DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment didum and Myo5c

DIOPT Version :9

Sequence 1:	NP_724569.1	Gene:	didum / 35680	FlyBaseID:	FBgn0261397	Length:	1800	Species:	Drosophila melanogaster
Sequence 2:	XP_006243475.1	Gene:	Myo5c / 315820	RGDID:	1309994	Length:	1749	Species:	Rattus norvegicus

Alignment Length:	1902	Identity:	725/1902 - (38%)
Similarity:	1054/1902 - (55%)	Gaps:	266/1902 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LYAQGAKIWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLRNPAILVG 71
            ||||..::|:|..:.||:||.:.:.||.|...|::..:.|  .|:....|...|||||||.||||
  Rat     6 LYAQYNRVWIPDPEEVWKSAEIAKDYRVGDQVLRLLLEDG--TELDYPVDPGSLPPLRNPDILVG 68

  Fly    72 QNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDL 136
            :||||.|||||||.||||||:||.|.::||||.||||||:|||.::|:||.:||.||.|..|||:
  Rat    69 ENDLTALSYLHEPAVLHNLRIRFAESKLIYTYSGIILVAMNPYKQLPIYGDAIIHAYSGQNMGDM 133

  Fly   137 EPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESETQVERKVLASS 201
            :|||||:|||||.::.|.|.|.||||||||||||||||:|||||||.|..|.|...||.|||||:
  Rat   134 DPHIFAVAEEAYKQMARNNRNQSIIVSGESGAGKTVSARYAMRYFATVSKSSSNAHVEEKVLASN 198

  Fly   202 PIMEAFGNAKTTRNDNSSRFGKFTKLLF--RNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYH 264
            ||.||.||||||||||||||||:|::.|  |||     :.||.|.||||||||||:|::.|||||
  Rat   199 PITEAVGNAKTTRNDNSSRFGKYTEISFDERNQ-----IIGANMRTYLLEKSRVVFQSENERNYH 258

  Fly   265 IFYQLCAA--RSKYPELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIADI 327
            |||||||:  :|::..|.|...::|.:..|||...||.|.|.....||.:..|:|||......|:
  Rat   259 IFYQLCASAQQSEFKHLKLGSAEEFNYTRMGGNTVIEGVDDRADMAETQKTFTLLGFKKDFQMDV 323

  Fly   328 VKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKIES 392
            .||||.||||||:||:...||.|...:.||        ||::..:||.:....:.:||..|||.:
  Rat   324 FKILAAILHLGNVQVTTVGNERSAVSEDDS--------HLKVFCELLGLETIKVAQWLCNRKIVT 380

  Fly   393 VNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIYGFETFEVN 457
            .:|.|:.|.:...|..|||||||.|||.||.:||..:|::|:...||.:|||||||||||||:||
  Rat   381 SSETVVKPMTRPQAINARDALAKKIYAHLFDFIVEQINQALHFSGKQHTFIGVLDIYGFETFDVN 445

  Fly   458 SFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIESRLGVLDLLDEE 522
            |||||||||||||||||||.||||||||||:||.|.||:||||||||.|||||:::|:|:|||||
  Rat   446 SFEQFCINYANEKLQQQFNLHVFKLEQEEYMKEDIPWTLIDFYDNQPVIDLIEAKMGILELLDEE 510

  Fly   523 CRMPKGSDESWAGKLIGK-CNKFPHFEKPRFGTTSFFIKHFSDTVEYDVNGFLEKNRDTVSKELT 586
            |.:|.|:||:|..||... .||...|||||...:||.|:||:|.|||...||||||||||...|.
  Rat   511 CLLPHGTDENWLQKLYNNFVNKNSLFEKPRMSNSSFIIQHFADKVEYQCEGFLEKNRDTVYDMLV 575

  Fly   587 QVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQH-RKTV 650
            :||..|...|.........:        .||..|..:.:.:.::.        :.|:.:| |.||
  Rat   576 EVLRASKFHLCAAFFQESPV--------PSSPFGAMITVKSAKQV--------IKPNTKHFRTTV 624

  Fly   651 GSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAGFPSR 715
            |::|:.||..|:.||:||||||||||||||:|:.|::::.:|:|||||||||||:||||..:|||
  Rat   625 GNKFRSSLFLLMETLNATTPHYVRCIKPNDEKLPFEFDSKRIVQQLRACGVLETIRISAQSYPSR 689

  Fly   716 WLYPDFYMRYQLLVYRSKLDKNDMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAFLEQVRAN 780
            |.|.:||.||.:|:.:.:|..:|.|..|:.::.:.|||.::|:||.|:|||||||||:||::|.:
  Rat   690 WTYLEFYSRYGVLMTQQELSLSDKKEVCKVVLHRLIQDSNQYQFGRTKIFFRAGQVAYLEKLRLD 754

  Fly   781 LRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQK------MREARAGLILSK 839
            ..::...::|..||.::.|::|||.::....||::.||   ::..:|      ::||.|.:||.|
  Rat   755 KLRQGCIVIQKHVRGWLQRKKFLRERRAALTIQQYFRG---QQTVRKAITATALKEAWAAIILQK 816

  Fly   840 YARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAYQKRRRN 904
            :.||:|.|..|..:|.:...||.:.||.|||.::..:...::||.:|::.|..||||.:|..||.
  Rat   817 HCRGYLVRNLYQLIRVATITIQAHTRGFLARRRYRKLLQEHKAVILQKYARAWLARRRFQNIRRF 881

  Fly   905 IIICQAAIRRFLARRKFKRMKAEAKTISHMENKYMGLENKIISMQQRIDELNRDNSNLKHKTSEI 969
            ::..|                               |..::..:|:::::.||:|..|..|.:.:
  Rat   882 VLNIQ-------------------------------LTYRVQRLQKKLEDQNRENHGLVEKLTSL 915

  Fly   970 SVLKM-KLELKKTLEAEFKNVKAAC----------QDKDKLIEALNK------QLEAERDEKMQL 1017
            :.|:: .||..:.||||.:  |||.          :.:|.:.|.|:|      :||::|:...|.
  Rat   916 AALRVGDLEKVQRLEAELE--KAATHRHSYEEKGRRYRDSMEERLSKLQKHNAELESQRERAEQS 978

  Fly  1018 LEENGHAQEEWISQKQTWRQENEELRRQI-DEIIDMAKNAEVNQRNQEDRMLAEIDNRELNEAYQ 1081
            |:|          :.:..:::.::|.||: |::          |:.::.|:|.|.......:||:
  Rat   979 LQE----------RTEELKEKMDQLTRQLFDDV----------QKEEQQRLLLEKSFELKTQAYE 1023

  Fly  1082 RAIKDKEVIENENFMLKEELSRLTAGSFSLHARKASNASSQNEDDVGYASAKNTLDINRPPDLLS 1146
            :.|:.          |:||:..|......||       ....|..|...|.|.  ::.|    ||
  Rat  1024 KEIES----------LREEIKALKDERTQLH-------HQLEEGRVTSDSLKG--EVAR----LS 1065

  Fly  1147 KNYSYNDSTSLVVKLRSILEEEKQKHKVLQEQYIKLSSRHKPTEDSFRVSELEVENEKLRSEYD- 1210
            |            :.::|.|.||: .::||.|.|.:....:..:...|....||..:.|.| ||
  Rat  1066 K------------QAKTISEFEKE-IELLQAQKIDVEKHVQSQKREMRERMSEVTKQLLES-YDI 1116

  Fly  1211 ---QLRTSI---KHGVEINELNAQHAALQEEVRRRREECIQLKAVLLQQSQSMRSL---EPESLQ 1266
               :.|.|:   :|..|..||...:..|::..|           ||....||.:..   |.|.|.
  Rat  1117 EDVRSRLSVEDLEHLNEDGELWFAYEGLKKATR-----------VLESHFQSQKDCYEKEIEGLN 1170

  Fly  1267 MR----GNDVNELMEAFHSQKLINRQLESELKAITEEHNSKLVEMTQEIERLNNEKDELQKVMFE 1327
            .:    ..::|.|.:.|..:..||..:..|:..:|.| |..:.:..|:|..|..:|.:|:..:.|
  Rat  1171 FKVVHLSQEINHLQKLFREETDINESIRHEVTRLTSE-NMMIPDFKQQISELERQKQDLESRLKE 1234

  Fly  1328 SIDEFEDSNVDTLRQNDRYLRRELQ--KAVAQFL----------------LV------QEELKLA 1368
            ..::.|....:.....:|.|..|.:  ||...||                ||      ||.:|..
  Rat  1235 QAEKMEGKQEEPFSHLNRGLEEEGRQGKAPRPFLRAVEAQSETHPEGKERLVGKIQEPQEAIKFP 1299

  Fly  1369 NAKLKA-------YRQDGGQL---EHKIEEE------MIR-------------NKSNGTSADVGA 1404
            ..:.:|       .||:..:|   ...:|||      |||             .|:|......|
  Rat  1300 KKQAEAEEEVESILRQEASRLSLENRDLEEELDMKDRMIRKLQDQVKTLTRTIEKANSVPLPSG- 1363

  Fly  1405 NVTKQKSQNPQGLMKFHSSDLDKILQRLLSALTPR-TVVGLLPGFPAYLIFMCIRYTDLTNADDD 1468
                  |:...|::::...|..|::|.|:..|.|| .||.::||.||:::|||:||.|..|..:.
  Rat  1364 ------SREYLGMLEYKKEDETKLIQNLILDLKPRGVVVNMIPGLPAHILFMCVRYADSLNDANM 1422

  Fly  1469 VRELLSKFVIQIK---KMHRTPHPIENRVIWLVNSITLLNLMKQYGDVDEYVKFNTEKQNQQQLK 1530
            ::.|::..:..||   |.|.  ..:|....||.|:...||.:|||...:|::|.|:.:||:..|.
  Rat  1423 LKSLMNSAINGIKHVVKEHF--EDLEMLSFWLSNTCHFLNCLKQYSGEEEFMKCNSPQQNKNCLN 1485

  Fly  1531 NFNLFEYRRVILDLIVNLYQALIMQIQGLLDPKIVPAILNNDEIQ--RGRQAHGMRSRATSIGAS 1593
            ||:|.|||:::.|:.:.:|...|:.::..|.|.|||.:|..:.:|  .|.:..|.|.|::||..:
  Rat  1486 NFDLTEYRQILSDVAIRIYHQFILVMENNLQPIIVPGMLEYESLQGISGLKPTGFRKRSSSIDDT 1550

  Fly  1594 SSPEHGGGPAWKQLIGQLEHFYKQFQHFGLDNCYAEQIFHQLLYFICAVALNCLMLRGDICMWET 1658
            .:      .....::.||.:||......|||.....|...||.|.|.||.||.|:||.|:|....
  Rat  1551 DA------YTMTSILQQLSYFYSTMCQNGLDPEIVRQAVKQLFYLIGAVTLNSLLLRKDMCSCRK 1609

  Fly  1659 GMIIRYNIGCIEDWVRSKKMSNDVL-TALAPLNQVSQLLQSRK-SEQDVQTICDLCTSLSTAQVL 1721
            ||.||.||..:|:|::.|.:.|.:. ..|.||:|.:.|||.:| ::.|.:.|...|||||..|::
  Rat  1610 GMQIRCNISFLEEWLKDKNLQNSLAKETLEPLSQAAWLLQVKKTTDSDAKEISQCCTSLSAVQII 1674

  Fly  1722 KVMKSY-KLDDYESEITNVFLEKLTEKLNARQMQKSNSDEFTIDQKFIQPFKVVFRY--SDIKLE 1783
            |::.|| .:||:|..:...|:.|:...||.|    .:|.:..:|.|::  |:|.|.:  |...||
  Rat  1675 KILNSYTPIDDFEKRVNPSFVRKVQALLNNR----GDSSQLMLDTKYL--FQVTFPFTASPHALE 1733

  Fly  1784 DIELPSHLNLDEFLTKI 1800
            ..::||...|. ||.::
  Rat  1734 MTQIPSSFKLG-FLRRL 1749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc	65..778	CDD:214580	400/718 (56%)
		MYSc_Myo5	84..767	CDD:276831	375/688 (55%)
		IQ	900..922	CDD:197470	3/21 (14%)
		GBP_C	<971..1086	CDD:303769	31/132 (23%)
		coiled coil	1049..1068	CDD:293879	2/18 (11%)
		coiled coil	1077..1086	CDD:293879	3/8 (38%)
		JAKMIP_CC3	<1190..1299	CDD:292653	29/122 (24%)
		Myo5_CBD	1424..1792	CDD:271254	131/378 (35%)
Myo5c	XP_006243475.1	Myosin_N	12..48	CDD:280832	11/37 (30%)
		MYSc	62..752	CDD:214580	400/718 (56%)
		MYSc_Myo5	81..741	CDD:276831	375/688 (55%)
		IQ	755..776	CDD:197470	4/20 (20%)
		IQ	830..851	CDD:197470	8/20 (40%)
		COG1340	890..1150	CDD:224259	74/329 (22%)
		GBP_C	<929..1030	CDD:303769	28/132 (21%)
		RILP-like	<977..1096	CDD:304877	36/174 (21%)
		coiled coil	1001..1010	CDD:293879	2/18 (11%)
		coiled coil	1019..1030	CDD:293879	3/20 (15%)
		Myo5c_CBD	1376..1743	CDD:271260	131/380 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	771	1.000	Domainoid score	I79
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1251	1.000	Inparanoid score	I161
OMA	1	1.010	-	-		QHG52542
OrthoDB	1	1.010	-	-		D311886at2759
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		otm45187
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	1	1.100	-	-	O	PTHR13140
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X244
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.980