DRSC/TRiP Functional Genomics Resources

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Protein Alignment didum and Myo18b

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:XP_006249639.1 Gene:Myo18b / 304551 RGDID:1594542 Length:2551 Species:Rattus norvegicus


Alignment Length:1605 Identity:385/1605 - (23%)
Similarity:658/1605 - (40%) Gaps:323/1605 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 EEMLYAQGAKIWVPHADLVWESATL---EESYRKGAGFLKICTDSGK-LKEVKLKADGSDLPPLR 64
            |:..| :..|:|:...|....:..|   |.:....||.:::|.|:.: :.||     ..:.....
  Rat   499 EDRWY-EAQKVWLVQKDRFTLATVLKPDEGTADLPAGRVRLCIDADRTVTEV-----DEEQVHRA 557

  Fly    65 NPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYR 129
            ||:.|....||..|..::|..||:.|..|: :.|:.:|..|..|:|:.|.....   ||..:..|
  Rat   558 NPSELDQAEDLAFLVSVNESSVLNTLLKRY-QAQLPHTCSGPDLIALQPQTTTV---PSSGKVPR 618

  Fly   130 GHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGS-ESETQV 193
            |...| |..|:.:||:.||..|..:..:.||:..|.||||||...:..:.:...:.|| :....|
  Rat   619 GRQDG-LPAHVTSLAQRAYWALLSQRRDQSIVALGRSGAGKTTCCEQVLEHLVGMAGSVDGRVSV 682

  Fly   194 ERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQ 258
            | |:.|:..:::|||...|:.:..::||.....|.| |..|  .:..|.:.:.|||.|||..|.|
  Rat   683 E-KLRATFTVLQAFGCVSTSHSRRATRFAMVMSLDF-NATG--RVTAAQLQSMLLENSRVARQPQ 743

  Fly   259 GERNYHIFYQLCAA-----RSKYPELVLDHQDKFQFLNMG--GAPEIERVSDAEQFNETVQAMTV 316
            ||.|:.:|.||.|.     |:   ||.|....:.....||  ..|| ::...|..|::...||.:
  Rat   744 GEGNFEVFSQLLAGLDVDLRT---ELNLHQMAESSAFGMGLWSKPE-DKQKAATAFSQLRGAMEL 804

  Fly   317 LGFSIQQIADIVKILAGILHLGNIQVSK-------KFNEGSEEEDSDSCDIFHNDI-------HL 367
            ||....:...|.::||.|.|||.....|       :|...:...::..||  :.::       ||
  Rat   805 LGILEGEQRAIWRVLAAIYHLGAAGACKVGRKQFMRFEWANHAAEALGCD--YEELNTATFKHHL 867

  Fly   368 -----QITADLLRVSADDLR--RWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYI 425
                 |:|:...|....|..  ..|.|..:|.|                 :.:|..:|.:||..:
  Rat   868 RQIIEQMTSGPQRQGLQDNEACSGLKMTGVECV-----------------EGMASGLYQELFVAV 915

  Fly   426 VGVLNKSLNNGSKQCSFIGVLDIYGFET------FEVNSFEQFCINYANEKLQQQFNQHVFKLEQ 484
            |.::|:|.::.....:.|.|:|..||:.      ....:||:.|.|||.|:||..|....|....
  Rat   916 VSLINRSFSSQHLSMASIMVVDTPGFQNPRHQGKDRAATFEELCYNYAQERLQLLFYHRTFVSTL 980

  Fly   485 EEYLKEGI----------TWTMIDFYDNQPC-IDL-----IESRLGVLDLLDEECRMPKGSDESW 533
            |.|.:|||          ..|.:...|..|. :.|     ||...|:..:||||.|:...||...
  Rat   981 ERYREEGIPVPFDLPESSPGTTVAVVDQNPSQVHLTAGRGIEDAAGLFWVLDEEVRVEGSSDSVV 1045

  Fly   534 AGKLIGKCNKFPH--FEKPRFG--------------TTSFFIKHFSDTVEYDVNGFLEKNRDTVS 582
            ..:|        |  |||...|              ....|.:...|.|.||:.|:|.:.:..:|
  Rat  1046 LERL--------HAGFEKKASGAEEPPSMRTCEQPLNCELFHQLGRDPVRYDLTGWLRRAKPNLS 1102

  Fly   583 K-ELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQ----GNDTRRRVVP 642
            . |..|:|.:|..         ||:.:|....||...:...|....|..||    |...||....
  Rat  1103 ALEAPQILQQSKR---------EELQSLFQARAKLPPVCLMVAGLEGTSQQALHRGRVVRRAFAS 1158

  Fly   643 S--KQHRKTVGSQFQESLASLISTLHATTPHYVRCI-----------------KPNDDKVAFKWE 688
            |  ...||...:|.:..:.:|||.|..:..|::.|:                 :|..|:......
  Rat  1159 SLAAVKRKAPCAQIKLQMDALISLLRRSQLHFIHCLVPTTVETKAGQGTPTPSQPGGDQGGANEP 1223

  Fly   689 TAKIIQ----QLRACGVLETVRISAAGFPSRWLYPDFYMRYQLL--VYRSKLDKNDMKLSCRNIV 747
            .|..|.    ||....:||.:|:..||:........|..|:|.|  ....:||.....|..|..|
  Rat  1224 PAPDIPALRVQLAGSHILEALRLHRAGYAEHMGLAQFRRRFQALDPALLKRLDLTSEGLDERKAV 1288

  Fly   748 MKWIQDEDKYR----FGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQF--LRIQ 806
            .:.:|..|..:    .|::|:|.:||.|:.||:.|..|..:.|.:.|:..|.|:.|:::  |:|:
  Rat  1289 EELLQTLDLEKKAVAVGHSQVFLKAGVVSRLERQREKLVSRNIVLFQAACRGFLSRQEYKKLKIR 1353

  Fly   807 KVIN-GIQKHAR-----------GYLARER--------TQKMREARAGLILSKYARGWLCRRRYL 851
            ::.. .|||:..           |.||..|        |:::|.....|.        |.|::..
  Rat  1354 RLAALCIQKNLTVFLKVKDWPWWGLLASLRPLLSSTLSTEQLRAKEEELT--------LLRQKLQ 1410

  Fly   852 RLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAYQKRRRNIIICQAAIRRFL 916
            ...:|.|.::..|.  |..:|   :.|....:..:|| :|.:|.:|.:..|         ..|..
  Rat  1411 NSENSRSELRQSAD--LLESK---IADLTSELADERF-KGDVACQALESER---------AERLQ 1460

  Fly   917 ARRKFKRMKAEAKTISHMENKYMGLENKIISMQQRIDELNRDNSNLKHK-TSEISVLKMKLELKK 980
            |.|:.:.:||:.:.:   ::...|::.::...||||     ..:||:.| |......:|:|:..:
  Rat  1461 ALREVQELKAKYQQV---QDALGGVQKQLEEAQQRI-----QTANLEEKPTGGADEWQMRLDCAQ 1517

  Fly   981 TLEAEFKNVKAACQDKDKLIEALNKQLEAERDEKMQLLEENGHAQEEWISQKQTWRQENEELRRQ 1045
             ||.:|..         |.::...::|::|...:.:|.::.|..|..:...|:|..|    |||:
  Rat  1518 -LENDFLR---------KRLQQCEERLDSEMKARTELEQKLGELQSAYEEAKKTAHQ----LRRK 1568

  Fly  1046 IDEIIDMAKNAEVNQRNQEDRMLAEIDNRE----------LNEA-YQRAIKDK------------ 1087
            ...:....::..|...||:.|. .:::.|:          |.|: :::::::|            
  Rat  1569 CHHLTWDLEDTRVLLENQQSRN-HDLEKRQKKFDLQLAQALGESMFEKSLREKVSRENSGVRWEL 1632

  Fly  1088 -------EVIENENFMLKEELSRLTAGSFSLHARKASNASSQNEDDVGYASAKN---TLDINRPP 1142
                   |..|.|...||||:.||..     ..|:..|.:|....  |.||.|.   .|:.|   
  Rat  1633 GQLQQQLEQKEQEASKLKEEVERLQG-----QKRELLNCASVGNQ--GVASLKERVWELESN--- 1687

  Fly  1143 DLLSKNYSYNDSTSLVVKLRSI-------LEEEKQKH-KVLQEQYIKLSSRHKPTEDSFRVSELE 1199
             .|.:....:...:.:.:|..:       :|..||.| |..::|..:|....:..:...|..|::
  Rat  1688 -ALEQEKVRSQQENTIKQLEQLRQRFELEIERMKQMHQKDREDQEEELEDVRQSCQKRLRQLEMQ 1751

  Fly  1200 VENEKLRSEYDQLRTSI--KHGVE--INELNAQ--HAALQEEVRRRRE--------ECIQLKAVL 1250
            :|     .||::.:.::  ||.:|  |..|..|  |.....|.|.||:        ..:||....
  Rat  1752 LE-----QEYEEKQAALHEKHDLEGLIGTLCDQIGHRDFDVEKRLRRDLRRTHALLSDVQLLLAT 1811

  Fly  1251 LQQSQ---SMRSLEPESLQMRGNDVNELMEAFHSQKLINRQLE---SEL------KAITEEHNSK 1303
            ::.|:   |...||....|:..::. :..:|..:||::...||   |||      |::.:|...:
  Rat  1812 IEDSKTSISKEELEKVHSQLEQSEA-KCEDALKTQKVLTADLESMHSELENVTRSKSLVDEQLYR 1875

  Fly  1304 L-VEMTQEIERLNNEKDELQKVMFESIDEFEDSNVDTLRQNDRYLRRELQKAVAQFLLVQEELKL 1367
            | .|....::|::.::|:|..:|.:..|....|..|..:..:  |:.:|::|..:...:.|:|::
  Rat  1876 LQFERADLLKRIDEDQDDLNGLMQKHKDLIAQSAADIGQIQE--LQLQLEEAKKEKQKLWEQLQV 1938

  Fly  1368 ANAKLKAYRQDGGQLEHKIEEEMIRNKSNGTSADVGANVTKQKSQ 1412
            |..:::       .||....|..|.::......|:.:....||.|
  Rat  1939 AQLRIQ-------YLEQSTVERAIVSRQEAIICDLESKTEFQKVQ 1976

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 217/813 (27%)
MYSc_Myo5 84..767 CDD:276831 205/783 (26%)
IQ 900..922 CDD:197470 4/21 (19%)
GBP_C <971..1086 CDD:303769 24/125 (19%)
coiled coil 1049..1068 CDD:293879 4/18 (22%)
coiled coil 1077..1086 CDD:293879 1/9 (11%)
JAKMIP_CC3 <1190..1299 CDD:292653 32/134 (24%)
Myo5_CBD 1424..1792 CDD:271254
Myo18bXP_006249639.1 MYSc 558..1324 CDD:214580 217/814 (27%)
MYSc_Myo18 577..1312 CDD:276837 205/783 (26%)
KASH_CCD 1390..1579 CDD:291334 48/233 (21%)
GBP_C <1683..1766 CDD:303769 16/91 (18%)
coiled coil 1737..1751 CDD:293879 2/13 (15%)
Rab5-bind 1788..2082 CDD:286404 44/199 (22%)
DUF3585 <1889..2033 CDD:304905 20/97 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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