DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment didum and smyhc1

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:NP_001018343.1 Gene:smyhc1 / 321552 ZFINID:ZDB-GENE-030131-271 Length:1938 Species:Danio rerio


Alignment Length:2087 Identity:532/2087 - (25%)
Similarity:883/2087 - (42%) Gaps:571/2087 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 SSEEMLYAQ------GAKIWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDL 60
            |.:|.|.||      ..:.:||..::.:..|::  :.|.|.   |:..|:...|.:..|.  .|:
Zfish    19 SDKERLEAQTRIFDMKKECFVPDPEVEYVKASI--TSRDGD---KVTVDTEYGKTLTFKE--CDV 76

  Fly    61 PPLRNPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSII 125
            .| :||.......|:...::||||.||.||:.|:. ..:||||.|:..|.:|||..:|:|..|::
Zfish    77 HP-QNPPKFDKIEDMAMFTFLHEPAVLFNLKERYA-AWMIYTYSGLFCVTVNPYKWLPVYDSSVV 139

  Fly   126 RAYRGHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYF---AAVGG- 186
            :||||....:..||||::::.||..:..:..|.|::::|||||||||:.|..::||   |||.| 
Zfish   140 KAYRGKKRTEAPPHIFSISDNAYQYMLSDRENQSVLITGESGAGKTVNTKRVIQYFASIAAVSGK 204

  Fly   187 ----SESETQVERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVM-FLQGATMHTY 246
                ||.:..:|.:::.::|.:||||||||.|||||||||||.::.|    ||. .|..|.:.||
Zfish   205 KDAASEKKGTLEDQIIQANPALEAFGNAKTIRNDNSSRFGKFIRIHF----GVSGKLASADIETY 265

  Fly   247 LLEKSRVVYQAQGERNYHIFYQLCAARSKYPE-----LVLDHQDKFQFLNMGGAPEIERVSDAEQ 306
            |||||||.||.:.||:||||||:.:  .|.||     |:.::...:.:::. |..::..:.|||:
Zfish   266 LLEKSRVTYQLKAERDYHIFYQILS--QKKPELLEMLLITNNPYDYSYISQ-GETQVASIDDAEE 327

  Fly   307 FNETVQAMTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEE----EDSDSCDIFHNDIHL 367
            ...|..|..||||:..:.:.|.|:...|:|.||::..:|..|...|    ||:|.          
Zfish   328 LIATDDAFDVLGFTQDEKSGIYKLTGAIMHFGNMKFKQKQREEQAEADGTEDADK---------- 382

  Fly   368 QITADLLRVSADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKS 432
              .|.|:.:::.||.:.|...:::..||:|....:::....:..||||.:|.|:|.::|..:|:|
Zfish   383 --VAYLMGLNSADLIKGLCHPRVKVGNEWVTKGQNVQQVYYSIGALAKSVYEKMFLWMVVRINQS 445

  Fly   433 LNNGSKQCSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMI 497
            |:....:..|||||||.|||.|:.|:|||.|||:.||||||.||.|:|.||||||.||||.|..|
Zfish   446 LDTKQPRQYFIGVLDIAGFEIFDFNTFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIDWEFI 510

  Fly   498 DF-YDNQPCIDLIESRLGVLDLLDEECRMPKGSDESWAGKLI-GKCNKFPHFEKPRF----GTTS 556
            || .|.|.||:|||..:|::.:|:|||..||.||:::..||. ....|.|.|:|||.    ....
Zfish   511 DFGMDLQACIELIEKPMGIMSILEEECMFPKASDQTFKAKLYDNHLGKNPTFQKPRIVKGRPEAH 575

  Fly   557 FFIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGG 621
            |.:.|::.||:|:::.:|.||:|.:::.:..:..:|.:.|...:..    .....|||:.|. ||
Zfish   576 FALVHYAGTVDYNISNWLVKNKDPLNETVVGLFQKSTVKLLSFLFA----GYSGADSAQDSK-GG 635

  Fly   622 RVVISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFK 686
            :    .|.|::|:..           :||.:..:|:|..|::.|.:|.||:|||:.||:.|....
Zfish   636 K----GGGKKKGSSF-----------QTVSALHRENLNKLMTNLRSTHPHFVRCLIPNETKTPGA 685

  Fly   687 WETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKN--DMKLSCRNIVMK 749
            .|...::.|||..||||.:||...|||:|.||.||..||::|...:..:..  |.|.:...::..
Zfish   686 MENPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRILNPSANPEGQFIDNKKAAEKLLGS 750

  Fly   750 WIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQK 814
            ...|.::|:.|:|::||:||.:..||::|.:                       |:..:|.|||.
Zfish   751 LDIDHNQYKLGHTKVFFKAGLLGTLEEMRDD-----------------------RLALIITGIQA 792

  Fly   815 HARGYLARERTQKMREARAGLILSKY-------ARGWLCRRRYLRLRHSISGIQTYARGMLARNK 872
            .|||.|:|...||:.|.|..|::.::       .:.|...:.|.:::..:...:|.......:.:
Zfish   793 RARGILSRLEFQKIVERRDSLLVIQWNVRAFMGVKNWPWMKLYFKIKPLLKTAETEKEMANMKEE 857

  Fly   873 FHAMRDHY-----RAVQIQRFVRGALARR-----AYQKRRRNII----ICQAAIRRFL------- 916
            |..:::.|     |..:::..:...|..:     |.|..:.|::    .|:..|:..:       
Zfish   858 FTKLKEAYAKSEARKKELEEKMVSLLQEKNDLQLAVQSEQDNLVDAEERCEGLIKSKIQLEAKAK 922

  Fly   917 ------------------ARRKFKRMKAEAK--------TISHMENKYMGLENKIISM------- 948
                              .:||.:...:|.|        |::.:|.:....|||:.::       
Zfish   923 ELTERLEDEEEMNAELVAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAAL 987

  Fly   949 ------------------QQRIDELNRD------------------------------------- 958
                              ||.:|:|..:                                     
Zfish   988 DEIIAKLTKEKKALQEAHQQTLDDLQSEEDKVNTLTKAKAKLEQQVDDLEGSLEQEKKLRMDLER 1052

  Fly   959 --------------------------NSNLKHKTSEISVLKMKLELKKTLEAEFKNVKAACQDKD 997
                                      ...||.|..|||.|..|:|.::.|.|:.:......|.: 
Zfish  1053 AKRKLEGDLKLTQESIMDLENDKQQMEEKLKKKDFEISQLNSKIEDEQALGAQLQKKLKELQAR- 1116

  Fly   998 KLIEALNKQLEAER-----------------DEKMQLLEENGHAQEEWISQKQTWRQENEELRR- 1044
              ||.|.::|||||                 :|..:.|||.|.|....|...:....|.::||| 
Zfish  1117 --IEELEEELEAERAARAKVEKQRADLSRELEEISERLEEAGGATAAQIEMNKKREAEFQKLRRD 1179

  Fly  1045 ----------------------------QID------------------EIIDMAKNAE--VNQR 1061
                                        |||                  |:.|:..|.|  |..:
Zfish  1180 LEEATLQHEATAATLRKKHADSVADLGEQIDNLQRVKQKLEKEKSELKLELDDVVSNMEQIVKSK 1244

  Fly  1062 NQEDRMLAEIDN-----RELNEAYQRAIKD----KEVIENENFMLKEEL-------SRLTAGSFS 1110
            :..::|...:::     |...|..||.|.|    |..::.||..|..:|       |:||.|..|
Zfish  1245 SNLEKMCRTLEDQMSEYRTKAEEGQRTINDFTMQKAKLQTENGELSRQLEEKDSLVSQLTRGKQS 1309

  Fly  1111 LHARKASNASSQNEDDVGYASAKNTL-----DINRPPDLLSKNY------------SYNDSTSLV 1158
             :.::..:...|.|::|   .|||.|     ......|||.:.:            |.:.:.|.|
Zfish  1310 -YTQQIEDLKRQLEEEV---KAKNALAHAVQSARHDSDLLREQFEEEQEAKAELQRSLSKTNSEV 1370

  Fly  1159 VKLRSILEEEK-QKHKVLQEQYIKLSSRHKPTEDSF-----RVSELEVENEKLRSEYDQLRTSIK 1217
            .:.|:..|.:. |:.:.|::...||:.|.:..|::.     :.|.||....:|::|.:.|.    
Zfish  1371 AQWRTKYETDAIQRTEELEDAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLM---- 1431

  Fly  1218 HGVEINELNAQHAALQEEVR-----------RRREECIQLKAVLLQQSQSMRSLEPESLQMRGND 1271
              |::...||..|||.::.|           :..|...:|::.   |.:| |||..|..::: |.
Zfish  1432 --VDVERSNAAAAALDKKQRNFDKVLAEWKQKYEESQTELESA---QKES-RSLSTELFKLK-NS 1489

  Fly  1272 VNELMEAFHSQKLINRQLESELKAITE---EHNSKLVEMTQEIERLNNEKDELQKVMFESIDEFE 1333
            ..|:::...:.|..|:.|:.|:..:||   |....:.|:.:..::|..||.|:|    .:::|.|
Zfish  1490 YEEVLDQLETMKRENKNLQEEISDLTEQLGETGKSIHELEKIRKQLEQEKAEIQ----TALEEAE 1550

  Fly  1334 DSNVDTLRQNDRYLRRELQKAVAQFLLVQEELKLANAKLKAYRQDGGQLEHKI---EEEMIRNKS 1395
            .|                        |..||.|:..|:|: :.|....:|.|:   :|||     
Zfish  1551 GS------------------------LEHEEGKILRAQLE-FNQVKADIERKLSEKDEEM----- 1585

  Fly  1396 NGTSADVGANVTKQKSQNPQGLMKFHSSDLDKILQRLLSALTPRTVVGLLPGFPAYLIFMCIRYT 1460
                        :|..:|.|.::....|.|:...:....||                     |..
Zfish  1586 ------------EQAKRNQQRVVDTLQSSLESETRSRNEAL---------------------RLK 1617

  Fly  1461 DLTNADDDVRELLSKFVIQIKKMHRTPHPIENRVIWLVNSITLLNLMKQYGDV-DEYVKFNTEKQ 1524
            .....|      |::..||:.:.:|.....:.::..|            :|.| |..::.:...:
Zfish  1618 KKMEGD------LNEMEIQLSQANRQASEAQKQLKGL------------HGHVKDSQMQLDDALR 1664

  Fly  1525 NQQQLK-NFNLFEYRRVILDLIVNLYQALIMQIQGLLDPKIVPAILNNDEIQRGRQAHGMRSRAT 1588
            ....|| |..:.|.|.       ||.||.:.:::.|:           ::.:|||:.        
Zfish  1665 GNDDLKENIAIVERRN-------NLLQAELDELRSLV-----------EQTERGRKL-------- 1703

  Fly  1589 SIGASSSPEHGGGPAWKQLIGQLEHFYKQFQHFGLDNCYAEQIFHQLLYFICAVALN-CLMLRGD 1652
                          |.::|:...|..                   |||:......|| ...|.||
Zfish  1704 --------------AEQELMDVSERV-------------------QLLHAQNTSLLNQKKKLEGD 1735

  Fly  1653 ICMWETGMIIRYNIGCIEDWVRSKKMSNDVLTALAPLNQVSQLLQSRKSEQDV------------ 1705
            ....:|.         :|:.|:..:.:.:  .|...:...:.:.:..|.|||.            
Zfish  1736 NTQLQTE---------VEEAVQECRNAEE--KAKKAITDAAMMAEELKKEQDTSAHLERMKKNME 1789

  Fly  1706 QTICDLCTSLSTAQVLKVMKSYKLDDYESEITNVFLEKLTEKLNARQMQKSNSDEFTIDQKFIQP 1770
            |||.||              .::||:.| :|.....:|..:||.||..:..|..|.. .:|..:.
Zfish  1790 QTIKDL--------------QHRLDEAE-QIAMKGGKKQVQKLEARVRELENEVELE-QRKASES 1838

  Fly  1771 FKVVFRY 1777
            .|.|.:|
Zfish  1839 VKGVRKY 1845

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 278/738 (38%)
MYSc_Myo5 84..767 CDD:276831 267/708 (38%)
IQ 900..922 CDD:197470 5/50 (10%)
GBP_C <971..1086 CDD:303769 39/185 (21%)
coiled coil 1049..1068 CDD:293879 4/20 (20%)
coiled coil 1077..1086 CDD:293879 4/8 (50%)
JAKMIP_CC3 <1190..1299 CDD:292653 30/127 (24%)
Myo5_CBD 1424..1792 CDD:271254 65/369 (18%)
smyhc1NP_001018343.1 Myosin_N 35..72 CDD:280832 8/41 (20%)
Myosin_head 87..768 CDD:278492 271/720 (38%)
MYSc_class_II 99..768 CDD:276951 267/708 (38%)
Myosin_tail_1 848..1925 CDD:279860 219/1187 (18%)
RILP-like 963..1096 CDD:304877 15/132 (11%)
COG6 1374..>1507 CDD:303003 33/143 (23%)
TMPIT 1457..>1562 CDD:285135 30/137 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.910

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