DRSC/TRiP Functional Genomics Resources

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Protein Alignment didum and Myo10A

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster


Alignment Length:1692 Identity:449/1692 - (26%)
Similarity:717/1692 - (42%) Gaps:339/1692 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    71 GQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMP-LYGPSIIRAYRGHAMG 134
            |..|:|.|..|||..:|.|||:|: ::.:|||:.|.||:|:|||...| .||..:.:.|.|..:|
  Fly   156 GVEDMTLLDDLHEASLLWNLRLRY-DKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLG 219

  Fly   135 DLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAV--GGSESETQVERKV 197
            .|.||:||:...|:..|.....   :::|||||:|||.|.|..|:|.|||  ||..:...:..::
  Fly   220 SLPPHLFAIGAAAHAALPSPQV---VVISGESGSGKTESTKLVMQYLAAVVPGGGSASAVITEQI 281

  Fly   198 LASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERN 262
            |.::|::||||||:|.||||||||||:.::.|::..    :.||.:..|||||||:|.||.||||
  Fly   282 LEAAPLLEAFGNARTARNDNSSRFGKYLEVYFKSGA----IVGAKITQYLLEKSRIVTQAPGERN 342

  Fly   263 YHIFYQLCAA-----RSKYPELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQ 322
            ||:||:|...     ||||..|   ..||:.:||.|..   :..|....:.....||.|||.|..
  Fly   343 YHVFYELLGGLSETERSKYGLL---EADKYFYLNQGAT---DCASGRVDWESLQGAMQVLGVSEG 401

  Fly   323 QIADIVKILAGILHLGNIQVSKK-FNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLL 386
            :...||::||.:|||||:...:: ...|.|..:..|      |..::..|.||.:|||.|.|.|.
  Fly   402 EREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGS------DAEIKWAAHLLHISADGLHRALT 460

  Fly   387 MRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSL-NNGSKQCSFIGVLDIYG 450
            .|..|:..|.:..|..|:.|..||||.||.:||.||.::|..:|..: ..|:.....|.:|||:|
  Fly   461 SRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISILDIFG 525

  Fly   451 FETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIESR-LG 514
            ||....|||||.|||||||.||..||:|||||||.||.:|.:.||.:.:.||.|.|.|:..: :|
  Fly   526 FEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVG 590

  Fly   515 VLDLLDEECRMPKGSDESWAGKLIGKCNKFPH-----FEKPRFGTTSFFIKHFSDTVEYDVNGFL 574
            :..|||:|...|:.:|.|:    :.||: :.|     :.:||.|...|.:.|::..|.|.|:|||
  Fly   591 ICHLLDDESNFPRATDLSF----LEKCH-YNHALSELYARPRIGAQEFGVTHYAGQVWYCVDGFL 650

  Fly   575 EKNRDTVSKELTQVLSESNM----SLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGND 635
            :||||.:..::.::|:.|.:    .|.||:....       |:.|:...|               
  Fly   651 DKNRDALRGDVLELLASSRLPLVGELTKQLRAQR-------DAGKTLPKG--------------- 693

  Fly   636 TRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACG 700
            :..|.|..|....||.::|.:||..|:.::....|.:|||||||.:|.|.:.:...::||||..|
  Fly   694 SNGRFVTMKPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLG 758

  Fly   701 VLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKNDMKLSCRNIV----MKWIQDEDKYRFGN 761
            :|:|::|...|:|.|..:..|..||:.|:..........:..||.::    ...::..| |:.|.
  Fly   759 MLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLARGTPYRELCRALLEAMPRTGVEGPD-YQLGA 822

  Fly   762 TQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQ 826
            |::|.|......||..|..                       |:::....:|:|.||.|.|.:..
  Fly   823 TRVFLREALHRALESGRTE-----------------------RLRRAAVSVQRHVRGMLVRRQLA 864

  Fly   827 KMREARAGLILSKYARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMR-DHYRAVQIQRFVR 890
            : |:|.|..:.::: ||...::||.|||......|...||..||.:...:| ||.|..:      
  Fly   865 R-RQAAATRLQARW-RGQRAQQRYERLRKGALTAQRLWRGRQARRRVQQLRSDHRRRQE------ 921

  Fly   891 GALARRAYQKRRRNIIICQAAIRR----FL---ARRKFKRMKAEAKTISHMENKYMGLENKIISM 948
               ||.|.|:.|......||.:.|    :|   |...|...|.:..:..|.:...:.:...:...
  Fly   922 ---AREAAQRAREAREAKQAVLERSQLSYLDIPAELAFIYSKLQGWSPPHGDRHLVKVLGTVPGP 983

  Fly   949 QQRIDELNRDNSNLKH-KTSEISVLKMKLELKKTLEAEFKNVKAACQDKD--------KLIEALN 1004
            .....:|..|...... |.|.:....::|:.::.........:||.:|:|        |||    
  Fly   984 PSSAVQLPEDLGQFSFGKFSSVYCNGLRLQPRREPITAPLLTRAASRDQDFQDALAVFKLI---- 1044

  Fly  1005 KQLEAERDEKMQLLEENGHAQEEWISQKQTWRQENEELRRQIDEIIDMAKNAEVNQRNQEDRMLA 1069
              |....|:.::      .|:|:.::                |.|:..|    ::.|...|.:|.
  Fly  1045 --LRWSNDKALE------GAKEKLLA----------------DYIVHKA----LSSRGLRDEILV 1081

  Fly  1070 EIDNR------ELNEA----------------------YQRAIKDKEVIENENFMLKEELSRLTA 1106
            ::.|:      ...||                      |.....|.|..|:...:|..:|.|...
  Fly  1082 QLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQG 1146

  Fly  1107 GSFSLHARKASNASSQNEDDVGYASAKNTLDINRP---PDLLSKNYSYNDST-----------SL 1157
            |..|..|..|....|.....:.:.:.....|:..|   ||..|:..:.:..|           ||
  Fly  1147 GGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAALAVSSL 1211

  Fly  1158 VVKLRS---ILEEEKQKHKVLQEQYIKLSSRHKPTEDSFRVSELEVENEKLRSEYDQLRTSIKHG 1219
            .|..|.   :|::.:|........|:......|....:|...    .::.|||.....||::...
  Fly  1212 GVASRGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAP----RSDLLRSGAKFARTTLPDA 1272

  Fly  1220 VE---INELNAQHAALQEEVRRRREECIQLKAVLLQQSQSMR----SLEPESLQMRGNDVNELME 1277
            |:   :.......::.:|:|.|.|....:    ||.:|.::.    ..||.....:|:...    
  Fly  1273 VKRPAVPPPAPPTSSGKEDVPRERRSSRE----LLSRSSALNERYFEREPSPGPGQGSSTG---- 1329

  Fly  1278 AFHSQKLINRQLESELKAITEEHNSKLVEMTQEIERLNNEKDELQKVMFESIDEFEDSNVDTLRQ 1342
                      |.:|..|::.:.....:|.:..:.               :|.:......:...|.
  Fly  1330 ----------QAKSRSKSLDDLLAGDIVPVPTDC---------------DSQEPLHTLGLSESRL 1369

  Fly  1343 NDRYLRRELQKAVAQFLLVQEELKLANAKLKAYRQDGGQLEHKIEEEMIRN--KSNGTS----AD 1401
            ||||...|                    :|....:|.|....|.:....|:  .|:|:.    ||
  Fly  1370 NDRYHSAE--------------------RLAPVGKDTGPRYQKSQHAGRRSHAASHGSHSSKYAD 1414

  Fly  1402 VGANVTKQK-----SQNPQGLMKFH---------SSDLDKILQRLLSALTPRTVVGLLPGFPAYL 1452
            .....|:..     |:.|.  :..|         :||:|:.|..|.|.:...::..|   ..|..
  Fly  1415 KAEYATRSSAMSDTSEAPS--LASHVRRVRVPSQASDVDQFLDDLFSPVLDGSLDEL---SDARS 1474

  Fly  1453 IFMCIR---YTDLTNADDDVRELLSKFVIQIKKMHRTPHPIENRVIWLVNSITLLNLMKQYGDVD 1514
            :...||   |.....|:.::.: |..::..|.:    |.|:...:..|.:...|..::|..|...
  Fly  1475 LAASIRGGSYEQENEAESEIDD-LDDYINDIFQ----PIPLVQNLEKLTSKDQLAAIIKGGGVAS 1534

  Fly  1515 EYVKFNTEKQNQQQLKNFNLFEYRRVILDLIVNLYQALIMQIQGLLDPKIVPAILNNDEIQRGRQ 1579
            :    ..|:..:.:::  :|.:|                  |..|.:|  :|.....|::.    
  Fly  1535 K----PEERDEESEIE--DLDDY------------------INELFEP--IPVAEGLDKLT---- 1569

  Fly  1580 AHGMRSRATSI-GASSSPEHGGGPAWKQLI---GQLEH----FYKQFQHFGLDNCYAE--QIFHQ 1634
              .....|.|| |..|:..:|..|...||:   |:.|.    :.:|.|...|.:..|:  ||..|
  Fly  1570 --SKEHLAVSIRGGGSTDSNGADPLLHQLMQLPGETESGPALYQQQVQRAFLQSAMAQNLQIQQQ 1632

  Fly  1635 LL 1636
            ||
  Fly  1633 LL 1634

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 269/730 (37%)
MYSc_Myo5 84..767 CDD:276831 259/706 (37%)
IQ 900..922 CDD:197470 6/28 (21%)
GBP_C <971..1086 CDD:303769 22/150 (15%)
coiled coil 1049..1068 CDD:293879 4/18 (22%)
coiled coil 1077..1086 CDD:293879 3/30 (10%)
JAKMIP_CC3 <1190..1299 CDD:292653 20/115 (17%)
Myo5_CBD 1424..1792 CDD:271254 47/226 (21%)
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 267/727 (37%)
MYSc_Myo15 169..828 CDD:276838 259/706 (37%)
MyTH4 1014..1171 CDD:295320 32/188 (17%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45466255
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1389at50557
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100101
Panther 1 1.100 - - P PTHR13140
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
65.850

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