DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment didum and unc-54

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:NP_493596.1 Gene:unc-54 / 259839 WormBaseID:WBGene00006789 Length:1963 Species:Caenorhabditis elegans


Alignment Length:1923 Identity:495/1923 - (25%)
Similarity:865/1923 - (44%) Gaps:427/1923 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 YAQGAKIWVPHADLVWESATLEESYRKG------AGFLKICTDSGKLKEVKLKADGSDLPPLRNP 66
            |.....:|:|..         ||.|..|      ...:.|.|..|  .||.||   .:|....||
 Worm    27 YDSKKNVWIPDP---------EEGYLAGEITATKGDQVTIVTARG--NEVTLK---KELVQEMNP 77

  Fly    67 AILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGH 131
            .......|::.||:|::..||||||.|:. ..:||||.|:..|.||||..:|:|..|..|.:.|.
 Worm    78 PKFEKTEDMSNLSFLNDASVLHNLRSRYA-AMLIYTYSGLFCVVINPYKRLPIYTDSCARMFMGK 141

  Fly   132 AMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESE------ 190
            ...::.||:||:::|||..:.:::.|.|::::||||||||.:.|..:.||||||.|:.|      
 Worm   142 RKTEMPPHLFAVSDEAYRNMLQDHENQSMLITGESGAGKTENTKKVICYFAAVGASQQEGGAEVD 206

  Fly   191 -----TQVERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEK 250
                 ..:|.:::.::|::||||||||.||:||||||||.::.| |:.|  .|....:..|||||
 Worm   207 PNKKKVTLEDQIVQTNPVLEAFGNAKTVRNNNSSRFGKFIRIHF-NKHG--RLASCDIEHYLLEK 268

  Fly   251 SRVVYQAQGERNYHIFYQLCA--ARSKYPELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQA 313
            |||:.||.|||.||||||:.:  ......||:||...|..:........|:.:.|.|:|..|.:|
 Worm   269 SRVIRQAPGERCYHIFYQIYSDFRPELKKELLLDLPIKDYWFVAQAELIIDGIDDVEEFQLTDEA 333

  Fly   314 MTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSA 378
            ..:|.||..:..|..::::..:|:||::..::..|  |:.:.|..|      ..:..:::..:..
 Worm   334 FDILNFSAVEKQDCYRLMSAHMHMGNMKFKQRPRE--EQAEPDGTD------EAEKASNMYGIGC 390

  Fly   379 DDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLN-NGSKQCSF 442
            ::..:.|...:::...|:|....:.|....|..|:||.:|:::|.::|...|.:|: .|..:..|
 Worm   391 EEFLKALTKPRVKVGTEWVSKGQNCEQVNWAVGAMAKGLYSRVFNWLVKKCNLTLDQKGIDRDYF 455

  Fly   443 IGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDF-YDNQPCI 506
            ||||||.|||.|:.|||||..||:.||||||.||.|:|.||||||.:|||.|..||| .|.|.||
 Worm   456 IGVLDIAGFEIFDFNSFEQLWINFVNEKLQQFFNHHMFVLEQEEYAREGIQWVFIDFGLDLQACI 520

  Fly   507 DLIESRLGVLDLLDEECRMPKGSDESWAGKLIGK-CNKFPHFEKP-----RFGTTSFFIKHFSDT 565
            :|||..||::.:|||||.:||.:|.:.|.||:.: ..|.|:||||     :.|...|.::|::.|
 Worm   521 ELIEKPLGIISMLDEECIVPKATDLTLASKLVDQHLGKHPNFEKPKPPKGKQGEAHFAMRHYAGT 585

  Fly   566 VEYDVNGFLEKNRDTVSKELTQVLSESN-----MSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVI 625
            |.|:...:||||:|.::..:...:.:|.     :.:.:...|.||.      :||:...||    
 Worm   586 VRYNCLNWLEKNKDPLNDTVVSAMKQSKGNDLLVEIWQDYTTQEEA------AAKAKEGGG---- 640

  Fly   626 SAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETA 690
              |.|::|         ......||...::|||.:|::.|:.|.||::|||.||:.|.:...:.|
 Worm   641 --GGKKKG---------KSGSFMTVSMLYRESLNNLMTMLNKTHPHFIRCIIPNEKKQSGMIDAA 694

  Fly   691 KIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKNDMKLSCRNIVMKWIQD-- 753
            .::.||...||||.:||...|||:|.|:|||..||.:|..:.....:|.|.....|:.|.:.|  
 Worm   695 LVLNQLTCNGVLEGIRICRKGFPNRTLHPDFVQRYAILAAKEAKSDDDKKKCAEAIMSKLVNDGS 759

  Fly   754 --EDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHA 816
              |:.:|.|.|::||:||.:|.||.:|..                       ::..::.|.|...
 Worm   760 LSEEMFRIGLTKVFFKAGVLAHLEDIRDE-----------------------KLATILTGFQSQI 801

  Fly   817 RGYLARERTQKMREARAG-LILSKYARGWLCRR--RYLRLRHSISGIQTYARGMLARNK----FH 874
            |.:|..:..::..|.||| ||:.:..|.|...|  .:.:|...:       :.||...|    ..
 Worm   802 RWHLGLKDRKRRMEQRAGLLIVQRNVRSWCTLRTWEWFKLYGKV-------KPMLKAGKEAEELE 859

  Fly   875 AMRDHYRAVQIQRFVRGALARRAYQKRRRNIIICQAAIRRFLARRK---FKRMKAEAKTISHMEN 936
            .:.|..:|::      .:||:.  :|.|:.:....|.    |...|   |..:::....:|..|.
 Worm   860 KINDKVKALE------DSLAKE--EKLRKELEESSAK----LVEEKTSLFTNLESTKTQLSDAEE 912

  Fly   937 KYMGLENKIISMQQRIDELNRDNSNLKHKTSEISVLKMKLELKKTLEAEFKNVKAACQDKDKLIE 1001
            :...||.:.....:::.|||...::.:.:|:::.      ..||.:|||.:.:|...||    :|
 Worm   913 RLAKLEAQQKDASKQLSELNDQLADNEDRTADVQ------RAKKKIEAEVEALKKQIQD----LE 967

  Fly  1002 ALNKQLEAE---RDEKMQLLEENGHAQEEWISQKQTWRQENEELRRQIDEIIDMAKNAEVNQRNQ 1063
            ...::.|:|   :|.:::.|::....|:|.|::....::..||:.|::.|.:    .:|.::.|.
 Worm   968 MSLRKAESEKQSKDHQIRSLQDEMQQQDEAIAKLNKEKKHQEEINRKLMEDL----QSEEDKGNH 1028

  Fly  1064 EDRMLAEIDNR--ELNEAYQRAIKDKEVIENENFMLKEELSRLTAGSFSLHARKASNASSQNEDD 1126
            ::::.|:::..  :|.::.:|..:.:..::.:...::.||                ..:.:|.|:
 Worm  1029 QNKVKAKLEQTLDDLEDSLEREKRARADLDKQKRKVEGEL----------------KIAQENIDE 1077

  Fly  1127 VGYASAKNTLDINRPPDLLSKNYSYNDSTSLVVKLRSILEEEKQKHKVLQEQYIKLSSRHKPTED 1191
            .|  ..::.|:.|     |.|..|...|.|      |.||:|:.....||.| ||        :.
 Worm  1078 SG--RQRHDLENN-----LKKKESELHSVS------SRLEDEQALVSKLQRQ-IK--------DG 1120

  Fly  1192 SFRVSEL--EVENEK-LRSEYDQLRTSIKHGVEINELNAQ------HAALQEEVRRRRE-ECIQL 1246
            ..|:|||  |:|||: .||:.|:.::.::.  |:.||..:      ..|.|.||.::|| |..:|
 Worm  1121 QSRISELEEELENERQSRSKADRAKSDLQR--ELEELGEKLDEQGGATAAQVEVNKKREAELAKL 1183

  Fly  1247 KAVLLQQSQSMRSLEPESLQMRGNDVNELMEAFHSQKLINRQLESELKAITEEHNSKLVEMTQEI 1311
            :          |.||               ||       |...|::|..:.::|...:.|:|.::
 Worm  1184 R----------RDLE---------------EA-------NMNHENQLGGLRKKHTDAVAELTDQL 1216

  Fly  1312 ERLNNEKDELQKVMFESIDEFEDSNVDTLRQNDRYLRRELQKAVAQFLLVQEELKLANAKLKAYR 1376
            ::||..|.:::|...:::.:.||......::....|..|  |...||     ||:|...:.||..
 Worm  1217 DQLNKAKAKVEKDKAQAVRDAEDLAAQLDQETSGKLNNE--KLAKQF-----ELQLTELQSKADE 1274

  Fly  1377 Q----------------DGGQLEHKIEE------EMIRNKSNGTS----ADVGANVTKQKSQNPQ 1415
            |                :.|.|..::|:      ::.|.||..||    |...|:...::.|...
 Worm  1275 QSRQLQDFTSLKGRLHSENGDLVRQLEDAESQVNQLTRLKSQLTSQLEEARRTADEEARERQTVA 1339

  Fly  1416 GLMKFHSSDLDKILQRLLSALTPRTVVGLLPGFPAYLIFMCIRYTDLTNADDDVRELLSKF---- 1476
            ...|.:..:.:::.:.|...:..:..:                ...|:.|:.|:::..::|    
 Worm  1340 AQAKNYQHEAEQLQESLEEEIEGKNEI----------------LRQLSKANADIQQWKARFEGEG 1388

  Fly  1477 VIQIKKMHRTPHPIENRVIWLVNSITLLN---------LMKQYGDVDEYVKFNTEKQN------Q 1526
            :::..::.........::..|..::...|         ..:..||:|: .:.:.|:.|      :
 Worm  1389 LLKADELEDAKRRQAQKINELQEALDAANSKNASLEKTKSRLVGDLDD-AQVDVERANGVASALE 1452

  Fly  1527 QQLKNFN--LFEYRRVILDLIV--------------------NLYQALIMQIQGL------LDPK 1563
            ::.|.|:  :.|:|:...||..                    |..:.|...::||      |..:
 Worm  1453 KKQKGFDKIIDEWRKKTDDLAAELDGAQRDLRNTSTDLFKAKNAQEELAEVVEGLRRENKSLSQE 1517

  Fly  1564 IVPAILNNDEI-QRGRQAHGMRSRATSIGASSSPEHGGGPAWKQLIGQLEHFYKQFQHFGLDNCY 1627
            |...   .|:: :.||..|.|                     :::|.:||...::.|| .||...
 Worm  1518 IKDL---TDQLGEGGRSVHEM---------------------QKIIRRLEIEKEELQH-ALDEAE 1557

  Fly  1628 AEQIFHQLLYFICAVALNCLMLRGDICMWETGMIIRYNIGCIEDWVRSKKMSNDVLTALAPLNQV 1692
            |              ||..          |...::|..:...:  :||               ::
 Worm  1558 A--------------ALEA----------EESKVLRAQVEVSQ--IRS---------------EI 1581

  Fly  1693 SQLLQSRKSE------QDVQTICDLCTSLST-----AQVLKVMKSYKLDDYESEITNVFLEKLTE 1746
            .:.:|.::.|      ...:.:..:..||.|     |::|::.|..:.|..|.||.         
 Worm  1582 EKRIQEKEEEFENTRKNHARALESMQASLETEAKGKAELLRIKKKLEGDINELEIA--------- 1637

  Fly  1747 KLNARQMQKSNSDEFTIDQKFIQPFKVVFRYSDIKLED 1784
               .....|:|:|.    ||.::.::...|...:::|:
 Worm  1638 ---LDHANKANADA----QKNLKRYQEQVRELQLQVEE 1668

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 274/742 (37%)
MYSc_Myo5 84..767 CDD:276831 262/712 (37%)
IQ 900..922 CDD:197470 5/24 (21%)
GBP_C <971..1086 CDD:303769 25/119 (21%)
coiled coil 1049..1068 CDD:293879 2/18 (11%)
coiled coil 1077..1086 CDD:293879 1/8 (13%)
JAKMIP_CC3 <1190..1299 CDD:292653 30/118 (25%)
Myo5_CBD 1424..1792 CDD:271254 62/420 (15%)
unc-54NP_493596.1 Myosin_N 31..68 CDD:280832 11/47 (23%)
Myosin_head 83..775 CDD:278492 266/724 (37%)
MYSc_class_II 95..775 CDD:276951 262/712 (37%)
Myosin_tail_1 855..1932 CDD:279860 188/1018 (18%)
Prefoldin 903..>969 CDD:298833 17/75 (23%)
YlqD 946..>1020 CDD:287979 20/87 (23%)
GluZincin 1649..>1784 CDD:301352 4/20 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.910

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