DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment didum and Myh9

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:NP_037326.2 Gene:Myh9 / 25745 RGDID:3140 Length:1960 Species:Rattus norvegicus


Alignment Length:1937 Identity:523/1937 - (27%)
Similarity:881/1937 - (45%) Gaps:355/1937 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 IWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLRNPAILVGQNDLTTL 78
            :|||.....:|.|:|:|..  |...:....::||    |:|.:..|:..: ||.......|:..|
  Rat    32 VWVPSTKNGFEPASLKEEV--GEEAIVELVENGK----KVKVNKDDIQKM-NPPKFSKVEDMAEL 89

  Fly    79 SYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLEPHIFAL 143
            :.|:|..|||||:.|:.. .:||||.|:..|.||||..:|:|...|:..|:|....::.|||:|:
  Rat    90 TCLNEASVLHNLKERYYS-GLIYTYSGLFCVVINPYKNLPIYSEEIVDMYKGKKRHEMPPHIYAI 153

  Fly   144 AEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGS----ESETQVERKVLASSPIM 204
            .:.||..:.::..:.||:.:||||||||.:.|..::|.|.|..|    :.:.::||::|.::||:
  Rat   154 TDTAYRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSHKSKKDQGELERQLLQANPIL 218

  Fly   205 EAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHIFYQL 269
            ||||||||.:||||||||||.::.| :..|  ::.||.:.||||||||.:.||:.||.:||||.|
  Rat   219 EAFGNAKTVKNDNSSRFGKFIRINF-DVNG--YIVGANIETYLLEKSRAIRQAKEERTFHIFYYL 280

  Fly   270 CAARSKY--PELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIADIVKILA 332
            .:...::  .:|:|:..:|::||: .|...|....|.:.|.||::||.::|....:...::::::
  Rat   281 LSGAGEHLKTDLLLEPYNKYRFLS-NGHVTIPGQQDKDMFQETMEAMRIMGIPEDEQMGLLRVIS 344

  Fly   333 GILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKIESVNEYV 397
            |:|.|||| |.||      |.::|...:..|.. .|..:.||.::..|..|.:|..:|:...:||
  Rat   345 GVLQLGNI-VFKK------ERNTDQASMPDNTA-AQKVSHLLGINVTDFTRGILTPRIKVGRDYV 401

  Fly   398 LIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQ-CSFIGVLDIYGFETFEVNSFEQ 461
            ....:.|.|..|.:||||..|.::|:::|..:||:|:...:| .||||:|||.|||.|::|||||
  Rat   402 QKAQTKEQADFAIEALAKATYERMFRWLVLRINKALDKTKRQGASFIGILDIAGFEIFDLNSFEQ 466

  Fly   462 FCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDF-YDNQPCIDLIESRL---GVLDLLDEE 522
            .||||.||||||.||..:|.||||||.:|||.|..||| .|.||||||||...   |:|.|||||
  Rat   467 LCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDLIEKPAGPPGILALLDEE 531

  Fly   523 CRMPKGSDESWAGKLIGKCNKFPHFEKPR--FGTTSFFIKHFSDTVEYDVNGFLEKNRDTVSKEL 585
            |..||.:|:|:..|::.:....|.|:||:  .....|.|.|::..|:|..:.:|.||.|.::..:
  Rat   532 CWFPKATDKSFVEKVVQEQGTHPKFQKPKQLKDKADFCIIHYAGKVDYKADEWLMKNMDPLNDNI 596

  Fly   586 TQVLSESNMSLAKQVMTLEEIDTLC----VDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQH 646
            ..:|.:|:.....::.  :::|.:.    |.....:.|.|..           .||:.:.     
  Rat   597 ATLLHQSSDKFVSELW--KDVDRIIGLDQVAGMSETALPGAF-----------KTRKGMF----- 643

  Fly   647 RKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAG 711
             :|||..::|.||.|::||..|.|::||||.||.:|.|.|.:...::.|||..||||.:||...|
  Rat   644 -RTVGQLYKEQLAKLMATLRNTNPNFVRCIIPNHEKKAGKLDPHLVLDQLRCNGVLEGIRICRQG 707

  Fly   712 FPSRWLYPDFYMRYQLLVYRSKLDKN--DMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAFL 774
            ||:|.::.:|..||::|...| :.|.  |.|.:|..::.....|.:.||.|.:::|||||.:|.|
  Rat   708 FPNRVVFQEFRQRYEILTPNS-IPKGFMDGKQACVLMIKALELDSNLYRIGQSKVFFRAGVLAHL 771

  Fly   775 EQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARER-TQKMREARAGLILS 838
            |:.|.                       |:|..||.|.|...||||||:. .::.::..|..:|.
  Rat   772 EEERD-----------------------LKITDVIIGFQACCRGYLARKAFAKRQQQLTAMKVLQ 813

  Fly   839 KYA------RGWLCRRRYLRLRHSISGIQTYARGMLA--------RNKFHAMRDHYRAVQIQRFV 889
            :..      |.|...|.:.:::..::.|: :...:||        |.|..|..:....::..:..
  Rat   814 RNCAAYLRLRNWQWWRLFTKVKPLLNSIR-HEDELLAKEAELTKVREKHLAAENRLTEMETMQSQ 877

  Fly   890 RGALARRAYQKRRRNIIICQAAIRRFLARRKFKRMKAEAKTISH-----MEN-----KYMGLENK 944
            ..|...:..::.:....:|..|..   .|.:....|.|.:.|.|     :|.     :|:..|.|
  Rat   878 LMAEKLQLQEQLQAETELCAEAEE---LRARLTAKKQELEEICHDLEARVEEEEERCQYLQAEKK 939

  Fly   945 IISMQQRIDELNRDNSNLKHKTSEISVLKMKLELKK-TLEAEFK------------NVKAACQDK 996
              .|||.|.|       |:.:..|....:.||:|:| |.||:.|            |.|.|.:.|
  Rat   940 --KMQQNIQE-------LEEQLEEEESARQKLQLEKVTTEAKLKKLEEDQIIMEDQNCKLAKEKK 995

  Fly   997 ---DKLIEALNKQLEAERDEKMQLLEENGHAQ-----EEWISQKQTWRQENEELRRQI------- 1046
               |::.|.....:|.|...|.....:|.|..     ||.:.:::..|||.|:.||::       
  Rat   996 LLEDRVAEFTTNLMEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDL 1060

  Fly  1047 -DEIIDM-AKNAEVNQR--NQEDRMLAEIDNRELNEAYQR--AIKDKEVIENENFMLKEELSRLT 1105
             |:|.:: |:.||:..:  .:|:.:.|.:...| .||.|:  |:|....:|.:...|:|:|.   
  Rat  1061 SDQIAELQAQIAELKMQLAKKEEELQAALARVE-EEAAQKNMALKKIRELETQISELQEDLE--- 1121

  Fly  1106 AGSFSLHARKASNASSQNEDDVG--YASAKNTLDINRPPDLLSKNYSYNDSTSLVVKLRSILEEE 1168
                  ..|...|.:.:.:.|:|  ..:.|..|:     |.|       |||:...:|||..|:|
  Rat  1122 ------SERACRNKAEKQKRDLGEELEALKTELE-----DTL-------DSTAAQQELRSKREQE 1168

  Fly  1169 KQKHKVLQEQYIKLSSRHKPTEDSFRVSELEVENEKLRSEYDQLRTSIKHGVEINELNAQHAALQ 1233
                         :|...|..||..:.                      |..:|.|:..:|:...
  Rat  1169 -------------VSILKKTLEDEAKT----------------------HEAQIQEMRQKHSQAV 1198

  Fly  1234 EEVRRRREECIQLKAVLLQQSQSMRSLEPESLQMRGNDVNELM----EAFHSQKLINRQLESELK 1294
            ||:..:.|:..::||.|   .::.::||.|..:: .|:|..|:    ::.|.:|.:..||: ||:
  Rat  1199 EELAEQLEQTKRVKATL---EKAKQTLENERGEL-ANEVKALLQGKGDSEHKRKKVEAQLQ-ELQ 1258

  Fly  1295 AITEEHNSKLVEMTQEIERLNNEKDELQKVMFESIDEFEDSNVDTLRQNDRYLRRELQKAVAQFL 1359
            ....|......|:..::.:|..|.|.:..::.:|     ||....|.::...|..:||....   
  Rat  1259 VKFSEGERVRTELADKVSKLQVELDSVTGLLNQS-----DSKSSKLTKDFSALESQLQDTQE--- 1315

  Fly  1360 LVQEE--LKLA-NAKLKAYRQDGGQLEHKI-EEEMIRNKSNGTSADVGANVTKQKSQNPQGLMKF 1420
            |:|||  .||: :.|||....:......:: |||..:.......|.:.|.||..|.:...|:...
  Rat  1316 LLQEENRQKLSLSTKLKQMEDEKNSFREQLEEEEEAKRNLEKQIATLHAQVTDMKKKMEDGVGCL 1380

  Fly  1421 HSS---------DLDKILQRLLSALT-----PRTVVGLLPGFPAYLIFMCIRYTDLTNADD---- 1467
            .::         ||:.:.|||...:.     .:|...|.......|:.:..:...::|.:.    
  Rat  1381 ETAEEAKRRLQKDLEGLSQRLEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSVSNLEKKQKK 1445

  Fly  1468 ------DVRELLSKFVIQIKKMHRTPHPIENRVIWLVNSITLLNLMKQYGDVDEYVK-FNTEKQN 1525
                  :.:.:.:|:..:..:........|.:.:.|..:  |...|:|..:::...| |.||.::
  Rat  1446 FDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARA--LEEAMEQKAELERLNKQFRTEMED 1508

  Fly  1526 QQQLKN------FNLFEYRRVILDLIVNL---YQALIMQIQGLLDPKI---VPAILNNDEIQRGR 1578
            ....|:      ..|.:.:|.:...:..:   .:.|..::|...|.|:   |.......:.:|..
  Rat  1509 LMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDL 1573

  Fly  1579 QAHGMRSRATSIGASSSPEHGGGPAWKQLIGQLEHFYKQFQ------------------------ 1619
            |....:|....               |||:.|:.....:.:                        
  Rat  1574 QGRDEQSEEKK---------------KQLVRQVREMEAELEDERKQRSIAMAARKKLEMDLKDLE 1623

  Fly  1620 -HFGLDNCYAEQIFHQLLYFICAVALNCLMLRGDICMWETGMIIRYNIGCIEDWVRSKKMSNDVL 1683
             |....|...|:...|         |..|..:...||.|           ::|    .:.|.:.:
  Rat  1624 AHIDTANKNREEAIKQ---------LRKLQAQMKDCMRE-----------LDD----TRASREEI 1664

  Fly  1684 TALAPLNQVSQLLQSRKSEQDVQTICDLCTSLSTAQVLKVMKSYKLDDYESEITN------VFLE 1742
            .|.|..|:  :.|:|.::|     :..|...|:.|:..|.....:.|:...||.|      :.||
  Rat  1665 LAQAKENE--KKLKSMEAE-----MIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALE 1722

  Fly  1743 KLTEKLNARQMQKSNSDEFTIDQKFIQPFKVVFRYSDIKLEDIELPSHLNLD 1794
            : ..:|.||..|.  .:|...:|...:......:.::::::.|.  :.|||:
  Rat  1723 E-KRRLEARIAQL--EEELEEEQGNTELINDRLKKANLQIDQIN--TDLNLE 1769

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 280/731 (38%)
MYSc_Myo5 84..767 CDD:276831 267/701 (38%)
IQ 900..922 CDD:197470 3/21 (14%)
GBP_C <971..1086 CDD:303769 39/148 (26%)
coiled coil 1049..1068 CDD:293879 5/21 (24%)
coiled coil 1077..1086 CDD:293879 4/10 (40%)
JAKMIP_CC3 <1190..1299 CDD:292653 24/112 (21%)
Myo5_CBD 1424..1792 CDD:271254 68/426 (16%)
Myh9NP_037326.2 Myosin_N 29..68 CDD:397036 12/41 (29%)
Motor_domain 95..764 CDD:419868 267/701 (38%)
Myosin_tail_1 842..1921 CDD:396244 211/1064 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.910

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