Protein Alignment didum and Myh6

DIOPT Version :10

• Sequence 1: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Sequence 2: NP_058935.2
• Gene: Myh6 / 29556
• RGDID: 62029
• Length: 1939
• Species: Rattus norvegicus
• Alignment Length: 2112
• Identity: 541/2112 - (25%)
• Similarity: 892/2112 - (42%)
• Gaps: 549/2112 - (25%)

  Fly     2 SSEEMLYAQ------GAKIWVPHADLVWESATLEESYRKG------AGFLKICTDSGKLKEVKLK 54
            |.:|.|.||      ..:.:||..         :|.|.|.      .|.:...|::||...||
  Rat    19 SEKERLEAQTRPFDIRTECFVPDD---------KEEYVKAKIVSREGGKVTAETENGKTVTVK-- 72

  Fly    55 ADGSDLPPLRNPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPL 119
               .|....:||.......|:..|::||||.||:||:.|:. ..:||||.|:..|.:|||..:|:
  Rat    73 ---EDQVMQQNPPKFDKIEDMAMLTFLHEPAVLYNLKERYA-AWMIYTYSGLFCVTVNPYKWLPV 133

  Fly   120 YGPSIIRAYRGHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAV 184
            |...::.||||....:..||||::::.||..:..:..|.||:::|||||||||:.|..::|||::
  Rat   134 YNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFASI 198

  Fly   185 G--GSESETQ--------VERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQ 239
            .  |..|:..        :|.:::.::|.:||||||||.|||||||||||.::.| ...|.  |.
  Rat   199 AAIGDRSKKDNPNANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHF-GATGK--LA 260

  Fly   240 GATMHTYLLEKSRVVYQAQGERNYHIFYQLCAARSKYPE-----LVLDHQDKFQFLNMGGAPEIE 299
            .|.:.|||||||||::|.:.|||||||||:.:  :|.||     ||.::...:.|::.|.. .:.
  Rat   261 SADIETYLLEKSRVIFQLKAERNYHIFYQILS--NKKPELLDMLLVTNNPYDYAFVSQGEV-SVA 322

  Fly   300 RVSDAEQFNETVQAMTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEE----EDSDSCDI 360
            .:.|:|:...|..|..||||:.::.|.:.|:...|:|.||::..:|..|...|    ||:|.
  Rat   323 SIDDSEELLATDSAFDVLGFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADK--- 384

  Fly   361 FHNDIHLQITADLLRVSADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYI 425
                     :|.|:.:::.||.:.|...:::..||||....|::....:..||||.:|.|:|.::
  Rat   385 ---------SAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSVQQVYYSIGALAKSVYEKMFNWM 440

  Fly   426 VGVLNKSLNNGSKQCSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKE 490
            |..:|.:|.....:..|||||||.|||.|:.|||||.|||:.||||||.||.|:|.||||||.||
  Rat   441 VTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKE 505

  Fly   491 GITWTMIDF-YDNQPCIDLIESRLGVLDLLDEECRMPKGSDESWAGKL----IGKCNKFPHFEKP 550
            ||.|..||| .|.|.||||||..:|::.:|:|||..||.:|.::..||    :||.|   :|:||
  Rat   506 GIEWEFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLYDNHLGKSN---NFQKP 567

  Fly   551 R----FGTTSFFIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNMSL-AKQVMTLEEIDTLC 610
            |    .....|.:.|::.||:|::.|:||||:|.:::.:..:..:|::.| |....|....||
  Rat   568 RNVKGKQEAHFSLVHYAGTVDYNILGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTYASADT-- 630

  Fly   611 VDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRC 675
            .||.|..          |.|::|:..           :||.:..:|:|..|::.|..|.||:|||
  Rat   631 GDSGKGK----------GGKKKGSSF-----------QTVSALHRENLNKLMTNLRTTHPHFVRC 674

  Fly   676 IKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKN--- 737
            |.||:.|.....:...::.|||..||||.:||...|||:|.||.||..||::|        |
  Rat   675 IIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRIL--------NPAA 731

  Fly   738 -------DMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRR 795
                   |.:.....::.....|.::|:||:|::||:||.:..||::|..
  Rat   732 IPEGQFIDSRKGAEKLLGSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDE--------------- 781

  Fly   796 FVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAGLILSKY-------ARGWLCRRRYLRL 853
                    |:.::|..||..|||.|.|...:||.|.|..|::.::       .:.|...:.|.::
  Rat   782 --------RLSRIITRIQAQARGQLMRIEFKKMVERRDALLVIQWNIRAFMGVKNWPWMKLYFKI 838

  Fly   854 RHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAYQKRRRNIIICQAAIRRFLAR 918
            :..:...:|.......:.:|..::|                                |:.:..||
  Rat   839 KPLLKSAETEKEMANMKEEFGRVKD--------------------------------ALEKSEAR 871

  Fly   919 RKFKRMKAEAKTISHMENKYMGLENKIISMQQRIDELNRDNSNLKHKTSEISVLKMKLELKKTLE 983
            ||                   .||.|::|:                       |:.|.:|:..::
  Rat   872 RK-------------------ELEEKMVSL-----------------------LQEKNDLQLQVQ 894

  Fly   984 AEFKNVKAACQDKDKLIEALNK-QLEAERDEKMQLLEENGHAQEEWISQKQTWRQENEELRRQID 1047
            ||..|:..|.:..|:||:  || ||||:..|..:.||:......|..::|:....|..||::.||
  Rat   895 AEQDNLADAEERCDQLIK--NKIQLEAKVKEMTERLEDEEEMNAELTAKKRKLEDECSELKKDID 957

  Fly  1048 EI------IDMAKNAEVNQ-RNQEDRM--LAEI------DNRELNEAYQRAIKDKEVIENE-NFM 1096
            ::      ::..|:|..|: :|..:.|  |.||      :.:.|.||:|:|:.|.:..|:: |.:
  Rat   958 DLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTL 1022

  Fly  1097 LKEELSRLTAGSFSLHARKASNASSQNEDDVGYA---SAKNTLDINRPPDLLSKNYSY------- 1151
            :|.::.                 ..|..||:..:   ..|..:|:.|....|..:...
  Rat  1023 IKSKVK-----------------LEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMD 1070

  Fly  1152 --NDSTSLVVKL-RSILEEEKQKHKVLQEQYIKLSSRHKPTEDSFRVSELEVENE---KLRSEYD 1210
              ||...|..|| :...:..:|..|:..||.:.|..:.|..|:..|:.|||.|.|   ..|::.:
  Rat  1071 LENDKLQLEEKLKKKEFDISQQNSKIEDEQALALQLQKKLKENQARIEELEEELEAERTARAKVE 1135

  Fly  1211 QLRTSIKHGVEINELNAQ------HAALQEEVRRRREECIQ-----LKAVLLQQSQSMRSLEPES 1264
            :||:.:..  |:.|::.:      ..::|.|:.::||...|     |:...||...:..:|.
  Rat  1136 KLRSDLTR--ELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALR--- 1195

  Fly  1265 LQMRGNDVNELMEAFHSQKLINRQLESELKAITEEHNSKLVEMTQEIERLNNEKDELQKV----- 1324
             :...:.|.||.|...:.:.:.::||.|    ..|...:|.::|..:|::...|..|:||
  Rat  1196 -KKHADSVAELGEQIDNLQRVKQKLEKE----KSEFKLELDDVTSNMEQIIKAKANLEKVSRTLE 1255

  Fly  1325 ------------MFESIDEFEDSNVDTLRQNDRYLRR--ELQKAVAQFL---------------L 1360
                        ...|:::|.........:|....|:  |.:..::|..               .
  Rat  1256 DQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQ 1320

  Fly  1361 VQEELKLANA---KLKAYRQDGGQLEHKIEEEMIRNKSNGTSADVGANVTKQKSQNPQGLMKFHS 1422
            ::||.|..||   .|::.|.|...|..:.||||      ...|::...::|..|:..|...|:.:
  Rat  1321 LEEEGKAKNALAHALQSARHDCDLLREQYEEEM------EAKAELQRVLSKANSEVAQWRTKYET 1379

  Fly  1423 SDLDKI--LQRLLSALTPRTVVGLLPGFPAYLIFMCIRYTDLTNADDDVRELLSKFVIQIKKMHR 1485
            ..:.:.  |:.....|..|                      |.:|::.|..:.:|.....|..||
  Rat  1380 DAIQRTEELEEAKKKLAQR----------------------LQDAEEAVEAVNAKCSSLEKTKHR 1422

  Fly  1486 TPHPIENRVI-------------------------WLVN------------------SITLLNLM 1507
            ..:.||:.::                         |...                  |..|..|.
  Rat  1423 LQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLK 1487

  Fly  1508 KQYGDVDEYVK-FNTEKQN-QQQLKNF---------NLFEYRRVILDLIV---NLYQAL------ 1552
            ..|.:..|::: |..|.:| |:::.:.         |:.|..::...|.|   .|..||
  Rat  1488 NAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKIRKQLEVEKLELQSALEEAEAS 1552

  Fly  1553 --------------IMQIQGLLDPKIVPAILNNDEIQRGRQAHGMR---SRATSIGASSSPEHGG 1600
                          ..||:..::.|:..   .::|:::.::.| :|   |..||:.|.:...:..
  Rat  1553 LEHEEGKILRAQLEFNQIKAEIERKLAE---KDEEMEQAKRNH-LRVVDSLQTSLDAETRSRNEA 1613

  Fly  1601 GPAWKQLIGQLEHFYKQFQHFG---------LDNCYAEQIFHQLLYFICAVALNCLMLRGDICMW 1656
            ....|::.|.|.....|.....         |.|..|.....||       .|:..:...|....
  Rat  1614 LRVKKKMEGDLNEMEIQLSQANRIASEAQKHLKNAQAHLKDTQL-------QLDDAVRANDDLKE 1671

  Fly  1657 ETGMIIRYNI----------GCIEDWVRSKKMSNDVL--------------TAL--------APL 1689
            ...::.|.|.          ..:|...||:|::...|              |:|        |.|
  Rat  1672 NIAIVERRNTLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADL 1736

  Fly  1690 NQV-------------------------SQLLQSRKSEQDV------------QTICDLCTSLST 1717
            :|:                         :.:.:..|.|||.            |||.||...|..
  Rat  1737 SQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDE 1801

  Fly  1718 AQVLKVMKSYK-LDDYESEITNVFLE-KLTEKLNARQMQKSNSDEFTIDQKFIQ---PFKVVFRY 1777
            |:.:.:....| |...|:.:..:..| :..:|.||..::.....|..|.:...|   ..|.:.|.
  Rat  1802 AEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLVRL 1866

  Fly  1778 SDI-------------KLEDIELPSHLNLDEF 1796
            .|:             :.|:.|..::.||.:|
  Rat  1867 QDLVDKLQLKVKAYKRQAEEAEEQANTNLSKF 1898

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	271/721 (38%)
		IQ	900..922	CDD:197470	5/21 (24%)
		SMC_prok_B	<942..1365	CDD:274008	107/500 (21%)
		Myo5_CBD	1424..1792	CDD:271254	88/545 (16%)
Myh6	NP_058935.2	Myosin_N	32..76	CDD:460670	12/57 (21%)
		MYSc_class_II	99..768	CDD:276951	271/721 (38%)
		Actin-binding	657..679		11/21 (52%)
		Actin-binding	759..773		7/13 (54%)
		Calmodulin-binding. /evidence=ECO:0000250	790..807		8/16 (50%)
		Calmodulin-binding. /evidence=ECO:0000250	816..833		1/16 (6%)
		Myosin_tail_1	848..1925	CDD:460256	223/1193 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1908..1939