DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment didum and Iqcb1

DIOPT Version :9

Sequence 1:	NP_724569.1	Gene:	didum / 35680	FlyBaseID:	FBgn0261397	Length:	1800	Species:	Drosophila melanogaster
Sequence 2:	NP_796102.2	Gene:	Iqcb1 / 320299	MGIID:	2443764	Length:	598	Species:	Mus musculus

Alignment Length:	707	Identity:	123/707 - (17%)
Similarity:	250/707 - (35%)	Gaps:	249/707 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   429 LNKSLNN---GSKQCSFIGVLDIYGFETFEVNSFEQFCINYANE-------------KLQQQFNQ 477
            |.:.:||   ||.:...: ..|||.::..      |:|:...::             :|.|..:.
Mouse    32 LKEIINNTPLGSSELKKV-KQDIYCYDLI------QYCLLVLSQDSSRIQGGWSTISQLTQILSH 89

  Fly   478 HVFKLEQ----EEYLKEGITWTMIDFYDNQPCIDLIESRLGVLDLLDEEC--RMPKGSDESWAGK 536
            ....||.    ||:.||.:.....:|.       ::..||       :.|  ...||.::
Mouse    90 CCVGLEPGEDGEEFYKELLPSAAENFL-------ILGRRL-------QTCFINATKGEEQ----- 135

  Fly   537 LIGKCNKFPHFEKPRFGTTSFFIKHFSDTVEYDVNGFLEKNRDTV-SKELTQVLSESNMSLAKQV 600
                 :|..|           |.:..:|::.:.:.|.::..::.: |.....:|...|:.:...|
Mouse   136 -----DKLLH-----------FFQIVTDSLFWLLGGHVQLIQNVLQSDHFLHLLQTDNVQIGASV 184

  Fly   601 MTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLASLIST- 664
            |||.: :.|.::|.....:.|                          |.:.|...|.|..|:||
Mouse   185 MTLLQ-NILQINSGNLLKIEG--------------------------KALHSILDEILFKLLSTP 222

  Fly   665 ---LHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQ 726
               :.:|....:..:..:..::.       |:.:|.||                         |:
Mouse   223 SPVIRSTATKLLLVLAESHQEIL-------ILLRLSAC-------------------------YK 255

  Fly   727 LLVYRSKLDKNDMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAFL------EQVRANLRKKY 785
            .|  ||.|:|.:..                     |:......|:..|      ::|......|.
Mouse   256 GL--RSLLNKQETL---------------------TEFSRELRQLVDLLTPKIHQEVEEQKLHKA 297

  Fly   786 ITIVQSVVRRFVYRRQFLRIQKVINGIQ-----KHARGYLARERTQKMREARAGLILSKYARGWL 845
            ..::|:..:.|..|::..::...:..:|     |..:..|...|.::..:.|..|.|.
Mouse   298 ACLIQAYWKGFQTRKRLKKLPSAVIALQRSFRSKRTKMMLELNRQKEEEDLRLKLQLQ------- 355

  Fly   846 CRRRYLRL-RHS-ISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAYQKRRRNI--- 905
             |:|.:|| |.| ::.::....|.:  .|::...:...|:.||:..||...|:.::::|.::
Mouse   356 -RQRAMRLSRESRLNMLEIIHPGQV--EKYNREMEEKSALTIQKHWRGYRERKNFRQQRPSLTEY 417

  Fly   906 ---IICQAAIRRFLAR-RKFKRMKAEAKTISHMENKYMGLEN----KIISMQQRIDELNRDNSNL 962
               :..|.|:.:|||: ||.|::.|          .:.||:.    :.:.::|::|:..:
Mouse   418 KAAVTLQRAVLKFLAKCRKKKKLFA----------SWHGLQELTDARRVELKQQVDDYVK----- 467

  Fly   963 KHKTSEISVLKMKLELKKTLEAEFKNVKAACQDK--------------DKLIEALNKQLEAERDE 1013
            :|..|::|            ||..:.:.|..|::              .:..|||..|:....::
Mouse   468 RHPCSQMS------------EAASRELHAQAQERLQHYFMGRAIEERAQQHREALMAQISTNIEQ 520

  Fly  1014 KMQ---LLEENGHAQEEWISQ--------KQT------------WRQENEELRRQID 1047
            .|:   |.|..|...|:::|:        ||.            |::..||...::|
Mouse   521 LMKAPSLKEAEGKEPEQFLSRSRPVAAKAKQAHLTTLKHIQAPWWKKLGEEPGDEVD 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc	65..778	CDD:214580	60/381 (16%)
		MYSc_Myo5	84..767	CDD:276831	58/364 (16%)
		IQ	900..922	CDD:197470	8/28 (29%)
		GBP_C	<971..1086	CDD:303769	20/114 (18%)
		coiled coil	1049..1068	CDD:293879
		coiled coil	1077..1086	CDD:293879
		JAKMIP_CC3	<1190..1299	CDD:292653
		Myo5_CBD	1424..1792	CDD:271254
Iqcb1	NP_796102.2	Interaction with BBS1, BBS8 and BBS9. /evidence=ECO:0000250\|UniProtKB:Q15051	1..157		29/166 (17%)
		Interaction with CEP290, BBS1, BBS2, BBS4, BBS5, BBS7, BBS8 and BBS9. /evidence=ECO:0000250\|UniProtKB:Q15051	287..598		63/328 (19%)
		COG5022	<293..>408	CDD:227355	25/124 (20%)
		Adgb_C_mid-like	<385..>430	CDD:412094	9/44 (20%)
		IQ motif	392..410	CDD:412094	5/17 (29%)
		Interaction with BBS1, BBS2, BBS4, BBS7, BBS8 and BBS9. /evidence=ECO:0000250\|UniProtKB:Q15051	530..598		9/48 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900