DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment didum and MYO1H

DIOPT Version :9

Sequence 1:	NP_724569.1	Gene:	didum / 35680	FlyBaseID:	FBgn0261397	Length:	1800	Species:	Drosophila melanogaster
Sequence 2:	XP_011536525.1	Gene:	MYO1H / 283446	HGNCID:	13879	Length:	1044	Species:	Homo sapiens

Alignment Length:	993	Identity:	324/993 - (32%)
Similarity:	481/993 - (48%)	Gaps:	183/993 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 VGQNDLTTL-SYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAM 133
            ||..|...| :|..|...:.|||.||.| .:||||.|.:||::|||.|:.:|..|.:..|:|...
Human    11 VGVQDFVLLDAYTSESAFVDNLRKRFSE-NLIYTYIGTLLVSVNPYQELGIYTVSQMELYQGVNF 74

  Fly   134 GDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESETQVER-KV 197
            .:|.||::|:|:.||..:..|..|..|::|||||||||.::|..:.|||.........|:.| ::
Human    75 FELPPHVYAIADNAYRMMCAELNNHFILISGESGAGKTEASKKILEYFAVTCPMTQSLQIARDRL 139

  Fly   198 LASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERN 262
            |.|:|::||||||:|.||||||||||:..:.|..| |:..  |..:.:||:||||||||.:||||
Human   140 LFSNPVLEAFGNARTLRNDNSSRFGKYMDIQFDFQ-GIPV--GGHIISYLIEKSRVVYQNEGERN 201

  Fly   263 YHIFYQLCAA----RSKYPELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQ 323
            :||||||.|.    |..|..|..|.| .:::|:.|...:...:||...:.....|.:|:.|:...
Human   202 FHIFYQLLAGGEEERLSYLGLERDPQ-LYKYLSQGHCAKESSISDKNDWKTVSNAFSVIDFTEAD 265

  Fly   324 IADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMR 388
            :.::..|:|.:||||||         ..|||...|....:...::..|.||.|....|...|..|
Human   266 LENLFGIIASVLHLGNI---------GFEEDDQGCATIPDTHEIKWIAKLLGVHPSVLLEALTHR 321

  Fly   389 KIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSL-NNGSKQCSFIGVLDIYGFE 452
            |||:..|.|:.|.::|.:..||||:||.:|.:.|.::|..:|.|| |....:.:.||:|||||||
Human   322 KIEAKTEEVICPLTLELSVYARDAMAKAVYGRTFTWLVNKINSSLVNKDFTRKTVIGLLDIYGFE 386

  Fly   453 TFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIESR-LGVL 516
            .|:.|.||||||||.||||||...:...|.||.||..|||.|..|.:::|:...||:|.| .|::
Human   387 VFDKNGFEQFCINYCNEKLQQLLIERTLKAEQAEYEMEGIEWEPIKYFNNKIICDLVEERHKGII 451

  Fly   517 DLLDEECRMP-KGSDESWAGKLIGKCNKFPHFE---------KPRFGTTSFFIKHFSDTVEYDVN 571
            .:|||||..| ..:|.|:..||..|..|..|||         :.|.|...|.:.|::..|.|...
Human   452 SILDEECIRPGPATDLSFLEKLEEKVGKHAHFETRKLAGPKGRKRIGWMEFRLLHYAGEVTYCTK 516

  Fly   572 GFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDT 636
            ||||||.|.:.:.|.:||.:|...:.::...|.|:                            :.
Human   517 GFLEKNNDLLYRHLKEVLCKSKNIILRECFLLAEL----------------------------EN 553

  Fly   637 RRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGV 701
            |||       ..|||:||:.||:||:.||.:..|.|:|||||||.|...|::...|..|::..|:
Human   554 RRR-------PPTVGTQFKNSLSSLLETLISKEPSYIRCIKPNDRKEPSKFDDFLIRHQIKYLGL 611

  Fly   702 LETVRISAAGFPSRWLYPDFYMRY----------QLLVYRSKLDKNDMKLSCRNI---------- 746
            :|.:|:..|||..|..|..|..||          :|::  |...|:..|..|.:.
Human   612 MEHLRVRRAGFAYRRKYEHFLQRYLGVELSHWVERLMM--SLFYKDRYKSLCPDTWPHWHGPPAE 674

  Fly   747 ----VMKWI-QDEDKYRFGNTQIFFRAGQVAFLEQVRANLRK-KYITIVQSVVRRFVYRRQFLRI 805
                ::|:| ...::|:.|.|:||.|..:..|..:......| :.:..:|:..:|.:.||::::.
Human   675 GVERLIKYIGYKPEEYKLGKTKIFIRFPRTLFATEDAFEFSKHQLVARIQATYKRCLGRREYVKK 739

  Fly   806 QKVINGIQKHARGYLARERTQKMREARAGLILSKYARGW------LC----------RRRY-LRL 853
            ::....::.|.||.|||:..|  |...|..|:.|:.:|:      ||          |:.| |.|
Human   740 RQAAIKLEAHWRGALARKAIQ--RRKWAVRIIRKFIKGFISRNKPLCPDNEEFIVFVRKNYILNL 802

  Fly   854 RHSI-----------------------------SGIQTYARGMLARNK------------FHAMR 877
            |:.:                             :.:|.|.||:.|..|            |...:
Human   803 RYHLPKTVLDKSWLRPPGILENASDLLRKMCVRNLVQKYCRGITAERKAMMQQKVVTSEIFRGRK 867

  Fly   878 DHYRAVQIQRFVRGAL---------------------------ARRAYQKRRRNIIICQ-AAIRR 914
            |.|.....|.||...:                           .|:.::.|:|.:|:.| ||...
Human   868 DGYTESLNQPFVNSRIDEGDINPKVLQLISHEKIQYGVPVIKYDRKGFKARQRQLILTQKAAYVV 932

  Fly   915 FLARRKFKRMKAEAKTIS 932
            .||:.|.|...:..|.:|
Human   933 ELAKIKQKIEYSALKGVS 950

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc	65..778	CDD:214580	275/750 (37%)
		MYSc_Myo5	84..767	CDD:276831	267/724 (37%)
		IQ	900..922	CDD:197470	9/22 (41%)
		GBP_C	<971..1086	CDD:303769
		coiled coil	1049..1068	CDD:293879
		coiled coil	1077..1086	CDD:293879
		JAKMIP_CC3	<1190..1299	CDD:292653
		Myo5_CBD	1424..1792	CDD:271254
MYO1H	XP_011536525.1	MYSc	8..711	CDD:214580	275/750 (37%)
		MYSc_Myo1	26..700	CDD:276829	267/724 (37%)
		Myosin_TH1	856..1019	CDD:283635	19/95 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910