DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment didum and Myh7

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:NP_058936.1 Gene:Myh7 / 29557 RGDID:62030 Length:1935 Species:Rattus norvegicus


Alignment Length:1950 Identity:506/1950 - (25%)
Similarity:860/1950 - (44%) Gaps:476/1950 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 SSEEMLYAQ------GAKIWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDL 60
            |.:|.|.||      ...::||.....:..|.:..  |:| |.:...|::||...||     .|.
  Rat    19 SEKERLEAQTRPFDLKKDVFVPDDKEEFVKAKIVS--REG-GKVTAETENGKTVTVK-----EDQ 75

  Fly    61 PPLRNPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSII 125
            ...:||.......|:..|::||||.||:||:.|:.. .:||||.|:..|.:|||..:|:|...::
  Rat    76 VMQQNPPKFDKIEDMAMLTFLHEPAVLYNLKERYAS-WMIYTYSGLFCVTVNPYKWLPVYNAQVV 139

  Fly   126 RAYRGHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYF---AAVGGS 187
            .||||....:..||||::::.||..:..:..|.||:::|||||||||:.|..::||   ||:|..
  Rat   140 AAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFAVIAAIGDR 204

  Fly   188 ESETQ------VERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTY 246
            ..:.|      :|.:::.::|.:||||||||.|||||||||||.::.| ...|.  |..|.:.||
  Rat   205 SKKDQTPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHF-GATGK--LASADIETY 266

  Fly   247 LLEKSRVVYQAQGERNYHIFYQLCAARSKYPE-----LVLDHQDKFQFLNMGGAPEIERVSDAEQ 306
            |||||||::|.:.||:||||||:.:  :|.||     |:.::...:.|.:. |...:..:.|:|:
  Rat   267 LLEKSRVIFQLKAERDYHIFYQILS--NKKPELLDMLLITNNPYDYAFFSQ-GETTVASIDDSEE 328

  Fly   307 FNETVQAMTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNE------GSEEEDSDSCDIFHNDI 365
            ...|..|..||||:.::...|.|:...|:|.||::..:|..|      |:||.|.          
  Rat   329 HMATDSAFDVLGFTPEEKNSIYKLTGAIMHFGNMKFKQKQREEQAEPDGTEEADK---------- 383

  Fly   366 HLQITADLLRVSADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLN 430
                :|.|:.:::.||.:.|...:::..||||....:::....|..||||.:|.|:|.::|..:|
  Rat   384 ----SAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQQVAYAIGALAKSVYEKMFNWMVTRIN 444

  Fly   431 KSLNNGSKQCSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWT 495
            .:|.....:..|||||||.|||.|:.|||||.|||:.||||||.||.|:|.||||||.||||.||
  Rat   445 ATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWT 509

  Fly   496 MIDF-YDNQPCIDLIESRLGVLDLLDEECRMPKGSDESWAGKL----IGKCNKFPHFEKPR---- 551
            .||| .|.|.||||||..:|::.:|:|||..||.:|.::..||    :||.|   :|:|||    
  Rat   510 FIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLYDNHLGKSN---NFQKPRNIKG 571

  Fly   552 FGTTSFFIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKS 616
            .....|.:.|::.||:|::.|:|:||:|.:::.:..:..:|::.|...:..........||..| 
  Rat   572 KQEAHFSLIHYAGTVDYNILGWLQKNKDPLNETVVGLYQKSSLKLLSNLFANYAGADAPVDKGK- 635

  Fly   617 STLGGRVVISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDD 681
                       |:.::|:..           :||.:..:|:|..|::.|.:|.||:||||.||:.
  Rat   636 -----------GKAKKGSSF-----------QTVSALHRENLNKLMTNLRSTHPHFVRCIIPNET 678

  Fly   682 KVAFKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKN--------- 737
            |.....:...::.|||..||||.:||...|||:|.||.||..||::|        |         
  Rat   679 KSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRIL--------NPAAIPEGQF 735

  Fly   738 -DMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQ 801
             |.:.....::.....|.::|:||:|::||:||.:..||::|..                     
  Rat   736 IDSRKGAEKLLGSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDE--------------------- 779

  Fly   802 FLRIQKVINGIQKHARGYLARERTQKMREARAGLILSKY-------ARGWLCRRRYLRLRHSISG 859
              |:.::|..||..:||.|:|...:|:.|.|..|::.::       .:.|...:.|.:::..:..
  Rat   780 --RLSRIITRIQAQSRGVLSRMEFKKLLERRDSLLIIQWNIRAFMGVKNWPWMKLYFKIKPLLKS 842

  Fly   860 IQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAYQKRRRNIIICQAAIRRFLARRKFKRM 924
            .:|.......:.:|..::|                                |:.:..||||    
  Rat   843 AETEKEMANMKEEFGRVKD--------------------------------ALEKSEARRK---- 871

  Fly   925 KAEAKTISHMENKYMGLENKIISMQQRIDELNRDNSNLKHKTSEISVLKMKLELKKTLEAEFKNV 989
                           .||.|::|:                       |:.|.:|:..::||..|:
  Rat   872 ---------------ELEEKMVSL-----------------------LQEKNDLQLQVQAEQDNL 898

  Fly   990 KAACQDKDKLIEALNK-QLEAERDEKMQLLEENGHAQEEWISQKQTWRQENEELRRQIDEI---- 1049
            ..|.:..|:||:  || ||||:..|..:.||:......|..::|:....|..||:|.||::    
  Rat   899 ADAEERCDQLIK--NKIQLEAKVKEMTERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTL 961

  Fly  1050 --IDMAKNAEVNQ-RNQEDRM--LAEI------DNRELNEAYQRAIKDKEVIENENFMLKEELSR 1103
              ::..|:|..|: :|..:.|  |.||      :.:.|.||:|:|:.|.:..|       ::::.
  Rat   962 AKVEKEKHATENKVKNLTEEMAGLDEIIVKLTKEKKALQEAHQQALDDLQAEE-------DKVNT 1019

  Fly  1104 LTAGSFSLHARKASNASSQNED-----DVGYASAK----------NTLDINRPPDLLSKNYSYND 1153
            ||.....|..:......|.::|     |:..|..|          :.:|:......|.:.....|
  Rat  1020 LTKAKVKLEQQVDDLEGSLDQDKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKD 1084

  Fly  1154 ----------------STSLVVKLRSI------LEEEKQKHKVLQEQYIKLSS--RHKPTEDSFR 1194
                            .:.|..||:.:      ||||.:..:..:.:..||.|  ..:..|.|.|
  Rat  1085 FELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISER 1149

  Fly  1195 VSE------LEVE-NEKLRSEYDQLRTSIKHGVEINELNAQHAALQEEVRRRREECIQLKAVLLQ 1252
            :.|      :::| |:|..:|:.::|.      ::.|...||.|....:|::..:.:   |.|.:
  Rat  1150 LEEAGGATSVQIEMNKKREAEFQKMRR------DLEEATLQHEATAAALRKKHADSV---AELGE 1205

  Fly  1253 QSQSMRSL------EPESLQMRGNDVNELMEAFHSQKL----INRQLESELKAITEEHNSKLVE- 1306
            |..:::.:      |....::..:||...||.....|.    :.|.||.::    .||.||..| 
  Rat  1206 QIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQM----NEHRSKAEET 1266

  Fly  1307 ------MTQEIERLNNEKDELQKVMFESIDEFEDSNVDTLRQNDRYLRRELQKAVAQFLLVQEEL 1365
                  :|::..:|..|..||.:    .:|| :::.:..|.:......::|:....|   ::||:
  Rat  1267 QRSVNDLTRQRAKLQTENGELSR----QLDE-KEALISQLTRGKLTYTQQLEDLKRQ---LEEEV 1323

  Fly  1366 KLANA---KLKAYRQDGGQLEHKIEEEMIRNKSNGTSADVGANVTKQKSQNPQGLMKFHSSDLDK 1427
            |..||   .|::.|.|...|..:.|||      ....|::...::|..|:..|...|:.:..:.:
  Rat  1324 KAKNALAHALQSARHDCDLLREQYEEE------TEAKAELQRVLSKANSEVAQWRTKYETDAIQR 1382

  Fly  1428 I--LQRLLSALTPRTVVGLLPGFPAYLIFMCIRYTDLTNADDDVRELLSKFVIQIKKMHRTPHPI 1490
            .  |:.....|..|                      |.:|::.|..:.:|    ...:.:|.|.:
  Rat  1383 TEELEEAKKKLAQR----------------------LQDAEEAVEAVNAK----CSSLEKTKHRL 1421

  Fly  1491 ENRVIWLVNSITLLN-----LMKQYGDVD--------EYVKFNTEKQNQQQLKNFNLFEYRRVIL 1542
            :|.:..|:..:...|     |.|:..:.|        :|.:..:|.::.|:       |.|.:..
  Rat  1422 QNEIEDLMVDVERSNAAAAALDKKQRNFDKILVEWKQKYEESQSELESSQK-------EARSLST 1479

  Fly  1543 DL--IVNLYQALIMQIQGLLDPKIVPAILNNDEIQRGRQAHGMRSRATSIGASSSPEHGGGPAWK 1605
            :|  :.|.|:..:..::...        ..|..:|  .:...:..:..|.|.|            
  Rat  1480 ELFKLKNAYEESLEHLETFK--------RENKNLQ--EEISDLTEQLGSTGKS------------ 1522

  Fly  1606 QLIGQLEHFYKQFQHFGLDNCYAEQIFHQLLYFICAVALNCLMLRGDICMWETGMIIRYNIGCIE 1670
              |.:||...||.:        ||::..|........:|.          .|.|.|:|       
  Rat  1523 --IHELEKIRKQLE--------AEKLELQSALEEAEASLE----------HEEGKILR------- 1560

  Fly  1671 DWVRSKKMSNDVLTALAPLNQVSQLLQSRKSEQD----------VQTICDLCTSL-----STAQV 1720
                          |....||:...::.:.:|:|          ::.:..|.|||     |..:.
  Rat  1561 --------------AQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEA 1611

  Fly  1721 LKVMKSYKLDDYESEITNVFLEKLTEKLNARQMQKSNSDEFTID-QKFIQPFKVVFRYSDIKLED 1784
            |:|.|                 |:...||..::|.|:::....: ||.::..:.:.:.:.|:|:|
  Rat  1612 LRVKK-----------------KMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDD 1659

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 277/751 (37%)
MYSc_Myo5 84..767 CDD:276831 265/721 (37%)
IQ 900..922 CDD:197470 5/21 (24%)
GBP_C <971..1086 CDD:303769 40/130 (31%)
coiled coil 1049..1068 CDD:293879 5/27 (19%)
coiled coil 1077..1086 CDD:293879 4/8 (50%)
JAKMIP_CC3 <1190..1299 CDD:292653 26/125 (21%)
Myo5_CBD 1424..1792 CDD:271254 63/393 (16%)
Myh7NP_058936.1 Myosin_N 35..72 CDD:280832 9/39 (23%)
Myosin_head 87..766 CDD:278492 270/733 (37%)
MYSc_class_II 99..766 CDD:276951 265/721 (37%)
Actin-binding 655..677 11/21 (52%)
Actin-binding 757..771 7/13 (54%)
Myosin_tail_1 846..1923 CDD:279860 195/1036 (19%)
MM_CoA_mutase <1132..1293 CDD:294532 39/177 (22%)
BAR 1232..1424 CDD:299863 47/235 (20%)
TMPIT 1740..>1830 CDD:285135
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1915..1935
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.910

Return to query results.
Submit another query.