Protein Alignment didum and Aspm

DIOPT Version :9

• Sequence 1: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Sequence 2: NP_001099425.2
• Gene: Aspm / 289054
• RGDID: 1307111
• Length: 3133
• Species: Rattus norvegicus
• Alignment Length: 1626
• Identity: 296/1626 - (18%)
• Similarity: 527/1626 - (32%)
• Gaps: 573/1626 - (35%)

  Fly   126 RAYRGHAM-GDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSES 189
            |.||.|.: .|:..| |....||...|:                             :|..|.:.
  Rat  1832 RWYRAHKVASDMRIH-FLKTREAVVVLQ-----------------------------SACRGWQV 1866

  Fly   190 ETQVERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQ-------GATMHT-Y 246
            ..|:.|:..|:..|..||..|:..|...          |.|| ..|:..|       |...|: |
  Rat  1867 RQQLRRQHQAAVKIQAAFRMARAQRQYK----------LVRN-AAVVIQQHVRARAAGERQHSEY 1920

  Fly   247 L-LEKSRVVYQAQ----------GERN-----YHIFYQLCAARSKYPELVLDHQDKFQFLNMGGA 295
            : |..:.:|:||.          .:|:     ...:|::.:.|.|:.            |....|
  Rat  1921 IRLRHAALVFQATWKGKMLRREIAQRHQCAALIQSYYRMYSQRRKWS------------LMKTAA 1973

  Fly   296 PEIE------RVSDAEQ--FNETVQAMTVLGFSI------QQIADIVKILAGILHLGNIQVSKKF 346
            .:|:      ||...::  :.:|..|:.:|..:.      :||.:        .|...:.:..||
  Rat  1974 RQIQVCYRAYRVGKEQRHLYLKTKAAVVILQSAYRGMKARRQITE--------CHKAAVTIQSKF 2030

  Fly   347 NEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKI--ESVNEYVLIPNSIEAAQAA 409
            .....::...:|                |.||..::||....||  :....|:.:..:....||.
  Rat  2031 RAYRTQKKYTTC----------------RTSAIIIQRWYRNIKITTQQREAYLTLKRAATKVQAV 2079

  Fly   410 RDAL--AKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIYGFETFEVNSFEQFCINYANEKLQ 472
            ...:  .:||.   ..|:...|.|:|                    |::..      :.|...:|
  Rat  2080 YRGIQVRRHIQ---HMYMAATLIKAL--------------------FKIQQ------SRAAAVIQ 2115

  Fly   473 QQFNQHVF-KLEQEEYLKEGITWTMIDFYDNQPCIDLIESRLGVLDLLDEECRMPKGSDESWAGK 536
            .::..:.. |::||:||                      :.|..:..|....|          |.
  Rat  2116 VRYRAYYLGKIQQEKYL----------------------TTLRAIKTLQAGVR----------GA 2148

  Fly   537 LIGKCNKFPHFEKPRFGTTSFFIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVM 601
            .:.|..:..||.....  .|:|.:|...|..:.:     :...||.::..:.:.|.:...
  Rat  2149 RVRKTLRKMHFAATLI--QSYFRRHRQRTYFHRL-----RKAATVVQQRYRAVKEGSSQF----- 2201

  Fly   602 TLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLASLISTLH 666
                                         |:.:..||.|:           ..|.:...|.:..|
  Rat  2202 -----------------------------QRYSRLRRSVI-----------LVQAAFRGLKARRH 2226

  Fly   667 ATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYR 731
            ....|.                .|.:||:                            |::.|:.|
  Rat  2227 LKAMHL----------------AATVIQR----------------------------RFRTLLMR 2247

  Fly   732 SKLDKNDMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRF 796
            .|.      ||.|..|: |||                      .|.||.|..||.
  Rat  2248 RKF------LSLRKTVI-WIQ----------------------RQYRARLHAKYC---------- 2273

  Fly   797 VYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAGLILSKYARGWLCRRRYLRLRHSISGIQ 861
               ||.|.::|.:..||...:|::.|:..|||..| |.:|.:.:.....| .||.||:.:...||
  Rat  2274 ---RQQLLLEKAVTKIQSSYKGWMVRKSVQKMHRA-ATVIQATFRMHRAC-VRYQRLKRASVVIQ 2333

  Fly   862 TYARGMLARNKFHAMRDHYRAVQIQR--FVRGALARRAYQKRRRNIIICQAAIRRFLARRKFKRM 924
            ...|.             :|..::||  |||          :|:..:..|||.|...||...|.|
  Rat  2334 KQYRA-------------HRTAELQRQLFVR----------QRQAALTLQAAFRGVKARNHLKTM 2375

  Fly   925 KAEAKTISH------MENKYMGLENKIISMQQRIDELNRDNSNLKHKTSEISVLKMKLELKK--- 980
            .|.|..|..      :..:::.|....|.:|::.    |.....|||      |...|:|:|
  Rat  2376 HASATLIQSKFRARIVRRQFLALRKAAIFVQRKY----RATLYAKHK------LHQFLQLRKAAI 2430

  Fly   981 TLEAEFKN--VKAACQDKDK---LIEA--------------------LNKQLEAERDEKMQLLEE 1020
            |:::.|:.  ||...|::.:   ||:|                    :.:.....|..|:|..:.
  Rat  2431 TIQSSFRRLMVKKQLQERHRAAALIQATFRMHRTYVRFHLWKRASIRIQQHYRTYRTRKLQREQL 2495

  Fly  1021 NGHAQEEWISQKQTWRQENE----ELRRQIDEIIDMAKNAEVNQRNQ-------EDRMLAEIDNR 1074
            :.......:..:.|:|...:    :..|...::|.  |....|:|.|       |:..|.::..:
  Rat  2496 SREEHRAAVRIQSTYRMHRQRCVYQQLRWAAKVIQ--KKYRANKRRQDLPMACKEETPLTQMHFQ 2558

  Fly  1075 ELNEAYQRAIK-DKEVIENENFMLKEELSRLTAGSFSLHARKASNA---SSQNEDDVGYASA--- 1132
            ..|.|.|..:: |..||..::|       |.......:.|.:.|.|   :|:...|:....|
  Rat  2559 GSNMAKQVQLQHDAAVIIQKHF-------RAFKARRLVEAERGSQAVWRTSEARQDLRRGEAACR 2616

  Fly  1133 -----------KNTLDINRPPDLLSKNYSYNDSTSLVVKLR--SILEEEKQKHKVLQE---QYIK 1181
                       :..|.:.:....:...:......:..:|:|  :|:.:.|.:..:...   :.:.
  Rat  2617 IQAWYRRCRVRRRYLTLLKAVKTIQGYFYAKQERTRFLKMRAAAIIIQRKWRAALCARAACESLT 2681

  Fly  1182 LSSRHKPTEDSFRVSELEVENEKLRSEYDQLRTSIKHGVEINE-LNAQHAALQEEVRRRREECIQ 1245
            | .||    .:..|.:......|.|..:.|.|::   .:.|.. :.|..||.||     |.:.:|
  Rat  2682 L-KRH----GAACVIQAHFRGYKGRQSFRQQRSA---ALTIQRYVRASVAARQE-----RTKYVQ 2733

  Fly  1246 LK--AVLLQQSQSMRSLEPESLQMRG----NDVNEL----------------MEAFHSQKLINRQ 1288
            .|  ||:||            ..:||    ..|:|.                |.|...|:...|.
  Rat  2734 FKKSAVVLQ------------ALVRGWLARKRVSEQKANIRRFRFIAAAYCHMCALRIQRAYRRH 2786

  Fly  1289 LESELKAITEEHNSKLVEMTQEIERLNNEK--DELQKVMFESIDEFEDSNVDTLRQNDRYLRREL 1351
            :  .::...:..||.:|.......||..::  ::.:|:|....|      |...|.........:
  Rat  2787 V--AMRNAKKHVNSVIVIQRWFRRRLQQQRFIEQYRKIMAAERD------VQARRHQQDRAASVI 2843

  Fly  1352 QKAVAQFLLVQEELKLANA--------------------KLKAYRQDGGQLEHKIEEEMIRNKSN 1396
            ||||.:|||.:.:.|:.::                    ::||.||....:...:|||   ||
  Rat  2844 QKAVRRFLLSRRQQKVNSSATRIQALWRGYASRKKNDRTEIKAIRQSLRAVSRNVEEE---NK-- 2903

  Fly  1397 GTSADVGANVTKQKSQNPQGLMKF-HSSDLDKILQRL--LSALTPRTVVGLLPGFPAYLIFMCIR 1458
                     :.::..:....|:.: |.|.:.:.::.|  ::.|:|.....:........:|:.||
  Rat  2904 ---------LYRRTERALHHLLTYKHLSAILEAMKHLEVVTRLSPLCCENMAESGAVSTVFVVIR 2959

  Fly  1459 YTDLTNADDDVRELLSKFVIQIKKMHRT---PHPIENRVIWLVNSITLLNLMKQYGDVDEYVKFN 1520
            ..:.:....:|.....:.::.:.|..:|   .:..||.|      .|||.|::.|
  Rat  2960 SCNRSVPCMEVVGCAVQVLLNVAKYDKTISAVYDAENCV------DTLLELLQAY---------- 3008

  Fly  1521 TEKQNQQQL-KNFNLF--------------------EYRRVILDLIVNLYQALI----MQIQGLL 1560
            .||...:.. |:.::|                    :.|..::|.|..||:..:    :..|||.
  Rat  3009 REKPGDRVAEKSASIFTRTCCLLAVLLKTEQCAFDAQSRSKVIDRIYRLYKFTVPKHKVNTQGLF 3073

  Fly  1561 D 1561
            |
  Rat  3074 D 3074

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc	65..778	CDD:214580	111/695 (16%)
		MYSc_Myo5	84..767	CDD:276831	110/684 (16%)
		IQ	900..922	CDD:197470	7/21 (33%)
		GBP_C	<971..1086	CDD:303769	28/154 (18%)
		coiled coil	1049..1068	CDD:293879	6/25 (24%)
		coiled coil	1077..1086	CDD:293879	3/9 (33%)
		JAKMIP_CC3	<1190..1299	CDD:292653	26/131 (20%)
		Myo5_CBD	1424..1792	CDD:271254	30/168 (18%)
Aspm	NP_001099425.2	ASH	29..126	CDD:292408
		CH	941..1037	CDD:294029
		CH	1095..>1148	CDD:278723

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900