DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment didum and Myo31DF

DIOPT Version :9

Sequence 1:	NP_724569.1	Gene:	didum / 35680	FlyBaseID:	FBgn0261397	Length:	1800	Species:	Drosophila melanogaster
Sequence 2:	NP_001188784.1	Gene:	Myo31DF / 34445	FlyBaseID:	FBgn0086347	Length:	1011	Species:	Drosophila melanogaster

Alignment Length:	1102	Identity:	340/1102 - (30%)
Similarity:	534/1102 - (48%)	Gaps:	205/1102 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 GQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGD 135
            |..|...|..:.....:.|||.|| :...||||.|.:.|::|||.:|.:|||..||.|:|..:.:
  Fly     8 GVQDFVLLDQVSMEKFMDNLRKRF-QNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGRELFE 71

  Fly   136 LEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESETQVER---KV 197
            ..||:||:|:.||..|::...:..|::|||||||||.::|..|:|.|||..::.:.::||   .:
  Fly    72 NAPHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVTNAQGQNEIERVKNVL 136

  Fly   198 LASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERN 262
            :.|:.|:|.||||||.||||||||||:..:.|..:...:   |..:..|||||||||.|..||||
  Fly   137 IQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPV---GGIITNYLLEKSRVVQQQPGERN 198

  Fly   263 YHIFYQLC--AARSKYPELVLDHQ-DKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQI 324
            :|.||||.  |..::..:..|..: .|:.:||.|....:...||   :..|..|...||||..::
  Fly   199 FHSFYQLLRGANDNELRQYELQKETGKYHYLNQGSMDILTEKSD---YKGTCNAFKTLGFSTDEV 260

  Fly   325 ADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRK 389
            ..|.:.:|.:|||||::.     :..|:|     .:..|..||:.||.||:|:..:|...|..|.
  Fly   261 QTIWRTIAAVLHLGNVEF-----QTIEDE-----LVISNKQHLKSTAKLLQVTETELSTALTKRV 315

  Fly   390 IESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKS-LNNGSK-QCSF---IGVLDIY 449
            |.:....:...::...|:..:|||||.||.:||.:|:..:|:: |..||| |..|   |||||||
  Fly   316 IAAGGNVMQKDHNATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQARFNSVIGVLDIY 380

  Fly   450 GFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIES-RL 513
            |||.|:.||||||||||.||||||.|.:.|.|.|||||.:|||.||.|::::|:...||:|. ..
  Fly   381 GFEIFDSNSFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIICDLVEQPHK 445

  Fly   514 GVLDLLDEEC-RMPKGSDESWAGKLIGKCNKFPHFEKPRFGTT--------SFFIKHFSDTVEYD 569
            |::.::||.| .:.|.:|::..|.:....:|.||:...:...|        .|.|.|::..|.|:
  Fly   446 GIIAIMDEACLSVGKVTDDTLLGAMDKNLSKHPHYTSRQLKPTDKELKHREDFRITHYAGDVIYN 510

  Fly   570 VNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGN 634
            :|||:|||:||:.::..::|..|                      |.:.|.  .:...|.:....
  Fly   511 INGFIEKNKDTLYQDFKRLLHNS----------------------KDANLS--EMWPEGAQDIKK 551

  Fly   635 DTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRAC 699
            .|:|.:        |.|:.||.|:|.|:.||....|.|||||||||.|.:..::..::..|:|..
  Fly   552 TTKRPL--------TAGTLFQRSMADLVVTLLKKEPFYVRCIKPNDLKSSTVFDEERVEHQVRYL 608

  Fly   700 GVLETVRISAAGFPSRWLYPDFYMRYQLLV------YRSKLDKNDMKLSCRNIVMKWIQDEDKYR 758
            |:||.:|:..|||..|..|..|.:||:::.      :|:..|::.:::....  .|:.||   .:
  Fly   609 GLLENLRVRRAGFVHRQRYDKFLLRYKMISQYTWPNFRAGSDRDGVRVLIEE--KKFAQD---VK 668

  Fly   759 FGNTQIFFRAGQVAF-LEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKH----ARG 818
            :|:|:||.|:.:..| ||..|..:....:|::|..||.::.||.|.:::..|..::.:    .|.
  Fly   669 YGHTKIFIRSPRTLFALEHQRNEMIPHIVTLLQKRVRGWIVRRNFKKMKAAITIVRAYKAYKLRS 733

  Fly   819 YLARERTQKMREARAGLILSKYARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRA- 882
            |: :|...::|:|:.   :..|.:             ||...|....|.....|.|.|.|.:||
  Fly   734 YV-QELANRLRKAKQ---MRDYGK-------------SIQWPQPPLAGRKVEAKLHRMFDFWRAN 781

  Fly   883 -------------VQIQRFVRGALA-RRAY--QKRR----------------------RNI---- 905
                         :::|.....||| ||.|  |.||                      :||
  Fly   782 MILHKYPRSEWPQLRLQIIAATALAGRRPYWGQARRWVGDYLANSQENSGYEAYNGSIKNIRNHP 846

  Fly   906 --------IICQAAIRRFLARRKFKRMKAEAKTISHME-NKYMGLENKIISMQQRIDELNRDNSN 961
                    ::..:.:::|   ..|.:....|..:|... :|..|::||...|::.|        .
  Fly   847 ADGETFQQVLFSSFVKKF---NHFNKQANRAFIVSDSTIHKLDGIKNKFKDMKRTI--------K 900

  Fly   962 LKHKTSEISVLKMKLELKKTLEAEFKNVKAACQDKDKLI---EALNKQLEAERDEKMQLLEENGH 1023
            ::..|| |||                     ...:|:||   .:.||.|....:.:...|:|:..
  Fly   901 IRELTS-ISV---------------------SPGRDQLIVFHSSKNKDLVFSLESEYTPLKEDRI 943

  Fly  1024 AQEEWISQKQTWRQENEELRRQIDE-------------IIDMAKNAEV-NQRNQEDRMLAEI 1071
            .:...|..|:.......|||..:..             .::.|.|.|| |.|.:|..::.|:
  Fly   944 GEVVGIVCKKYHDLTGTELRVNVTTNISCRLDGKARIITVEAASNVEVPNFRPKEGNIIFEV 1005

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc	65..778	CDD:214580	267/734 (36%)
		MYSc_Myo5	84..767	CDD:276831	260/709 (37%)
		IQ	900..922	CDD:197470	5/55 (9%)
		GBP_C	<971..1086	CDD:303769	22/118 (19%)
		coiled coil	1049..1068	CDD:293879	7/19 (37%)
		coiled coil	1077..1086	CDD:293879
		JAKMIP_CC3	<1190..1299	CDD:292653
		Myo5_CBD	1424..1792	CDD:271254
Myo31DF	NP_001188784.1	MYSc	6..690	CDD:214580	267/735 (36%)
		MYSc_Myo1	21..677	CDD:276829	260/709 (37%)
		Myosin_TH1	801..983	CDD:283635	39/214 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466253
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR13140
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940