Protein Alignment didum and myo51

DIOPT Version :10

• Sequence 1: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Sequence 2: NP_596233.1
• Gene: myo51 / 2540560
• PomBaseID: SPBC2D10.14C
• Length: 1471
• Species: Schizosaccharomyces pombe
• Alignment Length: 1794
• Identity: 507/1794 - (28%)
• Similarity: 809/1794 - (45%)
• Gaps: 432/1794 - (24%)

  Fly    11 GAKIWVPHADLVWESATLEESYRKGAG--FLKICTDSGKLKEVKLKADGSDLPPLRNPAILVGQ- 72
            |::.||.:.:..|::|.|.|....|.|  ...:...||.|:.|..:       .|:|..|  ||
pombe     9 GSECWVSNNNGHWDAARLIEIKDNGGGKVVATVAKSSGVLETVNYQ-------QLQNRNI--GQS 64

  Fly    73 ---NDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMP-LYGPSIIRAYRGHAM 133
               :|||.|.||:||.|||.|..|:..:| ||||.||:||:||||..:| .|..::|:.:.....
pombe    65 ESPSDLTNLPYLNEPSVLHALHNRYNNKQ-IYTYSGIVLVSINPYQNLPEFYNDNLIKHFHKDPE 128

  Fly   134 GDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSES----ETQVE 194
            ....||::::|...|..|..::.|.:|||||||||||||:|||.|||..:|.|.:.    :..||
pombe   129 AAKVPHLYSIASSCYHALTTDSKNQTIIVSGESGAGKTVAAKYIMRYLTSVQGVDHNGVVKRSVE 193

  Fly   195 RKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQG 259
            .:|||::|||||||||||.||||||||||:..:.|...   :.:.||.::|||||:||||...:|
pombe   194 NQVLATNPIMEAFGNAKTIRNDNSSRFGKYVTISFDEN---LLITGANVNTYLLERSRVVSLLKG 255

  Fly   260 ERNYHIFYQLCAA-----RSKYPELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGF 319
            ||||||||||...     |.|:   .|:....|.:|:.|...||..|.|:..|..|.:|::.:|.
pombe   256 ERNYHIFYQLITGCTEEQRDKW---FLESASSFNYLSQGNCDEISGVDDSNDFTITCRALSTIGI 317

  Fly   320 SIQQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRW 384
            |..:..|:..:||.:||||||:|....||         ..|...|.:||..|.||.|.:..|.:|
pombe   318 SESRQEDVFCLLAALLHLGNIEVCATRNE---------AQIQPGDGYLQKAALLLGVDSSTLAKW 373

  Fly   385 LLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSL-NNGSKQCS--FIGVL 446
            ::.|::::.:|.::..:::|.|.:.||::||::|:.||.:||.::|.|| :|..|:.:  :|||:
pombe   374 IVKRQLKTRSETIITSSTLEHAISIRDSVAKYLYSALFLWIVHMINASLDHNKVKRAAYKYIGVV 438

  Fly   447 DIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIES 511
            ||||||.||.||.||||||||||||||:||:||||||||||:|||:.|.:|::.|||.||.|||.
pombe   439 DIYGFEHFEKNSMEQFCINYANEKLQQEFNKHVFKLEQEEYVKEGLDWRLIEYSDNQGCISLIED 503

  Fly   512 RLGVLDLLDEECRMPKGSDESWAGKLIGKCNKFP-----HFEKPRFGTTSFFIKHFSDTVEYDVN 571
            :||:|.|||||||:|.|:.:|:..||   .|:.|     .::|.||...||.:||::..|.|.|:
pombe   504 KLGILSLLDEECRLPSGNHQSFLQKL---NNQLPTKHSQFYKKSRFNDGSFMVKHYALDVSYQVH 565

  Fly   572 GFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDT 636
            .||.||.|.:..|...:|..|.          .|..|..:|....       ::|:    |..:.
pombe   566 DFLAKNSDAIPDEFISLLQNSK----------NEFITYLLDFYMQ-------LVSS----QNKNP 609

  Fly   637 RRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGV 701
            |:..:..|   .|:.|.|:.||:.|::|:.:|..||:||||||::|:.:.:....::.|||||||
pombe   610 RKTAISRK---PTLSSMFKSSLSQLMTTVSSTNVHYIRCIKPNEEKLPWTFSPPMVLSQLRACGV 671

  Fly   702 LETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKNDMKLSCRNIVMKWI-QDEDKYRFGNTQIF 765
            .||:|||:.|||:|:.|.:|..|:::|:...:.::::.||:. |||...| .|...::.|.::||
pombe   672 FETIRISSLGFPARFSYEEFAHRFRILLSSKEWEEDNKKLTL-NIVNSVIPHDNLNFQVGRSKIF 735

  Fly   766 FRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMRE 830
            ||:..:...|:.......|...::||.:|.|..|:::.|..|.|..:|....|:|.|:|.::.:.
pombe   736 FRSNVIGNFEEAHRATCSKSTVLLQSAIRGFFTRKEYQRTVKFIIKLQSVIMGWLTRQRFEREKI 800

  Fly   831 ARAGLILSKYARGWLCRRRYLRLRHSISGIQTYARGMLARNKF-HAMRDHYRAVQIQRFVRGALA 894
            .||.:::..:.|.::.|:|||.|......||:..|..:|.::: :.:|:. .|..:.:|.|...|
pombe   801 ERAAILIQAHWRSYIQRKRYLSLIKCAIVIQSIVRKNIAYSRYINELRES-SATLLAKFWRAYNA 864

  Fly   895 RRAYQKRRRNIIICQAAIRRFLARRKFKRMKAEAKTISHMENKYMGLENKIISMQQRIDELNRDN 959
            |:.::..::::|..|...|..|.||..:|::..|...|.:..|...|:..|..:.::
pombe   865 RKTFRGLKKSVIALQCVSRSVLTRRYLRRLQDSAGRTSILYEKQKNLQASITEVSKQ-------- 921

  Fly   960 SNLKHKTSEISVLKMKLELKKTLEAEFKNVKAACQDKDKLIEALNKQLEAERDEKMQLLEENGHA 1024
              ||..:.:::||:.||.:   |.......|...:......|.::....:..::.:|||
pombe   922 --LKSNSKKVTVLRNKLNI---LNNSLSKWKCLIKKPSDFSEPVSMDFTSNDEQLVQLL------ 975

  Fly  1025 QEEWISQKQTWRQENEELRRQIDEIIDMAKNAEV----NQRNQEDRMLAEIDNRELNEAYQRAIK 1085
                        |...:||:...::...||.:|:    :|..:|:     :.|  ..:|.|..:.
pombe   976 ------------QAESKLRQASQQLYMAAKKSELGFVQSQTAREN-----LSN--YYQALQMTVS 1021

  Fly  1086 DKEVIENENF---MLKEELSRLTAGSFSLHARKASNASSQNEDDVGYASAKNTLDINRPPDLLSK 1147
            :|...:.|..   :|...:.|.    ||:|.:                 .|..|::
pombe  1022 EKFEYDTEQLPSRVLFYAMDRY----FSIHKK-----------------LKQLLEL--------- 1056

  Fly  1148 NYSYNDSTSLVVKLRSILEEE---KQKHKVLQEQYIKLSSRHKPTEDSFRVSELEVENEKLRSEY 1209
                     :.|:..|:|..|   ||...:|.|:.:...   |..:.:..||.|          :
pombe  1057 ---------VGVENASLLPNEVVNKQTKDLLYEKRVVFL---KQIKQALTVSSL----------F 1099

  Fly  1210 DQLRTSIKHGVEINELNAQHAALQEEVRRRREECIQLKAVLLQQSQSMRSLEPESLQMRGNDVNE 1274
            :.:  ..|.||                                    ||.||        .|.|.
pombe  1100 NAV--GYKDGV------------------------------------MRLLE--------TDQNS 1118

  Fly  1275 LMEAFHSQKLINRQLESELKAITEEHNSKLVEMTQEIERLNNEKDELQKVMFESIDEFEDSNVD- 1338
            |:.|.....||...:..:||....|..|:|.....:|                         ||
pombe  1119 LLFAGVVNFLIFAGISLDLKTQISEFLSQLCSYFTKI-------------------------VDG 1158

  Fly  1339 TLRQNDR---YLRRELQKAVAQFLLVQEELKLANAKLKAYRQDGGQLEHKIEE---EMIRNKSNG 1397
            |:.:||:   :..:.||..:..|..:                      |||..   .::...|:|
pombe  1159 TVIENDKTLDFYEKPLQAVLYWFATL----------------------HKIRSFLVHLLSINSHG 1201

  Fly  1398 TSADVGANVTKQKSQNPQGLMKF--HSSDLD----KILQRLLSALTPRTVVGLLPGFPAYLIFMC 1456
            ..:.|      :...||. ::||  |.|:|:    .::|:|||..|..::..||..       .|
pombe  1202 KQSVV------EDLWNPL-ILKFSKHFSNLENSFHSLVQKLLSCCTEGSINALLNS-------KC 1252

  Fly  1457 IRYTDLTNADDDVRELLSKFVIQIKKMHRTPHPIENRVIWLVNSITLLNLMKQYGDVDEYVKFNT 1521
            :  .:..:|.|:               :.||
pombe  1253 L--PEFIDAADE---------------NTTP---------------------------------- 1266

  Fly  1522 EKQNQQQLKNFNLFEYRRVILDLIVNLYQALIMQIQGLLDPKIVPAILNNDEIQRGRQAHGMRSR 1586
                    ...|::|    ::|. :||...|:  |...|.|.::..     .|....|..|.|:.
pombe  1267 --------TGMNIYE----LIDR-MNLIHKLL--ISSALQPNLLEL-----TISHMLQHIGQRAF 1311

  Fly  1587 ATSIGASSSPEHGGGPAWKQLIGQLEHFYKQFQHFGLDNCYAEQIFHQLLYFICAVALNCLMLRG 1651
            .|.|       ||..|                        |.
pombe  1312 QTLI-------HGRSP------------------------YT----------------------- 1322

  Fly  1652 DICMWETGMIIRYNIGCIEDWVRSKKMSNDVLTALAPLNQVSQLLQSRKSE-QDVQTICDLCTSL 1715
                |::...:.||...:.:|...|.:|. |.::|.||.|...:...||:: .|:..|..:|..|
pombe  1323 ----WKSASQVSYNASLLINWCHQKGISY-VNSSLLPLMQSPLVFCLRKNDANDLDVILSVCNLL 1382

  Fly  1716 STAQVLKVMKSYKLDDYESEITNVFLEKLTEKLNARQMQ 1754
            |..:|:.::..|:....|:.:...| .|..|.|:.:..|
pombe  1383 SPFEVVCLLNRYQPCAGENPLPKSF-SKAVEALSCKYKQ 1420

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	294/701 (42%)
		IQ	900..922	CDD:197470	6/21 (29%)
		SMC_prok_B	<942..1365	CDD:274008	72/436 (17%)
		Myo5_CBD	1424..1792	CDD:271254	58/336 (17%)
myo51	NP_596233.1	COG5022	1..1471	CDD:227355	507/1794 (28%)