DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment didum and Myh14

DIOPT Version :9

Sequence 1:	NP_724569.1	Gene:	didum / 35680	FlyBaseID:	FBgn0261397	Length:	1800	Species:	Drosophila melanogaster
Sequence 2:	XP_038967907.1	Gene:	Myh14 / 308572	RGDID:	1306821	Length:	2041	Species:	Rattus norvegicus

Alignment Length:	1688	Identity:	472/1688 - (27%)
Similarity:	768/1688 - (45%)	Gaps:	373/1688 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 IWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLR------NPAILVGQ 72
            :|||.....:|:|.|.:...:.|             ||:|...|..|...|      ||......
  Rat    52 VWVPSELHGFEAAALRDEGEEEA-------------EVELAESGRRLRLPRDQIQRMNPPKFSKA 103

  Fly    73 NDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLE 137
            .|:..|:.|:|..||||||.|:.. .:||||.|:..|.||||.::|:|..:|:..|||....::.
  Rat   104 EDMAELTCLNEASVLHNLRERYYS-GLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVP 167

  Fly   138 PHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSE-------------- 188
            |||:|:.|.||..:.::..:.||:.:||||||||.:.|..::|.|.|..|.
  Rat   168 PHIYAVTEGAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSPKGRKEPGVPASVST 232

  Fly   189 -SETQVERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSR 252
             |..::||::|.::||:||||||||.:||||||||||.::.| :..|  ::.||.:.||||||||
  Rat   233 MSYGELERQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINF-DIAG--YIVGANIETYLLEKSR 294

  Fly   253 VVYQAQGERNYHIFYQLC--AARSKYPELVLDHQDKFQFLNMG--GAPEIERVSDAEQFNETVQA 313
            .:.||:.|.::||||||.  |......:|:|:....::||..|  .:|..||    |.|.||:::
  Rat   295 AIRQAKDECSFHIFYQLLGGAGEQLKADLLLEPYSHYRFLTNGPSSSPGQER----ELFQETLES 355

  Fly   314 MTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSA 378
            :.|||...::|..:::.::.:|..|||.:.|       |.::|...:..|.. .|....||.:..
  Rat   356 LRVLGLLPEEITAMLRTVSAVLQFGNIVLKK-------ERNTDQATMPDNTA-AQKLCRLLGLGV 412

  Fly   379 DDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQ-CSF 442
            .|..|.||..:|:...:||....:.|.|..|.:||||..|.:||:::|..||::|:...:| .||
  Rat   413 TDFSRALLTPRIKVGRDYVQKAQTKEQADFALEALAKATYERLFRWLVLRLNRALDRSPRQGASF 477

  Fly   443 IGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDF-YDNQPCI 506
            :|:|||.|||.|::|||||.||||.||||||.||..:|.||||||.:|||.||.:|| .|.||||
  Rat   478 LGILDIAGFEIFQLNSFEQLCINYTNEKLQQLFNHTMFVLEQEEYQREGIPWTFLDFGLDLQPCI 542

  Fly   507 DLIE---SRLGVLDLLDEECRMPKGSDESWAGKLIGKCNKFPHFEKPR--FGTTSFFIKHFSDTV 566
            ||||   :..|:|.||||||..||.:|:|:..|:..:....|.|::||  .....|.:.|::..|
  Rat   543 DLIERPANPPGLLALLDEECWFPKATDKSFVEKVAQEQGSHPKFQRPRNLRDQADFSVLHYAGKV 607

  Fly   567 EYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEE-------------------------- 605
            :|..|.:|.||.|.::..:..:|.:|...|..::...|:
  Rat   608 DYKANEWLMKNMDPLNDNVAALLHQSTDRLTAEIWKDEQGGLQQFTFLGSFPSPSPGPAGGLSSG 672

  Fly   606 -----IDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLASLISTL 665
                 :.:||..:.: ..:|...|.|.|....|...||.:.      :|||..::|||:.|::||
  Rat   673 ASPPGLGSLCAPTVE-GIVGLEQVSSLGDGPPGGRPRRGMF------RTVGQLYKESLSRLMATL 730

  Fly   666 HATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVY 730
            ..|.|.:||||.||.:|.|.|.|...::.|||..||||.:||...|||:|.|:.:|..||::|.
  Rat   731 SNTNPSFVRCIVPNHEKRAGKLEPRLVLDQLRCNGVLEGIRICRQGFPNRILFQEFRQRYEILT- 794

  Fly   731 RSKLDKN--DMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVV 793
            .:.:.|.  |.|.:|..::.....|.:.||.|.::||||||.:|.||:.|.
  Rat   795 PNAIPKGFMDGKQACEKMIQALELDPNLYRVGQSKIFFRAGVLAQLEEERD-------------- 845

  Fly   794 RRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAGL-ILSKYARGWLCRR--RYLRLRH 855
                     |::..:|...|..|||||||...|:.::.::.| ::.:....:|..|  ::.||..
  Rat   846 ---------LKVTDIIVSFQAAARGYLARRAFQRRQQQQSALRVMQRNCAAYLKLRNWQWWRLFI 901

  Fly   856 SISGIQTYARGMLARNKFHAMRDHY---RAVQIQRFVRGALARRAYQKRRRNIIICQAAIRRFLA 917
            .:..:....|           :|..   ||.::|:      .:...|:..|.:...|..:.:...
  Rat   902 KVKPLLQVTR-----------QDEVLQARAQELQK------VQELQQQSAREVGELQGRVAQLEE 949

  Fly   918 RRK--FKRMKAEAKTISHMEN-------KYMGLENKIISMQQRIDE-------LNRDNSNLKHKT 966
            .|.  .::::|||:..|..|.       :...||..:..::.|:.|       |..:...|:...
  Rat   950 ERARLAEQLRAEAELCSEAEETRARLAARKQELELVVTELEARVGEEEECSRQLQSEKKRLQQHI 1014

  Fly   967 SEISV-------LKMKLELKK-TLEAEFKNVK---AACQDKDKLIEALNKQLE----------AE 1010
            .|:..       .:.||:|:| |.||:.|..:   ...:|::..:....:.||          ||
  Rat  1015 QELETHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERRLLEERLAEFSSQAAE 1079

  Fly  1011 RDEKMQLL-------EENGHAQEEWISQKQTWRQENEELRRQIDEIIDMAKNAEVNQRNQEDRML 1068
            .:||::.|       |......|:.:.:::..|||.|:|:|::|......:...:.|:.:.:.:|
  Rat  1080 EEEKVKSLNKLRVKYEATIADMEDRLKKEEKGRQELEKLKRRLDGESSELQEQMMEQKQRAEELL 1144

  Fly  1069 AEIDNR--ELNEAYQRAIKD----KEVIENENFMLKEELSRLTAGSFSLHARKASNASSQNE-DD 1126
            .::..:  ||..|..||.::    .:::::    |:|..:.|......|.|.:.:.|.::.: .|
  Rat  1145 IQLGRKEEELQSALVRAEEEGGARAQLLKS----LREAQAGLAEAQEDLEAERVARAKAEKQRRD 1205

  Fly  1127 VG------YASAKNTLD-INRPPDLLSKNYSYNDSTSLVVKLRSILEEEKQKHKV-LQE------ 1177
            :|      ....::||| .|...:|.||.      ...|.:|:..||||.:.|:| :||
  Rat  1206 LGEELEALRGELEDTLDSTNAQQELRSKR------EQEVTELKKTLEEEARTHEVAMQELRQRHS 1264

  Fly  1178 -------QYIKLSSRHKPTEDSFRVSELEVENEKLRSEYDQLRTSIKHG--------VEINELNA 1227
                   :.::.:.|.|...:..|:| ||.|..:|::|...|:||.:.|        .::.|:..
  Rat  1265 QALVELTEQLEQARRGKSVWEKTRLS-LEAEVSELKTELSSLQTSRQEGEQKRRRLESQLQEVQG 1328

  Fly  1228 Q-------HAALQEEVRRRREECIQLKAVLLQ-QSQSMR-SLEPESLQMRGNDVNELMEAFHSQK 1283
            :       .|...|:::|.:.|...:...|.: :|:::| |.|..|.:.:.:|..||::.....|
  Rat  1329 RSSDSERARAEAAEKLQRAQVELESVSTALSEAESKAIRLSKELSSAESQLHDTQELLQEETRAK 1393

  Fly  1284 LI----NRQLESELKAITEEHN------------------------------------------- 1301
            |.    .|.||:|...:.|:..
  Rat  1394 LALGSRVRALEAEAAGLREQMEEEVVARERAGRELQTTQAQLSEWRRRQEEEAAVLEAGEEARRR 1458

  Fly  1302 ---------SKLVEMTQEIERLNNEKDELQKVMFESIDEFEDSNVD---------TL----RQND 1344
                     .:|.|.|:.:|||...:..||:       |.:|:.||         ||    |:.|
  Rat  1459 AAREAETLAQRLAEKTEAVERLERARRRLQQ-------ELDDATVDLGQQKQLLSTLEKKQRKFD 1516

  Fly  1345 RYLRRE---------------------------LQKAVAQFLLVQEELKLANAKLKA-------Y 1375
            :.|..|                           |.:|:.:....:|||:..|..|:|       .
  Rat  1517 QLLAEEKAAVLRAVEDRERVEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSS 1581

  Fly  1376 RQDGGQLEHKIEEEMIRNKSNGTSADVGANVTKQKSQ-------------NPQGLMKFHSSDL 1425
            :.|.|:..|::|.  .|..:...::|:...||:.:.:             ..|.|...|..||
  Rat  1582 KDDVGKNVHELER--ARRVAEQAASDLRTQVTELEDELTAAEDAKLRLEVTVQALKAQHERDL 1642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc	65..778	CDD:214580	291/771 (38%)
		MYSc_Myo5	84..767	CDD:276831	278/741 (38%)
		IQ	900..922	CDD:197470	3/23 (13%)
		GBP_C	<971..1086	CDD:303769	32/144 (22%)
		coiled coil	1049..1068	CDD:293879	1/18 (6%)
		coiled coil	1077..1086	CDD:293879	3/8 (38%)
		JAKMIP_CC3	<1190..1299	CDD:292653	31/129 (24%)
		Myo5_CBD	1424..1792	CDD:271254	2/2 (100%)
Myh14	XP_038967907.1	Motor_domain	115..833	CDD:419868	278/741 (38%)
Myh14	XP_038967907.1	Myosin_tail_1	910..1990	CDD:396244	151/770 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000