DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment didum and Myo1a

DIOPT Version :9

Sequence 1:	NP_724569.1	Gene:	didum / 35680	FlyBaseID:	FBgn0261397	Length:	1800	Species:	Drosophila melanogaster
Sequence 2:	NP_062197.1	Gene:	Myo1a / 299509	RGDID:	3135	Length:	1043	Species:	Rattus norvegicus

Alignment Length:	1177	Identity:	355/1177 - (30%)
Similarity:	576/1177 - (48%)	Gaps:	215/1177 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 VGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMG 134
            ||..||..|..|.|..::.||::|: |::.||||.|.:::::|||.::|:|||..|..||.:...
  Rat     8 VGVEDLILLEPLDEESLIKNLQLRY-EKKEIYTYIGNVVISMNPYQQLPIYGPEFIAKYRDYTFY 71

  Fly   135 DLEPHIFALAEEAYTKL---ERENCNLSIIVSGESGAGKTVSAKYAMRYFAAV-GGSESETQVER 195
            :|:|||:|||..||..|   :|:.|   |:::||||||||.::|..|.|.||| |..|....|:.
  Rat    72 ELKPHIYALANVAYQSLKDRDRDQC---ILITGESGAGKTEASKLVMSYVAAVCGKGEQVNSVKE 133

  Fly   196 KVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGE 260
            ::|.|:|::||||||||.||||||||||:..:.|..:...:   |..:..|||||||||.|.:||
  Rat   134 QLLQSNPVLEAFGNAKTIRNDNSSRFGKYMDIEFDFKGSPL---GGVITNYLLEKSRVVKQLKGE 195

  Fly   261 RNYHIFYQLCAARSK--YPELVLDHQDK-FQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQ 322
            ||:||||||.|....  ...|.|:...: :.:|| |....:..:.||..|.....||.|:|||.:
  Rat   196 RNFHIFYQLLAGADTQLLKALKLEEDARGYAYLN-GEVSRVNGMDDASNFRAVQNAMAVIGFSEE 259

  Fly   323 QIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLM 387
            :|..::::.|.:|.|||::::.:| :.:....|..||    ...:|...:::.:::.:|.:.|..
  Rat   260 EIRQVLEVTALVLKLGNVKLADEF-QANGLPASGVCD----GKGIQEIGEMMGLNSAELEKALCS 319

  Fly   388 RKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGS-KQCSFIGVLDIYGF 451
            |.:|:..|.|:...::..||.|||||||:||::||.:||..:|:|:..|: ::...:||||||||
  Rat   320 RTMETGKEKVVTVLNVIQAQYARDALAKNIYSRLFDWIVNRINESIKVGTGEKRKVMGVLDIYGF 384

  Fly   452 ETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIE-SRLGV 515
            |..|.||||||.|||.||||||.|.:...|.|||||.:|||.||.::::||....|||| |:.|:
  Rat   385 EILEDNSFEQFVINYCNEKLQQVFIELTLKEEQEEYKREGIPWTKVEYFDNGIICDLIEHSQRGI 449

  Fly   516 LDLLDEECRMPKG--SDESWAGKLIGKCNKFPHFEKP-----------RFGTTSFFIKHFSDTVE 567
            |.:|||||..| |  ||.::..||....:|..|:|..           ..|.:.|.|.|::..|.
  Rat   450 LAMLDEECLRP-GVVSDTTFLAKLNQLFSKHSHYESKVTQNAQRQYDRTMGLSCFRICHYAGKVT 513

  Fly   568 YDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQ 632
            |:|..|::||.|.:.::|:|.:.::...|...:.                             .:
  Rat   514 YNVTSFIDKNNDLLFRDLSQTMWKAQHPLLHSLF-----------------------------PE 549

  Fly   633 GNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLR 697
            ||...    .|.:...|.|:||:.|:|.|:..|::..|:|:|||||||.:...::.:..::.|.|
  Rat   550 GNPKE----ASLKRPPTAGTQFKNSVAILMKNLYSKNPNYIRCIKPNDQQQQGRFTSELVMVQAR 610

  Fly   698 ACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDK--NDMKLSCRNIVMKWIQDEDKYRFG 760
            ..|:||.||:..||:..|..|..|..||:|| .||...:  .:.:.....::...|...::..:|
  Rat   611 YLGLLENVRVRRAGYAFRQAYKPFLERYRLL-SRSTWPRWNGEDREGVEKVLGSLILSSEELAYG 674

  Fly   761 NTQIFFRAGQVAF-LEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARER 824
            .|:||.|:.:..| ||:.|.                       ||:|::...|||..||:..|..
  Rat   675 RTKIFIRSPKTLFYLEEQRR-----------------------LRLQQLATLIQKVYRGWRCRTH 716

  Fly   825 TQKMREARAGLILSKYARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYR---AVQIQ 886
            .|:||:::  :::|.:.||...::.|.::|.|:..||.:.||..||..:   |.::|   |:.:.
  Rat   717 YQQMRKSQ--ILISAWFRGNKQKKHYGKIRSSVLLIQAFVRGWKARKNY---RKYFRSGAAITLA 776

  Fly   887 RFVRGALARRAYQKRRRNIIICQAAIRRFLARRKFKRMKAEAKTISHMENKYMGLENKIISMQQR 951
            .|                  |.|:..::||.     .:|....:...::|.:.....:.
  Rat   777 NF------------------IYQSITQKFLL-----NLKKNLPSTKVLDNTWPAAPYRC------ 812

  Fly   952 IDELNRDNSNLKHKTSEISVLKMKLELKKTLEAEFKNVKAACQDKDKLIEALNKQL---EAERDE 1013
               .|..|..|:|                 |..::|..|...|...|.::.|.::|   |..:.:
  Rat   813 ---FNTANQELQH-----------------LFYQWKCKKYRDQLSPKQVQTLREKLCASELFKGK 857

  Fly  1014 KMQLLEE------------NGHAQEEWISQKQTWRQENEELRRQIDEIIDMAKNAEVNQRNQEDR 1066
            |...|:.            .|:.:    .|:...|:|...|      :.|..|...........|
  Rat   858 KASYLQSVPVPFRGDYVGLQGNPK----LQRLKGREEGPVL------VADTVKKVNRGNGKTSSR 912

  Fly  1067 ML------AEIDNRELNEAYQRAIKDKEVIENENFMLKEELSRLTAGSFSLHARKASNASSQNED 1125
            :|      ..:.:.:.::| |..||.::|       ....::.|..|.||||..:.|:|:|:.
  Rat   913 ILLLTKGHVILTDAKKSQA-QIVIKLEDV-------AGVSVTSLEDGLFSLHLSEMSSAASKG-- 967

  Fly  1126 DVGYASAKNTLDINRPPDLLSKNYSYNDSTSLVVKLRSILEEEKQKHKVLQEQYIKLSSRHKPTE 1190
            |:       .|..:...:||:|.|            :::|:..:::..|...:  |.|.|.|...
  Rat   968 DI-------LLISDHLVELLTKMY------------QAVLDATQRQLPVTVTE--KFSVRFKEGS 1011

  Fly  1191 DSFRVSE 1197
            .:.:|::
  Rat  1012 VAVKVTQ 1018

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc	65..778	CDD:214580	270/732 (37%)
		MYSc_Myo5	84..767	CDD:276831	259/706 (37%)
		IQ	900..922	CDD:197470	4/21 (19%)
		GBP_C	<971..1086	CDD:303769	22/135 (16%)
		coiled coil	1049..1068	CDD:293879	3/18 (17%)
		coiled coil	1077..1086	CDD:293879	3/8 (38%)
		JAKMIP_CC3	<1190..1299	CDD:292653	1/8 (13%)
		Myo5_CBD	1424..1792	CDD:271254
Myo1a	NP_062197.1	MYSc_Myo1	22..681	CDD:276829	259/706 (37%)
		IQ	742..764	CDD:197470	8/24 (33%)
		Myosin_TH1	847..1042	CDD:399188	40/213 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910