DRSC/TRiP Functional Genomics Resources

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Protein Alignment didum and Myo7a

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:XP_006229804.1 Gene:Myo7a / 266714 RGDID:628830 Length:2276 Species:Rattus norvegicus


Alignment Length:1902 Identity:498/1902 - (26%)
Similarity:783/1902 - (41%) Gaps:479/1902 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 DLVWESATLEESYRKGAG-FLKICTDSGKLKEVKLKA--------DGSDLPPLRNPAILVGQNDL 75
            |.||......:.:....| .:|:| :||:::.|..:.        :.:.:.|: :|..:.|..|:
  Rat    69 DYVWMDLKSGQEFDVPIGAMVKLC-ESGQIQVVDDEGNEHWISPQNATHIKPM-HPTSVHGVEDM 131

  Fly    76 TTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLEPHI 140
            ..|..|:|.|:|.||.:|:.: .:||||.|.||||:|||..:.:|....||.|....:|::.|||
  Rat   132 IRLGDLNEAGILRNLLIRYRD-HLIYTYTGSILVAVNPYQLLSIYSSEHIRQYTNKKIGEMPPHI 195

  Fly   141 FALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESETQVERKVLASSPIME 205
            ||:|:..|..::|.|.:...|:|||||||||.|.|..:::.||:.|..|  .:|::||.::||:|
  Rat   196 FAIADNCYFNMKRNNRDQCCIISGESGAGKTESTKLILQFLAAISGQHS--WIEQQVLEATPILE 258

  Fly   206 AFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHIFYQLC 270
            |||||||.||||||||||:..:.| |:.|.  ::||.:..||||||||..||..|||||:||  |
  Rat   259 AFGNAKTIRNDNSSRFGKYIDIHF-NKRGA--IEGAKIEQYLLEKSRVCRQAPDERNYHVFY--C 318

  Fly   271 AARSKYPE----LVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIADIVKIL 331
            .......|    |.|.....:.:|.||.....|...|::::.....||.||.|:..:..:|:|:|
  Rat   319 MLEGMNEEEKKKLGLGQAADYNYLAMGNCITCEGRVDSQEYANIRSAMKVLMFTDTENWEILKLL 383

  Fly   332 AGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKIESVNEY 396
            |.|||:||:|.     |....|:.|:|::..:. .|...|..|.|:..||...|..|.:.:..|.
  Rat   384 AAILHMGNLQY-----EARTFENLDACEVLFSP-SLATAASHLEVNPPDLMSCLTSRTLITRGET 442

  Fly   397 VLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLN--------KSLNNGSKQCSFIGVLDIYGFET 453
            |..|.|.|.|...|||..|.||.:||.:||..:|        :.:.|..:.   ||:|||:|||.
  Rat   443 VSTPLSREQALDVRDAFVKGIYGRLFVWIVEKINAAIYKPPSQEVTNSRRS---IGLLDIFGFEN 504

  Fly   454 FEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIESR-LGVLD 517
            |.||||||.|||:|||.|||.|.:||||||||||..|.|.|..|:|.|||..:|:|.:| :.|:.
  Rat   505 FTVNSFEQLCINFANEHLQQFFVRHVFKLEQEEYDLESIDWLHIEFTDNQEALDMIANRPMNVIS 569

  Fly   518 LLDEECRMPKGSDESWAGKLIGKCNKFPHFEKPRFG-TTSFFIKHFSDTVEYDVNGFLEKNRDTV 581
            |:|||.:.|||:|.:...||..:.....::..|:.. .|.|.|.||:..|.|:..|||||||||:
  Rat   570 LIDEESKFPKGTDATMLHKLNSQHRLNANYVPPKNSHETQFGINHFAGIVYYESQGFLEKNRDTL 634

  Fly   582 SKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQH 646
            ..::.|::..|.....||:..        .|.|                 .|.:||:|       
  Rat   635 HGDIIQLVHSSRNKFVKQIFQ--------ADVA-----------------MGAETRKR------- 667

  Fly   647 RKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAG 711
            ..|:.|||:.||..|:.||.|..|.:|||||||:.|....::....::|||..|::||:||..||
  Rat   668 SPTLSSQFKRSLELLMRTLGACQPFFVRCIKPNEFKKPMLFDRHLCVRQLRYSGMMETIRIRHAG 732

  Fly   712 FPSRWLYPDFYMRYQLLV--YRSKLDKNDMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAFL 774
            :|.|:.:.:|..||::|:  .:....::|::.:|:.:....:...|.::.|.|:||.:......|
  Rat   733 YPIRYSFVEFVERYRVLLPGVKPAYKQDDLQGTCQRMAEAVLGTHDDWQIGKTKIFLKDHHDMLL 797

  Fly   775 EQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAGLILSK 839
            |..|.......:.::|.|:|.|..|..|||::.....||:|.||:                    
  Rat   798 EVERDKAITDRVILLQKVIRGFKDRSNFLRLKSAATLIQRHWRGH-------------------- 842

  Fly   840 YARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAYQKRRRN 904
                 .||:.|..:|.....:|...|......::...|.  |.::.|...|..|.|||::.|...
  Rat   843 -----HCRKNYELIRLGFLRLQALHRSRKLHKQYRLARQ--RIIKFQARCRAYLVRRAFRHRLWA 900

  Fly   905 IIICQAAIRRFLARRKFKRMKAEAKTISHMENKYMGLENKIISMQQRIDELNRDNSNLKHKTSEI 969
            :|..||..|..:|||..:|::.|.......|...:..|.|                         
  Rat   901 VITVQAYARGMIARRLHRRLRVEYWRRLEAERMRLAEEEK------------------------- 940

  Fly   970 SVLKMKLELKKTLEAEFKNVKAACQDKDKLIEALNKQLEAERDEKMQLLEENGHAQEEWISQKQT 1034
              |:.::..||..|                        ||||..:.:|.:......|..:.:|:.
  Rat   941 --LRKEMSAKKAKE------------------------EAERKHQERLAQLAREDAERELKEKEE 979

  Fly  1035 WRQENEELRRQIDEIIDMAKNAEVNQRNQEDRMLAEIDNR--------------ELNEAYQRAIK 1085
            .|::.|.|::     ::.|::..:|..:..|:|...:...              |..|..:|.:.
  Rat   980 ARRKKELLQQ-----MERARHEPINHSDMVDKMFGFLGTSSGLPGQEGQAPSGFEDLERGRREMV 1039

  Fly  1086 DKEV-----IENENFMLKEELSRLTAGSFSLHARKASNASSQNEDDVGYASAKNTLDINRPPDLL 1145
            :::|     :.:|:   :|:||......|:                ..|.....|....|.|  |
  Rat  1040 EEDVDAALPLPDED---EEDLSEYKFAKFA----------------ATYFQGTTTHSYTRRP--L 1083

  Fly  1146 SKNYSYNDS-----TSLVV--------------KLRSILEEEKQKHKVLQEQYIKLSSRHKPTED 1191
            .:...|:|.     .:|.|              |..:.:.:..:|..|:.:.|..|..:....| 
  Rat  1084 KQPLLYHDDEGDQLAALAVWITILRFMGDLPEPKYHTAMSDGSEKIPVMTKIYETLGKKTYKRE- 1147

  Fly  1192 SFRVSELEVENEKLRSEYDQLRTSIKHGVEINELNAQHAALQEEVRRRREECIQLKAVLLQQSQS 1256
               :..|:.|.|...|| .|.:||:||.: ::....:.:.|.|||.:|           |...:|
  Rat  1148 ---LQALQGEGEAQLSE-GQKKTSVKHKL-VHLTLKKKSKLTEEVTKR-----------LHDGES 1196

  Fly  1257 MRSLEPESLQMRGNDVNELMEAFHSQKL--------INRQLESEL-----KAITEEHN-SK---- 1303
            |         ::||.:.|.....:.:||        :...|..|:     |.:|  || ||    
  Rat  1197 M---------VQGNSMLEDRPTSNLEKLHFIIGNGILRPALRDEIYCQISKQLT--HNPSKSSYA 1250

  Fly  1304 ----LVEMTQEIERLNNEKDELQKVMFESIDEFEDSNVDTLRQNDRYLRRELQKAVAQFLLVQEE 1364
                ||.:...              .|...::|.           :|||..:.            
  Rat  1251 RGWILVSLCVG--------------CFAPSEKFV-----------KYLRNFIH------------ 1278

  Fly  1365 LKLANAKLKAYRQDGGQLEHK--IEEEMIRNKSNGTSADVGANVTKQ--KSQNP--------QGL 1417
                          ||...:.  .||.:.|...|||.....:.:..|  ||:.|        .|.
  Rat  1279 --------------GGPPGYAPYCEERLRRTFVNGTRTQPPSWLELQATKSKKPIMLPVTFMDGT 1329

  Fly  1418 MKFHSSDLDKILQRLLSALTPRTVVGLLPGFPAYLIFMCIRYTDLTNADDDVRELLSK------- 1475
            .|...:|.....:.|.:||..:..:....||..| |.:..:.:.|.:..|.|.:.:|:       
  Rat  1330 TKTLLADSATTAKELCNALADKISLKDRFGFSLY-IALFDKVSSLGSGSDHVMDAISQCEQYAKE 1393

  Fly  1476 ---------FVIQIKKMHRTP--HPIENRVIWLVNSITLLNLMKQYGDVDEYVKFN--------- 1520
                     :.:..:|...||  :|.|:.|        ..||:  |..|...|||.         
  Rat  1394 QGAQERNAPWRLFFRKEVFTPWHNPSEDNV--------ATNLI--YQQVVRGVKFGEYRCEKEDD 1448

  Fly  1521 -TEKQNQQQLKNFNLFEYRRVILDLIVNLYQALIMQIQGLLDPKIVPAILNNDE----------- 1573
             .|..:||...::.    ..:||:.:::|....|.      |.:|.|  |.|.|           
  Rat  1449 LAELASQQYFVDYG----SEMILERLLSLVPTYIP------DREITP--LKNLEKWAQLAIAAHK 1501

  Fly  1574 ----IQRGRQAHGMRSRATSIGASSSPEHGGGPAWKQLIGQLEHFYKQFQHFG------------ 1622
                .||...|..::....:.....         |..|..:   ||:.::..|            
  Rat  1502 KGIYAQRRTDAQKVKQDVVNYARFK---------WPLLFSR---FYEAYKFSGPPLPKSDVIVAV 1554

  Fly  1623 -------LDNCYAEQIFHQLLY-FICAVALN--CLMLRGDICMWETGMIIRYNIGCIEDWVRSKK 1677
                   :|.  .||:..:|.: .|.||:.:  |.:|              .::||.:....|..
  Rat  1555 NWTGVYFVDE--QEQVLLELSFPEIMAVSSSRECRVL--------------LSLGCSDLGCASCH 1603

  Fly  1678 MSNDVLTALAPLNQVSQLLQSRKSEQDVQTICDLCTSLSTAQVLK---VMKSYKLDDYESEITN- 1738
            .....||...|                    |..|.|...|:::.   .:.:.|.|:|....:| 
  Rat  1604 SGRAGLTPAGP--------------------CSPCWSCRGAKLMAPSFTLATIKGDEYTFTSSNA 1648

  Fly  1739 --------VFLEKLTEK 1747
                    .|||.|.::
  Rat  1649 EDIRDLVVTFLEGLRKR 1665

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 280/728 (38%)
MYSc_Myo5 84..767 CDD:276831 272/698 (39%)
IQ 900..922 CDD:197470 8/21 (38%)
GBP_C <971..1086 CDD:303769 21/128 (16%)
coiled coil 1049..1068 CDD:293879 3/18 (17%)
coiled coil 1077..1086 CDD:293879 2/8 (25%)
JAKMIP_CC3 <1190..1299 CDD:292653 28/121 (23%)
Myo5_CBD 1424..1792 CDD:271254 73/401 (18%)
Myo7aXP_006229804.1 MYSc 121..802 CDD:214580 280/729 (38%)
MYSc_Myo7 140..790 CDD:276832 272/698 (39%)
IQ 827..848 CDD:197470 8/45 (18%)
MAP7 <918..996 CDD:283355 20/133 (15%)
eIF3_subunit 936..>991 CDD:285763 16/110 (15%)
MyTH4 1078..1314 CDD:214535 60/316 (19%)
B41 1320..1535 CDD:214604 45/249 (18%)
FERM_N 1323..>1362 CDD:286467 8/38 (21%)
FERM_B-lobe 1424..1524 CDD:271216 23/113 (20%)
FERM_C1_MyoVII 1529..1665 CDD:270019 31/174 (18%)
SH3_MYO7A 1666..1730 CDD:212814 498/1902 (26%)
MyTH4 1808..1957 CDD:214535
B41 1964..2176 CDD:214604
FERM_M 2074..2176 CDD:278785
FERM_C2_MyoVII 2172..2267 CDD:270020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100101
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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