DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment didum and Myo10

DIOPT Version :10

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:NP_001388751.1 Gene:Myo10 / 310178 RGDID:1307193 Length:2060 Species:Rattus norvegicus


Alignment Length:1877 Identity:490/1877 - (26%)
Similarity:805/1877 - (42%) Gaps:445/1877 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 EMLYAQGAKIWVPHADLVWESATLEESYRKGAGFLKIC--------TDSGKLKEVKLKADGSDLP 61
            :..:.:||::|            |.|:.:.....:..|        ||.|::...|.....:...
  Rat     2 DSFFPEGARVW------------LRENGQHFPSTVNSCAEGVVVFQTDYGQVFTYKQSTITNQKV 54

  Fly    62 PLRNPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMP-LYGPSII 125
            ...:|....|.:|:.:|:.||...:::||..|: :|..||||.|.|:.::|||..:. ||..:.:
  Rat    55 TAMHPLHEEGVDDMASLTELHGGSIMYNLFQRY-KRNQIYTYIGSIIASVNPYQPIAGLYERATM 118

  Fly   126 RAYRGHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGG---- 186
            ..|....:|:|.|||||:|.|.|..|.:.:.|..:::|||||||||.|.|..:::.:.:..    
  Rat   119 EQYSRCHLGELPPHIFAIANECYRCLWKRHDNQCVLISGESGAGKTESTKLILKFLSVISQHSLD 183

  Fly   187 ---SESETQVERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLL 248
               .|..:.||:.:|.|||||||||||||..|:||||||||.:|....:..:   ||..:..|||
  Rat   184 LCLQEKSSSVEQAILQSSPIMEAFGNAKTVYNNNSSRFGKFVQLNICQKGNI---QGGRIVDYLL 245

  Fly   249 EKSRVVYQAQGERNYHIFYQLCAA--RSKYPELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETV 311
            ||:|||.|..|||||||||.|.|.  :.:..|..|...:.:.:||..|..|.:.:||.|.|.:.:
  Rat   246 EKNRVVRQNPGERNYHIFYALLAGLDQGEREEFYLSLPENYHYLNQSGCTEDKTISDQESFRQVI 310

  Fly   312 QAMTVLGFSIQQIADIVKILAGILHLGNI--------QVSKKFNEGSEEEDSDSCDIFHNDIHLQ 368
            :||.|:.||.:::.:::::||||||||||        |:|.|...|.                  
  Rat   311 EAMEVMQFSKEEVREVLRLLAGILHLGNIEFITAGGAQISFKTALGR------------------ 357

  Fly   369 ITADLLRVSADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSL 433
             :|:||.:....|...|..|.:....|.:|.|.|::.|..:||:||..:||:.|::::..:|..:
  Rat   358 -SAELLGLDPTQLTDALTQRSMFLRGEEILTPLSVQQAVDSRDSLAMALYARCFEWVIKKINSRI 421

  Fly   434 NNGSKQCSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMID 498
             .|......||:|||:|||.||||.||||.|||||||||:.||:|:|.|||.||.:||:.|..||
  Rat   422 -KGKDDFKSIGILDIFGFENFEVNHFEQFNINYANEKLQEYFNKHIFSLEQLEYSREGLVWEDID 485

  Fly   499 FYDNQPCIDLIESRLGVLDLLDEECRMPKGSDESWAGKLIGKCNKFPHFEKPRFGTTSFFIKHFS 563
            :.||..|:||||.:||:|.|::||...|:.:|.:...||..:......:.|||....:|.:||::
  Rat   486 WIDNGECLDLIEKKLGLLALINEESHFPQATDSTLLEKLHNQHANNHFYVKPRVAVNNFGVKHYA 550

  Fly   564 DTVEYDVNGFLEKNRDTVSKELTQVLSESNM----SLAKQVMTLEEIDTL-CVDSAKSSTLGGRV 623
            ..|:|||.|.|||||||...:|..:|.||..    .|.:.:.:....||| |             
  Rat   551 GEVQYDVRGILEKNRDTFRDDLLNLLRESRFDFIYDLFEHISSRNNQDTLKC------------- 602

  Fly   624 VISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWE 688
                              .||..|.||.|||::||.||::||.::.|.:|||||||..|:..:::
  Rat   603 ------------------GSKHRRPTVSSQFKDSLHSLMATLSSSNPFFVRCIKPNTQKMPDQFD 649

  Fly   689 TAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKNDMKLSCRNIVMKWIQD 753
            .|.::.|||..|:||||||..||:..|..:.|||.||::|: |......|::..|..::..:...
  Rat   650 QAVVLNQLRYSGMLETVRIRKAGYAVRRPFQDFYKRYKVLM-RDLALPEDIRGKCTVLLQFYDAS 713

  Fly   754 EDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARG 818
            ..:::.|.|::|.|..    |||.....|::.|.....|:|                   .|..|
  Rat   714 NSEWQLGKTKVFLRES----LEQKLEKRREEEIDRAAMVIR-------------------AHILG 755

  Fly   819 YLARERTQKMREARAGLI-LSKYARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRA 882
            ||||   ::.|:...|:: :.|..|.:|.|:|:|.|:.:....|...||.|||..:..:....|.
  Rat   756 YLAR---KQYRKVLCGVVTIQKNYRAFLARKRFLHLKKAAIVFQKQLRGRLARKVYRQLLAEKRE 817

  Fly   883 VQIQRFVRGALARRAYQKRRRNIIICQAAIRRFLARRKFKRMKA--EAKTISHMENKYMGLENKI 945
            ::.::.:.....|...::.|:.            |:|:...::|  ||:|     .|...||  .
  Rat   818 LEERKRLEEEKKREEEERERKR------------AQREADLLRAQQEAET-----RKQQELE--A 863

  Fly   946 ISMQQRIDELNRDNSNLKHKTSEISVLKMKLELKKTLEAEFKNVKAACQDKDKLIEALNKQLEAE 1010
            :...||..:|.|:....:.......:|:::.|::     :.:.:|.  |.:..|.||..::|:..
  Rat   864 LQKNQREADLTRELEKQRENKQVEEILRLEKEIE-----DLQRMKE--QQELSLTEASLQKLQQL 921

  Fly  1011 RDEKMQLLEENG-HAQEEWISQKQTWRQENEELRRQID-----------EIIDMAKNAEVNQRN- 1062
            |||:::.||:.. .|.:|::.....  .|.:|..|.|:           |:.::|:||...:.| 
  Rat   922 RDEELRRLEDEACRAAQEFLESLNF--DEIDECVRNIERSLSVGSEISGELSELAENASGEKPNF 984

  Fly  1063 --QEDRMLAEIDNRELNEAYQRAIKDK--------------------EVIENENFMLKEEL-SRL 1104
              .:.....|:|  |..||...|.||.                    :..|.:.:|....: :..
  Rat   985 NFSQPYPEEEVD--EGFEADDDAFKDSPNPSEHGHSDQRTSGIRTSDDSSEEDPYMNYTVVPTSP 1047

  Fly  1105 TAGSFSLHARKASNASSQNEDDVG---YASAKNTLDINRPPDLLSKNYSYND---------STSL 1157
            :|.|..|.|....:::|.:....|   |...:|..|:..|    ..:|.|:.         |.|.
  Rat  1048 SADSTVLLAASVQDSASLHNSSSGESTYCMPQNNGDLPSP----DGDYDYDQDDYEDGAITSGSS 1108

  Fly  1158 VVKLRSILEEEKQKHKVLQEQY-----IKLSSRHKPTEDSFRVSELEVE-----NEKLRSEYDQL 1212
            |....|...:....::.....|     .:.||  :..:.||..||.:.:     :::|....|.:
  Rat  1109 VTFSNSYGSQWSPDYRYSVGTYNSSGAYRFSS--EGAQSSFEDSEEDFDSRFDTDDELSYRRDSV 1171

  Fly  1213 RTSI-----------KHGVEINELNAQHAALQEEV---RRRREECI------------------- 1244
            .:.:           |.|: :|....:...|::|.   .|.::|.:                   
  Rat  1172 YSCVTLPYFHSFLYMKGGL-MNSWKRRWCVLKDETFLWFRSKQEALKQGWLHKKGGGSSTLSRRN 1235

  Fly  1245 -QLKAVLLQQSQSMRSLEPESLQMRG-----------------NDVNELM--EAFHSQKLINRQL 1289
             :.:..:|:||:.|........:::|                 |.::.:|  ..||   ||....
  Rat  1236 WKKRWFVLRQSKLMYFENDSEEKLKGTVEVRSAKEIIDNTNKENGIDIIMADRTFH---LIAESP 1297

  Fly  1290 ESE---LKAITEEHNSKLVEMTQEIERLNNEKDELQKVMFESIDEFEDSNVDTLRQNDRYLRREL 1351
            |..   ...:::.|:|    ..|||..:::|:...|    .::...:...:|::..:|...|.. 
  Rat  1298 EDASQWFSVLSQVHSS----TDQEIREMHDEQANPQ----NAVGTLDVGLIDSVCASDSPDRPN- 1353

  Fly  1352 QKAVAQFLLVQEELKLANAKLKAYRQDGGQLEHKIEEEMIRNKSNGTSADVGAN------VTKQK 1410
                 .|:::     .||..|........::.|.|   .:..:|.|.:...|..      :.|:.
  Rat  1354 -----SFVII-----TANRVLHCNADTPEEMHHWI---TLLQRSKGDTRVEGQEFIVRGWLHKEV 1405

  Fly  1411 SQNPQ----------------GLMKFHSSDLDK------ILQRLLSALTPRTVVGLLPGFPAYLI 1453
            ..:|:                .|..:.||:.:.      :|..|.|.:.|...:....|:....:
  Rat  1406 KNSPKMSSLKLKKRWFVLTHNSLDYYKSSEKNALKLGTLVLNSLCSVVPPDEKIFKETGYWNVTV 1470

  Fly  1454 F---MCIR-YTDLTNAD-------------------------DDVRE--LLSKFVIQIKK----M 1483
            :   .|.| ||.|.|..                         .|::|  |.|..|.||.|    :
  Rat  1471 YGRKHCYRLYTKLLNEATRWSSAIQNVTDTKAPIDTPTQQLIQDIKENCLNSDVVEQIYKRNPIL 1535

  Fly  1484 HRTPHPIENRVIWLVNSITLLNLMKQYGDVDEYVKFNTEKQNQQQLKNFNLFEYR--RVILDLIV 1546
            ..|.||:.:.::.|           .|||:                 |.||.:.:  ..:.|..:
  Rat  1536 RYTHHPLHSPLLPL-----------PYGDI-----------------NLNLLKDKGYTTLQDEAI 1572

  Fly  1547 NLYQALIMQIQGLLDP-KIVPAILNNDEIQRGRQAHGMRSRATSIGASSSPEHGGGPAWKQLIGQ 1610
            .::.:| .|::.:.|| .|:..||     |.|   |.:|                 |...:|..|
  Rat  1573 KIFNSL-QQLESMSDPIPIIQGIL-----QTG---HDLR-----------------PLRDELYCQ 1611

  Fly  1611 LEHFYKQFQHFG-LDNCYAEQIFHQLLYFICAVALNCLML--RGDICMWETGMIIRY 1664
            |.....:..|.| :.|.|:.||.         ..|:|..|  ||         |::|
  Rat  1612 LIKQTNKVPHPGSVGNLYSWQIL---------TCLSCTFLPSRG---------ILKY 1650

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc_Myo5 84..767 CDD:276831 269/705 (38%)
IQ 900..922 CDD:197470 3/21 (14%)
SMC_prok_B <942..1365 CDD:274008 94/536 (18%)
Myo5_CBD 1424..1792 CDD:271254 58/288 (20%)
Myo10NP_001388751.1 SH3_19 7..58 CDD:465815 10/62 (16%)
MYSc_Myo10 77..727 CDD:276840 269/705 (38%)
Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782 619..641 12/21 (57%)
PTZ00121 <726..1035 CDD:173412 78/364 (21%)
SAH. /evidence=ECO:0000250|UniProtKB:Q9HD67 814..882 16/86 (19%)
Smc <840..>981 CDD:440809 36/156 (23%)
MYO10_CC 882..932 CDD:465249 13/56 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 971..1039 13/69 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1064..1088 6/27 (22%)
PH-like 1183..>1225 CDD:473070 7/42 (17%)
PH2_MyoX 1217..1318 CDD:270108 15/107 (14%)
PH3_MyoX-like 1383..1508 CDD:270109 19/124 (15%)
MyTH4 1551..1697 CDD:214535 35/161 (22%)
FERM_F1_Myosin-X 1699..1794 CDD:340726
B41 1706..1960 CDD:214604
FERM_C_MyoX 1956..2044 CDD:270023
Blue background indicates that the domain is not in the aligned region.

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