DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment didum and ASPM

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:NP_060606.3 Gene:ASPM / 259266 HGNCID:19048 Length:3477 Species:Homo sapiens


Alignment Length:2145 Identity:377/2145 - (17%)
Similarity:723/2145 - (33%) Gaps:693/2145 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   105 GIILVAINPYAEMPLYGPSIIRAYRGHAMGDLEPHIFALA-EEA-----------------YTKL 151
            |:.:..:|..    |:.|.|...||...:    ||::... |||                 |.|:
Human   846 GLAMFILNRL----LWNPDIAAEYRHPTV----PHLYRDGHEEALSKFTLKKLLLLVCFLDYAKI 902

  Fly   152 ER----ENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESETQVERKV-LASSPIMEAFGNAK 211
            .|    :.|  ......|..|.|.:...::..:.:..|      .:.|.: |...|:        
Human   903 SRLIDHDPC--LFCKDAEFKASKEILLAFSRDFLSGEG------DLSRHLGLLGLPV-------- 951

  Fly   212 TTRNDNSSRFGKF----TKLLFRNQMGVMFLQGATMHTY---LLEKSRVVYQAQGERNYHIFYQL 269
               |...:.|.:|    |.|....|.||..::...:.|.   |.:|.|:...::.::.:::...|
Human   952 ---NHVQTPFDEFDFAVTNLAVDLQCGVRLVRTMELLTQNWDLSKKLRIPAISRLQKMHNVDIVL 1013

  Fly   270 CAARSKYPELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQ-----QIADIVK 329
            ...:|:..||..:|         |.....:.:.|..: .:|::.:..:.|:.|     .:..:.:
Human  1014 QVLKSRGIELSDEH---------GNTILSKDIVDRHR-EKTLRLLWKIAFAFQVDISLNLDQLKE 1068

  Fly   330 ILAGILHLGNIQVSKK------------FNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLR 382
            .:|.:.|..:|   ||            .|:...:.||.|.:.:..:|.|             |.
Human  1069 EIAFLKHTKSI---KKTISLLSCHSDDLINKKKGKRDSGSFEQYSENIKL-------------LM 1117

  Fly   383 RWL------LMRKIES--------------VNEY-------------------------VLIPNS 402
            .|:      ..:|:|:              ::.|                         |::.:|
Human  1118 DWVNAVCAFYNKKVENFTVSFSDGRVLCYLIHHYHPCYVPFDAICQRTTQTVECTQTGSVVLNSS 1182

  Fly   403 IEAAQAARDALAK--------HIYAKLFQYIVGVLNKSLNNGSKQCSFI--GVLDIYGFETFEVN 457
            .|:..::.|...|        .:|.:|           |.|..|....:  .|.|:.|....   
Human  1183 SESDDSSLDMSLKAFDHENTSELYKEL-----------LENEKKNFHLVRSAVRDLGGIPAM--- 1233

  Fly   458 SFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIESRLGVLDLLDEE 522
                  ||:::              .......|.:..|.:.|.    |..|::.|        :|
Human  1234 ------INHSD--------------MSNTIPDEKVVITYLSFL----CARLLDLR--------KE 1266

  Fly   523 CRMPKGSDESWAGKLIGKCNKFPHFEKPRFGTTSFFIKHFSDTVEYDVNGFLEKNR--------D 579
            .|..:....:|. |...|.:...|.|:.:          .:..::..|..||.|.|        .
Human  1267 IRAARLIQTTWR-KYKLKTDLKRHQEREK----------AARIIQLAVINFLAKQRLRKRVNAAL 1320

  Fly   580 TVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSK 644
            .:.|...:||::..:.:.|:    |:::.  |.:..:|.:.|        ..:...||:|.:..|
Human  1321 VIQKYWRRVLAQRKLLMLKK----EKLEK--VQNKAASLIQG--------YWRRYSTRQRFLKLK 1371

  Fly   645 QHRKTVGSQFQESLA--SLISTLHATTP---HYVRCIKPNDDKVAF---------------KWET 689
            .:...:.|:.:..:|  |....|.||..   |:...::...|:..:               ||:.
Human  1372 YYSIILQSRIRMIIAVTSYKRYLWATVTIQRHWRAYLRRKQDQQRYEMLKSSTLIIQSMFRKWKQ 1436

  Fly   690 AKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQ-------LLV---YR--SKLDKNDMKLS 742
            .|:..|::|..:|:..            :.::::|.|       :::   ||  .:|.|.....|
Human  1437 RKMQSQVKATVILQRA------------FREWHLRKQAKEENSAIIIQSWYRMHKELRKYIYIRS 1489

  Fly   743 CRNIVMK---WIQDEDKYRFGNTQI-----FFRA---GQVA---FLE------QVRANLRK---- 783
            |..|:.|   ..|.:..|:.....|     :::|   |::.   :|:      |::|..|:    
Human  1490 CVVIIQKRFRCFQAQKLYKRRKESILTIQKYYKAYLKGKIERTNYLQKRAAAIQLQAAFRRLKAH 1554

  Fly   784 ------KYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREA----------- 831
                  :...::||..|....|.:||.::|.|...|.|.|.:..|::.:||::|           
Human  1555 NLCRQIRAACVIQSYWRMRQDRVRFLNLKKTIIKFQAHVRKHQQRQKYKKMKKAAVIIQTHFRAY 1619

  Fly   832 --------------RAGLILSKYARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRD---- 878
                          .|.::|....||...|:.|:.:..|:..||:|.|..:::.:|.::::    
Human  1620 IFAMKVLASYQKTRSAVIVLQSAYRGMQARKMYIHILTSVIKIQSYYRAYVSKKEFLSLKNATIK 1684

  Fly   879 ---------------HYRA-----------------------------VQIQRFVRGALARRAYQ 899
                           |.||                             :::|.||||.|.|:..:
Human  1685 LQSTVKMKQTRKQYLHLRAAALFIQQCYRSKKIAAQKREEYMQMRESCIKLQAFVRGYLVRKQMR 1749

  Fly   900 KRRRNIIICQAAIRRFLARRKFKRM--------------KAEA----------KTISHMENKYMG 940
            .:|:.:|..|:..|...||:.:.:|              ||:.          |..:.::..|.|
Human  1750 LQRKAVISLQSYFRMRKARQYYLKMYKAIIVIQNYYHAYKAQVNQRKNFLQVKKAATCLQAAYRG 1814

  Fly   941 LENKIISMQQRIDELNRD------NSNLKHKTSEISVLKMK--LELKKTL---EAEFKNVKAACQ 994
            .:.:.:..||.|..|...      |..:|:::...|::|::  ....|||   ...|...|||..
Human  1815 YKVRQLIKQQSIAALKIQSAFRGYNKRVKYQSVLQSIIKIQRWYRAYKTLHDTRTHFLKTKAAVI 1879

  Fly   995 DKDKLIEA--LNKQLEAERDE--KMQLLEENGHAQEEW---------ISQK-QTWR------QEN 1039
            ........  :.||:..|...  |:|.......||:::         |.|. :.|.      .|.
Human  1880 SLQSAYRGWKVRKQIRREHQAALKIQSAFRMAKAQKQFRLFKTAALVIQQNFRAWTAGRKQCMEY 1944

  Fly  1040 EELRRQIDEIIDMAKNAEVNQRNQEDRMLAEIDNRELNEAYQRAIKDK--EVIENENFMLKEELS 1102
            .|||..:..:..|.|...:.::.|.....|.|    :...|:..::.|  ::::....::::...
Human  1945 IELRHAVLVLQSMWKGKTLRRQLQRQHKCAII----IQSYYRMHVQQKKWKIMKKAALLIQKYYR 2005

  Fly  1103 RLTAGSFSLHARKASNASSQNEDDVGYASAKNTLDINRPPDLLSKNYSYNDSTSLVVKLRSILEE 1167
            ..:.|....|....:.|:.     |...||...:.:.:         ...|.....|.::|....
Human  2006 AYSIGREQNHLYLKTKAAV-----VTLQSAYRGMKVRK---------RIKDCNKAAVTIQSKYRA 2056

  Fly  1168 EKQKHK---------VLQEQY--IKLSS-RHKPTEDSFRVSELEVENEKLRSEYDQLR------- 1213
            .|.|.|         ::|..|  ||::: :||      ....|:....|::|.|..:|       
Human  2057 YKTKKKYATYRASAIIIQRWYRGIKITNHQHK------EYLNLKKTAIKIQSVYRGIRVRRHIQH 2115

  Fly  1214 -----TSIK-----HGVEINELNAQHAALQEEVRRR--------REECIQ-LKAV-LLQQS---- 1254
                 |.||     |...|:....:.||:..:||.|        ||:.:. |||| :||.|    
Human  2116 MHRAATFIKAMFKMHQSRISYHTMRKAAIVIQVRCRAYYQGKMQREKYLTILKAVKVLQASFRGV 2180

  Fly  1255 ---QSMRSLEPESLQMRGNDVNELMEAFHSQKLINRQLESELKAITEEHNSK---LVEMTQEIER 1313
               :::|.::..:..::.|     ...:..|...|:     ||.||:....:   :.|...:.:|
Human  2181 RVRRTLRKMQTAATLIQSN-----YRRYRQQTYFNK-----LKKITKTVQQRYWAMKERNIQFQR 2235

  Fly  1314 LN--------------NEKDELQKVMFESIDEFEDSNVDTLRQNDRYLRRELQKAVAQFLLVQEE 1364
            .|              .:|......|.............||....|:|  .|:|..   :|:|.:
Human  2236 YNKLRHSVIYIQAIFRGKKARRHLKMMHIAATLIQRRFRTLMMRRRFL--SLKKTA---ILIQRK 2295

  Fly  1365 -------------LKLANAKLK---AYRQDGGQLEHKIEE---------------------EMIR 1392
                         |::.||.:|   :||:  ..:..::.|                     :.::
Human  2296 YRAHLCTKHHLQFLQVQNAVIKIQSSYRR--WMIRKRMREMHRAATFIQSTFRMHRLHMRYQALK 2358

  Fly  1393 NKSNGTSADVGANVTKQKSQNPQGLMKFHSSDLDKILQRLLSALTPR--------TVVGLLPGFP 1449
            ..|........|| ...|.|....|.:.||:   .|||.....:..|        :...:...|.
Human  2359 QASVVIQQQYQAN-RAAKLQRQHYLRQRHSA---VILQAAFRGMKTRRHLKSMHSSATLIQSRFR 2419

  Fly  1450 AYLIFMCIRYTDLTNADDDVRELLSKFVIQIKKMHRTPHPIENRVIWLVNSITLLNLMKQYGDVD 1514
            :.|:..  |:..|..|...|:......:....|:::..| :....|.:.:|...|.:.|:..::.
Human  2420 SLLVRR--RFISLKKATIFVQRKYRATICAKHKLYQFLH-LRKAAITIQSSYRRLMVKKKLQEMQ 2481

  Fly  1515 E--------------YVKFNTEKQN----QQQLKNFNLFEYRRVILDLIVNLYQALI-------M 1554
            .              |:.|.|.|..    ||..:.:...:.:|.  :.|...:.|::       |
Human  2482 RAAVLIQATFRMYRTYITFQTWKHASILIQQHYRTYRAAKLQRE--NYIRQWHSAVVIQAAYKGM 2544

  Fly  1555 QIQGLLDPKIVPAILNNDEIQRGRQ--AHGMRSRATSIGASSSPEHGGGPAWKQLIGQLEHFYKQ 1617
            :.:.||..|...:|:.....:..||  .:.....||.|    ..|.......||.:.|.....|:
Human  2545 KARQLLREKHKASIVIQSTYRMYRQYCFYQKLQWATKI----IQEKYRANKKKQKVFQHNELKKE 2605

  Fly  1618 ------FQHFGLDNCYAEQIFHQLLYFI---C---AVALNCLMLRGDICMWETGMIIRYN----- 1665
                  ||...:.....||  ||....|   |   .:..:.|.||..:...:.    ||.     
Human  2606 TCVQAGFQDMNIKKQIQEQ--HQAAIIIQKHCKAFKIRKHYLHLRATVVSIQR----RYRKLTAV 2664

  Fly  1666 ----IGCIEDWVRSKKMSNDVLTALAPLNQVSQLLQS----RKSEQDVQTICDLCTSLSTAQVLK 1722
                :.||:.:.|..|:..|:..    :::.:.|:||    .:::.|.:|        ....::.
Human  2665 RTQAVICIQSYYRGFKVRKDIQN----MHRAATLIQSFYRMHRAKVDYET--------KKTAIVV 2717

  Fly  1723 VMKSYKLDDYESEITNVFLEKLTEKLNARQMQKSNSDEFTIDQKFIQPFKVVFRYSDI--KLEDI 1785
            :...|:|          ::...||:.|...:|||           ::..:..||...:  ||:::
Human  2718 IQNYYRL----------YVRVKTERKNFLAVQKS-----------VRTIQAAFRGMKVRQKLKNV 2761

  Fly  1786  1785
            Human  2762  2761

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 137/834 (16%)
MYSc_Myo5 84..767 CDD:276831 133/811 (16%)
IQ 900..922 CDD:197470 6/21 (29%)
GBP_C <971..1086 CDD:303769 28/139 (20%)
coiled coil 1049..1068 CDD:293879 3/18 (17%)
coiled coil 1077..1086 CDD:293879 1/8 (13%)
JAKMIP_CC3 <1190..1299 CDD:292653 32/142 (23%)
Myo5_CBD 1424..1792 CDD:271254 75/424 (18%)
ASPMNP_060606.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..30
ASH 37..134 CDD:292408
Sufficient for interaction with KATNA1:KATNB1. /evidence=ECO:0000250|UniProtKB:Q8CJ27 308..409
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 415..443
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 559..581
CH 960..1056 CDD:294029 19/105 (18%)
CH 1114..>1171 CDD:278723 6/69 (9%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0160
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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