DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment didum and d

DIOPT Version :9

Sequence 1:	NP_724569.1	Gene:	didum / 35680	FlyBaseID:	FBgn0261397	Length:	1800	Species:	Drosophila melanogaster
Sequence 2:	NP_001188730.1	Gene:	d / 34179	FlyBaseID:	FBgn0262029	Length:	1426	Species:	Drosophila melanogaster

Alignment Length:	832	Identity:	246/832 - (29%)
Similarity:	372/832 - (44%)	Gaps:	146/832 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 DLTTLS-YLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLE 137
            ||..|| .|.|..|:..|:.||.||: .:|..|.||::||||.::.  .|..:.:.|  || .|.
  Fly   477 DLIHLSGPLTEHAVMRTLQARFNERR-YFTNVGPILLSINPYLDVG--NPLTLTSTR--AM-PLA 535

  Fly   138 PHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESETQVERKVLASSP 202
            |.:..:.:||..:........:||:||.||||||.:|...:|...|:.|...||...:.:.|:..
  Fly   536 PQLQKIVQEAVRQQSETGYPQAIILSGTSGAGKTANAMLMLRQLFAIAGGGPETDAFKHLAAAFT 600

  Fly   203 IMEAFGNAKTTRNDNSSRFGKFTKL------LFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGER 261
            ::.:.|:||||.|..|||.|:|.::      |:|.:          :|.|.|:::||:.....|:
  Fly   601 VLRSLGSAKTTTNSESSRIGQFIEVQVTDGALYRTK----------IHCYFLDQTRVIRPLPKEK 655

  Fly   262 NYHIFYQLCAARSKYPELVLDHQDKFQFLNM----GGAPEIERVSDAEQFNETVQAMTVLGFSIQ 322
            ||||||||.|..|:.....| |.|.:...|:    |...:.|: .||.:|......:.:||.
  Fly   656 NYHIFYQLLAGLSREERQKL-HLDGYSPANLRYLRGDIGQNEQ-EDAARFQAWKTCLGILGI--- 715

  Fly   323 QIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLM 387
            ...|:|::||.:|.|||:|    |.:|...|    .|: ..:..|...|.||.|....|.|.|..
  Fly   716 PFLDVVRVLAAVLLLGNVQ----FIDGGGLE----VDV-KGETELNSVASLLGVPPAALFRGLTT 771

  Fly   388 RKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIV-------------GVL----NKSLNN 435
            |......:.|........|...||.|||.:|.:....||             |.|    |:|::|
  Fly   772 RTHNVRGQLVKSVCGDGDANMTRDCLAKALYCRTVATIVRRANSLKRLGSTLGTLSSDSNESVHN 836

  Fly   436 -----------------GSKQCS-------------FIGVLDIYGFETFEVNS-FEQFCINYANE 469
                             |||..:             |||:||::|||....:: .|..|||...|
  Fly   837 QADVASQHASTIGGGNAGSKSMAALNNAVRHATSDGFIGILDMFGFEEPSPHAHLEHLCINLCAE 901

  Fly   470 KLQQQFNQHVFKLEQEEYLKEGITW-TMIDFYDNQPCIDLIES-RLGVLDLLDEECRMPKGSDES 532
            .:|..:|.|:||...|....|||.. |.:|:.||.||||||.| |.|:|.:||.||.: :|:.||
  Fly   902 TMQHFYNTHIFKSSVESCRDEGIVCDTEVDYVDNVPCIDLISSLRTGLLSMLDAECSV-RGTAES 965

  Fly   533 WAGKLIGKCNKFPHFEKPRFGT---------TSFFIKHFSDTVEYDVNGFLEKNRDTVSKELTQV 588
            :..||     |..|....|..|         ..|.|:||:..||||...||:.|||.|..:|..|
  Fly   966 YVTKL-----KVQHRSSTRLETKPTAEPHDPRMFLIRHFAGRVEYDTTDFLDTNRDVVPDDLVGV 1025

  Fly   589 LSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSK--------Q 645
            ..:..                |.....:...|..:.....::|.......|:.|:.        :
  Fly  1026 FYKHT----------------CNFGFATHLFGSELKALYAQQQAPRGLSFRISPTSHSDLLNGDE 1074

  Fly   646 HRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAA 710
            ...|:...|...|.:|:.||....||:||||:.|..:.|..::.|.:::|:|:..|||||.:.|:
  Fly  1075 PVSTLTQDFHTRLDNLLRTLVHARPHFVRCIRSNGTEAARSFDRATVVRQIRSLQVLETVNLMAS 1139

  Fly   711 GFPSRWLYPDFYMRYQLLV-YRSKLDKNDMKLSCRNIVMKWIQDED---------KYRFGNTQIF 765
            |||.|..:..|..||::|. :|......|..|....:::|:..::.         .:..|...:|
  Fly  1140 GFPHRMRFKQFNARYRMLAPFRLLRRSEDKALEDCQLILKYAMEQPPVLDGSVTLAWAPGKRHVF 1204

  Fly   766 FRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHAR 817
            ...|....||.:|..:|.|..|::|:..|.:.:|:      |:.||..|.::
  Fly  1205 LSEGIRQHLEHLRTEIRHKSATLMQATWRGWWWRK------KMGNGGAKRSK 1250

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc	65..778	CDD:214580	235/791 (30%)
		MYSc_Myo5	84..767	CDD:276831	226/769 (29%)
		IQ	900..922	CDD:197470
		GBP_C	<971..1086	CDD:303769
		coiled coil	1049..1068	CDD:293879
		coiled coil	1077..1086	CDD:293879
		JAKMIP_CC3	<1190..1299	CDD:292653
		Myo5_CBD	1424..1792	CDD:271254
d	NP_001188730.1	MYSc	476..1217	CDD:214580	235/791 (30%)
d	NP_001188730.1	MYSc_Myo20	488..1206	CDD:276847	226/769 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466230
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0160
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311886at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR13140
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850