DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment didum and myh9a

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:NP_001091647.2 Gene:myh9a / 333938 ZFINID:ZDB-GENE-030131-5870 Length:1961 Species:Danio rerio


Alignment Length:2072 Identity:550/2072 - (26%)
Similarity:902/2072 - (43%) Gaps:495/2072 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 SEEMLYAQGAKI---------------WVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVK 52
            :|:.|||....|               |||...|.:|:.:::|  ..|...|....||||    |
Zfish     4 AEKFLYADRNTINDPLAQADWATKKLVWVPSEKLGFEAGSIKE--ETGDECLVELADSGK----K 62

  Fly    53 LKADGSDLPPLRNPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEM 117
            :|.:..|:..: ||.......|:..|:.|:|..||||||.|:.. .:||||.|:..|.||||..:
Zfish    63 IKVNKDDIQKM-NPPKFSKVEDMAELTCLNEASVLHNLRERYYS-GLIYTYSGLFCVVINPYKYL 125

  Fly   118 PLYGPSIIRAYRGHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFA 182
            |:|...|:..|:|....::.|||:|:.:.||..:.::..:.||:.:||||||||.:.|..::|.|
Zfish   126 PIYTEEIVEMYKGKKRHEMPPHIYAITDTAYRSMMQDREDQSILCTGESGAGKTENTKKVIQYLA 190

  Fly   183 AVGGS-----------ESETQVERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVM 236
            .|..|           .|..::|:::|.::||:||||||||.:||||||||||.::.| :..|  
Zfish   191 YVASSFKTKKDQSSIALSHGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINF-DVNG-- 252

  Fly   237 FLQGATMHTYLLEKSRVVYQAQGERNYHIFYQLC--AARSKYPELVLDHQDKFQFLNMGGAPEIE 299
            ::.||.:.||||||||.:.||:.||.:||||.|.  |......||.|:..:|::||:.|.. .|.
Zfish   253 YIVGANIETYLLEKSRAIRQAKDERAFHIFYYLLTGAGDKLRSELCLEDYNKYRFLSNGNV-TIP 316

  Fly   300 RVSDAEQFNETVQAMTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHND 364
            ...|.|.|.||:.|..::|....:...::|:::.:|.|||:...|       |.:||...: .:|
Zfish   317 GQQDRELFAETIDAFRIMGIPEDEQTGLLKVVSAVLQLGNMSFKK-------ERNSDQASM-PDD 373

  Fly   365 IHLQITADLLRVSADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVL 429
            ...|..:.||.::..|..|.:|..:|:...::|....:.|.|:.|.:||||..|.:||:::|..:
Zfish   374 TAAQKVSHLLGMNVTDFTRAILSPRIKVGRDFVQKAQTQEQAEFAVEALAKATYERLFRWLVMRI 438

  Fly   430 NKSLNNGSKQ-CSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGIT 493
            ||:|:...:| .||||:|||.|||.||:|||||.||||.||||||.||..:|.||||||.:|||.
Zfish   439 NKALDKTKRQGASFIGILDIAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIE 503

  Fly   494 WTMIDF-YDNQPCIDLIE---SRLGVLDLLDEECRMPKGSDESWAGKLIGKCNKFPHFEKPR--F 552
            |:.||| .|.||||:|||   ...|:|.||||||..||.:|:|:..|::.:....|.|:||:  .
Zfish   504 WSFIDFGLDLQPCIELIEKPNGPPGILALLDEECWFPKATDKSFVEKVVQELGNNPKFQKPKKLK 568

  Fly   553 GTTSFFIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTL-EEIDTLCVDSAKS 616
            ....|.|.|::..|:|..|.:|.||.|.::..:..:|   |.|:.|.|..| :::|.:       
Zfish   569 DDADFCIIHYAGKVDYKANEWLMKNMDPLNDNVATLL---NQSVDKFVSELWKDVDRI------- 623

  Fly   617 STLGGRVVISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDD 681
              :|...|...|....|     .|...|...:|||..::|.|.:|::||..|.|::||||.||.:
Zfish   624 --VGLDKVAGMGESLHG-----AVKTRKGMFRTVGQLYKEQLMNLMTTLRNTNPNFVRCIIPNHE 681

  Fly   682 KVAFKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKN--DMKLSCR 744
            |.|.|.....::.|||..||||.:||...|||:|.::.:|..||::|. .:.:.|.  |.|.:|.
Zfish   682 KKAGKLAHHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILT-PNAIPKGFMDGKQACV 745

  Fly   745 NIVMKWIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVI 809
            .:|.....|.:.||.|.:::|||||.:|.||:.|.......|...|:..|.:|.||.|.:.|:.:
Zfish   746 LMVKALELDSNLYRIGQSKVFFRAGVLAHLEEERDMKITDVIINFQAWCRGYVARRAFAKRQQQL 810

  Fly   810 NG---IQKHARGYLARERTQKMREARAGLILSKYARGWLCRRRYLRLRHSISGIQTYARGMLARN 871
            ..   ||::...||.                   .|.|...|.:.:::..:. :......|:|:.
Zfish   811 TAMRVIQRNCAAYLK-------------------LRNWQWWRLFTKVKPLLQ-VTRQEEEMVAKE 855

  Fly   872 KFHAMRDHYRAVQIQRFVRGALARR--------AYQKR-RRNIIICQAAIRRFLARRKFKRMKAE 927
            : ..::...|..|.:..::.:.|::        |.|:: :....:||.|  ..:..|...||:..
Zfish   856 E-ELVKMKERQQQAEDQLKESEAKQKQLNAEKLALQEQLQAETELCQEA--EEMRSRLTARMQEM 917

  Fly   928 AKTISHMENKYMGLENKIISMQQRIDELNRDNSNLKHKTSEISVLKMKLELKK-TLEAEFKNVK- 990
            .:.:..:|::....|.::...|....::.::..:|:.:..|....:.||:|:| |::|:.|.:: 
Zfish   918 EEVLHELESRLEEEEERVAQFQSEKKKMQQNIGDLEQQLDEEEAARQKLQLEKVTMDAKLKKIEE 982

  Fly   991 --AACQDKDKLIEALNKQLE----------AERDEKMQLLEENGHAQEEWIS-------QKQTWR 1036
              ...:|::..:....||:|          ||.:||.:.|::.....|..|:       :::..|
Zfish   983 DLMVIEDQNAKLSKEKKQMEERISEFTTNLAEEEEKSKSLQKLKTKHETMITDLEDRLRKEEKMR 1047

  Fly  1037 QENEELRRQI--------DEIIDM-AKNAEVNQR--NQEDRM---LAEIDNR-ELNEAYQRAIKD 1086
            ||.|:.||::        |:|.:: |:.||:..:  .:|:.:   ||.|:.. .|..|.|::|::
Zfish  1048 QELEKNRRKLEGDSTELHDQIAELQAQIAELRAQLAKKEEELQAALARIEEEAALKNAAQKSIRE 1112

  Fly  1087 KEV------------------IENENFMLKEELSRL----------TAGSFSLHARKASNASSQN 1123
            .|.                  .|.:...|.|||..|          ||....|.|::.:..:...
Zfish  1113 MEAQISELQEDLELEKAARNKAEKQRRDLGEELEALKTELEDTLDSTAAQQELRAKRETEVTQLK 1177

  Fly  1124 ---EDDV----------------------------------------GYASAKNTLDINRPPDLL 1145
               ||:.                                        ...|.:|.|.|    :|.
Zfish  1178 KTLEDEARAHEQMLSEVRQKHNQAFEELNEQLEQSKRSKASVDKAKQALESERNELQI----ELK 1238

  Fly  1146 SKNYSYNDSTSLVVKLRSILEE--------EKQKHKVLQEQYIKLSSRHKPTEDSFRVSELEVEN 1202
            |.:.|.|||.:...|..|.|:|        |:|||::|.                 :||:::.|.
Zfish  1239 SLSQSKNDSENRRKKAESQLQELQVKHTESERQKHELLD-----------------KVSKMQAEL 1286

  Fly  1203 EKLRSEYDQLRT-SIKHGVEINELNAQ----HAALQEEVRRR----------------------- 1239
            |.|:....::.: |||...:.:.:.:|    .|.|:||.|::                       
Zfish  1287 ESLQGTVTKVESKSIKAAKDCSAVESQLKDAQALLEEETRQKLAISTRLRQLEDEQNNLKEMLEE 1351

  Fly  1240 ---------------REECIQLKAVLLQQSQSMRSLEP---------ES---------------- 1264
                           :.:..::|..:.|::||:.|:|.         ||                
Zfish  1352 EEESKKNVEKQLHTAQAQLAEMKKKIEQEAQSLESMEDGKKKLQREVESVLQQLEERNASYDKLD 1416

  Fly  1265 -----LQMRGNDV--------NELMEAFHSQKLINRQLESE-------------LKAITEEHNSK 1303
                 ||...:||        ..:.|....||..::.|..|             .:|...|..:|
Zfish  1417 KTKTRLQRELDDVLVDQGHLRQTVQELERKQKKFDQMLAEEKSISTKYAEERDRAEAEAREKETK 1481

  Fly  1304 LVEMTQEIERLNNEKDELQKVMFESIDEFED---------SNVDTLRQNDRYLRRELQKAVAQFL 1359
            .:.:.:|:|.:.:.|:||::|..:...|.||         .:|..|.:..|.:.::|::...|..
Zfish  1482 SLTLARELEAMTDLKNELERVNKQLKTEMEDLVSSKDDAGKSVHELERAKRGMEQQLEEMKTQLE 1546

  Fly  1360 LVQEELKLA-NAKLK----------------AYRQDGGQLEHKIEEEMIRNKSNGTSADVGANVT 1407
            .:::||:|. :|||:                ..|.:.|:.:.|...:.:|        ::...:.
Zfish  1547 ELEDELQLTEDAKLRLEVNMQALKAQFERDLQSRDEQGEEKRKQLVKQVR--------EMEMELE 1603

  Fly  1408 KQKSQNPQGLMKFHSSDLDKILQRLLSALTPRTVVGLLPGFPAYLIFMCIRYTDLTN-ADDDVRE 1471
            .::.|..|.:......:||      ||.|..:                    .||.| |.|:..:
Zfish  1604 DERKQRAQAVSVRKKLELD------LSELAAQ--------------------IDLANKARDEALK 1642

  Fly  1472 LLSKFVIQIKKMHRTPHPIENRVIWLVNSITLLNLMKQYGDV----DEYVKFNTEKQNQQQLKNF 1532
            .|.|...|:|:.                       |:::.|:    ||  ..|..|:|::::|:.
Zfish  1643 QLKKLQAQMKEQ-----------------------MREFEDLRLSRDE--SLNQAKENERKIKSM 1682

  Fly  1533 NLFEYRRVILDLIVNLYQALIMQIQGLLDPKIVPAILNNDEIQRGRQAHGMRSRATSIGASSSPE 1597
                             :|.|||    |...:..|.....:||:.|..  ::....|..|.:|..
Zfish  1683 -----------------EAEIMQ----LHEDLAAADRAKRQIQQERDE--LQDEINSQNAKNSLS 1724

  Fly  1598 HGGGPAWKQLIGQLEHFYKQFQHFGLD---------NCYAEQIFHQLLYFICAVALNCLMLRGDI 1653
            .......:..|.|||...:: :|..::         :..|||:..:|    .|...|...|.|  
Zfish  1725 SDERRRLEARIAQLEEELEE-EHLSVELVNDRLKKASLQAEQVTVEL----TAERSNSQRLEG-- 1782

  Fly  1654 CMWETGMIIRYN------IGCIEDWVRSKKMSNDVLTAL-APLNQVSQLLQSRKSEQDVQTICDL 1711
               ....:.|.|      :..:|..|:||..|  .:||| ..:.|:.:.|.|...|:        
Zfish  1783 ---LRSQLDRQNKDMKQKLQELEGAVKSKYKS--TITALETKIQQLEEQLDSEMKER-------- 1834

  Fly  1712 CTSLSTAQVLKVMKSYK--LDDYESEITNVFLEKL-TEKLNARQMQKSNSDEFTIDQ 1765
              ..||.||.:|.|..|  |...|.|..|....|. |||.|.|..|.....|.|.::
Zfish  1835 --QQSTKQVRRVEKKLKEVLLQVEDERRNADQSKTETEKANIRLKQMKRQLEETEEE 1889

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 286/735 (39%)
MYSc_Myo5 84..767 CDD:276831 273/705 (39%)
IQ 900..922 CDD:197470 4/22 (18%)
GBP_C <971..1086 CDD:303769 37/150 (25%)
coiled coil 1049..1068 CDD:293879 5/24 (21%)
coiled coil 1077..1086 CDD:293879 3/8 (38%)
JAKMIP_CC3 <1190..1299 CDD:292653 32/202 (16%)
Myo5_CBD 1424..1792 CDD:271254 81/366 (22%)
myh9aNP_001091647.2 Myosin_N 28..66 CDD:280832 14/43 (33%)
Myosin_head 81..768 CDD:278492 277/717 (39%)
MYSc_Myh18 93..768 CDD:276895 273/705 (39%)
Myosin_tail_1 845..1925 CDD:279860 228/1173 (19%)
crotonase-like 1067..>1101 CDD:304874 8/33 (24%)
DUF2570 1777..1878 CDD:305162 33/117 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.910

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