DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment didum and Myh15

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:XP_038944797.1 Gene:Myh15 / 303965 RGDID:1565858 Length:1987 Species:Rattus norvegicus


Alignment Length:2001 Identity:513/2001 - (25%)
Similarity:845/2001 - (42%) Gaps:450/2001 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 KIWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLRNPAILVGQNDLTT 77
            |.|||.....:..|.::||  .|.|.:.:.|..|:...::     .|.....|||.|....||:.
  Rat    33 KCWVPDGKNAYTEAEVKES--SGDGHVIVETRDGESLRIR-----EDEIQQMNPAELEMIEDLSM 90

  Fly    78 LSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLEPHIFA 142
            |.|::|..|||.||.|: :..:||||.|:..||||||..:|:|...::.||:.....:..|||||
  Rat    91 LLYINEGSVLHTLRKRY-DHWMIYTYSGLFCVAINPYKWLPVYQKEVMAAYKRKRRSEAPPHIFA 154

  Fly   143 LAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESETQ----VERKVLASSPI 203
            :|..|:..:.|...|.||:.:||||:||||:.|..::|||.:..:....:    :|.:::..:||
  Rat   155 VANHAFQDMLRNGENQSILFTGESGSGKTVNTKMIIQYFATMAATSEPKKKLGNLEDQIVQMNPI 219

  Fly   204 MEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVM-FLQGATMHTYLLEKSRVVYQAQGERNYHIFY 267
            :||||||||.|||||||||||.::.|    ||. .|..|.:..|.|||||||||..|||||||||
  Rat   220 LEAFGNAKTLRNDNSSRFGKFIRMYF----GVRGTLSFADIQIYFLEKSRVVYQQPGERNYHIFY 280

  Fly   268 QLCAARSKYPELVLDHQDKFQF-LNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIADIVKIL 331
            |:.:.:.:..:::|...:...| :...|...:|.:.||:.|..|.:|:.||||...:.....|::
  Rat   281 QILSGKQELQDMLLVSTNPSDFHICSCGVVAVENLDDAKGFLATEKAIDVLGFLPDEKFGCYKLV 345

  Fly   332 AGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITAD----------LLRVSADDLRRWLL 386
            ..|:|.||:    ||.:...||              |:.||          |:.::|.:|.:.|:
  Rat   346 GAIMHFGNL----KFRQNPREE--------------QLEADGTENADKAALLMGINASELLKGLI 392

  Fly   387 MRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIYGF 451
            ..:|:..||||....:|:....|..||:|.||.::|:::|..:|:.|:.......|||:|||.||
  Rat   393 YPRIKVGNEYVTRSQNIQQVTYAVGALSKSIYERMFKWLVARMNQVLDAKVTSHFFIGILDITGF 457

  Fly   452 ETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDF-YDNQPCIDLIESRLGV 515
            |..:.||.||.|||:.||||||.|||.:|.|||||..|||:.|..||: .|.|.||||||..:|:
  Rat   458 EILDYNSLEQLCINFTNEKLQQFFNQQLFVLEQEECRKEGLDWMSIDYGLDLQACIDLIEKPMGI 522

  Fly   516 LDLLDEECRMPKGSDESWAGKLIG-KCNKFPHFEKPRFGTTSFFI----KHFSDTVEYDVNGFLE 575
            |.:|:|||.:||.:|.::..||.. ...|..:|:||.....:|.:    .|::..|.||::|::.
  Rat   523 LSILEEECMLPKATDNTFKTKLFAHHFGKSAYFQKPTAPEKNFEVHFELAHYAGVVPYDISGWIG 587

  Fly   576 KNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRV 640
            ||::.:::.:..:|.:|:..:...:.|...|       |.|..|..   |..|.|.      ||.
  Rat   588 KNKELLNETVVALLQKSSNKVLASLFTNNTI-------AGSGELDS---IEFGEKP------RRK 636

  Fly   641 VPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETV 705
            ..|.|   .:.|..:||:..|::.|.:|.||:||||.||::|:....:...::||||..||||..
  Rat   637 ATSFQ---LITSLHKESINKLMADLKSTAPHFVRCINPNENKIPGVMDPFWVLQQLRCNGVLEGT 698

  Fly   706 RISAAGFPSRWLYPDFYMRYQLLVYR--SKLDKNDMKLSCRNIVMKWIQDEDKYRFGNTQIFFRA 768
            |:....||.|.||.||..||.:|..|  ||....:::.:...::.....|:.:|:.|.|::||:|
  Rat   699 RVCCKAFPIRMLYDDFKQRYCILNPRIFSKSKFVNIRKATEEVLALLEIDQSQYQCGVTKVFFKA 763

  Fly   769 GQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARA 833
            ..:..||:                       |:..:|.||....|..|||.|.|...||:.|.|.
  Rat   764 RILDRLEE-----------------------RRDEKISKVFTLFQARARGKLMRITFQKILEERD 805

  Fly   834 GLILSK-------YARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRG 891
            .|.|.:       ..:.|.....:.:       ::..|:.:.|..:...:::  ...|:|:.:..
  Rat   806 ALALIQENIRAFIAVKTWPWMGLFFK-------VKPLAKSVGAGEEIAGLKE--ECAQLQKSLET 861

  Fly   892 ALARRAYQK-------RRRNIIICQAAIRRFLARRKFKRMKAEAKTISHMENKYMGLENKIISMQ 949
            :.::|...|       :.||.::.|              ::||.:|:::.|.....|....|.::
  Rat   862 SESQREELKTKQVSLVQERNDLLLQ--------------LQAEQETLANSEELCESLIKSKIELE 912

  Fly   950 QRIDELNRDNSNLKHKTSEISVLKMKL-----ELKK---TLEAEF-KNVKAAC------------ 993
            .:|.||:|.....:...||::....||     ||||   .|||.. |:.||.|            
  Rat   913 AKIKELSRRVEEEEEINSELTARGRKLEDECSELKKEIYDLEAILAKSEKAKCAAEHKVRNLTEE 977

  Fly   994 -----QDKDKLIEALNKQLEAERDEKMQLLEENGHAQEEWISQKQTWRQENEELRRQIDEIIDMA 1053
                 :|..||..|:....||:     |..:|:.|.:||.:|...   :.|::|.:|:|     |
  Rat   978 VHSLHEDVSKLTRAMQAAQEAQ-----QQTQEHLHIEEEKLSNVS---KVNQKLSQQVD-----A 1029

  Fly  1054 KNAEVNQRNQEDRMLAEIDNRELNEAYQRAIKDKEVIENENFMLKEELSRLTAGSFSLHARKASN 1118
            ...:: :|.::.||..|              ::|..:|               |...|:...|.|
  Rat  1030 LEGDL-ERERKARMKCE--------------REKHKLE---------------GELKLNQEGAEN 1064

  Fly  1119 ASSQNEDDVGYASAKNTLDINRPPDLLSKNYSYNDSTSLVVKLRSILEEEKQKHKVLQEQYIKLS 1183
            ..|..:..:              ..|..|.:......|.|...::::.:.::..|.||.|.:.| 
  Rat  1065 LESSRQQLI--------------EQLRKKEFEMGQMNSKVENEKNLVSQLQKTVKELQTQILNL- 1114

  Fly  1184 SRHKPTEDSFRVSELEVENEK--LRSEYDQLRTSIKH--GVEINEL---NAQHAALQ------EE 1235
               |...:|.|....:||.|:  |..:.:.|...::.  |..:.::   ..|.|..|      ||
  Rat  1115 ---KEELESERTIRAKVERERGDLAQDLEDLNERLEEAGGTSLAQMEITRQQEARFQKLRHDMEE 1176

  Fly  1236 V------------RRRREECIQLKAVL--LQQSQSMRSLEPESLQMRGND----VNELMEA-FHS 1281
            .            ||..|...:|:..:  |||.:.:...|...||::.:|    |:::..| .::
  Rat  1177 TTRHFEATSVSLKRRHAENVAELEGQVEHLQQVRQVLDQEKSDLQLQVDDLLTRVDQMARAKANA 1241

  Fly  1282 QK---LINRQLESELKAITEEHNSKLVEMTQEIERLNNEKDELQKVMFESIDEFEDSNVDTLRQN 1343
            :|   |..|:|        .|.|:||.|.||..:.|.:::.:||....|.....|:...      
  Rat  1242 EKLCGLYERRL--------NEANTKLDEATQLAKDLTSQRTKLQNESGEFFKRLEEKEA------ 1292

  Fly  1344 DRYLRRELQKAVAQFLLVQEELK------------LANAKLKAYRQDGGQL------EHKIEEEM 1390
               |..:|.:..:..:|..|||:            ||:| |::.:.|...|      |.:::.|:
  Rat  1293 ---LISQLSREKSNLILQVEELRVQLEEESKSQSALAHA-LQSTKHDYDLLREQYEEEQEVKSEL 1353

  Fly  1391 IRNKSNGTSADV----------------------GANVTKQKSQNPQGLMKFHSSDLDKILQRL- 1432
            .|..|.|....|                      ...:..|::.....:....::.|::...|| 
  Rat  1354 HRALSKGNKETVQWRTKYEHDAMQRTEDLEEAKKKLAIRLQEAAEAMEVSNAKNASLERARHRLQ 1418

  Fly  1433 ------LSALTPRTVVGLLPGFPAYLIFMCIRYTDLTNA-----DDDVRELLSKFVIQIKKMHRT 1486
                  ||.|.....|....|...       :::|...|     .::.:|||       :...:.
  Rat  1419 LELGDALSDLGKARSVAAALGQKQ-------QHSDKALASWKQKQEEAQELL-------QASQKE 1469

  Fly  1487 PHPIENRVIWLVNSITLLN-----LMKQYGDVDEYVKFNTEKQNQQQLKNFNLFEYRRVILDLIV 1546
            ...:.:.|:.|..:....|     |.:|..|:.|.:...| .|.::.:||....|..:.:::...
  Rat  1470 ARALSSEVLMLRQACEESNEAQETLKRQNQDLQERICCLT-NQVREGIKNLTEVEKAKKLIEQEK 1533

  Fly  1547 NLYQALIMQIQGLL---DPKIVPAILN---------------NDEIQRGRQAH--GMRSRATSIG 1591
            ...||.:.:.:|.|   :.||:...|:               .||..|.|:.|  .:.|..:|:.
  Rat  1534 TEIQARLEEAEGALERNESKILRFQLDLSEAKAELGRKLSEKEDEAGRLREKHQQALGSLQSSLD 1598

  Fly  1592 ASSSPEHGGGPAWKQL------------------------IGQLEHFYKQFQHFGLDNCYAEQIF 1632
            :.:|.........|::                        :|||:...|..|....|:.|..:  
  Rat  1599 SEASSRIEATKMRKKIEGDLKEMEIQLCTANRQVSQTTRALGQLQSQMKDLQQHLDDSIYQNK-- 1661

  Fly  1633 HQLLYFICAVALNCLMLRGDI--------------------CMWETGMIIRYNIGCIEDWVRSKK 1677
             .|...:.......::|:.::                    .:..|..|..::........:.||
  Rat  1662 -DLKDQVALAEQRNILLQSELEELRSLQEQTERGRKLAEKELLEATERISLFHTQNASLLSQKKK 1725

  Fly  1678 MSNDVLTALAPLNQVSQLLQSR------------------KSEQDV------------QTICDLC 1712
            :..||..|.....::.|..|..                  |.|||.            |||.||.
  Rat  1726 LEADVAQAQKEAGEMLQACQKAEEKAKKTAAEAANMWEELKKEQDTNAHLERTRKNMEQTIKDLQ 1790

  Fly  1713 TSLSTAQVLKVMKSYK--------LDDYESEITNVFLEKLTEKLNARQMQK 1755
            ..|..|:...|:.|.|        :.|.|.|:.:........:..||::::
  Rat  1791 KRLDEAEQTAVVGSKKQIQKLESRVRDLEGELESEVRRSAEAQREARRLER 1841

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 273/736 (37%)
MYSc_Myo5 84..767 CDD:276831 260/706 (37%)
IQ 900..922 CDD:197470 4/28 (14%)
GBP_C <971..1086 CDD:303769 34/140 (24%)
coiled coil 1049..1068 CDD:293879 3/18 (17%)
coiled coil 1077..1086 CDD:293879 0/8 (0%)
JAKMIP_CC3 <1190..1299 CDD:292653 30/143 (21%)
Myo5_CBD 1424..1792 CDD:271254 78/451 (17%)
Myh15XP_038944797.1 Myosin_N 31..70 CDD:397036 11/38 (29%)
Motor_domain 98..762 CDD:419868 260/705 (37%)
Myosin_tail_1 843..1919 CDD:396244 209/1112 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
22.000

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