRWLYPDFYMRYQLL---VYRSKLDKNDMKLSCRNIVMKWIQDEDKY 757
            ::..|::|.:|:..|||..|..|..|..||:.|   .:.:.......|...:.:|.....||:||
  Fly   633 VKYLGLMENLRVRRAGFAYRRTYELFLERYKSLSKSTWPNYKGPGGPKAGVQQLVKDLGWDEEKY 697

  Fly   758 RFGNTQIFFRAGQVAF-LEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLA 821
            |.|.|::|.|..:..| .|......:.:...|:|:..:..:.||::|:::..:..:|.:.|..||
  Fly   698 RVGETKLFIRWPRTLFDTEDAYQEKKHEIAAIIQAHWKGLMQRRKYLKLRAQVIIMQSYCRRKLA 762

  Fly   822 RERTQKMREA----RA---GLI-------------LSKYARGWLCRRRYLRLRHSI--------- 857
            ::..:|.|||    ||   |.|             ::...|.||     |||...:         
  Fly   763 QQAAKKRREAADKIRAFIKGFITRNDAPNGFNEEFIANAKRMWL-----LRLAKELPTKVLDKSW 822

  Fly   858 ---SGIQTYARGMLAR-NKFHAMRDHYR----AVQIQRFVRGALARRAYQKRRRNII-------- 906
               .|....|.|:|.| ::.|..| .||    ..|.::|....||.:.::.::.|..        
  Fly   823 PHAPGHCEEASGILHRLHRLHLAR-IYRLKLTPQQKRQFELKVLAEKVFKGKKNNYASSVSTWFQ 886

  Fly   907 ---ICQAAIRR---FLAR-------------RKFKR--MKAEAKTISHMENK--YMGLENKIISM 948
               |.:..|:|   |:|.             .||.|  .|:..:.|. :.||  |: |:.|....
  Fly   887 EDRIPKEHIQRVNDFVASTFGSEQLKYQSFCTKFDRHGYKSRDRFIL-LSNKAIYV-LDGKTYKQ 949

  Fly   949 QQRIDELNRDNSNLKHKTSEISVLKMKLELKKTLEAEFKNVKAACQDKDKLIEALNKQLE 1008
            :.|: .|::.:..|.:...::.|:::.|:|||              ||..||..:.:.:|
  Fly   950 KHRL-PLDKIDFTLTNHNDDLMVIRIPLDLKK--------------DKGDLILIIPRIIE 994

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 266/735 (36%)
MYSc_Myo5 84..767 CDD:276831 258/709 (36%)
IQ 900..922 CDD:197470 7/48 (15%)
GBP_C <971..1086 CDD:303769 10/38 (26%)
coiled coil 1049..1068 CDD:293879
coiled coil 1077..1086 CDD:293879
JAKMIP_CC3 <1190..1299 CDD:292653
Myo5_CBD 1424..1792 CDD:271254
Myo61FNP_476934.2 MYSc 32..720 CDD:214580 266/736 (36%)
MYSc_Myo1 52..707 CDD:276829 258/709 (36%)
Myosin_TH1 863..1035 CDD:283635 31/149 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45466259
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR13140
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
32.940

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