DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment didum and ck

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:NP_001285949.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster


Alignment Length:1903 Identity:500/1903 - (26%)
Similarity:820/1903 - (43%) Gaps:462/1903 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 VPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSD---LPPLR-----NPAILVGQ 72
            |...|.:|........:....| .::.:..|  :.::::.|..|   |.|.|     :.:.:.|.
  Fly     4 VTRGDYIWIEPASGREFDVAIG-ARVVSAEG--RRIQVRDDDGDEVWLAPERRIKAMHASSVQGV 65

  Fly    73 NDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLE 137
            .|:.:|..|||.|:|.||.:|:.| .:||||.|.||||:|||..:|:|....|:.|:...:|:|.
  Fly    66 EDMISLGDLHEAGILRNLLIRYKE-NLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELP 129

  Fly   138 PHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESETQVERKVLASSP 202
            |||||:.:.||..::|...:..|::|||||||||.|.|..::|.||:.|..|  .:|:::|.::|
  Fly   130 PHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISGKHS--WIEQQILEANP 192

  Fly   203 IMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHIFY 267
            |:||||||||.||||||||||:..:.| :..||  ::||.:..|||||||:|.|...|||||:||
  Fly   193 ILEAFGNAKTIRNDNSSRFGKYIDIHF-SANGV--IEGAKIEQYLLEKSRIVSQNHSERNYHVFY 254

  Fly   268 QLCAARS--KYPELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIADIVKI 330
            .:.|..|  :...|.|.....:::|..|.:...|...||.:|::...||.||.||.|:|.:|:|:
  Fly   255 CILAGLSADEKSRLDLGMAADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWEIIKL 319

  Fly   331 LAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKIESVNE 395
            ||.:||.|||:.     :.:..::.|:.:| ...|:::..|.||.:....|...|..|.:.:..|
  Fly   320 LAALLHCGNIKY-----KATVVDNLDATEI-PEHINVERVAGLLGLPIQPLIDALTRRTLFAHGE 378

  Fly   396 YVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSL--NNGSKQCSFIGVLDIYGFETFEVNS 458
            .|:...|.:.:...|||..|.||.::|.:||..:|.::  ..|:.: :.||||||:|||.|:.||
  Fly   379 TVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSR-NAIGVLDIFGFENFDQNS 442

  Fly   459 FEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIE-SRLGVLDLLDEE 522
            |||||||||||.|||.|.||:||||||||..|.|.|..|:|.|||..:|||. .:|.::.|:|||
  Fly   443 FEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLNIMALIDEE 507

  Fly   523 CRMPKGSDESWAGKLIGKCNKFPHFEKPRFG-TTSFFIKHFSDTVEYDVNGFLEKNRDTVSKELT 586
            .|.|||:|::...||........::.||:.. .|||.:.||:..|.||..|||:|||||.|.:|.
  Fly   508 ARFPKGTDQTMLAKLHKTHGSHKNYLKPKSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPDLL 572

  Fly   587 QVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQHRKTVG 651
            .::|:|.....:|:.. ::|                        :.|.:||:|.       .|:.
  Fly   573 HLVSQSTNKFLRQIFA-QDI------------------------EMGAETRKRT-------PTLS 605

  Fly   652 SQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAGFPSRW 716
            :||::||.:|:.||.:..|.::||||||:.|....::.....:|||..|::||:||..||:|.|.
  Fly   606 TQFRKSLDALMKTLSSCQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRH 670

  Fly   717 LYPDFYMRYQLLV------YRSKLDKNDMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAFLE 775
            .:.:|..||:.|:      :|:.......:: |..::.|     ..|:.|:|::|.:.....|||
  Fly   671 GFREFVERYRFLIPGVPPAHRTDCQAATSRI-CAVVLGK-----SDYQLGHTKVFLKDAHDLFLE 729

  Fly   776 QVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAGLILSKY 840
            |.|..:..:.|.|:|..:|.:||||:|||::.....:|:..:||..|:|.:.||..         
  Fly   730 QERDRVLTRKILILQRSIRGWVYRRRFLRLRAAAITVQRFWKGYAQRKRYRNMRVG--------- 785

  Fly   841 ARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAYQKRRRNI 905
                     |:||       |...|..:..::|..:|.|  .|.:|...||.|.||.|..:...:
  Fly   786 ---------YMRL-------QALIRSRVLSHRFRHLRGH--IVGLQAHARGYLVRREYGHKMWAV 832

  Fly   906 IICQAAIRRFLARRKFKRMKAEAKTISHMENKYMGLENKIISMQQRIDELNRDNSNLKHKTSEIS 970
            |..|:.:||.:|.|::::::.|.|..:.:                                    
  Fly   833 IKIQSHVRRMIAMRRYRKLRLEHKQFAEV------------------------------------ 861

  Fly   971 VLKMKLELKKTLEAEFKNVKAACQDKDKLIEALNKQLEAERDEKMQLLEE-NGHAQEEWISQKQT 1034
                 |:|:|.                               |:.:||.. |.||:|   ..:|.
  Fly   862 -----LQLRKL-------------------------------EEQELLHRGNKHARE---IAEQH 887

  Fly  1035 WRQENEEL-RRQIDEIIDMAKNAEVNQRNQEDRMLAEIDNRELNEAYQRAIKDKEVIENENFMLK 1098
            :|....|| ||:|.|.::..:..|||.             ..:|:|   |.|.:|.:::      
  Fly   888 YRDRLHELERREIQEQLENRRRVEVNM-------------NIINDA---ARKQEEPVDD------ 930

  Fly  1099 EELSRLTAGSFSLHARKASNASSQNEDDVGYASAKNTLDINRPPDLLSKNYSYNDSTSLVVKLRS 1163
               .:|....|......:|:|.:.:       ..:.|...|..|.  ::|.:.:|    ::....
  Fly   931 ---GKLVEAMFDFLPDSSSDAPTPH-------GGRETSVFNDLPH--AQNVNQDD----IIAPIH 979

  Fly  1164 ILEEEKQ----KHKVLQEQYIKLSSRHKPTEDSFRVSELEVENEKLRSEYDQLR------TSIKH 1218
            |.|:|:.    |.:.....|.:.:..|:..:.:.:...|     .|.::.|||.      |.::.
  Fly   980 ISEDEEDLSEFKFQKFAATYFQGNVNHQYAKKALKHPLL-----PLHTQGDQLAAQALWITILRF 1039

  Fly  1219 GVEINELNAQHAALQEEVRRRREECIQLKAVLLQQSQSMRSLEPESLQMRGNDVNELMEAFHSQK 1283
            ..::.|      .....:.|.....:..|.........:||.|.:..|:.|.|    .:||..||
  Fly  1040 TGDMPE------PKYHTMDRMDTTSVMSKVTATLGRNFIRSKEFQEAQLMGLD----PDAFLKQK 1094

  Fly  1284 LINRQLESELKAITEEHNSKLVEMTQEIERLNNEKDELQKVMFES-IDEFEDSNVDTLR--QNDR 1345
              .|.:..:|.::|.:..:||.|   ::.| ..:.||.....::| :.....||::.|.  ....
  Fly  1095 --PRSIRHKLVSLTLKRKNKLGE---DVRR-RLQDDEYTADSYQSWLQSRPTSNLEKLHFIIGHG 1153

  Fly  1346 YLRRELQKAV-AQFL--LVQEELKLANAK---------------------LKAYRQDG--GQLEH 1384
            .||.||:..: .|..  |....||.::|:                     |:|:.::|  |...:
  Fly  1154 ILRAELRDEIYCQICKQLTNNPLKSSHARGWILLSLCVGCFAPSEKFVNYLRAFIREGPPGYAPY 1218

  Fly  1385 KIEEEMIRNKSNGTSADVGANVTKQKSQNPQGLMKFHSSDLDKILQRLL--SALTPRTVVGLLP- 1446
             .||.:.|..:|||.....:.:..|.:::.:.:| ...:.:|...:.||  ||.|.|.:...|. 
  Fly  1219 -CEERLKRTFNNGTRNQPPSWLELQATKSKKPIM-LPITFMDGNTKTLLADSATTARELCNQLSD 1281

  Fly  1447 --------GFPAYLIFMCIRYTDLTNADDDVRELLSKFVIQIKKMHRTPHPIENRVIWLVNSITL 1503
                    ||..| |.:..:.:.|.:..|.|.:.:|:                            
  Fly  1282 KISLKDQFGFSLY-IALFDKVSSLGSGGDHVMDAISQ---------------------------- 1317

  Fly  1504 LNLMKQYGDVDEYVKFNTEKQNQQQLKNFNLFEYRRVIL---------DLIVNL-YQALIMQIQG 1558
                     .::|.|   |:..|::...:.|| :|:.|.         .:..|| ||.::     
  Fly  1318 ---------CEQYAK---EQGAQERNAPWRLF-FRKEIFAPWHEPTHDQVATNLIYQQVV----- 1364

  Fly  1559 LLDPKIVPAILNNDEIQRGRQAHGMRSRATSIGASSSPEHGGGPAWKQLIGQLEHFYKQFQHFGL 1623
                                       |....|.....:...    ..:|...::|.:......:
  Fly  1365 ---------------------------RGVKFGEYRCDKEED----LAMIAAQQYFIEYSTDMSM 1398

  Fly  1624 DNCYAEQIFHQLLYFICAVALNCLMLRGDICMWETGMIIRYNIGCIEDW----VRSKKMSNDVLT 1684
                 |::|..|..||           .|.|:  :|:     ...||.|    :::.|.|..|..
  Fly  1399 -----ERLFTLLPNFI-----------PDFCL--SGV-----DKAIERWAALVLQAYKKSYYVKD 1440

  Fly  1685 ALAPLNQVSQLLQSRKSEQDVQTICDLCTSLSTAQVLKVMKS-------------------YKLD 1730
            .:|||          |.::|:.:.......|..::..:..::                   |.:|
  Fly  1441 KIAPL----------KIKEDIVSYAKYKWPLLFSRFYEAYRNSGPNLPKNDVIIAVNWTGVYVVD 1495

  Fly  1731 DYESEITNVFLEKLTEKLNARQMQKSN-------------SDEFTIDQK-----------FIQPF 1771
            |.|    .|.||....::.|...||:|             .:|||....           |:...
  Fly  1496 DQE----QVLLELSFPEITAVSSQKTNKVFTQTFSLSTVRGEEFTFQSPNAEDIRDLVVYFLDGL 1556

  Fly  1772 KVVFRYSDIKLEDIELPS 1789
            |...:|. |.|:|...||
  Fly  1557 KKRSKYV-IALQDYRAPS 1573

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 279/724 (39%)
MYSc_Myo5 84..767 CDD:276831 269/694 (39%)
IQ 900..922 CDD:197470 6/21 (29%)
GBP_C <971..1086 CDD:303769 24/116 (21%)
coiled coil 1049..1068 CDD:293879 3/18 (17%)
coiled coil 1077..1086 CDD:293879 3/8 (38%)
JAKMIP_CC3 <1190..1299 CDD:292653 22/114 (19%)
Myo5_CBD 1424..1792 CDD:271254 74/434 (17%)
ckNP_001285949.1 MYSc 64..733 CDD:214580 279/719 (39%)
MYSc_Myo7 77..721 CDD:276832 269/694 (39%)
MyTH4 <1138..1245 CDD:214535 23/107 (21%)
B41 1251..1467 CDD:214604 53/327 (16%)
FERM_B-lobe 1355..1439 CDD:271216 21/142 (15%)
FERM_C1_MyoVII 1461..1559 CDD:270019 17/101 (17%)
SH3 1560..1624 CDD:302595 6/15 (40%)
MyTH4 1701..1849 CDD:214535
B41 1856..2068 CDD:214604
FERM_M 1966..2068 CDD:278785
FERM_C2_MyoVII 2064..2159 CDD:270020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45466258
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1389at50557
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100101
Panther 1 1.100 - - P PTHR13140
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
54.850

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