DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment didum and Myo1f

DIOPT Version :9

Sequence 1:	NP_724569.1	Gene:	didum / 35680	FlyBaseID:	FBgn0261397	Length:	1800	Species:	Drosophila melanogaster
Sequence 2:	NP_001101546.1	Gene:	Myo1f / 314654	RGDID:	1309750	Length:	1098	Species:	Rattus norvegicus

Alignment Length:	962	Identity:	310/962 - (32%)
Similarity:	498/962 - (51%)	Gaps:	157/962 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 GQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGD 135
            |.:|:..|..:.|..::.|||.||.: ..|:||.|.:|:::||:.:||.:....|..|:|.|..:
  Rat    18 GVDDMVLLPQITEDAIVSNLRKRFMD-DYIFTYIGSVLISVNPFKQMPYFTDREIDLYQGAAQYE 81

  Fly   136 LEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAV-GGSESETQVERKVLA 199
            ..|||:||.:..|..:..:..|..:|:||||||||||:|||.|.|.:.| ||.:....|:..:|.
  Rat    82 NPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAAKYIMGYISKVSGGGDKVQHVKDIILQ 146

  Fly   200 SSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYH 264
            |:|::||||||||.||:|||||||:.::.| ::.|..  .|..:..:||||||||.|.:.|||:|
  Rat   147 SNPLLEAFGNAKTVRNNNSSRFGKYFEIQF-SRGGEP--DGGKISNFLLEKSRVVMQNENERNFH 208

  Fly   265 IFYQLC--AARSKYPELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGF--SIQQIA 325
            |:|||.  |::.:...|.|...|.:.:||.....::|...|...||||:.||.|:|.  |:||:
  Rat   209 IYYQLLEGASQEQQQNLGLMTPDYYYYLNQSDTYKVEGTDDRSDFNETLNAMQVIGIPTSVQQL- 272

  Fly   326 DIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKI 390
             :::::|||||||||...::.|....|    |.|:      |...|.||.:.:..|:..|..||:
  Rat   273 -VLQLVAGILHLGNISFCEEGNYARVE----SVDL------LAFPAYLLGIDSGRLQEKLTSRKM 326

  Fly   391 ESV----NEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIYGF 451
            :|.    :|.:.:..::|.|...||||||.:||:||.::|..:|:::....::.| |||||||||
  Rat   327 DSKWGGRSESIDVTLNVEQAAYTRDALAKGLYARLFDFLVEAINRAMQKPQEEYS-IGVLDIYGF 390

  Fly   452 ETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIESRL--- 513
            |.|:.|.|||||||:.||||||.|.:...|.|||||::|||.||.|::::|:...||||::|
  Rat   391 EIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIEYFNNKIVCDLIENKLNPP 455

  Fly   514 GVLDLLDEECRMPK----GSDESWAGKLIGKCNKFPHFEKPRFGTTSFFIKHFSDTVEYDVNGFL 574
            |::.:||:.|....    |:|::...||........||..   .:..|.|.|::..|.|||:||.
  Rat   456 GIMSVLDDVCATMHATGGGADQTLLQKLQAAVGTHEHFNS---WSAGFVIHHYAGKVSYDVSGFC 517

  Fly   575 EKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVD-SAKSSTLGGRVVISAGRKQQGNDTRR 638
            |:|||.:..:|.:::..|:.:..:.:.. |::|   || ..:.||.|.::      |:|.||
  Rat   518 ERNRDVLFSDLIELMQSSDQAFLRMLFP-EKLD---VDKKGRPSTAGSKI------KKQAND--- 569

  Fly   639 RVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLE 703
                                  |:|||...||||:||||||:.|....||.:::..|:...|:.|
  Rat   570 ----------------------LVSTLKKCTPHYIRCIKPNETKRPRDWEESRVKHQVEYLGLRE 612

  Fly   704 TVRISAAGFPSRWLYPDFYMRYQLLVYRS-KLDKNDMKLSCRNIVMKWIQDEDKYRFGNTQIFFR 767
            .:|:..|||..|..:..|..||.:|...: ...:.|.:...::::.....:.|:|:.|:|::|.:
  Rat   613 NIRVRRAGFAYRRQFSKFLQRYAILTPETWPRWRGDERQGVQHLLRAVNMEPDQYQMGSTKVFVK 677

  Fly   768 AGQVAF-LEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREA 831
            ..:..| ||::|.              |:|   ..|.|.      |||..|.::|..:.::|||.
  Rat   678 NPESLFLLEEMRE--------------RKF---DGFART------IQKAWRRHIAVRKYEEMREE 719

  Fly   832 RAGLILSKYARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARR 896
            .:.::|:|..          |.|:||:           ||                ||...|...
  Rat   720 ASNILLNKKE----------RRRNSIN-----------RN----------------FVGDYLGLE 747

  Fly   897 AYQKRRRNIIICQAAIRRFLARRKFKRMKAEAKTISHMENKYMGLENKIISMQQRIDELNRDNSN 961
            .           :..:|:|||:|  :|:.. |.:::..:.::..::..:|...:.:..:.|:...
  Rat   748 E-----------RPELRQFLAKR--ERVDF-ADSVTKYDRRFKPIKRDLILTPKCVYVIGREKVK 798

  Fly   962 LKHKTSEI-SVLKMKLELKKTLEAEFKNVKAACQDKDKLI---EALNKQLEA 1009
            ...:...: .|||.|||::     ..:.|..:.:..|..|   ||.:..||:
  Rat   799 KGPEKGLVREVLKKKLEIQ-----ALRGVSLSTRQDDFFILQEEAADSFLES 845

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc	65..778	CDD:214580	264/725 (36%)
		MYSc_Myo5	84..767	CDD:276831	257/700 (37%)
		IQ	900..922	CDD:197470	5/21 (24%)
		GBP_C	<971..1086	CDD:303769	13/42 (31%)
		coiled coil	1049..1068	CDD:293879
		coiled coil	1077..1086	CDD:293879
		JAKMIP_CC3	<1190..1299	CDD:292653
		Myo5_CBD	1424..1792	CDD:271254
Myo1f	NP_001101546.1	MYSc	12..690	CDD:214580	264/726 (36%)
		MYSc_Myo1	31..677	CDD:276829	257/700 (37%)
		Myosin_TH1	717..899	CDD:283635	35/185 (19%)
		SH3_MyoIe_If_like	1045..1097	CDD:212761
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910