Protein Alignment didum and myh7

DIOPT Version :10

• Sequence 1: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Sequence 2: NP_001106204.1
• Gene: myh7 / 30616
• ZFINID: ZDB-GENE-991123-5
• Length: 1938
• Species: Danio rerio
• Alignment Length: 2058
• Identity: 542/2058 - (26%)
• Similarity: 927/2058 - (45%)
• Gaps: 441/2058 - (21%)

  Fly     2 SSEEMLYAQ------GAKIWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDL 60
            |..|.|.||      ..:.:||..|..:..|::..  |:|.   |:...:.|.|.|.:|.  :|:
Zfish    19 SDRERLEAQTRPFDMKKECFVPDPDEEYVKASIVS--REGD---KVTVQTEKRKTVTVKE--ADI 76

  Fly    61 PPLRNPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSII 125
            .| :||.......|:...::||||.||.||:.|:. ..:||||.|:..|.:|||..:|:|...::
Zfish    77 HP-QNPPKFDKIEDMAMFTFLHEPAVLFNLKERYA-AWMIYTYSGLFCVTVNPYKWLPVYNQEVV 139

  Fly   126 RAYRGHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFA--AVGGSE 188
            .||||....:..||||::::.||..:..:..|.||:::|||||||||:.|..::|||  |.|||.
Zfish   140 VAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFASIAAGGSA 204

  Fly   189 SETQVERK------VLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYL 247
            .:...|:|      ::.::|.:||||||||.|||||||||||.::.| ...|.  |..|.:.|||
Zfish   205 KKEGAEKKGTLEDQIIQANPALEAFGNAKTIRNDNSSRFGKFIRIHF-GASGK--LASADIETYL 266

  Fly   248 LEKSRVVYQAQGERNYHIFYQLCAARSKYPE-----LVLDHQDKFQFLNMGGAPEIERVSDAEQF 307
            ||||||.:|.:.||:||||||:.:.|.  ||     |:.::...:.:::. |...:..::|.|:.
Zfish   267 LEKSRVTFQLKAERDYHIFYQILSQRK--PELLEMLLITNNPYDYAYISQ-GETTVASINDGEEL 328

  Fly   308 NETVQAMTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEE----EDSDSCDIFHNDIHLQ 368
            ..|.:|..||||:.::...|.|::..|:|.||::..:|..|...|    ||.|.
Zfish   329 LATDEAFDVLGFTQEEKNGIYKLIGAIMHFGNMKFKQKQREEQAEADGTEDGDK----------- 382

  Fly   369 ITADLLRVSADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSL 433
             .|.|:.:::.||.:.|...:::..||:|....:::....|..||||.:|.|:|.::|..:|:||
Zfish   383 -VAYLMGLNSADLIKGLCHPRVKVGNEWVTKGQNVQQVYYAIGALAKSVYEKMFLWMVVRINQSL 446

  Fly   434 NNGSKQCSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMID 498
            :....:..|||||||.|||.|:.|:|||.|||:.||||||.||.|:|.||||||.||||.|..||
Zfish   447 DTKQPRQYFIGVLDIAGFEIFDFNTFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFID 511

  Fly   499 F-YDNQPCIDLIESRLGVLDLLDEECRMPKGSDESWAGKL----IGKCNKFPHFEKPRF----GT 554
            | .|.|.||||||..:|::.:|:|||..||.||.::..||    :||.|   :|:|||.    ..
Zfish   512 FGMDLQACIDLIEKPMGIMSILEEECMFPKASDSTFKAKLYDNHLGKSN---NFQKPRAIKGKPE 573

  Fly   555 TSFFIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTL 619
            :.|.:.|::.||:|::|.:|.||:|.:::.:..:..:|.:.|         :..|..:.|.:.:.
Zfish   574 SHFSLVHYAGTVDYNINNWLVKNKDPLNETVVGLFQKSTVKL---------LSMLFANYAGTESD 629

  Fly   620 GGRVVISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVA 684
            .|:.....|.|::|:..           :||.:..:|:|..|::.|.:|.||:||||.||:.|..
Zfish   630 NGKGGKGGGSKKKGSSF-----------QTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKTP 683

  Fly   685 FKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKN----------DM 739
            ...|...::.|||..||||.:||...|||:|.||.||..||::|        |          |.
Zfish   684 GAMENPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRIL--------NPAAIPEGQFIDS 740

  Fly   740 KLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLR 804
            :.....::.....|.::|:||:|::||:||.:..||::|.:                       |
Zfish   741 RKGAEKLLGSLDIDHNQYKFGHTKVFFKAGLLGQLEEMRDD-----------------------R 782

  Fly   805 IQKVINGIQKHARGYLARERTQKMREARAGLILSKY-------ARGWLCRRRYLRLRHSISGIQT 862
            :..:|:|||..:||.|||...||:.|.|..|::.::       .:.|...:.:.:::..:...:
Zfish   783 LSLIISGIQARSRGLLARVEFQKIVERRDALLVIQWNVRAFMGVKNWPWMKLFFKIKPLLKSAE- 846

  Fly   863 YARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAYQKRRRNIIICQAAIRRFLARRKFKRMKAE 927
                  |..:...|:|.:           |..:.||.|..              ||||    :.|
Zfish   847 ------AEKEMANMKDEF-----------AKLKEAYAKSE--------------ARRK----ELE 876

  Fly   928 AKTISHMENK------YMGLENKIISMQQRIDELNRDNSNLKHK--------------TSEISVL 972
            .|.:|.::.|      ....::.:...::|.|:|.::...|:.|              .:|::..
Zfish   877 EKMVSLLQEKNDLQLQVQAEQDNLCDAEERCDQLIKNKIQLEAKAKELTERLEDEEEMNAELTAK 941

  Fly   973 KMKL-----ELKKTLE------AEFKNVKAACQDK-----------DKLIEALNKQLEAERDEKM 1015
            |.||     ||||.::      |:.:..|.|.::|           |.:|..|.|:.:|.::...
Zfish   942 KRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAALDDIIAKLTKEKKALQEAHQ 1006

  Fly  1016 QLLEENGHAQEEWISQKQTWRQENEELRRQIDEI---IDMAKNAEVN------------QRNQED 1065
            |.|::. .::|:.::   |..:...:|.:|:|::   ::..|...::            :..||.
Zfish  1007 QTLDDL-QSEEDKVN---TLTKAKAKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLTQES 1067

  Fly  1066 RMLAEIDNRELNEAYQRAIKDKEV------IENENFM-------LKEELSRLTAGSFSLHARKAS 1117
            .|..|.|.::|.|..::  ||.|:      ||:|..:       |||..:|:......|.|.:|:
Zfish  1068 LMDLENDKQQLEERLKK--KDFEISQLNGKIEDEQTICIQLQKKLKELQARIEELEEELEAERAA 1130

  Fly  1118 NAS---------------SQNEDDVGYASAKNTLDINRPPDLLSKNYSYNDSTSLVVKLRSILEE 1167
            .|.               |:..::.|.|:|.. :::|:..:            :...|||..|||
Zfish  1131 RAKVEKQRADLARELEEISERLEEAGGATAAQ-IEMNKKRE------------AEFQKLRRDLEE 1182

  Fly  1168 EKQKHK-----VLQEQYIKLSSRHKPTEDSFRVSE-LEVENEKLRSEYDQLRTSIKHGVEIN-EL 1225
            ...:|:     :.::|...::...:..::..||.: ||.|..:||.|.|.:.::::|.|:.. .|
Zfish  1183 ATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELRLELDDVVSNMEHVVKTKANL 1247

  Fly  1226 NAQHAALQE---EVRRRREE---CIQLKAVLLQQSQSMRSLEPESLQMRGNDVNELMEA--FHSQ 1282
            .....:|::   |.:.:.||   ||....:...:.||........|:.:.:.|::|..:  .::|
Zfish  1248 EKMTRSLEDQMNEYKTKYEEGQRCINDFTMQKSKLQSENGELSRQLEEKDSLVSQLTRSKMSYTQ 1312

  Fly  1283 KL--INRQLESELKA--------ITEEHNSKLVEMTQEIERLNNEKDELQKVMFESIDEFED--- 1334
            ::  :.||||.|.||        .:..|::.|  :.::.|.....|.|||:.|.::..|...
Zfish  1313 QIEDLKRQLEEETKAKSALAHAVQSARHDTDL--LREQYEEEQEAKAELQRGMSKANSEVAQWRT 1375

  Fly  1335 -SNVDTLRQNDRYLRRELQKAVAQFLLVQEE-LKLANAKLKAYRQDGGQLEHKIEEEMI-RNKSN 1396
             ...|.:::.:..  .|.:|.:||.|...|| ::..|||..:..:...:|:::||:.|: ..:||
Zfish  1376 KYETDAIQRTEEL--EEAKKKLAQRLQETEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDLERSN 1438

  Fly  1397 GTSA---------DVGANVTKQKSQNPQGLMKFH-------SSDLDKILQRLLSALTPRTVVGLL 1445
            ..:|         |...:..|||.:..|..::..       |::|.|:......||.
Zfish  1439 AAAAALDKKQRNFDKVLSEWKQKFEESQAELESSQKEARCLSTELFKLKNSYEEALD-------- 1495

  Fly  1446 PGFPAYLIFMCIRYTDLTNADDDVRELL---SKFVIQIKKMHRTPHPIENRVIWLVNSI------ 1501
                 :|..|.....:|.....|:.|.|   .|.:.:::||.:   .:|.....:.:::
Zfish  1496 -----HLETMKRENKNLQEEISDLTEQLGEGGKSIHELEKMRK---QLEQEKSEIQSALEEAEAS 1552

  Fly  1502 ------TLLNLMKQYGDVDEYVKFN-TEKQNQQQLKNFNLFEYRRVILDLIVNLYQALIMQIQGL 1559
                  .:|....::..:...::.. .||..:.:....||   :|.|..|..:|......:.:.|
Zfish  1553 LEHEEGKILRAQLEFSQIKADIERKLAEKDEEMEQSKRNL---QRTIDTLQSSLESETRSRNEAL 1614

  Fly  1560 LDPKIVPAILNNDEI---QRGRQAHGMRSRATSIGA----------------------SSSPEHG 1599
            ...|.:...||..||   |..|||...:.:..|:.|                      ::..|..
Zfish  1615 RIKKKMEGDLNEMEIQLSQANRQAAEAQKQLKSVHAHMKDAQLQLDDSLRTNEDLKENTAIVERR 1679

  Fly  1600 GGPAWKQL------IGQLEHFYKQFQHFGLDNCYAEQIFHQLLYFICAVALN-CLMLRGDICMWE 1657
            ......:|      :.|.|...|..:...||.  :|::  |||:......|| ...|..||...:
Zfish  1680 NNLLQAELEELRAALEQTERGRKLAEQELLDT--SERV--QLLHSQNTSLLNQKKKLETDISQLQ 1740

  Fly  1658 TGMIIRYNIGCIEDWVRSKKMSNDVLTALAPLNQVSQLLQSRKSEQDV------------QTICD 1710
            |.         :|:.|:..:.:.:  .|...:...:.:.:..|.|||.            |||.|
Zfish  1741 TE---------VEEAVQECRNAEE--KAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKD 1794

  Fly  1711 LCTSLSTAQVLKVMKSYK---------LDDYESEITNVFLEKLTEKLNARQMQKSNSDEFTIDQK 1766
            |...|..|:.: .||..|         :.:.|||:.:. .:|.:|.:...:..:....|.|...:
Zfish  1795 LQHRLDEAEQI-AMKGGKKQVQKLEARVRELESEVESE-QKKSSEAVKGIRKYERRIKELTYQTE 1857

  Fly  1767 FIQPFKVVFRYSDI--KL-----------EDIELPSHLNLDEF 1796
              :..|.:.|..|:  ||           |:.|..::.||.:|
Zfish  1858 --EDRKNLARLQDLVDKLQLKVKAYKRAAEEAEEQANTNLSKF 1898

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	267/718 (37%)
		IQ	900..922	CDD:197470	5/21 (24%)
		SMC_prok_B	<942..1365	CDD:274008	112/531 (21%)
		Myo5_CBD	1424..1792	CDD:271254	83/449 (18%)
myh7	NP_001106204.1	COG5022	36..1438	CDD:227355	442/1541 (29%)
		MYSc_class_II	99..768	CDD:276951	267/718 (37%)
		SMC_prok_B	1146..>1938	CDD:274008	163/808 (20%)