DRSC/TRiP Functional Genomics Resources

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Protein Alignment didum and myo7aa

DIOPT Version :9

Sequence 1:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster
Sequence 2:XP_021323248.1 Gene:myo7aa / 252846 ZFINID:ZDB-GENE-020709-1 Length:2185 Species:Danio rerio


Alignment Length:1684 Identity:470/1684 - (27%)
Similarity:746/1684 - (44%) Gaps:385/1684 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 DLVWESATLEESYRKGAG-FLKICTDSGKLKEVKLKADGSD----------LPPLRNPAILVGQN 73
            |.||........:....| .:|:| |||:::  .|..:|::          :.|: :|..:.|..
Zfish     8 DYVWLDLKTGHEFEVPIGAVVKLC-DSGQIQ--VLDDEGNEHWISPQNATNIKPM-HPTSIHGVE 68

  Fly    74 DLTTLSYLHEPGVLHNLRVRFCERQIIYTYC------GIILVAINPYAEMPLYGPSIIRAYRGHA 132
            |:..|..|:|.|:|.||.:|:.| .:|||.|      |.||||:|||..:|:|....||.|....
Zfish    69 DMIRLGDLNEAGILRNLLIRYRE-HLIYTNCGGRTYTGSILVAVNPYQLLPIYTADQIRLYTNKK 132

  Fly   133 MGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESETQVERKV 197
            :|::.|||||:|:..|..::|.|.:...|:|||||||||.|.|..:::.||:.|..|  .:|::|
Zfish   133 IGEMPPHIFAIADNCYFNMQRNNKDQCCIISGESGAGKTESTKLILQFLAAISGQHS--WIEQQV 195

  Fly   198 LASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERN 262
            |.::||:||||||||.||||||||||:..:.| |:.|.  ::||.:..||||||||..||:.|||
Zfish   196 LEANPILEAFGNAKTIRNDNSSRFGKYIDIHF-NKRGA--IEGAKIEQYLLEKSRVCRQARDERN 257

  Fly   263 YHIFYQLCAARSKYP----ELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQ 323
            |||||  |..:...|    :|.|.....:.:|.:|.....:...|.::::....||.||.|:.::
Zfish   258 YHIFY--CMLKGMTPDQKKQLGLSKATDYTYLTIGNCTVCDGRDDQKEYSNIRSAMKVLMFTDKE 320

  Fly   324 IADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMR 388
            ..:|.|:||.|||:||::.     |....::.|:|::..... |...|.||.|...||...|..|
Zfish   321 NWEISKLLAAILHMGNLRY-----EARTYDNLDACEVVRCSA-LTTAAVLLEVDLKDLMNCLTSR 379

  Fly   389 KIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLN------KSLNNGSKQCSFIGVLD 447
            .|.:..|.|..|.|||.|...|||..|.||.:||.:||..:|      .||...:.:.| ||:||
Zfish   380 TIITRGETVSTPLSIEQALDVRDAFVKGIYGRLFVWIVEKINAAIYKPPSLELKAVRRS-IGLLD 443

  Fly   448 IYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIESR 512
            |:|||.|.||||||.|||:|||.|||.|.:||||||||||..|.|.|..|:|.|||..:|:|..:
Zfish   444 IFGFENFMVNSFEQLCINFANENLQQFFVRHVFKLEQEEYNLENINWQHIEFTDNQDALDMIAIK 508

  Fly   513 -LGVLDLLDEECRMPKGSDESWAGKLIGKCNKFPHFEKPRFGT--TSFFIKHFSDTVEYDVNGFL 574
             :.::.|:|||.:.|||:|.:...||..:.....::..|: .|  |.|.|:||:..|.|:..|||
Zfish   509 PMNIISLIDEESKFPKGTDTTMLNKLNSQHKLNTNYIPPK-NTYETQFGIQHFAGVVYYETRGFL 572

  Fly   575 EKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRR 639
            ||||||:..::.|::..|.....||:..        .|.|                 .|.:||:|
Zfish   573 EKNRDTLHGDIIQLVHSSKNKFIKQIFQ--------ADVA-----------------MGAETRKR 612

  Fly   640 VVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLET 704
                   ..|:.|||:.||..|:.||....|.:|||||||:.|....::....::|||..|::||
Zfish   613 -------SPTLSSQFKRSLELLMRTLSVCQPFFVRCIKPNEYKKPMLFDRELCVRQLRYSGMMET 670

  Fly   705 VRISAAGFPSRWLYPDFYMRYQLLV--YRSKLDKNDMKLSCRNIVMKWIQDEDKYRFGNTQIFFR 767
            :||..||:|.|:.:.:|..||::|:  .:....:.|::.:|:.|....:..:|.::.|.|:||.:
Zfish   671 IRIRRAGYPIRYTFVEFVDRYRVLMPGVKPAYKQEDLRGTCQRIAEAVLGRDDDWQMGKTKIFLK 735

  Fly   768 AGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREAR 832
            ......||..|.......:.::|.|||.|..|..||:::|                         
Zfish   736 DHHDMLLEIERDKAITDKVILIQKVVRGFKDRSNFLKMKK------------------------- 775

  Fly   833 AGLILSKYARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRA 897
            :.:::.|..||:.||:.|..:|...|.:|...|.......:|..|.  |.:..|...||.|.|||
Zfish   776 SAMLIQKTWRGYYCRKNYGAMRGGFSRLQALYRSRKLYQTYHVARQ--RIMLFQGRCRGFLVRRA 838

  Fly   898 YQKRRRNIIICQAAIRRFLARRKFKRMKAEAKTISHMENKYMGLENKIISMQQRIDELNRDNSNL 962
            ::.|...:|..||..|..:|||.:||:|.                                    
Zfish   839 FRHRLWAVITIQAYTRGMIARRLYKRLKG------------------------------------ 867

  Fly   963 KHKTSEISVLKMKLELKKTLEAEFKNVKAACQDKDKLIEALNKQLEAERDEKM------QLLEEN 1021
                          |.::.||||    |....::.||...::.:...|..|||      ||..|:
Zfish   868 --------------EYRRRLEAE----KLRLAEEQKLRNQMSARKAKEEAEKMHQERLAQLARED 914

  Fly  1022 GHAQEEWISQKQTWRQENEELRRQIDEI--IDMAKNAEVNQRNQEDRMLAEIDNREL-------- 1076
              |:.|        ::|.:|.||:::.:  ::.|:...||..:..|:|...:.....        
Zfish   915 --AERE--------KKERQEARRKMEMLDQMEKARQEPVNDSDMVDKMFGFLGTTNSFPGQEGQA 969

  Fly  1077 ---NEAYQRAIKDKEVIE-NENFMLKEELSRLTAGSFSLHARKASNASSQNEDDVGYASAKNTLD 1137
               .|..:|..::.||.: :|:..|.|:                     ..||...|..||.:. 
Zfish   970 PAGFEDLERTHRELEVEDLDESLPLPED---------------------DLEDLSEYKFAKFSA- 1012

  Fly  1138 INRPPDLLSKNYSYNDSTSLVVKLRSILEEEKQKHKVLQEQYIKLSSRHKPTEDSFRVSELEVEN 1202
                        :|...||....:|..|::....|:                ::..:::.|.|..
Zfish  1013 ------------TYFQGTSTHTYMRRPLKQPLLFHE----------------DEGDQLAALAVWI 1049

  Fly  1203 EKLRSEYD----QLRTSIKHGVE-INELNAQHAALQEEVRRRREECIQLKAVLLQQSQSMRSLEP 1262
            ..||...|    :..|:|..|.| |..:...:..|.::..:|                     |.
Zfish  1050 TVLRFMGDLPEPKYHTAISDGSEKIPVMTKIYETLGKKTYKR---------------------EL 1093

  Fly  1263 ESLQMRGNDVNELMEAFHSQ-----KLINRQLESELKAITEE------------HNSKLVEMTQE 1310
            ::||..|.:.|  :|: |.:     ||::..|:.:.| ||||            |.:.::|    
Zfish  1094 QALQGEGENTN--IES-HKKSSVRHKLVSLTLKKKSK-ITEEVTKRLNDGEYTVHGNSMLE---- 1150

  Fly  1311 IERLNNEKDELQKVMFESIDEFEDSNVDTLRQNDRYLRRELQKAVAQFLLVQEELKLANAK---- 1371
             :|..:..::|..::...|          ||..   ||.|:...:.: .|.|...|.::|:    
Zfish  1151 -DRPTSNLEKLHFIIGNGI----------LRPG---LRDEIYCQICK-QLNQNPSKSSHARGWIL 1200

  Fly  1372 -----------------LKAYRQDG--GQLEHKIEEEMIRNKSNGTSADVGANVTKQ--KSQNP- 1414
                             |:.:..:|  |...: .||.:.|...|||.....:.:..|  ||:.| 
Zfish  1201 MSLCVGCFAPSEKFVKYLRNFISEGPPGYAPY-CEERLRRTFVNGTRTQPPSWLELQATKSKKPI 1264

  Fly  1415 -------QGLMKFHSSDLDKILQRLLSALTPRTVVGLLPGFPAYLIFMCIRYTDLTNADDDVREL 1472
                   .|..|...:|.....:.|.:||:.:..:....||..| |.:..:.:.|.:.:|.|.:.
Zfish  1265 MLPVTFMDGTTKTLLTDSATTAKELCNALSDKISLQDRFGFSLY-IALFDKVSSLGSGNDHVMDA 1328

  Fly  1473 LSK----------------FVIQIKKMHRTP--HPIENRVIWLVNSITLLNLMKQYGDVDEYVKF 1519
            :|:                :.:..:|...||  .|.|:.|        ..||:  |..:...|||
Zfish  1329 VSQCEQYAKEQGAQERNAPWRLFFRKEIFTPWHDPAEDAV--------ATNLI--YQQIVRGVKF 1383

  Fly  1520 NTEKQNQQQLKNFNLFEYRRVILDLIVNLYQALIMQIQGLLDPKIVPAILNNDEIQRGR 1578
            ...:.:::.|......:|   .:|     |.:.|: ::.||  .::|:.:.:.||...:
Zfish  1384 GEYRCDREDLAELASQQY---YVD-----YGSEIL-VERLL--SLIPSYIPDREISSAK 1431

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
didumNP_724569.1 MYSc 65..778 CDD:214580 283/733 (39%)
MYSc_Myo5 84..767 CDD:276831 275/703 (39%)
IQ 900..922 CDD:197470 8/21 (38%)
GBP_C <971..1086 CDD:303769 28/133 (21%)
coiled coil 1049..1068 CDD:293879 4/20 (20%)
coiled coil 1077..1086 CDD:293879 2/8 (25%)
JAKMIP_CC3 <1190..1299 CDD:292653 25/118 (21%)
Myo5_CBD 1424..1792 CDD:271254 34/173 (20%)
myo7aaXP_021323248.1 MYSc_Myo7 79..735 CDD:276832 275/703 (39%)
IQ 772..793 CDD:197470 6/45 (13%)
MAP7 <863..941 CDD:310345 25/141 (18%)
UFD1 893..>1160 CDD:332114 66/356 (19%)
MyTH4 1023..1259 CDD:214535 54/296 (18%)
B41 1265..1479 CDD:214604 36/189 (19%)
FERM_C1_MyoVII 1473..1571 CDD:270019
SH3 1572..1636 CDD:327375
MyTH4 1716..1864 CDD:214535
B41 1871..2083 CDD:214604
FERM_C2_MyoVII 2079..2174 CDD:270020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100101
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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