DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment didum and Myh6

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:NP_058935.2 Gene:Myh6 / 29556 RGDID:62029 Length:1939 Species:Rattus norvegicus


Alignment Length:2112 Identity:541/2112 - (25%)
Similarity:892/2112 - (42%) Gaps:549/2112 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 SSEEMLYAQ------GAKIWVPHADLVWESATLEESYRKG------AGFLKICTDSGKLKEVKLK 54
            |.:|.|.||      ..:.:||..         :|.|.|.      .|.:...|::||...||  
  Rat    19 SEKERLEAQTRPFDIRTECFVPDD---------KEEYVKAKIVSREGGKVTAETENGKTVTVK-- 72

  Fly    55 ADGSDLPPLRNPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPL 119
               .|....:||.......|:..|::||||.||:||:.|:. ..:||||.|:..|.:|||..:|:
  Rat    73 ---EDQVMQQNPPKFDKIEDMAMLTFLHEPAVLYNLKERYA-AWMIYTYSGLFCVTVNPYKWLPV 133

  Fly   120 YGPSIIRAYRGHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAV 184
            |...::.||||....:..||||::::.||..:..:..|.||:::|||||||||:.|..::|||::
  Rat   134 YNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFASI 198

  Fly   185 G--GSESETQ--------VERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQ 239
            .  |..|:..        :|.:::.::|.:||||||||.|||||||||||.::.| ...|.  |.
  Rat   199 AAIGDRSKKDNPNANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHF-GATGK--LA 260

  Fly   240 GATMHTYLLEKSRVVYQAQGERNYHIFYQLCAARSKYPE-----LVLDHQDKFQFLNMGGAPEIE 299
            .|.:.|||||||||::|.:.|||||||||:.:  :|.||     ||.::...:.|::.|.. .:.
  Rat   261 SADIETYLLEKSRVIFQLKAERNYHIFYQILS--NKKPELLDMLLVTNNPYDYAFVSQGEV-SVA 322

  Fly   300 RVSDAEQFNETVQAMTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEE----EDSDSCDI 360
            .:.|:|:...|..|..||||:.::.|.:.|:...|:|.||::..:|..|...|    ||:|.   
  Rat   323 SIDDSEELLATDSAFDVLGFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADK--- 384

  Fly   361 FHNDIHLQITADLLRVSADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYI 425
                     :|.|:.:::.||.:.|...:::..||||....|::....:..||||.:|.|:|.::
  Rat   385 ---------SAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSVQQVYYSIGALAKSVYEKMFNWM 440

  Fly   426 VGVLNKSLNNGSKQCSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKE 490
            |..:|.:|.....:..|||||||.|||.|:.|||||.|||:.||||||.||.|:|.||||||.||
  Rat   441 VTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKE 505

  Fly   491 GITWTMIDF-YDNQPCIDLIESRLGVLDLLDEECRMPKGSDESWAGKL----IGKCNKFPHFEKP 550
            ||.|..||| .|.|.||||||..:|::.:|:|||..||.:|.::..||    :||.|   :|:||
  Rat   506 GIEWEFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLYDNHLGKSN---NFQKP 567

  Fly   551 R----FGTTSFFIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNMSL-AKQVMTLEEIDTLC 610
            |    .....|.:.|::.||:|::.|:||||:|.:::.:..:..:|::.| |....|....||  
  Rat   568 RNVKGKQEAHFSLVHYAGTVDYNILGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTYASADT-- 630

  Fly   611 VDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRC 675
            .||.|..          |.|::|:..           :||.:..:|:|..|::.|..|.||:|||
  Rat   631 GDSGKGK----------GGKKKGSSF-----------QTVSALHRENLNKLMTNLRTTHPHFVRC 674

  Fly   676 IKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKN--- 737
            |.||:.|.....:...::.|||..||||.:||...|||:|.||.||..||::|        |   
  Rat   675 IIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRIL--------NPAA 731

  Fly   738 -------DMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRR 795
                   |.:.....::.....|.::|:||:|::||:||.:..||::|..               
  Rat   732 IPEGQFIDSRKGAEKLLGSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDE--------------- 781

  Fly   796 FVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAGLILSKY-------ARGWLCRRRYLRL 853
                    |:.::|..||..|||.|.|...:||.|.|..|::.::       .:.|...:.|.::
  Rat   782 --------RLSRIITRIQAQARGQLMRIEFKKMVERRDALLVIQWNIRAFMGVKNWPWMKLYFKI 838

  Fly   854 RHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAYQKRRRNIIICQAAIRRFLAR 918
            :..:...:|.......:.:|..::|                                |:.:..||
  Rat   839 KPLLKSAETEKEMANMKEEFGRVKD--------------------------------ALEKSEAR 871

  Fly   919 RKFKRMKAEAKTISHMENKYMGLENKIISMQQRIDELNRDNSNLKHKTSEISVLKMKLELKKTLE 983
            ||                   .||.|::|:                       |:.|.:|:..::
  Rat   872 RK-------------------ELEEKMVSL-----------------------LQEKNDLQLQVQ 894

  Fly   984 AEFKNVKAACQDKDKLIEALNK-QLEAERDEKMQLLEENGHAQEEWISQKQTWRQENEELRRQID 1047
            ||..|:..|.:..|:||:  || ||||:..|..:.||:......|..::|:....|..||::.||
  Rat   895 AEQDNLADAEERCDQLIK--NKIQLEAKVKEMTERLEDEEEMNAELTAKKRKLEDECSELKKDID 957

  Fly  1048 EI------IDMAKNAEVNQ-RNQEDRM--LAEI------DNRELNEAYQRAIKDKEVIENE-NFM 1096
            ::      ::..|:|..|: :|..:.|  |.||      :.:.|.||:|:|:.|.:..|:: |.:
  Rat   958 DLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTL 1022

  Fly  1097 LKEELSRLTAGSFSLHARKASNASSQNEDDVGYA---SAKNTLDINRPPDLLSKNYSY------- 1151
            :|.::.                 ..|..||:..:   ..|..:|:.|....|..:...       
  Rat  1023 IKSKVK-----------------LEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMD 1070

  Fly  1152 --NDSTSLVVKL-RSILEEEKQKHKVLQEQYIKLSSRHKPTEDSFRVSELEVENE---KLRSEYD 1210
              ||...|..|| :...:..:|..|:..||.:.|..:.|..|:..|:.|||.|.|   ..|::.:
  Rat  1071 LENDKLQLEEKLKKKEFDISQQNSKIEDEQALALQLQKKLKENQARIEELEEELEAERTARAKVE 1135

  Fly  1211 QLRTSIKHGVEINELNAQ------HAALQEEVRRRREECIQ-----LKAVLLQQSQSMRSLEPES 1264
            :||:.:..  |:.|::.:      ..::|.|:.::||...|     |:...||...:..:|.   
  Rat  1136 KLRSDLTR--ELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALR--- 1195

  Fly  1265 LQMRGNDVNELMEAFHSQKLINRQLESELKAITEEHNSKLVEMTQEIERLNNEKDELQKV----- 1324
             :...:.|.||.|...:.:.:.::||.|    ..|...:|.::|..:|::...|..|:||     
  Rat  1196 -KKHADSVAELGEQIDNLQRVKQKLEKE----KSEFKLELDDVTSNMEQIIKAKANLEKVSRTLE 1255

  Fly  1325 ------------MFESIDEFEDSNVDTLRQNDRYLRR--ELQKAVAQFL---------------L 1360
                        ...|:::|.........:|....|:  |.:..::|..               .
  Rat  1256 DQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQ 1320

  Fly  1361 VQEELKLANA---KLKAYRQDGGQLEHKIEEEMIRNKSNGTSADVGANVTKQKSQNPQGLMKFHS 1422
            ::||.|..||   .|::.|.|...|..:.||||      ...|::...::|..|:..|...|:.:
  Rat  1321 LEEEGKAKNALAHALQSARHDCDLLREQYEEEM------EAKAELQRVLSKANSEVAQWRTKYET 1379

  Fly  1423 SDLDKI--LQRLLSALTPRTVVGLLPGFPAYLIFMCIRYTDLTNADDDVRELLSKFVIQIKKMHR 1485
            ..:.:.  |:.....|..|                      |.:|::.|..:.:|.....|..||
  Rat  1380 DAIQRTEELEEAKKKLAQR----------------------LQDAEEAVEAVNAKCSSLEKTKHR 1422

  Fly  1486 TPHPIENRVI-------------------------WLVN------------------SITLLNLM 1507
            ..:.||:.::                         |...                  |..|..|.
  Rat  1423 LQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLK 1487

  Fly  1508 KQYGDVDEYVK-FNTEKQN-QQQLKNF---------NLFEYRRVILDLIV---NLYQAL------ 1552
            ..|.:..|::: |..|.:| |:::.:.         |:.|..::...|.|   .|..||      
  Rat  1488 NAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKIRKQLEVEKLELQSALEEAEAS 1552

  Fly  1553 --------------IMQIQGLLDPKIVPAILNNDEIQRGRQAHGMR---SRATSIGASSSPEHGG 1600
                          ..||:..::.|:..   .::|:::.::.| :|   |..||:.|.:...:..
  Rat  1553 LEHEEGKILRAQLEFNQIKAEIERKLAE---KDEEMEQAKRNH-LRVVDSLQTSLDAETRSRNEA 1613

  Fly  1601 GPAWKQLIGQLEHFYKQFQHFG---------LDNCYAEQIFHQLLYFICAVALNCLMLRGDICMW 1656
            ....|::.|.|.....|.....         |.|..|.....||       .|:..:...|....
  Rat  1614 LRVKKKMEGDLNEMEIQLSQANRIASEAQKHLKNAQAHLKDTQL-------QLDDAVRANDDLKE 1671

  Fly  1657 ETGMIIRYNI----------GCIEDWVRSKKMSNDVL--------------TAL--------APL 1689
            ...::.|.|.          ..:|...||:|::...|              |:|        |.|
  Rat  1672 NIAIVERRNTLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADL 1736

  Fly  1690 NQV-------------------------SQLLQSRKSEQDV------------QTICDLCTSLST 1717
            :|:                         :.:.:..|.|||.            |||.||...|..
  Rat  1737 SQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDE 1801

  Fly  1718 AQVLKVMKSYK-LDDYESEITNVFLE-KLTEKLNARQMQKSNSDEFTIDQKFIQ---PFKVVFRY 1777
            |:.:.:....| |...|:.:..:..| :..:|.||..::.....|..|.:...|   ..|.:.|.
  Rat  1802 AEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLVRL 1866

  Fly  1778 SDI-------------KLEDIELPSHLNLDEF 1796
            .|:             :.|:.|..::.||.:|
  Rat  1867 QDLVDKLQLKVKAYKRQAEEAEEQANTNLSKF 1898

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 283/751 (38%)
MYSc_Myo5 84..767 CDD:276831 271/721 (38%)
IQ 900..922 CDD:197470 5/21 (24%)
GBP_C <971..1086 CDD:303769 39/130 (30%)
coiled coil 1049..1068 CDD:293879 5/27 (19%)
coiled coil 1077..1086 CDD:293879 4/8 (50%)
JAKMIP_CC3 <1190..1299 CDD:292653 28/122 (23%)
Myo5_CBD 1424..1792 CDD:271254 88/545 (16%)
Myh6NP_058935.2 Myosin_N 34..72 CDD:397036 9/46 (20%)
MYSc_class_II 99..768 CDD:276951 271/721 (38%)
Actin-binding 657..679 11/21 (52%)
Actin-binding 759..773 7/13 (54%)
Calmodulin-binding. /evidence=ECO:0000250 790..807 8/16 (50%)
Calmodulin-binding. /evidence=ECO:0000250 816..833 1/16 (6%)
Myosin_tail_1 848..1925 CDD:396244 223/1193 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1908..1939
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.910

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