DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment didum and Myh8

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:NP_001093955.1 Gene:Myh8 / 252942 RGDID:620356 Length:1937 Species:Rattus norvegicus


Alignment Length:2095 Identity:541/2095 - (25%)
Similarity:890/2095 - (42%) Gaps:517/2095 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 SSEEMLYAQGAKIWVPHADLVWESATLEESY------RKGAGFLKICTDSGKLKEVKLKADGSDL 60
            |.:|.:.||........:..|.|.   :|||      .|..|.:.:.|:||....||   :....
  Rat    22 SEKERIEAQNKPFDAKTSVFVAEP---KESYVKSVIQSKEGGKVTVKTESGATLTVK---EDQVF 80

  Fly    61 PPLRNPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSII 125
            |  .||.......|:..:::|||||||:||:.|:. ..:||||.|:..|.:|||..:|:|.|.::
  Rat    81 P--MNPPKYDKIEDMAMMTHLHEPGVLYNLKERYA-AWMIYTYSGLFCVTVNPYKWLPVYNPEVV 142

  Fly   126 RAYRGHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFA--AVGGSE 188
            .||||....:..||||::::.||..:..:..|.||:::|||||||||:.|..::|||  ||.|.:
  Rat   143 AAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGEK 207

  Fly   189 SETQ-------VERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTY 246
            .:.:       :|.::::::|::||||||||.|||||||||||.::.| ...|.  |..|.:.||
  Rat   208 KKEESGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHF-GTTGK--LASADIETY 269

  Fly   247 LLEKSRVVYQAQGERNYHIFYQLCAARSKYPE-----LVLDHQDKFQFLNMGGAPEIERVSDAEQ 306
            |||||||.:|.:.||:||||||:.:  :|.||     |:..:...:.|::.|.. .:..:.|.|:
  Rat   270 LLEKSRVTFQLKAERSYHIFYQITS--NKKPELIEMLLITTNPYDYAFVSQGEI-TVPSIDDQEE 331

  Fly   307 FNETVQAMTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQI-- 369
            ...|..|:.:||||.::...|.|:...::|.||::..:|..|  |:.:.|..::.....:||.  
  Rat   332 LMATDSAIDILGFSPEEKVSIYKLTGAVMHYGNMKFKQKQRE--EQAEPDGTEVADKAAYLQSLN 394

  Fly   370 TADLLRVSADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLN 434
            :||||:.        |...:::..||||....:::....|..||||.:|.|:|.::|..:|:.|:
  Rat   395 SADLLKA--------LCYPRVKVGNEYVTKGQTVQQVYNAVGALAKAVYEKMFLWMVTRINQQLD 451

  Fly   435 NGSKQCSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDF 499
            ....:..|||||||.|||.|:.||.||.|||:.||||||.||.|:|.||||||.||||.||.|||
  Rat   452 TKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDF 516

  Fly   500 -YDNQPCIDLIESRLGVLDLLDEECRMPKGSDESWAGKL----IGKCNKFPHFEKPR----FGTT 555
             .|...||:|||..||:..:|:|||..||.:|.|:..||    :||.|   :|:||:    ....
  Rat   517 GMDLAACIELIEKPLGIFSILEEECMFPKATDTSFKNKLYDQHLGKSN---NFQKPKPTKGKAEA 578

  Fly   556 SFFIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNM-SLAKQVMTLEEIDTLCVDSAKSSTL 619
            .|.:.|::.||:|::.|:|:||:|.::..:..:..:|.| :||....|.          |.:...
  Rat   579 HFSLIHYAGTVDYNITGWLDKNKDPLNDTVVGLYQKSAMKTLASLFSTY----------ASAEAD 633

  Fly   620 GGRVVISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVA 684
            ||   ...|.|::|:..           :||.:.|:|:|..|::.|.:|.||:||||.||:.|..
  Rat   634 GG---AKKGAKKKGSSF-----------QTVSALFRENLNKLMTNLRSTHPHFVRCIIPNETKTP 684

  Fly   685 FKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKN---DMKLSCRNI 746
            ...|...::.|||..||||.:||...|||||.||.||..||::| ..|.:.:.   |.|.:...:
  Rat   685 GAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYGDFKQRYKVL-NASAIPEGQFIDSKKASEKL 748

  Fly   747 VMKWIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVING 811
            :.....|..:|:||:|::||:||.:..||::|.....:.||..|:|                   
  Rat   749 LGSIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDEKLAQIITRTQAV------------------- 794

  Fly   812 IQKHARGYLARERTQKMREARAGLILSKY-------ARGWLCRRRYLRLRHSISGIQTYARGMLA 869
                .||||.|...|||...|..:...:|       .:.|...:.:.:::..:...:|.......
  Rat   795 ----CRGYLMRVEYQKMLLRRESIFCIQYNIRAFMNVKHWPWMKLFFKIKPLLKSAETEKEMATM 855

  Fly   870 RNKFHAMRDHYRAVQIQRFVRGALARRAYQK-----RRRNIIICQAAIRRFLARRKFKRMKAEAK 929
            :.:|...:|.....:.:|       :...:|     :.:|.:..|              :::||.
  Rat   856 KEEFQKTKDELAKSEAKR-------KELEEKMVTLLKEKNDLQLQ--------------VQSEAD 899

  Fly   930 TISHMENKYMGLENKIISMQQRIDELNRDNSNLKHKTSEISVLKMKL-----ELKKTLE------ 983
            :::..|.:...|....|.::.:|.|:.....:.:...:|::..|.||     ||||.::      
  Rat   900 SLADAEERCEQLIKNKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL 964

  Fly   984 AEFKNVKAACQDK-----------DKLIEALNKQ--------------LEAERDEKMQL------ 1017
            |:.:..|.|.::|           |:.|..|.|:              |:||.|:...|      
  Rat   965 AKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKTK 1029

  Fly  1018 LEENGHAQEEWISQKQTWRQENEELRRQIDEIIDMAKNAEVNQRNQEDRMLAEIDNRELNEAYQR 1082
            ||:.....|..:.|::..|.:.|..:|:::..:.:|         ||..|..|.|.::|:|..::
  Rat  1030 LEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLA---------QESTMDIENDKQQLDEKLKK 1085

  Fly  1083 ----------AIKDKEVIENE-NFMLKEELSRLTAGSFSLHARKASNASSQNEDDVGYASAKNTL 1136
                      .|:|::.:|.: ...:||..:|:......:.|.:||.|.::          |...
  Rat  1086 KEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELEEEIEAERASRAKAE----------KQRS 1140

  Fly  1137 DINRPPDLLSKNY-SYNDSTSLVVKLRSILEEEKQK------HKVLQEQYIKLSSRHKPTEDSFR 1194
            |::|..:.:|:.. ....:||..|:|....|.|.||      ...||.:....:.|.|..:....
  Rat  1141 DLSRELEEISERLEEAGGATSAQVELNKKRETEFQKLRRDLEEATLQHEATSAALRKKHADSMAE 1205

  Fly  1195 VSE-----------LEVENEKLRSEYDQLRTS------IKHGVE--------------------- 1221
            :.|           ||.|..:|:.|.|.|.::      .|..:|                     
  Rat  1206 LGEQIDNLQRVKQKLEKEKSELKMEIDDLSSNAEAIAKAKGNLEKMCRTLEDQVSELKSKEEEQQ 1270

  Fly  1222 --INELNAQHAALQEEVRRRREECIQLKAVLLQQSQS-----------MRSLEPE---------S 1264
              ||||.||.|.||.|......:..:..|::.|.|:|           .|.||.|         :
  Rat  1271 RLINELTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKRQLEEETKAKNALAHA 1335

  Fly  1265 LQMRGNDVNELMEAFHSQK---------------------------LINR--QLESELKAI---- 1296
            ||...:|.:.|.|.:..::                           .|.|  :||...|.:    
  Rat  1336 LQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1400

  Fly  1297 --TEEH----NSKLVEMTQEIERLNNEKDEL---------------------QKVMFESIDEFED 1334
              .|||    |:|...:.:..:||.||.::|                     .||:.|...::|:
  Rat  1401 QAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKVLSEWRQKYEE 1465

  Fly  1335 --SNVDTLRQNDRYLRRELQK---AVAQFLLVQEELKLANAKLKAYRQD-------GGQLEHKIE 1387
              :.:::.::..|.|..||.|   |..:.|...|.|:..|..|:....|       ||:..|::|
  Rat  1466 TQAELESCQKESRTLSTELFKVKNAYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKHIHELE 1530

  Fly  1388 EEMIRNKSNGTSADVGANVTKQKSQNPQGLMKFHSS---DLDKILQRLLSALTPRTVVGLLPGFP 1449
            :             :...|.::|.:....|.:..:|   :..|||:..|.....::.:.      
  Rat  1531 K-------------IKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEID------ 1576

  Fly  1450 AYLIFMCIRYTDLTNADDDVRELLSKFVIQIKKMHRT-PHPIENRVIWLVNSITLLNLMKQYGDV 1513
                      ..:...|:::.:|....:..::.|..| ...|.:|      :..|....|..||:
  Rat  1577 ----------RKIAEKDEEIDQLKRNHIRVVETMQSTLDAEIRSR------NDALRVKKKMEGDL 1625

  Fly  1514 DEYVKFNTEKQNQQQLKNFNLFEYRR---VILDLIVNLYQALIMQIQGLLDPKIVPAILNNDEIQ 1575
            :|   ...:..:..:|...:|..||.   ::.|..::|..||    :|..|.|...||:.     
  Rat  1626 NE---MEIQLNHANRLAAESLRNYRNTQGILKDTQLHLDDAL----RGQEDLKEQLAIVE----- 1678

  Fly  1576 RGRQAHGMRSRATSIGASSSPEHGGGPAWKQLIGQLEHFYKQFQHFGLDNCYAEQIFHQLLYFIC 1640
              |:|:.:::....:.|:              :.|.|...|..:...||.....|:.|       
  Rat  1679 --RRANLLQAEIEELRAT--------------LEQTERSRKIAEQELLDASERVQLLH------- 1720

  Fly  1641 AVALNCLMLRGDICMWETGMIIRYNIGCIEDWVRSKKMSNDVLTALAPLNQVSQ----------- 1694
                                  ..|...|.   ..||:.|||....:.:.:|.|           
  Rat  1721 ----------------------TQNTSLIN---TKKKLENDVSQLQSEVEEVIQESRNAEEKAKK 1760

  Fly  1695 -------LLQSRKSEQDV------------QTICDLCTSLSTAQVLKVMKSYK--------LDDY 1732
                   :.:..|.|||.            ||:.||...|..|:.|.:....|        :.:.
  Rat  1761 AITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVREL 1825

  Fly  1733 ESEITNVFLEKLTEKLNARQMQKSNSDEFTIDQKFIQ---PFKVVFRYSDI-------------K 1781
            |.|:.|      .:|.||..::.....|..:.:...|   ..|.|.|..|:             :
  Rat  1826 EGEVEN------EQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQ 1884

  Fly  1782 LEDIELPSHLNLDEF 1796
            .|:.|..|::||.:|
  Rat  1885 AEEAEEQSNVNLAKF 1899

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 283/741 (38%)
MYSc_Myo5 84..767 CDD:276831 272/711 (38%)
IQ 900..922 CDD:197470 3/26 (12%)
GBP_C <971..1086 CDD:303769 36/166 (22%)
coiled coil 1049..1068 CDD:293879 3/18 (17%)
coiled coil 1077..1086 CDD:293879 2/18 (11%)
JAKMIP_CC3 <1190..1299 CDD:292653 38/203 (19%)
Myo5_CBD 1424..1792 CDD:271254 74/425 (17%)
Myh8NP_001093955.1 Myosin_N 38..75 CDD:280832 10/39 (26%)
Myosin_head 90..769 CDD:278492 276/723 (38%)
Motor_domain 102..769 CDD:277568 272/711 (38%)
Myosin_tail_1 849..1926 CDD:279860 224/1192 (19%)
RILP-like 964..1097 CDD:304877 28/141 (20%)
eIF-4B <1042..1099 CDD:283846 13/65 (20%)
COG6 1375..>1510 CDD:303003 30/134 (22%)
TMPIT 1456..>1584 CDD:285135 26/156 (17%)
TMPIT 1741..>1828 CDD:285135 15/86 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.000

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